JP2013523652A5 - - Google Patents
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- JP2013523652A5 JP2013523652A5 JP2013501501A JP2013501501A JP2013523652A5 JP 2013523652 A5 JP2013523652 A5 JP 2013523652A5 JP 2013501501 A JP2013501501 A JP 2013501501A JP 2013501501 A JP2013501501 A JP 2013501501A JP 2013523652 A5 JP2013523652 A5 JP 2013523652A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- compound
- alkyl
- group
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 20
- 229910052757 nitrogen Inorganic materials 0.000 claims 13
- 125000000217 alkyl group Chemical group 0.000 claims 12
- 229910052739 hydrogen Inorganic materials 0.000 claims 12
- 239000001257 hydrogen Substances 0.000 claims 12
- 125000005842 heteroatom Chemical group 0.000 claims 11
- 125000001072 heteroaryl group Chemical group 0.000 claims 9
- 229910052736 halogen Inorganic materials 0.000 claims 7
- 150000002367 halogens Chemical class 0.000 claims 7
- 150000002431 hydrogen Chemical group 0.000 claims 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 5
- 125000003545 alkoxy group Chemical group 0.000 claims 4
- 125000003118 aryl group Chemical group 0.000 claims 4
- 150000001204 N-oxides Chemical class 0.000 claims 3
- 125000000753 cycloalkyl group Chemical group 0.000 claims 3
- 125000000623 heterocyclic group Chemical group 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 206010016654 Fibrosis Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 230000033115 angiogenesis Effects 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000004761 fibrosis Effects 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 206010020718 hyperplasia Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 208000037803 restenosis Diseases 0.000 claims 1
- 125000000547 substituted alkyl group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31722310P | 2010-03-24 | 2010-03-24 | |
| US61/317,223 | 2010-03-24 | ||
| PCT/US2011/029879 WO2011119894A2 (en) | 2010-03-24 | 2011-03-24 | Heterocyclic compounds useful for kinase inhibition |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016236174A Division JP6391126B2 (ja) | 2010-03-24 | 2016-12-05 | キナーゼ阻害に役立つ複素環式化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013523652A JP2013523652A (ja) | 2013-06-17 |
| JP2013523652A5 true JP2013523652A5 (enExample) | 2014-05-15 |
| JP6065183B2 JP6065183B2 (ja) | 2017-01-25 |
Family
ID=44673873
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013501501A Expired - Fee Related JP6065183B2 (ja) | 2010-03-24 | 2011-03-24 | キナーゼ阻害に役立つ複素環式化合物 |
| JP2016236174A Expired - Fee Related JP6391126B2 (ja) | 2010-03-24 | 2016-12-05 | キナーゼ阻害に役立つ複素環式化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016236174A Expired - Fee Related JP6391126B2 (ja) | 2010-03-24 | 2016-12-05 | キナーゼ阻害に役立つ複素環式化合物 |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US8957216B2 (enExample) |
| EP (1) | EP2550266B1 (enExample) |
| JP (2) | JP6065183B2 (enExample) |
| KR (2) | KR101844088B1 (enExample) |
| CN (1) | CN102884060B (enExample) |
| AU (2) | AU2011232372B2 (enExample) |
| CA (1) | CA2794086A1 (enExample) |
| ES (1) | ES2677356T3 (enExample) |
| IL (1) | IL222068B (enExample) |
| MX (2) | MX339192B (enExample) |
| RU (2) | RU2640862C2 (enExample) |
| WO (1) | WO2011119894A2 (enExample) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI625121B (zh) | 2009-07-13 | 2018-06-01 | 基利科學股份有限公司 | 調節細胞凋亡信號之激酶的抑制劑 |
| US9260417B2 (en) * | 2010-02-08 | 2016-02-16 | Amitech Therapeutic Solutions, Inc. | Therapeutic methods and compositions involving allosteric kinase inhibition |
| CA2794086A1 (en) * | 2010-03-24 | 2011-09-29 | Amitech Therapeutic Solutions, Inc. | Heterocyclic compounds useful for kinase inhibition |
| KR101759759B1 (ko) | 2010-07-02 | 2017-07-19 | 길리애드 사이언시즈, 인코포레이티드 | 세포자멸사 신호-조절 키나아제 저해제 |
| PL2651417T3 (pl) | 2010-12-16 | 2017-08-31 | Calchan Limited | Pochodne pirolopirymidyny hamujące ASK1 |
| WO2012088266A2 (en) | 2010-12-22 | 2012-06-28 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3 |
| US9408885B2 (en) | 2011-12-01 | 2016-08-09 | Vib Vzw | Combinations of therapeutic agents for treating melanoma |
| UY34573A (es) | 2012-01-27 | 2013-06-28 | Gilead Sciences Inc | Inhibidor de la quinasa que regula la señal de la apoptosis |
| HUE042374T2 (hu) | 2012-06-13 | 2019-06-28 | Incyte Holdings Corp | Szubsztituált triciklusos vegyületek mint FGFR inhibitorok |
| US9388185B2 (en) | 2012-08-10 | 2016-07-12 | Incyte Holdings Corporation | Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors |
| US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
| HUE036571T2 (hu) | 2013-04-19 | 2018-07-30 | Incyte Holdings Corp | Biciklusos heterociklusok mint FGFR inhibitorok |
| WO2015162518A1 (en) | 2014-04-25 | 2015-10-29 | Pfizer Inc. | Heteroaromatic compounds and their use as dopamine d1 ligands |
| MD20160109A2 (ro) * | 2014-04-25 | 2017-04-30 | Pfizer Inc. | Compuşi heteroaromatici şi utilizarea lor ca liganzi ai dopaminei D1 |
| NZ729678A (en) | 2014-09-24 | 2018-07-27 | Gilead Sciences Inc | Methods of treating non-alcoholic steatohepatitis using ask1 inhibitor in combination with a fxr agonist |
| US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| MA41252A (fr) | 2014-12-23 | 2017-10-31 | Gilead Sciences Inc | Formes solides d'un inhibiteur d'ask 1 |
| TWI749934B (zh) | 2014-12-23 | 2021-12-11 | 美商基利科學股份有限公司 | 製備2-氟-4-甲基-5-(4-環丙基-1h-咪唑-1-基)苯甲酸之方法 |
| MX388991B (es) | 2015-02-20 | 2025-03-20 | Incyte Corp | Heterociclos biciclicos como inhibidores de receptores del factor de crecimiento fibroblastico (fgfr) |
| US9580423B2 (en) | 2015-02-20 | 2017-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
| CN112028825B (zh) * | 2015-04-07 | 2025-03-14 | 广东众生睿创生物科技有限公司 | 酪氨酸激酶抑制剂及包含该酪氨酸激酶抑制剂的药物组合物 |
| ES2928773T3 (es) | 2017-01-17 | 2022-11-22 | Heparegenix Gmbh | Inhibidores de proteína cinasas para fomentar la regeneración hepática o reducir o prevenir la muerte de hepatocitos |
| JP7341060B2 (ja) | 2017-02-10 | 2023-09-08 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | Ｍａｐｋ経路の活性化に関連付けられる癌の処置のための方法及び医薬組成物 |
| AR111960A1 (es) | 2017-05-26 | 2019-09-04 | Incyte Corp | Formas cristalinas de un inhibidor de fgfr y procesos para su preparación |
| WO2019133810A1 (en) | 2017-12-28 | 2019-07-04 | Tract Pharmaceuticals, Inc. | Stem cell culture systems for columnar epithelial stem cells, and uses related thereto |
| CN108191781B (zh) * | 2018-01-08 | 2020-01-21 | 浙江大学 | 取代三氮唑类衍生物及其在制备抗肿瘤转移药物中的应用 |
| GB201801226D0 (en) * | 2018-01-25 | 2018-03-14 | Redx Pharma Plc | Modulators of Rho-associated protein kinase |
| EP3788047B1 (en) | 2018-05-04 | 2024-09-04 | Incyte Corporation | Solid forms of an fgfr inhibitor and processes for preparing the same |
| BR112020022373A2 (pt) | 2018-05-04 | 2021-02-02 | Incyte Corporation | sais de um inibidor de fgfr |
| CN108586439A (zh) * | 2018-06-03 | 2018-09-28 | 刘思良 | 一种Raf激酶抑制剂及其在癌症治疗中的应用 |
| CN108864060A (zh) * | 2018-06-03 | 2018-11-23 | 刘思良 | 一种重氮类衍生物及其在癌症治疗中的应用 |
| CN108610336A (zh) * | 2018-06-03 | 2018-10-02 | 刘思良 | 一种重氮类衍生物及其在癌症治疗中的应用 |
| US11628162B2 (en) | 2019-03-08 | 2023-04-18 | Incyte Corporation | Methods of treating cancer with an FGFR inhibitor |
| US20220143049A1 (en) | 2019-03-21 | 2022-05-12 | Onxeo | A dbait molecule in combination with kinase inhibitor for the treatment of cancer |
| US12523663B2 (en) | 2019-06-04 | 2026-01-13 | Inserm (Institut National De La Santé Et De La Rescherche Médicale) | Use of CD9 as a biomarker and as a biotarget in glomerulonephritis or glomerulosclerosis |
| US11591329B2 (en) | 2019-07-09 | 2023-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| WO2021067374A1 (en) | 2019-10-01 | 2021-04-08 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| KR20220100879A (ko) | 2019-10-14 | 2022-07-18 | 인사이트 코포레이션 | Fgfr 저해제로서의 이환식 헤테로사이클 |
| US11566028B2 (en) | 2019-10-16 | 2023-01-31 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| EP4054579A1 (en) | 2019-11-08 | 2022-09-14 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Methods for the treatment of cancers that have acquired resistance to kinase inhibitors |
| WO2021113479A1 (en) | 2019-12-04 | 2021-06-10 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
| KR20220131900A (ko) | 2019-12-04 | 2022-09-29 | 인사이트 코포레이션 | Fgfr 억제제의 유도체 |
| US12012409B2 (en) | 2020-01-15 | 2024-06-18 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| US12195490B2 (en) | 2020-01-30 | 2025-01-14 | The Regents Of The University Of California | STRAD-binding agents and uses thereof |
| WO2022221170A1 (en) | 2021-04-12 | 2022-10-20 | Incyte Corporation | Combination therapy comprising an fgfr inhibitor and a nectin-4 targeting agent |
| TW202313611A (zh) | 2021-06-09 | 2023-04-01 | 美商英塞特公司 | 作為ｆｇｆｒ抑制劑之三環雜環 |
| EP4352060A1 (en) | 2021-06-09 | 2024-04-17 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
| AU2023274003A1 (en) | 2022-05-19 | 2025-01-02 | Astrazeneca Ab | Amido heteroaromatic compounds useful in the treatment of liver diseases |
| WO2023222849A1 (en) * | 2022-05-19 | 2023-11-23 | Astrazeneca Ab | Amino heteroaromatic compounds useful in the treatment of liver diseases |
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| US9260417B2 (en) | 2010-02-08 | 2016-02-16 | Amitech Therapeutic Solutions, Inc. | Therapeutic methods and compositions involving allosteric kinase inhibition |
| CA2794086A1 (en) | 2010-03-24 | 2011-09-29 | Amitech Therapeutic Solutions, Inc. | Heterocyclic compounds useful for kinase inhibition |
-
2011
- 2011-03-24 CA CA2794086A patent/CA2794086A1/en not_active Abandoned
- 2011-03-24 EP EP11760266.4A patent/EP2550266B1/en not_active Not-in-force
- 2011-03-24 MX MX2012010980A patent/MX339192B/es active IP Right Grant
- 2011-03-24 MX MX2016006136A patent/MX345552B/es unknown
- 2011-03-24 RU RU2012144751A patent/RU2640862C2/ru active
- 2011-03-24 CN CN201180023503.5A patent/CN102884060B/zh not_active Expired - Fee Related
- 2011-03-24 RU RU2018100142A patent/RU2018100142A/ru unknown
- 2011-03-24 ES ES11760266.4T patent/ES2677356T3/es active Active
- 2011-03-24 KR KR1020127027421A patent/KR101844088B1/ko not_active Expired - Fee Related
- 2011-03-24 JP JP2013501501A patent/JP6065183B2/ja not_active Expired - Fee Related
- 2011-03-24 AU AU2011232372A patent/AU2011232372B2/en not_active Ceased
- 2011-03-24 WO PCT/US2011/029879 patent/WO2011119894A2/en not_active Ceased
- 2011-03-24 US US13/636,298 patent/US8957216B2/en active Active
- 2011-03-24 KR KR1020187008081A patent/KR20180032686A/ko not_active Ceased
-
2012
- 2012-09-23 IL IL222068A patent/IL222068B/en not_active IP Right Cessation
-
2015
- 2015-02-12 US US14/620,527 patent/US9212151B2/en not_active Expired - Fee Related
- 2015-12-10 US US14/965,334 patent/US10214513B2/en active Active
-
2016
- 2016-09-23 AU AU2016231623A patent/AU2016231623B2/en not_active Ceased
- 2016-12-05 JP JP2016236174A patent/JP6391126B2/ja not_active Expired - Fee Related
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