CA2661223A1 - 4-aminoquinazoline derivatives and methods of use thereof - Google Patents

Info

Publication number

CA2661223A1

CA2661223A1 CA002661223A CA2661223A CA2661223A1 CA 2661223 A1 CA2661223 A1 CA 2661223A1 CA 002661223 A CA002661223 A CA 002661223A CA 2661223 A CA2661223 A CA 2661223A CA 2661223 A1 CA2661223 A1 CA 2661223A1

Authority

CA

Canada

Prior art keywords

compound

cancer

subject

carcinoma

mmol

Prior art date

2006-08-22

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Abandoned

Links

• Espacenet
• Global Dossier
• CIPO
• Discuss

• 238000000034 method Methods 0.000 title claims abstract description 73
• DRYRBWIFRVMRPV-UHFFFAOYSA-N quinazolin-4-amine Chemical class C1=CC=C2C(N)=NC=NC2=C1 DRYRBWIFRVMRPV-UHFFFAOYSA-N 0.000 title abstract description 4
• 150000001875 compounds Chemical class 0.000 claims abstract description 242
• 239000000203 mixture Substances 0.000 claims abstract description 115
• 150000003839 salts Chemical class 0.000 claims abstract description 25
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• 239000012453 solvate Substances 0.000 claims abstract description 9
• -1 trastuzumab Chemical compound 0.000 claims description 70
• 229910052805 deuterium Inorganic materials 0.000 claims description 50
• YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 claims description 49
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• 230000009826 neoplastic cell growth Effects 0.000 claims description 15
• AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims description 13
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