KR20080030566A - 리포펩티드를 사용하여 아폽토시스에 대항하는 보호방법 - Google Patents

리포펩티드를 사용하여 아폽토시스에 대항하는 보호방법 Download PDF

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Publication number
KR20080030566A
KR20080030566A KR1020077029227A KR20077029227A KR20080030566A KR 20080030566 A KR20080030566 A KR 20080030566A KR 1020077029227 A KR1020077029227 A KR 1020077029227A KR 20077029227 A KR20077029227 A KR 20077029227A KR 20080030566 A KR20080030566 A KR 20080030566A
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South Korea
Prior art keywords
radiation
cblb601
mice
peptide
compound
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Ceased
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KR1020077029227A
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English (en)
Korean (ko)
Inventor
알렉산더 엔. 샤코프
안드레이 구드코프
Original Assignee
클리브랜드 바이오랩스, 아이엔씨.
클리블랜드 클리닉 파운데이션
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Publication of KR20080030566A publication Critical patent/KR20080030566A/ko
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020077029227A 2005-06-13 2006-06-13 리포펩티드를 사용하여 아폽토시스에 대항하는 보호방법 Ceased KR20080030566A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68981005P 2005-06-13 2005-06-13
US60/689,810 2005-06-13

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020147004582A Division KR101604799B1 (ko) 2005-06-13 2006-06-13 리포펩티드를 사용하여 아폽토시스에 대항하는 보호방법

Publications (1)

Publication Number Publication Date
KR20080030566A true KR20080030566A (ko) 2008-04-04

Family

ID=37571018

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020077029227A Ceased KR20080030566A (ko) 2005-06-13 2006-06-13 리포펩티드를 사용하여 아폽토시스에 대항하는 보호방법
KR1020147004582A Expired - Fee Related KR101604799B1 (ko) 2005-06-13 2006-06-13 리포펩티드를 사용하여 아폽토시스에 대항하는 보호방법

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020147004582A Expired - Fee Related KR101604799B1 (ko) 2005-06-13 2006-06-13 리포펩티드를 사용하여 아폽토시스에 대항하는 보호방법

Country Status (16)

Country Link
US (4) US8008260B2 (enExample)
EP (2) EP1904084B1 (enExample)
JP (1) JP5000644B2 (enExample)
KR (2) KR20080030566A (enExample)
CN (1) CN101242852B (enExample)
AU (1) AU2006259630B2 (enExample)
BR (1) BRPI0611586A2 (enExample)
CA (1) CA2612102C (enExample)
EA (1) EA014644B1 (enExample)
ES (2) ES2421447T3 (enExample)
IL (1) IL188091A (enExample)
MX (1) MX2007015834A (enExample)
NZ (1) NZ565063A (enExample)
PT (1) PT1904084E (enExample)
WO (1) WO2006138238A2 (enExample)
ZA (1) ZA200800126B (enExample)

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CA2654446C (en) 2005-06-07 2014-02-25 The Regents Of The University Of Colorado Inhibitors of serine protease activity and their use in methods and compositions for treatment of graft rejection and promotion of graft survival
WO2006138238A2 (en) * 2005-06-13 2006-12-28 Cleveland Biolabs, Inc. Methods of protecting against apoptosis using lipopeptides
EP2502628B1 (en) * 2006-06-23 2016-12-14 Alethia Biotherapeutics Inc. Polynucleotides and polypeptide sequences involved in cancer
KR101493474B1 (ko) * 2007-01-09 2015-02-16 클리브랜드 바이오랩스, 아이엔씨. 조혈 줄기 세포를 증가시키고 이동시키는 방법들
WO2009074569A1 (en) * 2007-12-11 2009-06-18 Bracco International Bv Targeting and therapeutic compounds with a polyproline-comprising spacer and gas-filled microvesicles comprising said compounds
AU2009287339B2 (en) * 2008-08-28 2015-11-26 The University Of Queensland Mutant bacterial glycoproteins and uses thereof
AU2009293750C1 (en) * 2008-09-18 2016-02-04 Nippon Zoki Pharmaceutical Co., Ltd. Amino acid derivative
WO2010060186A1 (en) 2008-11-03 2010-06-03 Alethia Biotherapeutics Inc. Antibodies that specifically block the biological activity of a tumor antigen
US8404444B2 (en) * 2009-02-25 2013-03-26 Diacarta Llc Method for predicting the level of damage to cells by measuring free circulating Alu nucleic acid
JP5210405B2 (ja) * 2010-03-17 2013-06-12 日本臓器製薬株式会社 アミノ酸誘導体を含有する医薬及び該誘導体の製造方法
EP2490021A1 (en) 2011-02-18 2012-08-22 Biotempt B.V. Modulators of PRR and GPCR signalling
EP2683398A1 (en) 2011-03-11 2014-01-15 Omni Bio Pharmaceutical, Inc. Compositions, methods and uses for radioprotectants
DK3173427T3 (da) 2011-03-31 2019-08-05 Adc Therapeutics Sa Antistoffer mod nyre-associeret antigen 1 og antigen-bindende fragmenter deraf
DE102011018499A1 (de) * 2011-04-23 2012-10-25 Emc Microcollections Gmbh Topische Nanopartikel-Vakzine zur Immunstimulation der dendritischen Zellen in der Haut
HRP20190946T1 (hr) 2012-01-09 2019-07-26 Adc Therapeutics Sa Sredstva za liječenje trostruko negativnog raka dojke
JP5686841B2 (ja) * 2013-04-26 2015-03-18 フレゼニウス メディカル ケア ドイッチェランド ゲゼルシャフト ミット ベシュレンクテル ハフツング 損傷しまたは傷害を受けた組織または臓器の内皮／上皮再生用医薬の製造のための、幹細胞由来微小胞（ｍｖ）の使用ならびにインビトロおよびインビボでの関連した方法
US20160287553A1 (en) 2013-11-22 2016-10-06 Deutsches Krebsforschungszentrum Translation inhibitors in high-dose chemo- and/or high-dose radiotherapy
WO2016073733A1 (en) * 2014-11-06 2016-05-12 Cleveland Biolabs, Inc. Methods of treating cancer using lipopeptides
CN112851755B (zh) * 2021-01-13 2023-09-01 中国人民解放军军事科学院军事医学研究院 一种线性脂肽化合物及其制备方法与应用

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Also Published As

Publication number Publication date
AU2006259630A1 (en) 2006-12-28
US20150306168A1 (en) 2015-10-29
IL188091A0 (en) 2008-03-20
CA2612102A1 (en) 2006-12-28
US20110237507A1 (en) 2011-09-29
HK1123495A1 (en) 2009-06-19
IL188091A (en) 2014-06-30
AU2006259630B2 (en) 2011-10-27
NZ565063A (en) 2011-04-29
WO2006138238A2 (en) 2006-12-28
EP1904084A2 (en) 2008-04-02
EP2554181A3 (en) 2013-03-13
ES2421447T3 (es) 2013-09-02
MX2007015834A (es) 2008-09-15
US20140045750A1 (en) 2014-02-13
CA2612102C (en) 2016-02-09
US9381225B2 (en) 2016-07-05
EP2554181B1 (en) 2015-03-18
CN101242852B (zh) 2012-10-10
EP1904084A4 (en) 2012-03-21
CN101242852A (zh) 2008-08-13
US8008260B2 (en) 2011-08-30
PT1904084E (pt) 2013-07-22
BRPI0611586A2 (pt) 2010-09-21
JP2008543847A (ja) 2008-12-04
WO2006138238A3 (en) 2007-07-19
EP1904084B1 (en) 2013-04-24
US20090214467A1 (en) 2009-08-27
JP5000644B2 (ja) 2012-08-15
ES2539490T3 (es) 2015-07-01
ZA200800126B (en) 2009-10-28
EA014644B1 (ru) 2010-12-30
EA200702510A1 (ru) 2008-06-30
US9006183B2 (en) 2015-04-14
KR20140041874A (ko) 2014-04-04
KR101604799B1 (ko) 2016-03-28
HK1181684A1 (en) 2013-11-15
EP2554181A2 (en) 2013-02-06
US8524668B2 (en) 2013-09-03

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Appeal identifier: 2014101000815

Request date: 20140212

Appeal kind category: Appeal against decision to decline refusal