JP2015511217A5 - - Google Patents

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Publication number
JP2015511217A5
JP2015511217A5 JP2014552503A JP2014552503A JP2015511217A5 JP 2015511217 A5 JP2015511217 A5 JP 2015511217A5 JP 2014552503 A JP2014552503 A JP 2014552503A JP 2014552503 A JP2014552503 A JP 2014552503A JP 2015511217 A5 JP2015511217 A5 JP 2015511217A5
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JP
Japan
Prior art keywords
independently
heterocyclyl
alkyl
optionally substituted
pharmaceutically acceptable
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JP2014552503A
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English (en)
Japanese (ja)
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JP6228130B2 (ja
JP2015511217A (ja
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Priority claimed from PCT/CN2013/070755 external-priority patent/WO2013107405A1/en
Publication of JP2015511217A publication Critical patent/JP2015511217A/ja
Publication of JP2015511217A5 publication Critical patent/JP2015511217A5/ja
Application granted granted Critical
Publication of JP6228130B2 publication Critical patent/JP6228130B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2014552503A 2012-01-19 2013-01-21 治療活性化合物およびそれらの使用方法 Expired - Fee Related JP6228130B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CNPCT/CN2012/070607 2012-01-19
CN2012070607 2012-01-19
PCT/CN2013/070755 WO2013107405A1 (en) 2012-01-19 2013-01-21 Therapeutically active compounds and their methods of use

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2017198488A Division JP2018021072A (ja) 2012-01-19 2017-10-12 治療活性化合物およびそれらの使用方法

Publications (3)

Publication Number Publication Date
JP2015511217A JP2015511217A (ja) 2015-04-16
JP2015511217A5 true JP2015511217A5 (enExample) 2017-10-12
JP6228130B2 JP6228130B2 (ja) 2017-11-08

Family

ID=48798662

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2014552503A Expired - Fee Related JP6228130B2 (ja) 2012-01-19 2013-01-21 治療活性化合物およびそれらの使用方法
JP2017198488A Withdrawn JP2018021072A (ja) 2012-01-19 2017-10-12 治療活性化合物およびそれらの使用方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2017198488A Withdrawn JP2018021072A (ja) 2012-01-19 2017-10-12 治療活性化合物およびそれらの使用方法

Country Status (7)

Country Link
US (2) US20150087600A1 (enExample)
EP (1) EP2804850B1 (enExample)
JP (2) JP6228130B2 (enExample)
CA (1) CA2860858A1 (enExample)
ES (1) ES2698625T3 (enExample)
MX (1) MX350432B (enExample)
WO (1) WO2013107405A1 (enExample)

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CR20170071A (es) 2009-06-29 2017-03-28 Agios Pharmaceuticals Inc Compuestos terapeuticos y composiciones
WO2011050210A1 (en) 2009-10-21 2011-04-28 Agios Pharmaceuticals, Inc. Methods and compositions for cell-proliferation-related disorders
ME03074B (me) 2011-05-03 2019-01-20 Agios Pharmaceuticals Inc Akтivatori piruvat kinaze za upotrebu u terapiji
CN102827170A (zh) 2011-06-17 2012-12-19 安吉奥斯医药品有限公司 治疗活性组合物和它们的使用方法
CN102827073A (zh) 2011-06-17 2012-12-19 安吉奥斯医药品有限公司 治疗活性组合物和它们的使用方法
KR101893112B1 (ko) 2012-01-06 2018-08-30 아지오스 파마슈티컬스 아이엔씨. 치료학적으로 활성인 화합물 및 이의 이용 방법
US9474779B2 (en) 2012-01-19 2016-10-25 Agios Pharmaceuticals, Inc. Therapeutically active compositions and their methods of use
WO2014062511A1 (en) 2012-10-15 2014-04-24 Agios Pharmaceuticals, Inc. Therapeutic compounds and compositions
PE20160744A1 (es) 2013-07-11 2016-08-01 Agios Pharmaceuticals Inc Compuestos de n,6-bis(aril o heteroaril)-1,3,5-triazin-2,4-diamina como inhibidores de idh2 mutantes para el tratamiento de cancer
WO2015003360A2 (en) 2013-07-11 2015-01-15 Agios Pharmaceuticals, Inc. Therapeutically active compounds and their methods of use
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KR101861869B1 (ko) * 2013-09-10 2018-05-28 경희대학교 산학협력단 신규한 비스-아미드 유도체 및 이의 용도
CN103694142A (zh) * 2013-11-28 2014-04-02 浙江科技学院 4-N-Boc-氨基环己酮的制备方法
PH12021551647A1 (en) 2014-03-14 2022-06-06 Agios Pharmaceuticals Inc Pharmaceutical compositions of therapeutically active compounds
CA2946538A1 (en) 2014-04-04 2015-10-08 Del Mar Pharmaceuticals Use of dianhydrogalactitol and analogs or derivatives thereof to treat non-small-cell carcinoma of the lung and ovarian cancer
DK3202766T3 (da) 2014-10-01 2020-03-23 Daiichi Sankyo Co Ltd Isoxazolderivat som muteret isocitratdehydrogenase 1-inhibitor
EP3209646B1 (en) * 2014-10-23 2020-07-22 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Benzimidazol-2-amines as midh1 inhibitors
WO2016089833A1 (en) 2014-12-05 2016-06-09 Merck Sharp & Dohme Corp. Novel tricyclic compounds as inhibitors of mutant idh enzymes
MA44392B1 (fr) 2015-06-11 2023-10-31 Agios Pharmaceuticals Inc Procédés d'utilisation d'activateurs de la pyruvate kinase
KR20250126877A (ko) 2015-10-15 2025-08-25 르 라보레또레 쎄르비에르 악성 종양의 치료를 위한 조합물 요법
ES2897959T3 (es) 2015-10-15 2022-03-03 Servier Lab Terapia de combinación para tratar neoplasias malignas
WO2017140758A1 (en) 2016-02-19 2017-08-24 Debiopharm International S.A. Derivatives of 2-amino-4-(2-oxazolidinon-3-yl)-pyrimidine fused with a five-membered heteroaromatic ring in 5,6-position which are useful for the treatment of various cancers
US11111240B2 (en) * 2016-03-22 2021-09-07 Chai Tai Tianqing Pharmaceutical Group Co., Ltd. Sultam compound and application method thereof
CN109071429B (zh) * 2016-03-22 2021-04-02 正大天晴药业集团股份有限公司 丙啶磺酰胺类化合物及其使用方法
SG11201907945YA (en) * 2017-02-28 2019-09-27 Chia Tai Tianqing Pharmaceutical Group Co Ltd Azetidine derivative
WO2019057142A1 (zh) 2017-09-22 2019-03-28 正大天晴药业集团股份有限公司 一种内磺酰胺化合物结晶
CN107827880B (zh) * 2017-10-17 2020-05-22 浙江工业大学上虞研究院有限公司 一种含咪唑和1,3,4-噁二唑结构的甲腈类化合物及其制备方法和应用
US11013734B2 (en) 2018-05-16 2021-05-25 Forma Therapeutics, Inc. Treating patients harboring an isocitrate dehydrogenase-1 (IDH-1) mutation
US20210196701A1 (en) 2018-05-16 2021-07-01 Forma Therapeutics, Inc. Inhibiting mutant idh-1
US11311527B2 (en) 2018-05-16 2022-04-26 Forma Therapeutics, Inc. Inhibiting mutant isocitrate dehydrogenase 1 (mIDH-1)
WO2019222551A1 (en) 2018-05-16 2019-11-21 Forma Therapeutics, Inc. Solid forms of ((s)-5-((1-(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl)amino)-1-methyl-6-oxo-1,6-dihydropyridine-2-carbonitrile
US11013733B2 (en) 2018-05-16 2021-05-25 Forma Therapeutics, Inc. Inhibiting mutant isocitrate dehydrogenase 1 (mlDH-1)
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CN109535025B (zh) * 2018-12-18 2022-09-09 尚科生物医药(上海)有限公司 一种艾伏尼布中间体3,3-二氟环丁胺盐酸盐的制备方法
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TW202120486A (zh) * 2019-08-09 2021-06-01 英商阿帝歐斯製藥有限公司 新穎化合物
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WO2024153143A1 (zh) * 2023-01-18 2024-07-25 中国药科大学 含氮并环类化合物及其应用
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WO2012009678A1 (en) * 2010-07-16 2012-01-19 Agios Pharmaceuticals, Inc. Therapeutically active compositions and their method of use
US9474779B2 (en) * 2012-01-19 2016-10-25 Agios Pharmaceuticals, Inc. Therapeutically active compositions and their methods of use
US20150031627A1 (en) * 2013-07-25 2015-01-29 Agios Pharmaceuticals, Inc Therapeutically active compounds and their methods of use

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