HRP20100354T1 - Nova formulacija tumoru pridruženih peptida koji se vežu na antigene humanih leukocita (hla) razreda i i ii za uporabu u cjepivima - Google Patents
Nova formulacija tumoru pridruženih peptida koji se vežu na antigene humanih leukocita (hla) razreda i i ii za uporabu u cjepivima Download PDFInfo
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- HRP20100354T1 HRP20100354T1 HR20100354T HRP20100354T HRP20100354T1 HR P20100354 T1 HRP20100354 T1 HR P20100354T1 HR 20100354 T HR20100354 T HR 20100354T HR P20100354 T HRP20100354 T HR P20100354T HR P20100354 T1 HRP20100354 T1 HR P20100354T1
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- 108090000765 processed proteins & peptides Proteins 0.000 title claims abstract 30
- 102000004196 processed proteins & peptides Human genes 0.000 title claims abstract 19
- 239000000203 mixture Substances 0.000 title claims abstract 8
- 206010028980 Neoplasm Diseases 0.000 title claims abstract 6
- 238000009472 formulation Methods 0.000 title claims 2
- 229960005486 vaccine Drugs 0.000 title claims 2
- 239000000427 antigen Substances 0.000 title 1
- 102000036639 antigens Human genes 0.000 title 1
- 108091007433 antigens Proteins 0.000 title 1
- 210000000265 leukocyte Anatomy 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract 13
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims abstract 7
- 229930195725 Mannitol Natural products 0.000 claims abstract 7
- 235000010355 mannitol Nutrition 0.000 claims abstract 7
- 239000000594 mannitol Substances 0.000 claims abstract 7
- CTKXFMQHOOWWEB-UHFFFAOYSA-N Ethylene oxide/propylene oxide copolymer Chemical compound CCCOC(C)COCCO CTKXFMQHOOWWEB-UHFFFAOYSA-N 0.000 claims abstract 5
- 229920001993 poloxamer 188 Polymers 0.000 claims abstract 5
- 229940044519 poloxamer 188 Drugs 0.000 claims abstract 5
- 150000001413 amino acids Chemical class 0.000 claims abstract 4
- 229920001184 polypeptide Polymers 0.000 claims abstract 3
- 150000003839 salts Chemical class 0.000 claims abstract 3
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- 239000002671 adjuvant Substances 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 2
- 229920000053 polysorbate 80 Polymers 0.000 claims 2
- 230000004936 stimulating effect Effects 0.000 claims 1
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 abstract 1
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/10—Peptides having 12 to 20 amino acids
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
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- A61P35/00—Antineoplastic agents
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
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- A61K39/00—Medicinal preparations containing antigens or antibodies
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- A61K2039/55511—Organic adjuvants
- A61K2039/55522—Cytokines; Lymphokines; Interferons
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- A61K39/00—Medicinal preparations containing antigens or antibodies
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- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
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- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
Farmaceutski sastav koji uključuje najmanje dva peptida, naznačeno time da se spomenuti peptidi sastoje od slijeda aminokiselina odabranih u skupini koja se sastoji od SEQ ID BR: 1 do SEQ ID BR: 11 pod uvjetom da sastav uključuje najmanje jedan peptid koji se sastoji od SEQ ID NO:1 ili SEQ ID NO:2 ili varijante ili soli spomenutih peptida, te da peptid nije dugolančani polipeptid pridružen humanom tumoru i nadalje, da se sastoji od manitola i poloksamera 188, naznačeno time da je maseni udio peptida u odnosu na manitol i poloksamer 188 u rasponu od 1:5:1,5 do 1:8:2,2. Patent sadrži još 11 patentnih zahtjeva.
Claims (12)
1. Farmaceutski sastav koji uključuje najmanje dva peptida, naznačeno time da se spomenuti peptidi sastoje od slijeda aminokiselina odabranih u skupini koja se sastoji od SEQ ID BR: 1 do SEQ ID BR: 11 pod uvjetom da sastav uključuje najmanje jedan peptid koji se sastoji od SEQ ID NO:1 ili SEQ ID NO:2 ili varijante ili soli spomenutih peptida, te da peptid nije dugolančani polipeptid pridružen humanom tumoru i nadalje, da se sastoji od manitola i poloksamera 188, naznačeno time da je maseni udio peptida u odnosu na manitol i poloksamer 188 u rasponu od 1:5:1,5 do 1:8:2,2.
2. Farmaceutski sastav prema zahtjevu 1, naznačeno time da je maseni udio peptida naspram manitola i poloksamera 188 u rasponu od 1:0:2 do 1:0:2,2.
3. Farmaceutski sastav koji uključuje najmanje dva peptida naznačeno time da spomenuti peptidi sadrže slijeda aminokiselina odabranih u skupini koja se sastoji od SEQ ID BR: I do SEQ ID BR: 11 pod uvjetom da formulacija uključuje najmanje jedan peptid koji se sastoji od SEQ ID BR:1 ili SEQ ID BR:2 ili varijante ili soli spomenutih peptida, te da peptid nije dugolančani polipeptid pridružen humanom tumoru i nadalje, da sadrži manitol i Tvveen 80®, naznačeno time da je maseni udio peptida u odnosu na manitol i Tween 80® urasponuod 1:2:1,5 do 1:8:2,2.
4. Farmaceutski sastav prema bilo kojem od zahtjeva 1 do 3, naznačeno time da spomenuti peptidi imaju ukupnu duljinu između 9 i 16 aminokiselina.
5. Farmaceutski sastav prema bilo kojem od zahtjeva 1 do 4, naznačeno time da najmanje jedan od spomenutih peptida uključuje veze koje nisu peptidne.
6. Farmaceutski sastav prema bilo kojem od zahtjeva 1 do 5, naznačeno time da spomenuti sastav sadrži peptide koji se sastoje od sljedova aminokiselina koji su prethodno definirani u SEQ ID BR: 1 i/ili SEQ ID BR: 2, te nadalje sadrži najmanje jedan peptid koji se sastoji od slijeda aminokiselina prethodno definiranog u bilo kojem od SEQ ID BR: 3 do SEQ ID BR: 10.
7. Farmaceutski sastav prema bilo kojem od zahtjeva 1 do 6 gdje spomenuti sastav sadrži peptide koji sadrže slijeda aminokiselina koji je prethodno definiran u SEQ ID BR: 11.
8. Farmaceutski sastav prema bilo kojem od zahtjeva 1 do 6 gdje spomenuti sastav sadrži peptide koji se sastoje od slijeda aminokiselina koji je prethodno definiran u SEQ ID BR: 11.
9. Farmaceutski sastav prema bilo kojem od zahtjeva 1 do 6, naznačeno time da je količina prisutnih peptida u sastavu kao i u tkivu, karcinomu, te je i/ili specifična za svakog pacijenta.
10. Farmaceutski sastav prema bilo kojem od zahtjeva 1 do 9 koji nadalje sadrži najmanje jedan prikladni adjuvans.
11. Farmaceutski sastav prema zahtjevu 10, naznačeno time da je spomenuti adjuvans čimbenik stimulacije rasta kolonije.
12. Farmaceutski sastav prema bilo kojem od zahtjeva 1 do 11 za uporabu kao cjepivo protiv karcinoma.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08008292A EP2113253B1 (en) | 2008-04-30 | 2008-04-30 | Novel formulations of tumour-associated peptides binding to human leukocyte antigen (HLA) class I or II molecules for vaccines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20100354T1 true HRP20100354T1 (hr) | 2010-07-31 |
Family
ID=39643855
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20100354T HRP20100354T1 (hr) | 2008-04-30 | 2010-06-28 | Nova formulacija tumoru pridruženih peptida koji se vežu na antigene humanih leukocita (hla) razreda i i ii za uporabu u cjepivima |
| HR20110965T HRP20110965T1 (hr) | 2008-04-24 | 2011-12-21 | Nove formulacije peptida povezanih s tumorima koji se vežu za molekule ljudskog leukocitnog antigena (hla) klase i ili ii za cjepiva |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20110965T HRP20110965T1 (hr) | 2008-04-24 | 2011-12-21 | Nove formulacije peptida povezanih s tumorima koji se vežu za molekule ljudskog leukocitnog antigena (hla) klase i ili ii za cjepiva |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US9289478B2 (hr) |
| EP (2) | EP2113253B1 (hr) |
| JP (1) | JP5717268B2 (hr) |
| CN (1) | CN105749285A (hr) |
| AT (2) | ATE462442T1 (hr) |
| AU (1) | AU2009201589C1 (hr) |
| BR (1) | BRPI0900798A8 (hr) |
| CA (1) | CA2665510C (hr) |
| CY (1) | CY1110178T1 (hr) |
| DE (1) | DE602008000891D1 (hr) |
| DK (2) | DK2113253T3 (hr) |
| EA (1) | EA017492B1 (hr) |
| ES (2) | ES2342506T3 (hr) |
| HR (2) | HRP20100354T1 (hr) |
| MX (1) | MX2009004468A (hr) |
| NZ (1) | NZ576423A (hr) |
| PL (2) | PL2113253T3 (hr) |
| PT (2) | PT2113253E (hr) |
| RS (1) | RS52115B (hr) |
| SI (2) | SI2113253T1 (hr) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7030219B2 (en) | 2000-04-28 | 2006-04-18 | Johns Hopkins University | B7-DC, Dendritic cell co-stimulatory molecules |
| WO2006023598A2 (en) | 2004-08-19 | 2006-03-02 | University Of Maryland, Baltimore | Prostate-specific antigen-derived mhc class ii-restricted peptides and their use in vaccines to treat or prevent prostate cancer |
| PL2338907T3 (pl) | 2007-07-27 | 2016-03-31 | Immatics Biotechnologies Gmbh | Nowe immunogenne epitopy do immunoterapii |
| PT2660248E (pt) | 2007-07-27 | 2015-10-12 | Immatics Biotechnologies Gmbh | Nova imunoterapia para tumores neuronais e cerebrais |
| CY1112212T1 (el) * | 2008-04-24 | 2015-12-09 | Immatics Biotechnologies Gmbh | Νεα σκευασματα πεπτιδιων που σχετιζονται με ογκους τα οποια συνδεονται σε μορια του αντιγονου ανθρωπινων λευκοκυτταρων (hla) ταξης i ή ii για εμβολια |
| NO2119726T3 (hr) | 2008-05-14 | 2015-05-23 | ||
| SI2350129T1 (sl) | 2008-08-25 | 2015-11-30 | Amplimmune, Inc. | Sestavki PD-1 antagonistov in postopek njihove uporabe |
| CN102203125A (zh) * | 2008-08-25 | 2011-09-28 | 安普利穆尼股份有限公司 | Pd-1拮抗剂及其使用方法 |
| AU2014271235B2 (en) * | 2008-10-01 | 2017-03-02 | Immatics Biotechnologies Gmbh | Novel immunotherapy against several tumors including neuronal and brain tumors |
| AU2016204711B2 (en) * | 2008-10-01 | 2018-03-01 | Immatics Biotechnologies Gmbh | Novel immunotherapy against several tumors including neuronal and brain tumors |
| EP2172211B1 (en) | 2008-10-01 | 2014-12-03 | Immatics Biotechnologies GmbH | Composition of tumor-associated peptides and related anti-cancer vaccine for the treatment of glioblastoma (GBM) and other cancers |
| GB201019331D0 (en) | 2010-03-19 | 2010-12-29 | Immatics Biotechnologies Gmbh | Methods for the diagnosis and treatment of cancer based on AVL9 |
| GB201004551D0 (en) | 2010-03-19 | 2010-05-05 | Immatics Biotechnologies Gmbh | NOvel immunotherapy against several tumors including gastrointestinal and gastric cancer |
| GB201004575D0 (en) | 2010-03-19 | 2010-05-05 | Immatics Biotechnologies Gmbh | Composition of tumor associated peptides and related anti cancer vaccine for the treatment of gastric cancer and other cancers |
| AU2015200751B2 (en) * | 2010-03-19 | 2016-11-10 | Immatics Biotechnologies Gmbh | Novel immunotherapy against several tumors including gastrointestinal and gastric cancer |
| GB201006360D0 (en) | 2010-04-16 | 2010-06-02 | Immatics Biotechnologies Gmbh | Method for differentially quantifying naturally processed HLA-restricted peptides for cancer, autoimmune and infectious diseases immunotherapy development |
| NZ609916A (en) * | 2010-12-14 | 2015-03-27 | Immatics Biotechnologies Gmbh | Hla-binding peptides derived from prostate-associated antigenic molecules and methods of use thereof |
| WO2013041542A1 (en) * | 2011-09-19 | 2013-03-28 | Alf Lamprecht | Pharmaceutical formulations comprising spherolyophilisates of biological molecules |
| US20150359864A1 (en) * | 2012-03-09 | 2015-12-17 | Oncotherapy Science, Inc. | Pharmaceutical composition containing peptides |
| CN104602675B (zh) | 2012-06-21 | 2019-06-28 | 法斯瑞斯公司 | 靛玉红的奈米粒子、其衍生物以及制造和使用所述奈米粒子的方法 |
| TWI819228B (zh) | 2013-08-05 | 2023-10-21 | 德商伊瑪提克斯生物科技有限公司 | 新穎肽類，細胞及其用於治療多種腫瘤的用途，其製造方法及包含其等之醫藥組成物（八） |
| GB201319446D0 (en) | 2013-11-04 | 2013-12-18 | Immatics Biotechnologies Gmbh | Personalized immunotherapy against several neuronal and brain tumors |
| GB201408255D0 (en) | 2014-05-09 | 2014-06-25 | Immatics Biotechnologies Gmbh | Novel immunotherapy against several tumours of the blood, such as acute myeloid leukemia (AML) |
| KR20180006945A (ko) | 2015-05-13 | 2018-01-19 | 아게누스 인코포레이티드 | 암 치료 및 예방용 백신 |
| NL2014935B1 (en) | 2015-06-08 | 2017-02-03 | Applied Immune Tech Ltd | T cell receptor like antibodies having fine specificity. |
| SG10202107374UA (en) * | 2015-06-19 | 2021-08-30 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy and methods for generating scaffolds for the use against pancreatic cancer and other cancers |
| CA2936070C (en) | 2015-07-14 | 2023-07-04 | Professional Compounding Centers Of America (Pcca) | Poloxamer-based intralesional injections for the delivery of chemotherapeutic agents |
| CN108601731A (zh) | 2015-12-16 | 2018-09-28 | 磨石肿瘤生物技术公司 | 新抗原的鉴别、制造及使用 |
| WO2018138257A1 (en) * | 2017-01-27 | 2018-08-02 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against ovarian cancer and other cancers |
| KR102699622B1 (ko) | 2017-01-27 | 2024-08-28 | 이매틱스 바이오테크놀로지스 게엠베하 | 난소암 및 다른 암에 대한 면역요법에 사용을 위한 신규 펩티드 및 펩티드의 조합 |
| EA201991444A1 (ru) | 2017-01-27 | 2019-12-30 | Имматикс Байотекнолоджиз Гмбх | Новые пептиды и комбинации пептидов для применения в иммунотерапии рака яичника и других видов рака |
| CA3078744A1 (en) | 2017-10-10 | 2019-04-18 | Gritstone Oncology, Inc. | Neoantigen identification using hotspots |
| CA3083097A1 (en) | 2017-11-22 | 2019-05-31 | Gritstone Oncology, Inc. | Reducing junction epitope presentation for neoantigens |
| DE102018107224A1 (de) | 2018-02-21 | 2019-08-22 | Immatics Biotechnologies Gmbh | Peptide und Kombinationen von Peptiden nicht-kanonischen Ursprungs zur Verwendung in der Immuntherapie gegen verschiedene Krebsarten |
| JP2021522239A (ja) | 2018-04-26 | 2021-08-30 | アジェナス インコーポレイテッド | 熱ショックタンパク質結合ペプチド組成物およびその使用方法 |
| FR3087448B1 (fr) | 2018-10-23 | 2023-10-13 | Pdc Line Pharma | Lignee pdc modifiee pour secreter une cytokine |
| JP2023526228A (ja) * | 2020-05-12 | 2023-06-21 | ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム | 膠芽腫を処置するための方法 |
| DE102020125457A1 (de) | 2020-09-29 | 2022-03-31 | Immatics Biotechnologies Gmbh | Amidierte Peptide und ihre deamidierten Gegenstücke, die durch HLA-A*02-Moleküle präsentiert werden, zur Verwendung in der Immuntherapie gegen verschiedene Krebsarten |
| DE102020125465A1 (de) | 2020-09-29 | 2022-03-31 | Immatics Biotechnologies Gmbh | Amidierte Peptide und ihre deamidierten Gegenstücke, die durch nicht-HLA-A*02-Moleküle präsentiert werden, zur Verwendung in der Immuntherapie gegen verschiedene Krebsarten |
| WO2023148333A1 (en) | 2022-02-03 | 2023-08-10 | CeCaVa GmbH & Co. KG | Co-vaccination with cd4 and cd8 antigens |
| EP4410767A1 (de) | 2023-02-03 | 2024-08-07 | Röhm GmbH | Nachhaltiges c3 verfahren mit integrierter erzeugung von rohstoffen |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6045796A (en) * | 1992-12-17 | 2000-04-04 | Anergen, Inc. | Vaccination with peptide of MHC class II molecules for treatment of autoimmune disease |
| AUPM322393A0 (en) | 1993-12-24 | 1994-01-27 | Austin Research Institute, The | Mucin carbohydrate compounds and their use in immunotherapy |
| CN100360184C (zh) * | 1995-07-27 | 2008-01-09 | 基因技术股份有限公司 | 稳定等渗的冻干蛋白质制剂 |
| US5849589A (en) | 1996-03-11 | 1998-12-15 | Duke University | Culturing monocytes with IL-4, TNF-α and GM-CSF TO induce differentiation to dendric cells |
| US5861483A (en) * | 1996-04-03 | 1999-01-19 | Pro-Neuron, Inc. | Inhibitor of stem cell proliferation and uses thereof |
| US20030162711A1 (en) * | 1996-04-24 | 2003-08-28 | Soren Bjorn | Pharmaceutical formulation |
| US7312196B2 (en) * | 1997-01-08 | 2007-12-25 | Amylin Pharmaceuticals, Inc. | Formulations for amylin agonist peptides |
| US6406705B1 (en) | 1997-03-10 | 2002-06-18 | University Of Iowa Research Foundation | Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant |
| DE19917195B4 (de) | 1999-04-16 | 2006-09-28 | Immatics Biotechnologies Gmbh | Peptid zur Auslösung einer Immunreaktion gegen Tumorzellen, diese enthaltende pharmzeutische Zusammensetzungen, dessen Verwendungen, dafür codierende Nukleinsäure und diese Nukleinsäure enthaltender Expressionsvektor |
| US6897288B1 (en) * | 1999-10-19 | 2005-05-24 | Ludwig Institute For Cancer Research | Mage-A12 antigenic peptides and uses thereof |
| JP2003512057A (ja) * | 1999-10-19 | 2003-04-02 | ルードヴィッヒ インスティテュート フォー キャンサー リサーチ | Ｍａｇｅ−ａ１２抗原ペプチド及びその利用 |
| US7919467B2 (en) * | 2000-12-04 | 2011-04-05 | Immunotope, Inc. | Cytotoxic T-lymphocyte-inducing immunogens for prevention, treatment, and diagnosis of cancer |
| BRPI0311959B8 (pt) * | 2002-06-21 | 2021-05-25 | Novo Nordisk Healthcare Ag | composição, métodos para preparar um polipeptídeo estável do fator vii, e para tratar uma síndrome responsiva do fator vii, e, uso do polipeptídeo do fator vii |
| AU2003256912A1 (en) * | 2002-08-16 | 2004-03-03 | Yeda Research And Development Co. Ltd. | Tumor associated antigen, peptides thereof, and use of same as anti-tumor vaccines |
| MXPA05010881A (es) * | 2003-04-11 | 2006-05-31 | Antigenics Inc | Vacunas e inmunoterapias a base de proteina de choque termico mejorada. |
| TW200539855A (en) * | 2004-03-15 | 2005-12-16 | Wyeth Corp | Calicheamicin conjugates |
| DE102004026135A1 (de) * | 2004-05-25 | 2006-01-05 | Immatics Biotechnologies Gmbh | An MHC-Moleküle bindende Tumor-assoziierte Peptide |
| US20080125361A1 (en) * | 2004-11-12 | 2008-05-29 | Novo Nordisk A/S | Stable Formulations Of Peptides |
| EP1674082A1 (de) * | 2004-12-22 | 2006-06-28 | Zentaris GmbH | Verfahren zur Herstellung von sterilen Suspensionen oder Lyophilisaten schwerlöslicher basischer Peptidkomplexe, diese enthaltende pharmazeutische Formulierungen sowie ihre Verwendung als Arzneimittel |
| EP1717245B1 (en) | 2005-04-26 | 2011-06-08 | Immatics Biotechnologies GmbH | T-cell epitopes from the oncofetal antigen-immature laminin receptor protein and medical uses thereof |
| DK1760089T3 (da) * | 2005-09-05 | 2009-11-16 | Immatics Biotechnologies Gmbh | Tumor-associeret peptides bindende til human leukocyte antigen (HLA) class I eller II molecules og relateret anti-cancer vaccine |
| DK1806359T3 (da) | 2005-09-05 | 2010-06-14 | Immatics Biotechnologies Gmbh | Tumorassocierede peptider, der bindes promiskuøst til Humant Leukocyt-Antigen (HLA) klasse II molekyler |
| WO2007028753A2 (de) | 2005-09-09 | 2007-03-15 | Basf Aktiengesellschaft | Fungizide mischungen auf der basis von triazolen |
| US20080242606A1 (en) * | 2006-06-06 | 2008-10-02 | Zhong Jiang | Use of IMP3 as a Prognostic Marker for Cancer |
| NO2119726T3 (hr) * | 2008-05-14 | 2015-05-23 | ||
| EP2172211B1 (en) * | 2008-10-01 | 2014-12-03 | Immatics Biotechnologies GmbH | Composition of tumor-associated peptides and related anti-cancer vaccine for the treatment of glioblastoma (GBM) and other cancers |
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