UA99308C2 - Аналог азацитидина и его применение - Google Patents
Аналог азацитидина и его применениеInfo
- Publication number
- UA99308C2 UA99308C2 UAA201004927A UAA201004927A UA99308C2 UA 99308 C2 UA99308 C2 UA 99308C2 UA A201004927 A UAA201004927 A UA A201004927A UA A201004927 A UAA201004927 A UA A201004927A UA 99308 C2 UA99308 C2 UA 99308C2
- Authority
- UA
- Ukraine
- Prior art keywords
- integer
- formula
- rchoc
- rchnhc
- ris
- Prior art date
Links
- NMUSYJAQQFHJEW-KVTDHHQDSA-N 5-azacytidine Chemical class O=C1N=C(N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 NMUSYJAQQFHJEW-KVTDHHQDSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/12—Triazine radicals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97543707P | 2007-09-26 | 2007-09-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA99308C2 true UA99308C2 (ru) | 2012-08-10 |
Family
ID=40511851
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA201004927A UA99308C2 (ru) | 2007-09-26 | 2008-09-25 | Аналог азацитидина и его применение |
| UAA201004928A UA99836C2 (en) | 2007-09-26 | 2008-09-25 | Azacytidine analogue and using thereof |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA201004928A UA99836C2 (en) | 2007-09-26 | 2008-09-25 | Azacytidine analogue and using thereof |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US8399420B2 (enExample) |
| EP (2) | EP2205073A4 (enExample) |
| JP (2) | JP2010540556A (enExample) |
| KR (2) | KR20100072230A (enExample) |
| CN (2) | CN101815437A (enExample) |
| AU (2) | AU2008304380A1 (enExample) |
| BR (2) | BRPI0817269A2 (enExample) |
| CA (2) | CA2700267A1 (enExample) |
| IL (1) | IL204690A0 (enExample) |
| MX (2) | MX2010003261A (enExample) |
| NZ (2) | NZ583824A (enExample) |
| RU (1) | RU2488591C2 (enExample) |
| UA (2) | UA99308C2 (enExample) |
| WO (2) | WO2009042766A1 (enExample) |
| ZA (1) | ZA201001660B (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8497292B2 (en) * | 2005-12-28 | 2013-07-30 | Translational Therapeutics, Inc. | Translational dysfunction based therapeutics |
| US8399420B2 (en) | 2007-09-26 | 2013-03-19 | Mount Sanai School of Medicine | Azacytidine analogues and uses thereof |
| DK3692983T3 (da) | 2008-05-15 | 2021-09-20 | Celgene Corp | Orale formuleringer af cytidinanaloger og fremgangsmåder til anvendelse deraf |
| EP2321302B1 (en) | 2008-08-01 | 2014-10-29 | Dr. Reddy's Laboratories Ltd. | Azacitidine process and polymorphs |
| WO2010129211A2 (en) * | 2009-04-27 | 2010-11-11 | Dr. Reddy's Laboratories Ltd. | Preparation of decitabine |
| EP2670396A1 (en) | 2011-01-31 | 2013-12-11 | Celgene Corporation | Pharmaceutical compositions of cytidine analogs and methods of use thereof |
| US20120264710A1 (en) * | 2011-04-15 | 2012-10-18 | Marit Liland Sandvold | Systems and Methods for Detecting hENT1 Expression in Hematological Disorders |
| TW201700103A (zh) | 2011-11-01 | 2017-01-01 | 西建公司 | 利用胞嘧啶核苷類似物之口服配方治療癌症的方法 |
| JP6114317B2 (ja) | 2012-02-24 | 2017-04-12 | シグナル ファーマシューティカルズ，エルエルシー | Ｔｏｒキナーゼ阻害剤の組合せ療法を用いて、非小細胞肺がんを処置する方法 |
| US9493500B2 (en) | 2012-07-19 | 2016-11-15 | Richard Daifuku | Fluorinated pyrimidine analogs and methods of use thereof |
| WO2014172432A1 (en) * | 2013-04-17 | 2014-10-23 | Signal Pharmaceuticals, Llc | Combination therapy comprising a tor kinase inhibitor and a cytidine analog for treating cancer |
| WO2015195786A2 (en) | 2014-06-17 | 2015-12-23 | Celgene Corporation | Methods for treating cancers using oral formulations of cytidine analogs |
| SG11201705069YA (en) * | 2014-12-26 | 2017-07-28 | Univ Emory | N4-hydroxycytidine and derivatives and anti-viral uses related thereto |
| WO2017090264A1 (ja) | 2015-11-27 | 2017-06-01 | 大原薬品工業株式会社 | ５－アザシチジン又は其の２'－デオキシ体の５'位ジベンジル燐酸エステル |
| CA3007357C (en) | 2015-12-03 | 2023-12-05 | Epidestiny, Inc. | Compositions containing decitabine, 5azacytidine and tetrahydrouridine and uses thereof |
| CN110446504B (zh) | 2017-03-20 | 2024-07-26 | 瓦西尼斯公司 | 用脑信号蛋白-4d抗体联合表观遗传调节剂治疗癌症 |
| MX2019015731A (es) | 2017-06-22 | 2020-08-03 | Celgene Corp | Tratamiento de carcinoma hepatocelular caracterizado por infeccion por virus de hepatitis b. |
| WO2019204637A1 (en) * | 2018-04-19 | 2019-10-24 | Southern Research Institute | 4'-thio-nucleotide and -nucleoside prodrugs for the treatment of cancer |
| US20230416294A1 (en) * | 2020-08-10 | 2023-12-28 | The Johns Hopkins University | Decitabine analogs for immunological and oncological therapy |
Family Cites Families (69)
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|---|---|---|---|---|
| BE612384A (fr) | 1961-01-10 | 1962-05-02 | Spofa Vereinigte Pharma Werke | Procédé de préparation des 1-glycosyle-6-aza-uraciles |
| GB1050899A (enExample) | 1963-12-22 | |||
| DE2012888C3 (de) | 1970-03-14 | 1981-04-02 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Verfahren zur Herstellung von 5-Azapyrimidinnucleosiden |
| DE2122991C2 (de) | 1971-05-04 | 1982-06-09 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Verfahren zur Herstellung von Cytosin- und 6-Azacytosinnucleosiden |
| US3984396A (en) | 1971-06-01 | 1976-10-05 | Icn Pharmaceuticals, Inc. | 1-(β,-D-ribofuranosyl)-1,2,4-triazole acid esters |
| US3998807A (en) | 1972-03-03 | 1976-12-21 | Syntex (U.S.A.) Inc. | Arabinofuranosyl cytosines and methods of making |
| US4172889A (en) | 1976-03-29 | 1979-10-30 | The Upjohn Company | Method of treating rheumatoid arthritis |
| US4405611A (en) | 1980-06-27 | 1983-09-20 | The United States Of America As Represented By The Department Of Health And Human Services | Bisulfite stabilization of 5-azacytidine |
| DE3100478A1 (de) | 1981-01-09 | 1982-08-12 | Dr. Thilo & Co GmbH, 8021 Sauerlach | 5'ester von pyrimidinnucleosiden mit antiviraler wirksamkeit, verfahren zur herstellung und daraus hergestellte arzneimittel |
| US5223263A (en) | 1988-07-07 | 1993-06-29 | Vical, Inc. | Liponucleotide-containing liposomes |
| DE3737456A1 (de) | 1986-11-04 | 1988-05-19 | Fuji Photo Film Co Ltd | Laserlichtquelle |
| CS264456B1 (cs) | 1987-08-28 | 1989-08-14 | Piskala Alois | Způsob výroby 5,6-dihydro-S-azacytidinu |
| CS264454B1 (cs) | 1987-08-28 | 1989-08-14 | Piskala Alois | 2'-Deoxy-5,6-dihydro-5-azacytidin a způsob jeho výroby |
| US5994392A (en) | 1988-02-26 | 1999-11-30 | Neuromedica, Inc. | Antipsychotic prodrugs comprising an antipsychotic agent coupled to an unsaturated fatty acid |
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| JP2559917B2 (ja) * | 1990-06-15 | 1996-12-04 | 三共株式会社 | ピリミジンヌクレオシド誘導体 |
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| GB2260319B (en) | 1991-10-07 | 1995-12-06 | Norsk Hydro As | Acyl derivatives of nucleosides and nucleoside analogues having anti-viral activity |
| GB9307043D0 (en) | 1993-04-05 | 1993-05-26 | Norsk Hydro As | Chemical compounds |
| GB9515279D0 (en) | 1995-07-25 | 1995-09-20 | Norsk Hydro As | Improved therapeutic agents |
| DE19505168A1 (de) | 1995-02-16 | 1996-08-22 | Boehringer Mannheim Gmbh | Spezifische Lipidkonjugate von Nucleosid-Diphosphonaten und deren Verwendung als Arzneimittel |
| WO1997005143A1 (en) | 1995-07-25 | 1997-02-13 | Asahi Kasei Kogyo Kabushiki Kaisha | Novel group 4 transition metal compounds |
| AU6764396A (en) | 1995-08-08 | 1997-03-05 | Thomas Jefferson University | Recombinant c-proteinase and processes, methods and uses thereof |
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| US5919815A (en) | 1996-05-22 | 1999-07-06 | Neuromedica, Inc. | Taxane compounds and compositions |
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| JPH10158192A (ja) | 1996-10-03 | 1998-06-16 | Eisai Co Ltd | 移植片対宿主疾患（ｇｖｈｄ）の治療および臓器移植時の移植片拒絶反応抑制のための医薬組成物 |
| GB2321455A (en) | 1997-01-24 | 1998-07-29 | Norsk Hydro As | Lipophilic derivatives of biologically active compounds |
| DK0986570T3 (da) | 1997-01-24 | 2003-07-28 | Conpharma As | Gemcitabinderivat |
| DE69813231T2 (de) * | 1997-06-03 | 2003-12-04 | Itochu Techno-Chemical Inc., Tokio/Tokyo | Natürliche antitumor- oder antivirale substanzen und ihre anwendung |
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| HUP0203142A3 (en) | 1999-10-15 | 2003-03-28 | Hoffmann La Roche | Benzodiazepine derivatives, process for preparation of the compounds, pharmaceutical compositions containing them and their use |
| US6670341B1 (en) | 1999-10-28 | 2003-12-30 | Wake Forest University Health Sciences | Compositions and methods for double-targeting virus infections and targeting cancer cells |
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| US20080033172A1 (en) | 2003-12-19 | 2008-02-07 | Koronis Pharmaceuticals, Incorporated | Mutagenic Heterocycles |
| WO2005066162A1 (en) | 2003-12-23 | 2005-07-21 | Human Biomolecular Research Institute | Synthetic compounds and derivatives as modulators of smoking or nicotine ingestion and lung cancer |
| WO2005075482A1 (en) | 2004-02-04 | 2005-08-18 | Neurosearch A/S | Diazabicyclic aryl derivatives as nicotinic acetylcholine receptor ligands |
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| US8158770B2 (en) | 2004-05-06 | 2012-04-17 | University Of Rochester | Content dependent inhibitors of cytidine deaminases and uses thereof |
| GB0419416D0 (en) | 2004-09-01 | 2004-10-06 | Inst Of Ex Botany Ascr | 4-Arylazo-3,5-Diamino-Pyrazole compounds and use thereof |
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| WO2007035783A2 (en) * | 2005-09-19 | 2007-03-29 | Celator Pharmaceuticals, Inc. | Combination formulations of cytidine analogs and platinum agents |
| EP2407459A1 (en) | 2005-09-27 | 2012-01-18 | Shionogi & Co., Ltd. | Synthetic intermediate in the production of a sulfonamide derivative having PGD2 receptor antagonistic activity |
| NO324263B1 (no) | 2005-12-08 | 2007-09-17 | Clavis Pharma Asa | Kjemiske forbindelser, anvendelse derav ved behandling av kreft, samt farmasoytiske preparater som omfatter slike forbindelser |
| US20070225248A1 (en) | 2006-03-21 | 2007-09-27 | Clavis Pharma As | Oral dosage forms of gemcitabine derivatives |
| US8399420B2 (en) | 2007-09-26 | 2013-03-19 | Mount Sanai School of Medicine | Azacytidine analogues and uses thereof |
-
2008
- 2008-09-25 US US12/238,054 patent/US8399420B2/en not_active Expired - Fee Related
- 2008-09-25 JP JP2010527140A patent/JP2010540556A/ja active Pending
- 2008-09-25 EP EP08832961A patent/EP2205073A4/en not_active Withdrawn
- 2008-09-25 BR BRPI0817269-2A2A patent/BRPI0817269A2/pt not_active IP Right Cessation
- 2008-09-25 MX MX2010003261A patent/MX2010003261A/es not_active Application Discontinuation
- 2008-09-25 UA UAA201004927A patent/UA99308C2/ru unknown
- 2008-09-25 CN CN200880108584A patent/CN101815437A/zh active Pending
- 2008-09-25 KR KR1020107007252A patent/KR20100072230A/ko not_active Withdrawn
- 2008-09-25 CN CN2008801085550A patent/CN101877964A/zh active Pending
- 2008-09-25 WO PCT/US2008/077669 patent/WO2009042766A1/en not_active Ceased
- 2008-09-25 AU AU2008304380A patent/AU2008304380A1/en not_active Abandoned
- 2008-09-25 MX MX2010003002A patent/MX2010003002A/es active IP Right Grant
- 2008-09-25 US US12/238,125 patent/US8158605B2/en not_active Expired - Fee Related
- 2008-09-25 EP EP08834291A patent/EP2197274A4/en not_active Withdrawn
- 2008-09-25 NZ NZ583824A patent/NZ583824A/en not_active IP Right Cessation
- 2008-09-25 BR BRPI0817234-0A2A patent/BRPI0817234A2/pt not_active IP Right Cessation
- 2008-09-25 UA UAA201004928A patent/UA99836C2/ru unknown
- 2008-09-25 AU AU2008304381A patent/AU2008304381A1/en not_active Abandoned
- 2008-09-25 RU RU2010116274/04A patent/RU2488591C2/ru not_active IP Right Cessation
- 2008-09-25 KR KR1020107008902A patent/KR20100102092A/ko not_active Withdrawn
- 2008-09-25 WO PCT/US2008/077673 patent/WO2009042767A1/en not_active Ceased
- 2008-09-25 CA CA2700267A patent/CA2700267A1/en not_active Abandoned
- 2008-09-25 JP JP2010527139A patent/JP2010540555A/ja active Pending
- 2008-09-25 NZ NZ583923A patent/NZ583923A/en not_active IP Right Cessation
- 2008-09-25 CA CA2700207A patent/CA2700207A1/en not_active Abandoned
-
2010
- 2010-03-08 ZA ZA2010/01660A patent/ZA201001660B/en unknown
- 2010-03-23 IL IL204690A patent/IL204690A0/en unknown
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