JP2013542241A5 - - Google Patents
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- Publication number
- JP2013542241A5 JP2013542241A5 JP2013538215A JP2013538215A JP2013542241A5 JP 2013542241 A5 JP2013542241 A5 JP 2013542241A5 JP 2013538215 A JP2013538215 A JP 2013538215A JP 2013538215 A JP2013538215 A JP 2013538215A JP 2013542241 A5 JP2013542241 A5 JP 2013542241A5
- Authority
- JP
- Japan
- Prior art keywords
- inhibitor
- pharmaceutically acceptable
- acceptable salt
- cancer
- alkylating agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10382300.1 | 2010-11-12 | ||
| EP10382300 | 2010-11-12 | ||
| PCT/EP2011/069976 WO2012062920A1 (en) | 2010-11-12 | 2011-11-11 | Combination therapy with an antitumor alkaloid |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016092369A Division JP6723815B2 (ja) | 2010-11-12 | 2016-05-02 | 抗腫瘍アルカロイドを用いる、組み合わせの治療法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013542241A JP2013542241A (ja) | 2013-11-21 |
| JP2013542241A5 true JP2013542241A5 (enExample) | 2014-12-25 |
| JP6382516B2 JP6382516B2 (ja) | 2018-08-29 |
Family
ID=44936282
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013538215A Active JP6382516B2 (ja) | 2010-11-12 | 2011-11-11 | 抗腫瘍アルカロイドを用いる、組み合わせの治療法 |
| JP2016092369A Active JP6723815B2 (ja) | 2010-11-12 | 2016-05-02 | 抗腫瘍アルカロイドを用いる、組み合わせの治療法 |
| JP2018059776A Active JP6724055B2 (ja) | 2010-11-12 | 2018-03-27 | 抗腫瘍アルカロイドを用いる、組み合わせの治療法 |
| JP2018059777A Active JP6724056B2 (ja) | 2010-11-12 | 2018-03-27 | 抗腫瘍アルカロイドを用いる、組み合わせの治療法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016092369A Active JP6723815B2 (ja) | 2010-11-12 | 2016-05-02 | 抗腫瘍アルカロイドを用いる、組み合わせの治療法 |
| JP2018059776A Active JP6724055B2 (ja) | 2010-11-12 | 2018-03-27 | 抗腫瘍アルカロイドを用いる、組み合わせの治療法 |
| JP2018059777A Active JP6724056B2 (ja) | 2010-11-12 | 2018-03-27 | 抗腫瘍アルカロイドを用いる、組み合わせの治療法 |
Country Status (24)
| Country | Link |
|---|---|
| US (5) | US20130266666A1 (enExample) |
| EP (6) | EP2786756B1 (enExample) |
| JP (4) | JP6382516B2 (enExample) |
| KR (9) | KR102301175B1 (enExample) |
| CN (3) | CN103282037B (enExample) |
| AU (4) | AU2011328004C1 (enExample) |
| BR (4) | BR122017028566B1 (enExample) |
| CA (4) | CA2995025C (enExample) |
| CY (4) | CY1117466T1 (enExample) |
| DK (4) | DK2786753T3 (enExample) |
| ES (4) | ES2719091T3 (enExample) |
| HK (1) | HK1202422A1 (enExample) |
| HR (4) | HRP20160361T1 (enExample) |
| HU (4) | HUE027516T2 (enExample) |
| LT (3) | LT2786754T (enExample) |
| ME (3) | ME03501B (enExample) |
| PL (4) | PL2786754T3 (enExample) |
| PT (3) | PT2786754T (enExample) |
| RS (4) | RS58609B1 (enExample) |
| RU (4) | RU2605335C2 (enExample) |
| SI (4) | SI2786753T1 (enExample) |
| SM (4) | SMT202000211T1 (enExample) |
| TR (2) | TR201903859T4 (enExample) |
| WO (1) | WO2012062920A1 (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8491927B2 (en) * | 2009-12-02 | 2013-07-23 | Nimble Epitech, Llc | Pharmaceutical composition containing a hypomethylating agent and a histone deacetylase inhibitor |
| SI2786753T1 (sl) * | 2010-11-12 | 2019-05-31 | Pharma Mar S.A. | Kombinacijska terapija s protitumorskim antibiotikom |
| JP2016519684A (ja) | 2013-04-08 | 2016-07-07 | デニス エム ブラウン | 準最適に投与された薬物療法の有効性を改善するための及び／又は副作用を低減するための方法および組成物 |
| KR101588949B1 (ko) * | 2014-03-13 | 2016-01-29 | 아주대학교산학협력단 | 플루나리진을 유효성분으로 함유하는 뇌암에 대한 항암 활성 보조제 |
| US11326210B2 (en) * | 2015-01-30 | 2022-05-10 | Glax Llc | Compositions and methods for monitoring, diagnosis, prognosis, detection, and treatment of cancer |
| CA3239447A1 (en) * | 2016-01-11 | 2017-07-20 | Syndevrx, Inc. | Treatment for tumors driven by metabolic dysfunction |
| JOP20190254A1 (ar) | 2017-04-27 | 2019-10-27 | Pharma Mar Sa | مركبات مضادة للأورام |
| EP3870231A1 (en) | 2018-10-26 | 2021-09-01 | Syndevrx, Inc. | Biomarkers of metap2 inhibitors and applications thereof |
| BR112022003149A2 (pt) * | 2019-09-03 | 2022-05-17 | Pharma Mar Sa | Lurbinectedina no tratamento de mesotelioma maligno |
| KR20210049403A (ko) * | 2019-10-25 | 2021-05-06 | 연세대학교 산학협력단 | 암의 예방 또는 치료용 조성물 |
| PH12022551216A1 (en) | 2019-11-21 | 2023-07-17 | Pharma Mar Sa | Methods of treating small cell lung cancer with lurbinectedin formulations |
| WO2021228414A1 (en) * | 2020-05-14 | 2021-11-18 | Pharma Mar, S.A. | Methods of treating small cell lung cancer with lurbinectedin formulations |
| MA56827B2 (fr) * | 2019-11-21 | 2023-09-27 | Pharma Mar Sa | Procédés de traitement du cancer du poumon à petites cellules avec des formulations de lurbinectédine |
| CN111298122B (zh) * | 2019-12-04 | 2021-12-21 | 哈尔滨商业大学 | 用于治疗小细胞肺癌的药物组合物及其应用 |
| WO2021138391A1 (en) | 2019-12-30 | 2021-07-08 | Tyra Biosciences, Inc. | Indazole compounds |
| CN113491771A (zh) * | 2020-03-18 | 2021-10-12 | 苏州大学 | 小分子化合物在制备glut5摄取转运果糖的抑制剂中的应用 |
| WO2021215952A1 (ru) | 2020-04-24 | 2021-10-28 | Общество С Ограниченной Ответственностью "Индженик" | Способ получения частиц бактериофагов семейства levivirus |
| CN115835864A (zh) * | 2020-07-01 | 2023-03-21 | 国立癌症中心 | 包含3-酮脂酰辅酶a硫解酶抑制剂以及肉碱酰基肉碱载体抑制剂的用于预防或治疗癌症的药物组合物 |
| CN118576601A (zh) * | 2020-10-23 | 2024-09-03 | 和记黄埔医药（上海）有限公司 | 一种药物组合产品在制备用于治疗结肠癌的药物中的用途 |
| CN112870194B (zh) * | 2021-01-06 | 2022-06-21 | 广州医科大学附属肿瘤医院 | 治疗肝癌的组合物及其应用 |
| CN115957188A (zh) * | 2021-06-17 | 2023-04-14 | 中国医学科学院医药生物技术研究所 | 米铂脂质体在抗耐药性肿瘤的应用 |
| CN115246846B (zh) * | 2021-11-19 | 2024-10-01 | 江苏慧聚药业股份有限公司 | 卢比替定新晶型及其制备 |
| WO2023165603A1 (en) * | 2022-03-03 | 2023-09-07 | Zai Lab (Shanghai) Co., Ltd. | Dna-pk inhibitor and combination use thereof |
| WO2024188978A1 (en) * | 2023-03-10 | 2024-09-19 | Pharma Mar, S.A. | Lurbinectedin as mcl-1 inhibitor and combinations thereof for use in treating cancer |
| EP4563149A1 (en) * | 2023-11-30 | 2025-06-04 | Pharma Mar, S.A. | Lurbinectedin, ecubectedin and a related compound for use in the treatment of skin cancers |
| WO2025228597A1 (en) | 2024-04-30 | 2025-11-06 | Pharma Mar, S.A. | Combination of compound ia and a topoisomerase i inhibitor in the treatment of cancer |
| WO2025228596A1 (en) | 2024-04-30 | 2025-11-06 | Pharma Mar, S.A. | Combination of pm14 and a topoisomerase i inhibitor in the treatment of cancer |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59225189A (ja) | 1983-06-03 | 1984-12-18 | Shionogi & Co Ltd | キノナミン誘導体およびその製造法 |
| JPS6084288A (ja) | 1983-10-13 | 1985-05-13 | Shionogi & Co Ltd | シアノキノナミンアセテ−ト類およびその製造法 |
| DE3774435D1 (de) | 1986-06-09 | 1991-12-12 | Univ Pennsylvania | Ekteinascidine 729, 743, 745, 759a, 759b and 770. |
| US5256663A (en) | 1986-06-09 | 1993-10-26 | The Board Of Trustees Of The University Of Illinois | Compositions comprising ecteinascidins and a method of treating herpes simplex virus infections therewith |
| US5149804A (en) | 1990-11-30 | 1992-09-22 | The Board Of Trustees Of The University Of Illinois | Ecteinascidins 736 and 722 |
| US5089273A (en) | 1986-06-09 | 1992-02-18 | Board Of Trustees Of The University Of Illinois | Ecteinascidins 729, 743, 745, 759A, 759B and 770 |
| US5478932A (en) | 1993-12-02 | 1995-12-26 | The Board Of Trustees Of The University Of Illinois | Ecteinascidins |
| US5721362A (en) | 1996-09-18 | 1998-02-24 | President And Fellows Of Harvard College | Process for producing ecteinascidin compounds |
| US5985876A (en) | 1997-04-15 | 1999-11-16 | Univ Illinois | Nucleophile substituted ecteinascidins and N-oxide ecteinascidins |
| EP1876180A3 (en) | 1998-04-06 | 2009-12-16 | The Board Of Trustees Of The University Of Illinois | Semi-synthetic ecteinascidins |
| KR100643092B1 (ko) | 1998-05-11 | 2006-11-10 | 파르마 마르, 에스.에이. | 엑테인아시딘 743의 대사산물 |
| US6124292A (en) | 1998-09-30 | 2000-09-26 | President And Fellows Of Harvard College | Synthetic analogs of ecteinascidin-743 |
| US7311924B2 (en) * | 1999-04-01 | 2007-12-25 | Hana Biosciences, Inc. | Compositions and methods for treating cancer |
| AR035842A1 (es) | 1999-05-14 | 2004-07-21 | Pharma Mar Sa | Metodo de hemisintesis para la formacion de compuestos intermediarios y derivados y de estructuras relacionadas con la ecteinascidina y de tetrahidroisoquinolinfenoles y compuestos intermediarios de aplicacion en dicho metodo |
| JP2003520801A (ja) | 2000-01-19 | 2003-07-08 | ザ・トラスティーズ・オブ・コランビア・ユニバーシティー・イン・ザ・シティー・オブ・ニューヨーク | サフラマイシン−エクテイナシジン系列の化合物、それらの使用及び合成 |
| MXPA02010088A (es) | 2000-04-12 | 2004-08-19 | Pharma Mar Sa | Derivados de ecteinascidina antitumorales. |
| MXPA02011319A (es) | 2000-05-15 | 2003-06-06 | Pharma Mar Sa | Analogos antitumorales de ecteinascidina 743. |
| BR0115162A (pt) * | 2000-11-06 | 2003-10-21 | Pharma Mar Sa | Tratamentos antitumorais eficazes |
| SE0102232L (sv) | 2001-06-25 | 2003-02-06 | Anoto Ab | Förfarande och anordning i ett digitalt kommunikationssystem |
| GB0119243D0 (en) * | 2001-08-07 | 2001-10-03 | Pharma Mar Sa | Antitumoral analogs of ET-743 |
| RS20050106A (sr) | 2002-08-19 | 2007-11-15 | Pfizer Products Inc., | Kombinovana terapija hiperproliferativnih bolesti |
| CN100591691C (zh) * | 2002-10-18 | 2010-02-24 | 马尔药品公司 | 新型抗肿瘤化合物 |
| FR2856688B1 (fr) * | 2003-06-25 | 2008-05-30 | Sod Conseils Rech Applic | PRODUIT COMPRENANT AU MOINS UN INHIBITEUR DE PHOSPHATASE CDc25 EN ASSOCIATION AVEC AU MOINS UN AUTRE AGENT ANTI-CANCEREUX |
| US7393277B2 (en) * | 2003-08-25 | 2008-07-01 | Igt | Horseshoe payline system and games using that system |
| PT1689404E (pt) * | 2003-11-13 | 2008-12-15 | Pharma Mar Sau | Combinação de et-743 com pró-fármacos de fluorouracil para o tratamento do cancro |
| GB0326486D0 (en) * | 2003-11-14 | 2003-12-17 | Pharma Mar Sau | Combination treatment |
| US20080255132A1 (en) * | 2003-11-14 | 2008-10-16 | Eric Rowinsky | Combination Therapy Comprising the Use of Et-743 and Paclitaxel for Treating Cancer |
| EP1771174A1 (en) * | 2004-05-28 | 2007-04-11 | Pfizer Products Inc. | Method for treating abnormal cell growth |
| DK1658848T3 (da) | 2004-10-29 | 2007-11-26 | Pharma Mar Sa | Formuleringer omfattende ecteinascidin og et disaccharid |
| US8975248B2 (en) | 2004-12-15 | 2015-03-10 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Combinations of therapeutic agents for treating cancer |
| TW200744603A (en) * | 2005-08-22 | 2007-12-16 | Chugai Pharmaceutical Co Ltd | Novel anticancer concomitant drug |
| KR20140101014A (ko) * | 2006-02-28 | 2014-08-18 | 파르마 마르 에스.에이. | 개선된 항종양 치료 |
| US20110070232A1 (en) * | 2008-05-16 | 2011-03-24 | Pharma Mar, S.A. | Combination Therapy with an Antitumor Alkaloid |
| SI2786753T1 (sl) * | 2010-11-12 | 2019-05-31 | Pharma Mar S.A. | Kombinacijska terapija s protitumorskim antibiotikom |
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2011
- 2011-11-11 SI SI201131699T patent/SI2786753T1/sl unknown
- 2011-11-11 LT LTEP14175268.3T patent/LT2786754T/lt unknown
- 2011-11-11 ES ES14175268T patent/ES2719091T3/es active Active
- 2011-11-11 ES ES11781807.0T patent/ES2569180T3/es active Active
- 2011-11-11 KR KR1020197033700A patent/KR102301175B1/ko active Active
- 2011-11-11 RS RS20190397A patent/RS58609B1/sr unknown
- 2011-11-11 CA CA2995025A patent/CA2995025C/en active Active
- 2011-11-11 RS RS20200506A patent/RS60236B1/sr unknown
- 2011-11-11 DK DK14175259.2T patent/DK2786753T3/en active
- 2011-11-11 AU AU2011328004A patent/AU2011328004C1/en active Active
- 2011-11-11 TR TR2019/03859T patent/TR201903859T4/tr unknown
- 2011-11-11 PL PL14175268T patent/PL2786754T3/pl unknown
- 2011-11-11 BR BR122017028566-1A patent/BR122017028566B1/pt active IP Right Grant
- 2011-11-11 CN CN201180063925.5A patent/CN103282037B/zh active Active
- 2011-11-11 CN CN201610032547.9A patent/CN105664165A/zh active Pending
- 2011-11-11 SM SM20200211T patent/SMT202000211T1/it unknown
- 2011-11-11 ES ES14175282T patent/ES2790414T3/es active Active
- 2011-11-11 HR HRP20160361TT patent/HRP20160361T1/hr unknown
- 2011-11-11 KR KR1020177013349A patent/KR20170057472A/ko not_active Withdrawn
- 2011-11-11 EP EP14175282.4A patent/EP2786756B1/en active Active
- 2011-11-11 BR BR112013011480-0A patent/BR112013011480B1/pt active IP Right Grant
- 2011-11-11 PT PT14175268T patent/PT2786754T/pt unknown
- 2011-11-11 CA CA2817420A patent/CA2817420C/en active Active
- 2011-11-11 US US13/884,874 patent/US20130266666A1/en not_active Abandoned
- 2011-11-11 HU HUE11781807A patent/HUE027516T2/en unknown
- 2011-11-11 LT LTEP14175259.2T patent/LT2786753T/lt unknown
- 2011-11-11 SM SM20190186T patent/SMT201900186T1/it unknown
- 2011-11-11 EP EP14175259.2A patent/EP2786753B1/en active Active
- 2011-11-11 KR KR1020177022535A patent/KR20170096065A/ko not_active Ceased
- 2011-11-11 HU HUE14175259A patent/HUE042802T2/hu unknown
- 2011-11-11 EP EP11781807.0A patent/EP2637663B1/en active Active
- 2011-11-11 ES ES14175259T patent/ES2719052T3/es active Active
- 2011-11-11 KR KR1020177013350A patent/KR20170058454A/ko not_active Withdrawn
- 2011-11-11 SI SI201131880T patent/SI2786756T1/sl unknown
- 2011-11-11 BR BR122017028568-8A patent/BR122017028568B1/pt active IP Right Grant
- 2011-11-11 KR KR1020137015020A patent/KR101716804B1/ko active Active
- 2011-11-11 PL PL14175282T patent/PL2786756T3/pl unknown
- 2011-11-11 LT LTEP14175282.4T patent/LT2786756T/lt unknown
- 2011-11-11 DK DK11781807.0T patent/DK2637663T3/en active
- 2011-11-11 EP EP14175268.3A patent/EP2786754B1/en active Active
- 2011-11-11 WO PCT/EP2011/069976 patent/WO2012062920A1/en not_active Ceased
- 2011-11-11 EP EP14175275.8A patent/EP2786755A3/en not_active Withdrawn
- 2011-11-11 ME MEP-2019-77A patent/ME03501B/me unknown
- 2011-11-11 CA CA2995033A patent/CA2995033C/en active Active
- 2011-11-11 BR BR122017028570-0A patent/BR122017028570B1/pt active IP Right Grant
- 2011-11-11 KR KR1020217011747A patent/KR102452022B1/ko active Active
- 2011-11-11 JP JP2013538215A patent/JP6382516B2/ja active Active
- 2011-11-11 TR TR2019/04459T patent/TR201904459T4/tr unknown
- 2011-11-11 RS RS20160181A patent/RS54648B1/sr unknown
- 2011-11-11 RS RS20190380A patent/RS58608B1/sr unknown
- 2011-11-11 DK DK14175268.3T patent/DK2786754T3/en active
- 2011-11-11 ME MEP-2016-54A patent/ME02395B/me unknown
- 2011-11-11 RU RU2013126630/15A patent/RU2605335C2/ru active
- 2011-11-11 SI SI201131698T patent/SI2786754T1/sl unknown
- 2011-11-11 PL PL14175259T patent/PL2786753T3/pl unknown
- 2011-11-11 RU RU2016144668A patent/RU2743643C2/ru active
- 2011-11-11 HU HUE14175268A patent/HUE042801T2/hu unknown
- 2011-11-11 KR KR1020167019709A patent/KR20160088956A/ko not_active Ceased
- 2011-11-11 KR KR1020177022534A patent/KR20170096224A/ko not_active Ceased
- 2011-11-11 DK DK14175282.4T patent/DK2786756T3/da active
- 2011-11-11 ME MEP-2019-91A patent/ME03408B/me unknown
- 2011-11-11 KR KR1020177031575A patent/KR102247982B1/ko active Active
- 2011-11-11 SI SI201130769A patent/SI2637663T1/sl unknown
- 2011-11-11 CA CA2995018A patent/CA2995018C/en active Active
- 2011-11-11 CN CN201710123189.7A patent/CN106860870B/zh active Active
- 2011-11-11 EP EP20155618.0A patent/EP3666275A3/en not_active Withdrawn
- 2011-11-11 PL PL11781807T patent/PL2637663T3/pl unknown
- 2011-11-11 HU HUE14175282A patent/HUE049389T2/hu unknown
- 2011-11-11 PT PT141752824T patent/PT2786756T/pt unknown
- 2011-11-11 SM SM20190190T patent/SMT201900190T1/it unknown
- 2011-11-11 PT PT14175259T patent/PT2786753T/pt unknown
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2014
- 2014-02-24 HK HK15102911.5A patent/HK1202422A1/en unknown
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2016
- 2016-01-13 AU AU2016200191A patent/AU2016200191B2/en active Active
- 2016-04-19 SM SM201600112T patent/SMT201600112B/it unknown
- 2016-04-22 CY CY20161100333T patent/CY1117466T1/el unknown
- 2016-05-02 JP JP2016092369A patent/JP6723815B2/ja active Active
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2017
- 2017-09-21 US US15/711,478 patent/US20180008602A1/en not_active Abandoned
- 2017-11-28 US US15/824,551 patent/US11590129B2/en active Active
- 2017-11-28 US US15/824,506 patent/US20180078550A1/en not_active Abandoned
- 2017-12-11 AU AU2017276157A patent/AU2017276157B2/en active Active
- 2017-12-11 AU AU2017276155A patent/AU2017276155B2/en active Active
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2018
- 2018-01-19 RU RU2018102080A patent/RU2767664C2/ru active
- 2018-01-19 RU RU2018102078A patent/RU2757373C2/ru active
- 2018-03-27 JP JP2018059776A patent/JP6724055B2/ja active Active
- 2018-03-27 JP JP2018059777A patent/JP6724056B2/ja active Active
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2019
- 2019-03-21 HR HRP20190554TT patent/HRP20190554T1/hr unknown
- 2019-03-22 HR HRP20190565TT patent/HRP20190565T1/hr unknown
- 2019-03-29 CY CY20191100361T patent/CY1121504T1/el unknown
- 2019-03-29 CY CY20191100362T patent/CY1121501T1/el unknown
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2020
- 2020-04-30 HR HRP20200696TT patent/HRP20200696T1/hr unknown
- 2020-05-08 CY CY20201100423T patent/CY1122904T1/el unknown
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2023
- 2023-01-11 US US18/095,877 patent/US20230404999A1/en not_active Abandoned
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