JP2007502832A5 - - Google Patents
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- Publication number
- JP2007502832A5 JP2007502832A5 JP2006524037A JP2006524037A JP2007502832A5 JP 2007502832 A5 JP2007502832 A5 JP 2007502832A5 JP 2006524037 A JP2006524037 A JP 2006524037A JP 2006524037 A JP2006524037 A JP 2006524037A JP 2007502832 A5 JP2007502832 A5 JP 2007502832A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- pharmaceutically acceptable
- pharmaceutical composition
- acceptable salt
- mixture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 42
- 239000000203 mixture Substances 0.000 claims 22
- 150000003839 salts Chemical class 0.000 claims 22
- 239000008194 pharmaceutical composition Substances 0.000 claims 21
- 201000010099 disease Diseases 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
- 239000006186 oral dosage form Substances 0.000 claims 3
- 239000006201 parenteral dosage form Substances 0.000 claims 3
- 239000000546 pharmaceutical excipient Substances 0.000 claims 3
- 239000006211 transdermal dosage form Substances 0.000 claims 3
- 208000020084 Bone disease Diseases 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 206010031240 Osteodystrophy Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 206010052779 Transplant rejections Diseases 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 208000005368 osteomalacia Diseases 0.000 claims 1
- 238000011200 topical administration Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49641503P | 2003-08-20 | 2003-08-20 | |
| US60/496,415 | 2003-08-20 | ||
| PCT/US2004/026925 WO2005018658A1 (en) | 2003-08-20 | 2004-08-18 | 2-methylene-19-nor-vitamin d2 compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007502832A JP2007502832A (ja) | 2007-02-15 |
| JP2007502832A5 true JP2007502832A5 (enExample) | 2007-10-11 |
| JP5009617B2 JP5009617B2 (ja) | 2012-08-22 |
Family
ID=34215997
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006524037A Expired - Fee Related JP5009617B2 (ja) | 2003-08-20 | 2004-08-18 | ２−メチレン−１９−ノル−ビタミンｄ２化合物 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7232810B2 (enExample) |
| EP (1) | EP1656157B1 (enExample) |
| JP (1) | JP5009617B2 (enExample) |
| AT (1) | ATE537834T1 (enExample) |
| AU (1) | AU2004266706B2 (enExample) |
| CA (1) | CA2535185C (enExample) |
| NZ (1) | NZ545862A (enExample) |
| WO (1) | WO2005018658A1 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1689412A4 (en) * | 2003-11-25 | 2009-03-11 | Wisconsin Alumni Res Found | VITAMIN D ANALOGUE FOR THE PREVENTION AND TREATMENT OF ADIPOSITAS |
| US8404667B2 (en) | 2006-12-29 | 2013-03-26 | Wisconsin Alumni Research Foundation | Compounds, compositions, kits and methods of use to orally and topically treat acne and other skin conditions by 19-Nor vitamin D analog |
| US7915242B2 (en) * | 2004-02-17 | 2011-03-29 | Wisconsin Alumni Research Foundation | Vitamin D receptor antagonists and their use in treating asthma |
| US7713951B2 (en) * | 2004-04-09 | 2010-05-11 | Wisconsin Alumni Research Foundation | 2-alkylidene-18,19-dinor-vitamin D compounds |
| DE602005026694D1 (de) * | 2004-11-22 | 2011-04-14 | Wisconsin Alumni Res Found | 2-methylen-19,21-dinor-1alpha-hydroxy-bishomopregnacalciferol |
| US7511030B2 (en) * | 2005-02-11 | 2009-03-31 | Wisconsin Alumni Research Foundation | 2-methylene-19-nor-(20S-24epi)-1α,25-dihydroxyvitamin D2 |
| EP1853274B1 (en) * | 2005-02-11 | 2013-01-23 | Wisconsin Alumni Research Foundation | 2-methylene-19-nor- (20s-24s) - 1alpha, 25-dihydroxyvitamine-d2 |
| US7888339B2 (en) * | 2008-07-10 | 2011-02-15 | Wisconsin Alumni Research Foundation | 2-methylene-20(21)-dehydro-19-nor-vitamin D analogs |
| US8222236B2 (en) * | 2008-07-10 | 2012-07-17 | Wisconsin Alumni Research Foundation | 2-methylene-(20E)-20(22)-dehydro-19-nor-vitamin D analogs |
| US8399439B2 (en) * | 2008-07-10 | 2013-03-19 | Wisconsin Alumni Research Foundation | 2-methylene-19,26-dinor-(20S,22E,25R)-vitamin D analogs |
| US8193170B2 (en) * | 2008-07-10 | 2012-06-05 | Wisconsin Alumni Research Foundation | 2-methylene-19,26-dinor-(20R,22E,25R)-vitamin D analogs |
| PL216135B1 (pl) * | 2009-08-07 | 2014-03-31 | Inst Farmaceutyczny | Nowe syntony i ich zastosowanie do otrzymywania pochodnych 19-nor witamin D |
| US8445468B2 (en) * | 2009-10-02 | 2013-05-21 | Wisconsin Alumni Research Foundation | (20S,22E)-2-methylene-19-nor-22-ene-1α,25-dihydroxyvitamin D3 |
| CA2794006C (en) * | 2010-03-23 | 2017-11-28 | Wisconsin Alumni Research Foundation | (20s)-2-methylene-19-nor-22-dimethyl-1.alpha.,25-dihydroxyvitamin d3 and (20r)-2-methylene-19-nor-22-dimethyl-1.alpha.,25-hydroxyvitamin d3 |
| US8664206B2 (en) | 2010-03-23 | 2014-03-04 | Wisconsin Alumni Research Foundation | Diastereomers of 2-methylene-19-nor-22-methyl-1α,25-dihydroxyvitamin D3 |
| AU2011232562B2 (en) * | 2010-03-23 | 2014-10-02 | Wisconsin Alumni Research Foundation | Diastereomers of 2-methylene-19-nor-22-methyl-1alpha,25- dihydroxyvitamin D3 |
| WO2012166938A2 (en) | 2011-06-03 | 2012-12-06 | Wisconsin Alumni Research Foundation | (22e)-2-methylene-26,27-cyclo-22-dehydro-1alpha-hydroxy-19-norvitamin d3 derivatives |
| WO2012174095A1 (en) * | 2011-06-14 | 2012-12-20 | Wisconsin Alumni Research Foundation | 3-desoxy-2-methylene-19-nor-vitamin d analogs and their uses |
| US9416102B2 (en) * | 2013-01-23 | 2016-08-16 | Wisconsin Alumni Research Foundation | (22E)-2-methylene-22-dehydro-1α,24,25-trihydroxy-19-nor-vitamin D3 analogs |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5036061A (en) * | 1983-05-09 | 1991-07-30 | Deluca Hector F | Process for the preparation of 1 alpha,25-dihydroxylated vitamin D2 and related compounds |
| US4769181A (en) * | 1983-11-07 | 1988-09-06 | Wisconsin Alumni Research Foundation | 1,25-dihydroxyvitamin D2 compounds |
| US4588716A (en) * | 1984-05-04 | 1986-05-13 | Wisconsin Alumni Research Foundation | Method for treating metabolic bone disease in mammals |
| US4666634A (en) * | 1984-12-05 | 1987-05-19 | Chugai Seiyaku Kabushiki Kaisha | vitamin D3 derivatives having a substituent at 2-position |
| DE3639488A1 (de) * | 1986-11-18 | 1988-05-19 | Basf Lacke & Farben | Kathodisch abscheidbare wasserverduennbare bindemittel, wasserverduennbare ueberzugszusammensetzungen und verfahren zur herstellung von kathodisch abscheidbaren wasserverduennbaren bindemitteln |
| US4973584A (en) * | 1989-03-09 | 1990-11-27 | Deluca Hector F | Novel 1α-hydroxyvitamin D2 epimer and derivatives |
| JP2818493B2 (ja) * | 1990-02-14 | 1998-10-30 | ウイスコンシン アラムナイ リサーチ フオンデーシヨン | ２５−ヒドロキシビタミンＤ２ 化合物および対応する１α−ヒドロキシル化誘導体の製造方法 |
| US5086191A (en) | 1991-05-28 | 1992-02-04 | Wisconsin Alumni Research Foundation | Intermediates for the synthesis of 19-nor vitamin D compounds |
| EP0619306B1 (en) * | 1993-04-05 | 1996-09-11 | Wisconsin Alumni Research Foundation | 19-Nor-vitamin D3 compounds with substituent at 2-position |
| US6392071B1 (en) * | 1997-03-17 | 2002-05-21 | Wisconsin Alumni: Research Foundation | 26,27-homologated-20-EPI-2-alkylidene-19-nor-vitamin D compounds |
| US6316642B1 (en) * | 1997-03-17 | 2001-11-13 | Wisconsin Alumni Research Foundation | 26,27-Homologated-20-EPI-2alkyl-19-nor-vitamin D compounds |
| US5843928A (en) * | 1997-03-17 | 1998-12-01 | Wisconsin Alumni Research Foundation | 2-alkylidene-19-nor-vitamin D compounds |
| US5945410A (en) * | 1997-03-17 | 1999-08-31 | Wisconsin Alumni Research Foundation | 2-alkyl-19-nor-vitamin D compounds |
| US6673782B2 (en) * | 1999-04-29 | 2004-01-06 | Wisconsin Alumni Research Foundation | Treatment of systemic lupus erythematosis |
| US6479474B2 (en) * | 1999-07-08 | 2002-11-12 | Wisconsin Alumni Research Foundation | Dietary calcium as a supplement to vitamin D compound treatment of multiple sclerosis |
| DE60134549D1 (de) * | 2000-05-31 | 2008-08-07 | Wisconsin Alumni Res Found | 2-ethyl und 2-ethyliden-19-nor-vitamin d-verbindungen |
| CA2420026C (en) * | 2000-09-08 | 2010-01-19 | Wisconsin Alumni Research Foundation | 1alpha-hydroxy-2-methylene-19-nor-homopregnacalciferol and its therapeutic applications |
| US7259143B2 (en) * | 2002-09-05 | 2007-08-21 | Wisconsin Alumni Research Foundation | Method of extending the dose range of vitamin D compounds |
| EP1689412A4 (en) * | 2003-11-25 | 2009-03-11 | Wisconsin Alumni Res Found | VITAMIN D ANALOGUE FOR THE PREVENTION AND TREATMENT OF ADIPOSITAS |
| EP1853274B1 (en) * | 2005-02-11 | 2013-01-23 | Wisconsin Alumni Research Foundation | 2-methylene-19-nor- (20s-24s) - 1alpha, 25-dihydroxyvitamine-d2 |
| US7511030B2 (en) * | 2005-02-11 | 2009-03-31 | Wisconsin Alumni Research Foundation | 2-methylene-19-nor-(20S-24epi)-1α,25-dihydroxyvitamin D2 |
-
2004
- 2004-08-18 US US10/922,114 patent/US7232810B2/en not_active Expired - Lifetime
- 2004-08-18 AT AT04781584T patent/ATE537834T1/de active
- 2004-08-18 NZ NZ545862A patent/NZ545862A/en not_active IP Right Cessation
- 2004-08-18 AU AU2004266706A patent/AU2004266706B2/en not_active Ceased
- 2004-08-18 CA CA2535185A patent/CA2535185C/en not_active Expired - Fee Related
- 2004-08-18 JP JP2006524037A patent/JP5009617B2/ja not_active Expired - Fee Related
- 2004-08-18 EP EP04781584A patent/EP1656157B1/en not_active Expired - Lifetime
- 2004-08-18 WO PCT/US2004/026925 patent/WO2005018658A1/en not_active Ceased