JP2005500345A5 - - Google Patents
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- Publication number
- JP2005500345A5 JP2005500345A5 JP2003516514A JP2003516514A JP2005500345A5 JP 2005500345 A5 JP2005500345 A5 JP 2005500345A5 JP 2003516514 A JP2003516514 A JP 2003516514A JP 2003516514 A JP2003516514 A JP 2003516514A JP 2005500345 A5 JP2005500345 A5 JP 2005500345A5
- Authority
- JP
- Japan
- Prior art keywords
- indol
- alkyl
- substituted
- sulfonyl
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 47
- 125000003118 aryl group Chemical group 0.000 claims 30
- 229910052739 hydrogen Inorganic materials 0.000 claims 28
- 229910052799 carbon Inorganic materials 0.000 claims 24
- 125000000547 substituted alkyl group Chemical group 0.000 claims 21
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 14
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 13
- 125000001072 heteroaryl group Chemical group 0.000 claims 12
- 125000001624 naphthyl group Chemical group 0.000 claims 12
- 229910052736 halogen Inorganic materials 0.000 claims 11
- 150000002367 halogens Chemical class 0.000 claims 11
- 150000003839 salts Chemical class 0.000 claims 11
- -1 substituted Chemical class 0.000 claims 11
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 10
- 239000003814 drug Substances 0.000 claims 9
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 241000124008 Mammalia Species 0.000 claims 5
- 239000001257 hydrogen Substances 0.000 claims 5
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 5
- 230000037396 body weight Effects 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000035475 disorder Diseases 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- NELPBEUIKAVHQD-UHFFFAOYSA-N 2-(2-methyl-5-naphthalen-1-ylsulfonyl-1h-indol-3-yl)ethanamine Chemical compound C1=CC=C2C(S(=O)(=O)C3=CC=C4NC(=C(C4=C3)CCN)C)=CC=CC2=C1 NELPBEUIKAVHQD-UHFFFAOYSA-N 0.000 claims 3
- UREMGOQLUQXFJL-UHFFFAOYSA-N 2-[5-(3,5-difluorophenyl)sulfonyl-1,2-dimethylindol-3-yl]-n-methylethanamine Chemical compound C1=C2C(CCNC)=C(C)N(C)C2=CC=C1S(=O)(=O)C1=CC(F)=CC(F)=C1 UREMGOQLUQXFJL-UHFFFAOYSA-N 0.000 claims 3
- RQBLNPUMXBCFNO-UHFFFAOYSA-N 2-[5-(3,5-difluorophenyl)sulfonyl-1,2-dimethylindol-3-yl]ethanamine Chemical compound C=1C=C2N(C)C(C)=C(CCN)C2=CC=1S(=O)(=O)C1=CC(F)=CC(F)=C1 RQBLNPUMXBCFNO-UHFFFAOYSA-N 0.000 claims 3
- LLIOTKAPGWUDLW-UHFFFAOYSA-N 2-[5-(benzenesulfonyl)-1,2-dimethylindol-3-yl]ethanamine Chemical compound C=1C=C2N(C)C(C)=C(CCN)C2=CC=1S(=O)(=O)C1=CC=CC=C1 LLIOTKAPGWUDLW-UHFFFAOYSA-N 0.000 claims 3
- UZKANRSZEKXWBK-UHFFFAOYSA-N 2-[5-(benzenesulfonyl)-1-methylindol-3-yl]ethanamine Chemical compound C=1C=C2N(C)C=C(CCN)C2=CC=1S(=O)(=O)C1=CC=CC=C1 UZKANRSZEKXWBK-UHFFFAOYSA-N 0.000 claims 3
- MNKKKEXJDXIOMJ-UHFFFAOYSA-N 2-(1,2-dimethyl-5-naphthalen-1-ylsulfonylindol-3-yl)ethanamine Chemical compound C1=CC=C2C(S(=O)(=O)C=3C=C4C(CCN)=C(N(C4=CC=3)C)C)=CC=CC2=C1 MNKKKEXJDXIOMJ-UHFFFAOYSA-N 0.000 claims 2
- JDDNLLGCJUJSHT-UHFFFAOYSA-N 2-[5-(benzenesulfonyl)-1,2-dimethylindol-3-yl]-n-methylethanamine Chemical compound C1=C2C(CCNC)=C(C)N(C)C2=CC=C1S(=O)(=O)C1=CC=CC=C1 JDDNLLGCJUJSHT-UHFFFAOYSA-N 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 2
- 208000019901 Anxiety disease Diseases 0.000 claims 2
- 206010003805 Autism Diseases 0.000 claims 2
- 208000020706 Autistic disease Diseases 0.000 claims 2
- 208000008589 Obesity Diseases 0.000 claims 2
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 claims 2
- 230000036506 anxiety Effects 0.000 claims 2
- 206010015037 epilepsy Diseases 0.000 claims 2
- 125000001041 indolyl group Chemical group 0.000 claims 2
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 2
- 235000020824 obesity Nutrition 0.000 claims 2
- 201000000980 schizophrenia Diseases 0.000 claims 2
- 208000011580 syndromic disease Diseases 0.000 claims 2
- MLUOGHSPITZEOK-UHFFFAOYSA-N 2-(1,2-dimethyl-5-naphthalen-1-ylsulfonylindol-3-yl)-n-methylethanamine Chemical compound C1=CC=C2C(S(=O)(=O)C3=CC=C4N(C)C(C)=C(C4=C3)CCNC)=CC=CC2=C1 MLUOGHSPITZEOK-UHFFFAOYSA-N 0.000 claims 1
- ITFGBWUSEPYTHU-UHFFFAOYSA-N 2-[1,2-dimethyl-5-(4-methylphenyl)sulfonylindol-3-yl]-n-methylethanamine Chemical compound C1=C2C(CCNC)=C(C)N(C)C2=CC=C1S(=O)(=O)C1=CC=C(C)C=C1 ITFGBWUSEPYTHU-UHFFFAOYSA-N 0.000 claims 1
- ZIEOCPTYWQLJCV-UHFFFAOYSA-N 2-[1,2-dimethyl-5-(4-methylphenyl)sulfonylindol-3-yl]ethanamine Chemical compound C=1C=C2N(C)C(C)=C(CCN)C2=CC=1S(=O)(=O)C1=CC=C(C)C=C1 ZIEOCPTYWQLJCV-UHFFFAOYSA-N 0.000 claims 1
- RAOZZDDCVWLTRO-UHFFFAOYSA-N 2-[1,2-dimethyl-5-[4-(trifluoromethyl)phenyl]sulfonylindol-3-yl]-n-methylethanamine Chemical compound C1=C2C(CCNC)=C(C)N(C)C2=CC=C1S(=O)(=O)C1=CC=C(C(F)(F)F)C=C1 RAOZZDDCVWLTRO-UHFFFAOYSA-N 0.000 claims 1
- WBQZOOCVAVTLOQ-UHFFFAOYSA-N 2-[1,2-dimethyl-5-[4-(trifluoromethyl)phenyl]sulfonylindol-3-yl]ethanamine Chemical compound C=1C=C2N(C)C(C)=C(CCN)C2=CC=1S(=O)(=O)C1=CC=C(C(F)(F)F)C=C1 WBQZOOCVAVTLOQ-UHFFFAOYSA-N 0.000 claims 1
- OUGAFGRZMQOEIF-UHFFFAOYSA-N 2-[1-methyl-5-(4-methylphenyl)sulfonylindol-3-yl]ethanamine Chemical compound C1=CC(C)=CC=C1S(=O)(=O)C1=CC=C(N(C)C=C2CCN)C2=C1 OUGAFGRZMQOEIF-UHFFFAOYSA-N 0.000 claims 1
- PXKPSYOITWSBKH-UHFFFAOYSA-N 2-[2-methyl-5-(4-methylphenyl)sulfonyl-1h-indol-3-yl]ethanamine Chemical compound C1=C2C(CCN)=C(C)NC2=CC=C1S(=O)(=O)C1=CC=C(C)C=C1 PXKPSYOITWSBKH-UHFFFAOYSA-N 0.000 claims 1
- JQJQAQDABDUXML-UHFFFAOYSA-N 2-[2-methyl-5-[4-(trifluoromethyl)phenyl]sulfonyl-1h-indol-3-yl]ethanamine Chemical compound C1=C2C(CCN)=C(C)NC2=CC=C1S(=O)(=O)C1=CC=C(C(F)(F)F)C=C1 JQJQAQDABDUXML-UHFFFAOYSA-N 0.000 claims 1
- OQHKVIGXVGSBCT-UHFFFAOYSA-N 2-[5-(3,5-difluorophenyl)sulfonyl-2-methyl-1h-indol-3-yl]ethanamine Chemical compound C1=C2C(CCN)=C(C)NC2=CC=C1S(=O)(=O)C1=CC(F)=CC(F)=C1 OQHKVIGXVGSBCT-UHFFFAOYSA-N 0.000 claims 1
- HJHIRISEUZGYTQ-UHFFFAOYSA-N 2-[5-(3-methoxyphenyl)sulfonyl-1,2-dimethylindol-3-yl]-n-methylethanamine Chemical compound C1=C2C(CCNC)=C(C)N(C)C2=CC=C1S(=O)(=O)C1=CC=CC(OC)=C1 HJHIRISEUZGYTQ-UHFFFAOYSA-N 0.000 claims 1
- BARSALPWPUGACB-UHFFFAOYSA-N 2-[5-(3-methoxyphenyl)sulfonyl-1,2-dimethylindol-3-yl]ethanamine Chemical compound COC1=CC=CC(S(=O)(=O)C=2C=C3C(CCN)=C(C)N(C)C3=CC=2)=C1 BARSALPWPUGACB-UHFFFAOYSA-N 0.000 claims 1
- KDCIXEOCFNUDCE-UHFFFAOYSA-N 2-[5-(benzenesulfonyl)-1,2-dimethylindol-3-yl]-n,n-dimethylethanamine Chemical compound C1=C2C(CCN(C)C)=C(C)N(C)C2=CC=C1S(=O)(=O)C1=CC=CC=C1 KDCIXEOCFNUDCE-UHFFFAOYSA-N 0.000 claims 1
- RWGCLAKCGJWBIT-UHFFFAOYSA-N 2-[5-(benzenesulfonyl)-2-methyl-1h-indol-3-yl]-n-methylethanamine Chemical compound C1=C2C(CCNC)=C(C)NC2=CC=C1S(=O)(=O)C1=CC=CC=C1 RWGCLAKCGJWBIT-UHFFFAOYSA-N 0.000 claims 1
- UAKBZSDLNOGZRK-UHFFFAOYSA-N 2-[5-(benzenesulfonyl)-2-methyl-1h-indol-3-yl]ethanamine Chemical compound C1=C2C(CCN)=C(C)NC2=CC=C1S(=O)(=O)C1=CC=CC=C1 UAKBZSDLNOGZRK-UHFFFAOYSA-N 0.000 claims 1
- 125000004211 3,5-difluorophenyl group Chemical group [H]C1=C(F)C([H])=C(*)C([H])=C1F 0.000 claims 1
- SGZZILDVPIWUDJ-UHFFFAOYSA-N COc1cccc(c1)S(=O)(=O)c1ccc2[nH]c(C)c(CCN)c2c1.COc1cccc(c1)S(=O)(=O)c1ccc2n(C)c(C)c(CCN)c2c1 Chemical compound COc1cccc(c1)S(=O)(=O)c1ccc2[nH]c(C)c(CCN)c2c1.COc1cccc(c1)S(=O)(=O)c1ccc2n(C)c(C)c(CCN)c2c1 SGZZILDVPIWUDJ-UHFFFAOYSA-N 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- QJGQUHMNIGDVPM-BJUDXGSMSA-N Nitrogen-13 Chemical compound [13N] QJGQUHMNIGDVPM-BJUDXGSMSA-N 0.000 claims 1
- KRHYYFGTRYWZRS-BJUDXGSMSA-N ac1l2y5h Chemical compound [18FH] KRHYYFGTRYWZRS-BJUDXGSMSA-N 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- OKTJSMMVPCPJKN-BJUDXGSMSA-N carbon-11 Chemical compound [11C] OKTJSMMVPCPJKN-BJUDXGSMSA-N 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- SURZCVYFPAXNGN-UHFFFAOYSA-N methyl-carbamic acid ethyl ester Chemical compound CCOC(=O)NC SURZCVYFPAXNGN-UHFFFAOYSA-N 0.000 claims 1
- WDFVUCPIPLUHNA-UHFFFAOYSA-N n-methyl-2-[1-methyl-5-(4-methylphenyl)sulfonylindol-3-yl]ethanamine Chemical compound C1=C2C(CCNC)=CN(C)C2=CC=C1S(=O)(=O)C1=CC=C(C)C=C1 WDFVUCPIPLUHNA-UHFFFAOYSA-N 0.000 claims 1
- 238000013421 nuclear magnetic resonance imaging Methods 0.000 claims 1
- QVGXLLKOCUKJST-BJUDXGSMSA-N oxygen-15 atom Chemical compound [15O] QVGXLLKOCUKJST-BJUDXGSMSA-N 0.000 claims 1
- 238000007911 parenteral administration Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 238000002600 positron emission tomography Methods 0.000 claims 1
- 238000006268 reductive amination reaction Methods 0.000 claims 1
- 230000002829 reductive effect Effects 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 1
- SSAVDLPACQMBQP-UHFFFAOYSA-N tert-butyl n-[2-[5-(benzenesulfonyl)-1,2-dimethylindol-3-yl]ethyl]-n-methylcarbamate Chemical compound C1=C2C(CCN(C)C(=O)OC(C)(C)C)=C(C)N(C)C2=CC=C1S(=O)(=O)C1=CC=CC=C1 SSAVDLPACQMBQP-UHFFFAOYSA-N 0.000 claims 1
- GPSPPHXFEULOET-UHFFFAOYSA-N tert-butyl n-[2-[5-(benzenesulfonyl)-1,2-dimethylindol-3-yl]ethyl]carbamate Chemical compound C=1C=C2N(C)C(C)=C(CCNC(=O)OC(C)(C)C)C2=CC=1S(=O)(=O)C1=CC=CC=C1 GPSPPHXFEULOET-UHFFFAOYSA-N 0.000 claims 1
- OGGRXWQJARUWQH-UHFFFAOYSA-N tert-butyl n-[2-[5-(benzenesulfonyl)-1-methylindol-3-yl]ethyl]carbamate Chemical compound C=1C=C2N(C)C=C(CCNC(=O)OC(C)(C)C)C2=CC=1S(=O)(=O)C1=CC=CC=C1 OGGRXWQJARUWQH-UHFFFAOYSA-N 0.000 claims 1
- DJNPSJIAUHAEOX-UHFFFAOYSA-N tert-butyl n-[2-[5-(benzenesulfonyl)-1h-indol-3-yl]ethyl]carbamate Chemical compound C1=C2C(CCNC(=O)OC(C)(C)C)=CNC2=CC=C1S(=O)(=O)C1=CC=CC=C1 DJNPSJIAUHAEOX-UHFFFAOYSA-N 0.000 claims 1
- XNKVQFRXQMVMRV-UHFFFAOYSA-N tert-butyl n-[2-[5-(benzenesulfonyl)-2-methyl-1h-indol-3-yl]ethyl]carbamate Chemical compound C1=C2C(CCNC(=O)OC(C)(C)C)=C(C)NC2=CC=C1S(=O)(=O)C1=CC=CC=C1 XNKVQFRXQMVMRV-UHFFFAOYSA-N 0.000 claims 1
- 230000000699 topical effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30983201P | 2001-08-03 | 2001-08-03 | |
| US32688501P | 2001-10-03 | 2001-10-03 | |
| PCT/US2002/024759 WO2003011284A1 (en) | 2001-08-03 | 2002-08-01 | 5-arylsulfonyl indoles having 5-ht6 receptor affinity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005500345A JP2005500345A (ja) | 2005-01-06 |
| JP2005500345A5 true JP2005500345A5 (enExample) | 2005-09-29 |
Family
ID=26977033
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003516514A Pending JP2005500345A (ja) | 2001-08-03 | 2002-08-01 | ５−ｈｔ６受容体親和性を有する５−アリールスルホニルインドール |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6565829B2 (enExample) |
| EP (1) | EP1411925A1 (enExample) |
| JP (1) | JP2005500345A (enExample) |
| BR (1) | BR0211561A (enExample) |
| CA (1) | CA2452743A1 (enExample) |
| MX (1) | MXPA04001089A (enExample) |
| WO (1) | WO2003011284A1 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR039127A1 (es) | 2002-03-27 | 2005-02-09 | Glaxo Group Ltd | Compuesto de quinolina, procedimiento para su preparacion, composicion farmaceutica que lo comprende y uso del mismo para la fabricacion de un medicamento |
| US7393537B2 (en) | 2003-04-25 | 2008-07-01 | Allergan, Inc. | Botulinum toxin for treatment of obsessive compulsive finger biting disorder |
| WO2004096269A2 (en) * | 2003-04-25 | 2004-11-11 | Allergan, Inc. | Botulinum neurotoxin for treating tics and obsessive compulsive behaviors |
| JP2006525972A (ja) * | 2003-05-09 | 2006-11-16 | ラボラトリオス・デル・ドクトル・エステベ・ソシエダッド・アノニマ | 食物摂取障害の予防および／または治療用の医薬品製造のためのスルホンアミド誘導体の使用 |
| NZ544331A (en) | 2003-07-22 | 2010-03-26 | Arena Pharm Inc | Diaryl and arylheteroaryl urea derivatives as modulators of the 5-HT2A serotonin receptor useful for the prophylaxis and treatment of disorders related thereto |
| DE102004048716A1 (de) * | 2004-10-06 | 2006-04-20 | Dr. Willmar Schwabe Gmbh & Co. Kg | Verwendung von Lavendelöl zur Prophylaxe und Behandlung von Neurasthenie, Somatisierungsstörungen und von anderen stress-assoziierten Erkrankungen |
| GB0422263D0 (en) * | 2004-10-07 | 2004-11-10 | Glaxo Group Ltd | Novel compounds |
| KR20070088798A (ko) * | 2004-12-21 | 2007-08-29 | 에프. 호프만-라 로슈 아게 | 크로만 유도체 및 그의 5-ｈｔ 수용체 리간드로서의 용도 |
| KR100899061B1 (ko) * | 2004-12-21 | 2009-05-25 | 에프. 호프만-라 로슈 아게 | 테트랄린 및 인단 유도체 및 이의 용도 |
| CN101119965B (zh) * | 2004-12-21 | 2012-09-26 | 弗·哈夫曼-拉罗切有限公司 | 萘满和茚满衍生物及其用途 |
| US7998981B2 (en) * | 2005-08-12 | 2011-08-16 | Suven Life Sciences Limited | Aminoaryl sulphonamide derivatives as functional 5-HT6 ligands |
| CN101300246A (zh) * | 2005-11-03 | 2008-11-05 | 弗·哈夫曼-拉罗切有限公司 | 作为5－ht6抑制剂的芳基磺酰基色满类化合物作为蛋白激酶抑制剂的吲哚基马来酰亚胺衍生物 |
| JP2009541249A (ja) * | 2006-06-20 | 2009-11-26 | エフ．ホフマン−ラ ロシュ アーゲー | アリールスルホニルナフタレン誘導体およびその使用 |
| JP2009541423A (ja) * | 2006-06-23 | 2009-11-26 | ラボラトリオス・デル・ドクトル・エステベ・ソシエダッド・アノニマ | コリンエステラーゼ阻害剤と５‐ｈｔ６レセプター親和性の化合物との組合せ |
| EP2254564A1 (en) | 2007-12-12 | 2010-12-01 | Glaxo Group Limited | Combinations comprising 3-phenylsulfonyl-8-piperazinyl-1yl-quinoline |
| EP2236511A4 (en) | 2007-12-21 | 2011-04-13 | Alla Chem Llc | LIGANDS OF ALPHA ADRENOCEPTORS AND OF DOPAMINE, HISTAMIN, IMIDAZOLIN AND SEROTONIN RECEPTORS AND THEIR APPLICATION THEREOF |
| WO2009123714A2 (en) | 2008-04-02 | 2009-10-08 | Arena Pharmaceuticals, Inc. | Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor |
| US9126946B2 (en) | 2008-10-28 | 2015-09-08 | Arena Pharmaceuticals, Inc. | Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)urea and crystalline forms related thereto |
| JP2018516992A (ja) | 2015-06-12 | 2018-06-28 | アクソファント サイエンシーズ ゲーエムベーハーＡｘｏｖａｎｔ Ｓｃｉｅｎｃｅｓ Ｇｍｂｈ | レム睡眠行動障害の予防および処置のために有用なジアリールおよびアリールヘテロアリール尿素誘導体 |
| CN108472285A (zh) | 2015-07-15 | 2018-08-31 | 阿速万科学有限责任公司 | 用于预防和治疗与神经退行性疾病相关联的幻觉的二芳基和芳基杂芳基脲衍生物 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9226532D0 (en) | 1992-12-21 | 1993-02-17 | Smithkline Beecham Plc | Compounds |
| GEP20032920B (en) | 1998-02-25 | 2003-03-25 | Genetics Inst | Inhibitors of Phospholipase Enzymes |
| GB9820113D0 (en) * | 1998-09-15 | 1998-11-11 | Merck Sharp & Dohme | Therapeutic agents |
| MY122278A (en) | 1999-07-19 | 2006-04-29 | Upjohn Co | 1,2,3,4,5,6-hexahydroazepino[4,5-b]indoles containing arylsulfones at the 9-position |
| ES2566056T3 (es) * | 2001-03-29 | 2016-04-08 | Eli Lilly And Company | N-(2-ariletil)bencilaminas como antagonistas del receptor 5-HT6 |
-
2002
- 2002-08-01 MX MXPA04001089A patent/MXPA04001089A/es unknown
- 2002-08-01 BR BR0211561-1A patent/BR0211561A/pt not_active IP Right Cessation
- 2002-08-01 CA CA002452743A patent/CA2452743A1/en not_active Abandoned
- 2002-08-01 WO PCT/US2002/024759 patent/WO2003011284A1/en not_active Ceased
- 2002-08-01 US US10/210,377 patent/US6565829B2/en not_active Expired - Fee Related
- 2002-08-01 JP JP2003516514A patent/JP2005500345A/ja active Pending
- 2002-08-01 EP EP02756958A patent/EP1411925A1/en not_active Withdrawn
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