JP2008543847A5 - - Google Patents
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- Publication number
- JP2008543847A5 JP2008543847A5 JP2008516988A JP2008516988A JP2008543847A5 JP 2008543847 A5 JP2008543847 A5 JP 2008543847A5 JP 2008516988 A JP2008516988 A JP 2008516988A JP 2008516988 A JP2008516988 A JP 2008516988A JP 2008543847 A5 JP2008543847 A5 JP 2008543847A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- compound
- peptide
- composition according
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 25
- 150000001875 compounds Chemical class 0.000 claims 7
- 108090000765 processed proteins & peptides Proteins 0.000 claims 7
- 238000011282 treatment Methods 0.000 claims 4
- 150000007824 aliphatic compounds Chemical class 0.000 claims 3
- 239000000718 radiation-protective agent Substances 0.000 claims 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims 2
- 102000004127 Cytokines Human genes 0.000 claims 2
- 108090000695 Cytokines Proteins 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 239000003963 antioxidant agent Substances 0.000 claims 2
- 230000003078 antioxidant effect Effects 0.000 claims 2
- 235000006708 antioxidants Nutrition 0.000 claims 2
- 230000006907 apoptotic process Effects 0.000 claims 2
- 230000003537 radioprotector Effects 0.000 claims 2
- 108010040721 Flagellin Proteins 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000005374 Poisoning Diseases 0.000 claims 1
- 102000004887 Transforming Growth Factor beta Human genes 0.000 claims 1
- 108090001012 Transforming Growth Factor beta Proteins 0.000 claims 1
- 229930003427 Vitamin E Natural products 0.000 claims 1
- 208000027418 Wounds and injury Diseases 0.000 claims 1
- 239000012190 activator Substances 0.000 claims 1
- JKOQGQFVAUAYPM-UHFFFAOYSA-N amifostine Chemical compound NCCCNCCSP(O)(O)=O JKOQGQFVAUAYPM-UHFFFAOYSA-N 0.000 claims 1
- 229960001097 amifostine Drugs 0.000 claims 1
- 210000001185 bone marrow Anatomy 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 210000000748 cardiovascular system Anatomy 0.000 claims 1
- 210000003169 central nervous system Anatomy 0.000 claims 1
- 238000002512 chemotherapy Methods 0.000 claims 1
- 230000006378 damage Effects 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims 1
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 1
- 210000003780 hair follicle Anatomy 0.000 claims 1
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims 1
- 210000000987 immune system Anatomy 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 208000014674 injury Diseases 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 210000004185 liver Anatomy 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 210000001428 peripheral nervous system Anatomy 0.000 claims 1
- 231100000572 poisoning Toxicity 0.000 claims 1
- 230000000607 poisoning effect Effects 0.000 claims 1
- 229940124553 radioprotectant Drugs 0.000 claims 1
- 238000001959 radiotherapy Methods 0.000 claims 1
- 210000004994 reproductive system Anatomy 0.000 claims 1
- 230000035939 shock Effects 0.000 claims 1
- 210000000952 spleen Anatomy 0.000 claims 1
- 210000000130 stem cell Anatomy 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 210000001541 thymus gland Anatomy 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 210000003556 vascular endothelial cell Anatomy 0.000 claims 1
- 235000019165 vitamin E Nutrition 0.000 claims 1
- 229940046009 vitamin E Drugs 0.000 claims 1
- 239000011709 vitamin E Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68981005P | 2005-06-13 | 2005-06-13 | |
| US60/689,810 | 2005-06-13 | ||
| PCT/US2006/022865 WO2006138238A2 (en) | 2005-06-13 | 2006-06-13 | Methods of protecting against apoptosis using lipopeptides |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008543847A JP2008543847A (ja) | 2008-12-04 |
| JP2008543847A5 true JP2008543847A5 (enExample) | 2009-07-30 |
| JP5000644B2 JP5000644B2 (ja) | 2012-08-15 |
Family
ID=37571018
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008516988A Expired - Fee Related JP5000644B2 (ja) | 2005-06-13 | 2006-06-13 | リポペプチドを用いてアポトーシスから保護するための方法 |
Country Status (16)
| Country | Link |
|---|---|
| US (4) | US8008260B2 (enExample) |
| EP (2) | EP2554181B1 (enExample) |
| JP (1) | JP5000644B2 (enExample) |
| KR (2) | KR20080030566A (enExample) |
| CN (1) | CN101242852B (enExample) |
| AU (1) | AU2006259630B2 (enExample) |
| BR (1) | BRPI0611586A2 (enExample) |
| CA (1) | CA2612102C (enExample) |
| EA (1) | EA014644B1 (enExample) |
| ES (2) | ES2539490T3 (enExample) |
| IL (1) | IL188091A (enExample) |
| MX (1) | MX2007015834A (enExample) |
| NZ (1) | NZ565063A (enExample) |
| PT (1) | PT1904084E (enExample) |
| WO (1) | WO2006138238A2 (enExample) |
| ZA (1) | ZA200800126B (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9457070B2 (en) | 2005-06-07 | 2016-10-04 | The Regents Of The University Of Colorado, A Body Corporate | Compositions, methods and uses of alpha 1-antitrypsin for early intervention in bone marrow transplantation and treatment of graft versus host disease |
| CA2654446C (en) | 2005-06-07 | 2014-02-25 | The Regents Of The University Of Colorado | Inhibitors of serine protease activity and their use in methods and compositions for treatment of graft rejection and promotion of graft survival |
| US8008260B2 (en) | 2005-06-13 | 2011-08-30 | Cleveland Clinic Foundation | Methods of protecting against apoptosis using lipopeptides |
| CA2655933C (en) * | 2006-06-23 | 2014-09-09 | Alethia Biotherapeutics Inc. | Polynucleotides and polypeptide sequences involved in cancer |
| KR101493474B1 (ko) * | 2007-01-09 | 2015-02-16 | 클리브랜드 바이오랩스, 아이엔씨. | 조혈 줄기 세포를 증가시키고 이동시키는 방법들 |
| WO2009074569A1 (en) * | 2007-12-11 | 2009-06-18 | Bracco International Bv | Targeting and therapeutic compounds with a polyproline-comprising spacer and gas-filled microvesicles comprising said compounds |
| US9150621B2 (en) * | 2008-08-28 | 2015-10-06 | The University Of Queensland | Mutant bacterial glycoproteins and uses thereof |
| JP5213961B2 (ja) * | 2008-09-18 | 2013-06-19 | 日本臓器製薬株式会社 | アミノ酸誘導体 |
| CN104829714A (zh) | 2008-11-03 | 2015-08-12 | 阿莱斯亚生物疗法股份有限公司 | 特异性地阻滞肿瘤抗原的生物活性的抗体 |
| US8404444B2 (en) * | 2009-02-25 | 2013-03-26 | Diacarta Llc | Method for predicting the level of damage to cells by measuring free circulating Alu nucleic acid |
| JP5210405B2 (ja) * | 2010-03-17 | 2013-06-12 | 日本臓器製薬株式会社 | アミノ酸誘導体を含有する医薬及び該誘導体の製造方法 |
| EP2490021A1 (en) | 2011-02-18 | 2012-08-22 | Biotempt B.V. | Modulators of PRR and GPCR signalling |
| WO2012125487A1 (en) * | 2011-03-11 | 2012-09-20 | Omni Bio Pharmaceutical, Inc. | Compositions, methods and uses for radioprotectants |
| CA2893376A1 (en) | 2011-03-31 | 2012-10-04 | Alethia Biotherapeutics Inc. | Antibodies against kidney associated antigen 1 and antigen binding fragemnts thereof |
| DE102011018499A1 (de) * | 2011-04-23 | 2012-10-25 | Emc Microcollections Gmbh | Topische Nanopartikel-Vakzine zur Immunstimulation der dendritischen Zellen in der Haut |
| AU2013209234B2 (en) | 2012-01-09 | 2017-11-09 | Adc Therapeutics Sa | Method for treating breast cancer |
| JP5686841B2 (ja) * | 2013-04-26 | 2015-03-18 | フレゼニウス メディカル ケア ドイッチェランド ゲゼルシャフト ミット ベシュレンクテル ハフツング | 損傷しまたは傷害を受けた組織または臓器の内皮／上皮再生用医薬の製造のための、幹細胞由来微小胞（ｍｖ）の使用ならびにインビトロおよびインビボでの関連した方法 |
| US20160287553A1 (en) | 2013-11-22 | 2016-10-06 | Deutsches Krebsforschungszentrum | Translation inhibitors in high-dose chemo- and/or high-dose radiotherapy |
| WO2016073733A1 (en) * | 2014-11-06 | 2016-05-12 | Cleveland Biolabs, Inc. | Methods of treating cancer using lipopeptides |
| CN112851755B (zh) * | 2021-01-13 | 2023-09-01 | 中国人民解放军军事科学院军事医学研究院 | 一种线性脂肽化合物及其制备方法与应用 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0000330B1 (de) | 1977-06-20 | 1981-08-05 | Ciba-Geigy Ag | Lipopeptide, Verfahren zu deren Herstellung und sie enthaltende pharmazeutische Präparate |
| US4554101A (en) | 1981-01-09 | 1985-11-19 | New York Blood Center, Inc. | Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity |
| US6024964A (en) | 1985-06-24 | 2000-02-15 | Hoechst Aktiengesellschaft | Membrane anchor/active compound conjugate, its preparation and its uses |
| US5192553A (en) | 1987-11-12 | 1993-03-09 | Biocyte Corporation | Isolation and preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood and methods of therapeutic use |
| EP0604945A1 (en) | 1992-12-28 | 1994-07-06 | Takeda Chemical Industries, Ltd. | TAN-1511, its derivatives, production and use thereof |
| AU666789B2 (en) * | 1992-12-28 | 1996-02-22 | Takeda Chemical Industries Ltd. | 2-amino-6,7-dihydroxy-4-thiaheptanoic acid derivatives, production and use thereof |
| US5449761A (en) * | 1993-09-28 | 1995-09-12 | Cytogen Corporation | Metal-binding targeted polypeptide constructs |
| WO1995012675A1 (en) | 1993-11-04 | 1995-05-11 | Cytoclonal Pharmaceutics, Inc. | A fusion protein and method for making and using same |
| WO1999035162A1 (en) | 1998-01-07 | 1999-07-15 | Jenner Biotherapies, Inc. | Therapeutic liposome-encapsulated immunomodulators |
| US6239119B1 (en) * | 1998-04-27 | 2001-05-29 | Medimmune Oncology, Inc. | Topical administration of amifostine and related compounds |
| DE19822820A1 (de) | 1998-05-20 | 1999-11-25 | Biotechnolog Forschung Gmbh | Pharmazeutisches Präparat zur Wundbehandlung |
| US20030170249A1 (en) * | 1999-02-19 | 2003-09-11 | Hakomori Sen-Itiroh | Vaccines directed to cancer-associated carbohydrate antigens |
| AU4972200A (en) * | 1999-04-26 | 2000-11-10 | Center For Molecular Medicine And Immunology | Use of antioxidants to mitigate radioimmunotherapy-induced radiation toxicity |
| EP1964854A2 (en) * | 1999-10-27 | 2008-09-03 | Cel-Sci Corporation | Methods of preparation and composition of peptide constructs useful for treatment of autoimmune and transplant related host versus graft conditions |
| DE10048840A1 (de) * | 2000-10-02 | 2002-04-11 | Biotechnolog Forschung Gmbh | Verwendung von Lipopeptiden oder Lipoproteinen zur Behandlung von Lungeninfektionen und -tumoren |
| CN102302493B (zh) | 2001-07-31 | 2015-08-12 | 健赞股份有限公司 | 活化祖细胞/干细胞的方法 |
| EP1490106B1 (de) | 2002-04-04 | 2008-05-28 | Helmholtz-Zentrum für Infektionsforschung GmbH | Verwendung eines lipopeptids oder lipoproteins als adjuvans bei therapeutischer oder prophylaktischer vakzinierung |
| US20030224422A1 (en) * | 2002-04-08 | 2003-12-04 | St. Jude Children's Research Hospital, Inc. | Pre-and post therapy gene expression profiling to identify drug targets |
| US20040259790A1 (en) * | 2003-01-30 | 2004-12-23 | Bali Pulendran | Methods for identifying and administering agents that bias the immune response via dendritic cells |
| WO2005030133A2 (en) * | 2003-09-22 | 2005-04-07 | Yale University | Treatment with agonists of toll-like receptors |
| EP1706133B1 (en) * | 2003-12-02 | 2010-10-06 | Cleveland Clinic Foundation | Methods of protecting against radiation using flagellin |
| WO2005056041A2 (en) | 2003-12-02 | 2005-06-23 | Cleveland Clinic Foundation | METHODS OF INHIBITING APOPTOSIS USING LATENT TGFβ |
| US20060039895A1 (en) * | 2004-02-28 | 2006-02-23 | Large Scale Biology Corporation | Ex-vivo rescue of hematopoietic stem cells after lethal irradiation |
| US8008260B2 (en) | 2005-06-13 | 2011-08-30 | Cleveland Clinic Foundation | Methods of protecting against apoptosis using lipopeptides |
| KR101493474B1 (ko) | 2007-01-09 | 2015-02-16 | 클리브랜드 바이오랩스, 아이엔씨. | 조혈 줄기 세포를 증가시키고 이동시키는 방법들 |
-
2006
- 2006-06-13 US US11/917,494 patent/US8008260B2/en not_active Expired - Fee Related
- 2006-06-13 AU AU2006259630A patent/AU2006259630B2/en not_active Ceased
- 2006-06-13 CA CA2612102A patent/CA2612102C/en not_active Expired - Fee Related
- 2006-06-13 WO PCT/US2006/022865 patent/WO2006138238A2/en not_active Ceased
- 2006-06-13 KR KR1020077029227A patent/KR20080030566A/ko not_active Ceased
- 2006-06-13 BR BRPI0611586-1A patent/BRPI0611586A2/pt not_active IP Right Cessation
- 2006-06-13 KR KR1020147004582A patent/KR101604799B1/ko not_active Expired - Fee Related
- 2006-06-13 EP EP20120190223 patent/EP2554181B1/en not_active Expired - Lifetime
- 2006-06-13 ES ES12190223.3T patent/ES2539490T3/es not_active Expired - Lifetime
- 2006-06-13 CN CN2006800293364A patent/CN101242852B/zh not_active Expired - Fee Related
- 2006-06-13 NZ NZ565063A patent/NZ565063A/en not_active IP Right Cessation
- 2006-06-13 JP JP2008516988A patent/JP5000644B2/ja not_active Expired - Fee Related
- 2006-06-13 ES ES06784792T patent/ES2421447T3/es not_active Expired - Lifetime
- 2006-06-13 EA EA200702510A patent/EA014644B1/ru not_active IP Right Cessation
- 2006-06-13 PT PT67847921T patent/PT1904084E/pt unknown
- 2006-06-13 EP EP20060784792 patent/EP1904084B1/en not_active Expired - Lifetime
- 2006-06-13 MX MX2007015834A patent/MX2007015834A/es active IP Right Grant
-
2007
- 2007-12-12 IL IL188091A patent/IL188091A/en not_active IP Right Cessation
-
2008
- 2008-01-04 ZA ZA200800126A patent/ZA200800126B/xx unknown
-
2011
- 2011-03-18 US US13/051,549 patent/US8524668B2/en not_active Expired - Fee Related
-
2013
- 2013-07-15 US US13/942,028 patent/US9006183B2/en not_active Expired - Fee Related
-
2015
- 2015-03-06 US US14/641,061 patent/US9381225B2/en not_active Expired - Fee Related