SI3350180T1 - Derivati spojine 8-(6-(3-(amino)propoksi)-3-piridil)-1-izpropil-imidazo (4,5-c)kinolin-2-on, kot selektivni modulatorji ataksijia telangiektazija mutirane (ATM) kinaze za zdravljenje raka - Google Patents

Derivati spojine 8-(6-(3-(amino)propoksi)-3-piridil)-1-izpropil-imidazo (4,5-c)kinolin-2-on, kot selektivni modulatorji ataksijia telangiektazija mutirane (ATM) kinaze za zdravljenje raka

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Publication number
SI3350180T1
SI3350180T1 SI201631074T SI201631074T SI3350180T1 SI 3350180 T1 SI3350180 T1 SI 3350180T1 SI 201631074 T SI201631074 T SI 201631074T SI 201631074 T SI201631074 T SI 201631074T SI 3350180 T1 SI3350180 T1 SI 3350180T1
Authority
SI
Slovenia
Prior art keywords
quinolin
imidazo
propoxy
pyridyl
atm
Prior art date
Application number
SI201631074T
Other languages
English (en)
Slovenian (sl)
Inventor
Kurt Gordon Pike
Bernard Christophe Barlaam
Thomas Anthony Hunt
Andrew John Eatherton
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of SI3350180T1 publication Critical patent/SI3350180T1/sl

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
SI201631074T 2015-09-17 2016-09-15 Derivati spojine 8-(6-(3-(amino)propoksi)-3-piridil)-1-izpropil-imidazo (4,5-c)kinolin-2-on, kot selektivni modulatorji ataksijia telangiektazija mutirane (ATM) kinaze za zdravljenje raka SI3350180T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1516504.6A GB201516504D0 (en) 2015-09-17 2015-09-17 Imadazo(4,5-c)quinolin-2-one Compounds and their use in treating cancer
EP16770461.8A EP3350180B1 (en) 2015-09-17 2016-09-15 8-[6-[3-(amino)propoxy]-3-pyridyl]-1-isopropyl-imidazo[4,5-c]quinolin-2-one derivatives as selective modulators of ataxia telangiectasia mutated (atm) kinase for the treatment of cancer
PCT/EP2016/071782 WO2017046216A1 (en) 2015-09-17 2016-09-15 8-[6-[3-(amino)propoxy]-3-pyridyl]-1 -isopropyl-imidazo[4,5-c]quinolin-2-one derivatives as selective modulators of ataxia telangiectasia mutated (atm) kinase for the treatment of cancer

Publications (1)

Publication Number Publication Date
SI3350180T1 true SI3350180T1 (sl) 2021-03-31

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SI201631074T SI3350180T1 (sl) 2015-09-17 2016-09-15 Derivati spojine 8-(6-(3-(amino)propoksi)-3-piridil)-1-izpropil-imidazo (4,5-c)kinolin-2-on, kot selektivni modulatorji ataksijia telangiektazija mutirane (ATM) kinaze za zdravljenje raka

Country Status (37)

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US (5) US9856255B2 (enExample)
EP (2) EP3350180B1 (enExample)
JP (1) JP6605130B2 (enExample)
KR (2) KR102028848B1 (enExample)
CN (1) CN108137576B (enExample)
AR (1) AR106053A1 (enExample)
AU (1) AU2016323399B2 (enExample)
BR (1) BR112018004325B1 (enExample)
CA (1) CA2997399C (enExample)
CL (1) CL2018000677A1 (enExample)
CO (1) CO2018002829A2 (enExample)
CR (1) CR20180172A (enExample)
CY (1) CY1124680T1 (enExample)
DK (2) DK3350180T3 (enExample)
DO (1) DOP2018000065A (enExample)
EA (1) EA033284B1 (enExample)
ES (2) ES2920876T3 (enExample)
GB (1) GB201516504D0 (enExample)
HR (1) HRP20210149T1 (enExample)
HU (2) HUE053066T2 (enExample)
IL (1) IL257847B (enExample)
LT (1) LT3350180T (enExample)
MX (1) MX384930B (enExample)
MY (2) MY198813A (enExample)
NI (1) NI201800033A (enExample)
PE (1) PE20181078A1 (enExample)
PH (1) PH12018500532A1 (enExample)
PL (2) PL3683220T3 (enExample)
PT (2) PT3683220T (enExample)
RS (1) RS61435B1 (enExample)
SI (1) SI3350180T1 (enExample)
SM (1) SMT202100071T1 (enExample)
SV (1) SV2018005655A (enExample)
TN (1) TN2018000078A1 (enExample)
TW (2) TWI762109B (enExample)
WO (1) WO2017046216A1 (enExample)
ZA (1) ZA202209171B (enExample)

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