JP2008543860A5 - - Google Patents

Info

Publication number

JP2008543860A5

JP2008543860A5 JP2008517067A JP2008517067A JP2008543860A5 JP 2008543860 A5 JP2008543860 A5 JP 2008543860A5 JP 2008517067 A JP2008517067 A JP 2008517067A JP 2008517067 A JP2008517067 A JP 2008517067A JP 2008543860 A5 JP2008543860 A5 JP 2008543860A5

Authority

JP

Japan

Prior art keywords

methyl

propyl

ethyl

phenyl

trifluoromethyl

Prior art date

2006-06-14

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

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• 150000001875 compounds Chemical class 0.000 claims 14
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 9
• 239000000203 mixture Substances 0.000 claims 9
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 7
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
• 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 6
• 201000010099 disease Diseases 0.000 claims 5
• UUIQMZJEGPQKFD-UHFFFAOYSA-N Methyl butyrate Chemical compound CCCC(=O)OC UUIQMZJEGPQKFD-UHFFFAOYSA-N 0.000 claims 4
• 229910052739 hydrogen Inorganic materials 0.000 claims 4
• 239000001257 hydrogen Substances 0.000 claims 4
• 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 4
• 125000000217 alkyl group Chemical group 0.000 claims 3
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 3
• 208000024827 Alzheimer disease Diseases 0.000 claims 2
• 208000012902 Nervous system disease Diseases 0.000 claims 2
• XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 claims 2
• KXKVLQRXCPHEJC-UHFFFAOYSA-N acetic acid trimethyl ester Natural products COC(C)=O KXKVLQRXCPHEJC-UHFFFAOYSA-N 0.000 claims 2
• 208000006673 asthma Diseases 0.000 claims 2
• NBIIXXVUZAFLBC-UHFFFAOYSA-M dihydrogenphosphate Chemical compound OP(O)([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-M 0.000 claims 2
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
• 230000002757 inflammatory effect Effects 0.000 claims 2
• CNMFHDIDIMZHKY-UHFFFAOYSA-N methyl 2,2-dimethylpropanoate Chemical compound COC(=O)C(C)(C)C CNMFHDIDIMZHKY-UHFFFAOYSA-N 0.000 claims 2
• 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 2
• -1 3- (trifluoromethyl) phenyl Chemical group 0.000 claims 1
• 201000001320 Atherosclerosis Diseases 0.000 claims 1
• 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
• 206010012689 Diabetic retinopathy Diseases 0.000 claims 1
• 206010012735 Diarrhoea Diseases 0.000 claims 1
• 208000018522 Gastrointestinal disease Diseases 0.000 claims 1
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
• 241000124008 Mammalia Species 0.000 claims 1
• 206010028980 Neoplasm Diseases 0.000 claims 1
• 208000018737 Parkinson disease Diseases 0.000 claims 1
• 206010039966 Senile dementia Diseases 0.000 claims 1
• 229940121359 adenosine receptor antagonist Drugs 0.000 claims 1
• 230000033115 angiogenesis Effects 0.000 claims 1
• 201000011510 cancer Diseases 0.000 claims 1
• 208000010643 digestive system disease Diseases 0.000 claims 1
• 208000018685 gastrointestinal system disease Diseases 0.000 claims 1
• 210000001035 gastrointestinal tract Anatomy 0.000 claims 1
• 150000002431 hydrogen Chemical class 0.000 claims 1
• 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 1
• 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
• 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
• 125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 239000000296 purinergic P1 receptor antagonist Substances 0.000 claims 1
• 150000003839 salts Chemical class 0.000 claims 1
• 0 *C[n]1ncc(-c2nc(N(*)C(N(*)C3=O)=O)c3[n]2C(*)*)c1 Chemical compound *C[n]1ncc(-c2nc(N(*)C(N(*)C3=O)=O)c3[n]2C(*)*)c1 0.000 description 1