CN107548391A - 嘧啶或吡啶类化合物、其制备方法和医药用途 - Google Patents

嘧啶或吡啶类化合物、其制备方法和医药用途 Download PDF

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CN107548391A
CN107548391A CN201580060134.5A CN201580060134A CN107548391A CN 107548391 A CN107548391 A CN 107548391A CN 201580060134 A CN201580060134 A CN 201580060134A CN 107548391 A CN107548391 A CN 107548391A
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江岳恒
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Yifang Biotechnology Shanghai Co ltd
Betta Pharmaceuticals Co Ltd
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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Abstract

本发明公开了一类嘧啶或吡啶化合物，及其药学上可接受的盐、立体异构体、前药和溶剂合物，其制备方法、药物组合物以及医药用途。该类所述化合物可以对EGFR蛋白酶的变异形态产生抑制作用，因此能有效地抑制多种肿瘤细胞的生长，可用于制备抗肿瘤药物，用于很多不同的癌症的治疗、联合治疗或预防，并可以克服现有药物吉非替尼、厄洛替尼等第一代EGFR抑制剂诱发的耐药性。更特别地，该类化合物可用于制备用于治疗或预防由某些变异形态的表皮生长因子受体(例如L858R激活突变体、Exon19缺失激活突变体、和T790M抗性突变体)所介导的疾病、障碍、紊乱或病况的药物。

Description

PCT国内申请，说明书已公开。

Claims (12)

  1. PCT国内申请，权利要求书已公开。
CN201580060134.5A 2014-11-05 2015-11-05 嘧啶或吡啶类化合物、其制备方法和医药用途 Active CN107548391B (zh)

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