JP2013538857A5 - - Google Patents
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- Publication number
- JP2013538857A5 JP2013538857A5 JP2013531861A JP2013531861A JP2013538857A5 JP 2013538857 A5 JP2013538857 A5 JP 2013538857A5 JP 2013531861 A JP2013531861 A JP 2013531861A JP 2013531861 A JP2013531861 A JP 2013531861A JP 2013538857 A5 JP2013538857 A5 JP 2013538857A5
- Authority
- JP
- Japan
- Prior art keywords
- crystalline oxalate
- composition
- crystalline
- salt
- powder
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims description 38
- 150000003891 oxalate salts Chemical class 0.000 claims description 16
- 239000008194 pharmaceutical composition Substances 0.000 claims description 12
- 238000000634 powder X-ray diffraction Methods 0.000 claims description 10
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 8
- 239000012453 solvate Substances 0.000 claims description 8
- 208000019693 Lung disease Diseases 0.000 claims description 6
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims description 4
- 241000124008 Mammalia Species 0.000 claims description 4
- 208000006673 asthma Diseases 0.000 claims description 4
- 238000000113 differential scanning calorimetry Methods 0.000 claims description 4
- 239000003937 drug carrier Substances 0.000 claims description 4
- 238000002844 melting Methods 0.000 claims description 4
- 230000008018 melting Effects 0.000 claims description 4
- 150000003839 salts Chemical class 0.000 claims description 4
- 239000002294 steroidal antiinflammatory agent Substances 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 3
- QMOVGVNKXUTCQU-UHFFFAOYSA-N (2-phenylphenyl)carbamic acid Chemical compound OC(=O)NC1=CC=CC=C1C1=CC=CC=C1 QMOVGVNKXUTCQU-UHFFFAOYSA-N 0.000 claims description 2
- -1 8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl Chemical group 0.000 claims description 2
- 230000007883 bronchodilation Effects 0.000 claims description 2
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 125000000031 ethylamino group Chemical group [H]C([H])([H])C([H])([H])N([H])[*] 0.000 claims description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 2
- 125000004482 piperidin-4-yl group Chemical group N1CCC(CC1)* 0.000 claims description 2
- 239000000843 powder Substances 0.000 claims description 2
- 238000002560 therapeutic procedure Methods 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 14
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 210000004072 lung Anatomy 0.000 claims 2
- 150000004677 hydrates Chemical class 0.000 claims 1
- 238000000034 method Methods 0.000 description 6
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38814810P | 2010-09-30 | 2010-09-30 | |
| US61/388,148 | 2010-09-30 | ||
| PCT/US2011/053997 WO2012044825A1 (en) | 2010-09-30 | 2011-09-29 | Crystalline oxalate salts of a diamide compound |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015111163A Division JP2015155470A (ja) | 2010-09-30 | 2015-06-01 | ジアミド化合物の結晶性シュウ酸塩 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013538857A JP2013538857A (ja) | 2013-10-17 |
| JP2013538857A5 true JP2013538857A5 (enExample) | 2014-09-04 |
Family
ID=44903347
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013531861A Ceased JP2013538857A (ja) | 2010-09-30 | 2011-09-29 | ジアミド化合物の結晶性シュウ酸塩 |
| JP2015111163A Pending JP2015155470A (ja) | 2010-09-30 | 2015-06-01 | ジアミド化合物の結晶性シュウ酸塩 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015111163A Pending JP2015155470A (ja) | 2010-09-30 | 2015-06-01 | ジアミド化合物の結晶性シュウ酸塩 |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US8697724B2 (enExample) |
| EP (1) | EP2621917A1 (enExample) |
| JP (2) | JP2013538857A (enExample) |
| KR (1) | KR20130139919A (enExample) |
| CN (1) | CN103140485B (enExample) |
| AR (1) | AR083115A1 (enExample) |
| AU (1) | AU2011308770B2 (enExample) |
| BR (1) | BR112013007062A2 (enExample) |
| CA (1) | CA2810896A1 (enExample) |
| CL (1) | CL2013000870A1 (enExample) |
| CO (1) | CO6700846A2 (enExample) |
| EA (1) | EA022018B1 (enExample) |
| IL (1) | IL224985A (enExample) |
| MX (1) | MX2013003558A (enExample) |
| NZ (1) | NZ608721A (enExample) |
| PH (1) | PH12013500567A1 (enExample) |
| SG (1) | SG188390A1 (enExample) |
| TW (1) | TW201217338A (enExample) |
| WO (1) | WO2012044825A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITRM20110083U1 (it) | 2010-05-13 | 2011-11-14 | De La Cruz Jose Antonio Freire | Piastra per la costruzione di carrelli per aeroplani |
| EP2386555A1 (en) | 2010-05-13 | 2011-11-16 | Almirall, S.A. | New cyclohexylamine derivatives having beta2 adrenergic agonist and m3 muscarinic antagonist activities |
| EP2592078A1 (en) | 2011-11-11 | 2013-05-15 | Almirall, S.A. | New cyclohexylamine derivatives having beta2 adrenergic agonist and M3 muscarinic antagonist activities |
| AU2013360866A1 (en) | 2012-12-18 | 2015-07-02 | Almirall, S.A. | New cyclohexyl and quinuclidinyl carbamate derivatives having beta2 adrenergic agonist and M3 muscarinic antagonist activity |
| TWI643853B (zh) | 2013-02-27 | 2018-12-11 | 阿爾米雷爾有限公司 | 同時具有β2腎上腺素受體促效劑和M3毒蕈鹼受體拮抗劑活性之2-氨基-1-羥乙基-8-羥基喹啉-2(1H)-酮衍生物之鹽類 |
| TW201517906A (zh) | 2013-07-25 | 2015-05-16 | Almirall Sa | 含有ｍａｂａ化合物和皮質類固醇之組合 |
| TWI641373B (zh) | 2013-07-25 | 2018-11-21 | 阿爾米雷爾有限公司 | 具有蕈毒鹼受體拮抗劑和β２腎上腺素受體促效劑二者之活性的２－胺基－１－羥乙基－８－羥基喹啉－２（１Ｈ）－酮衍生物之鹽 |
| CN104030933A (zh) * | 2014-05-16 | 2014-09-10 | 烟台恒迪克能源科技有限公司 | 一种β-异烷醇基氨基戊酸环己胺的合成方法 |
| TW201617343A (zh) | 2014-09-26 | 2016-05-16 | 阿爾米雷爾有限公司 | 具有β２腎上腺素促效劑及Ｍ３蕈毒拮抗劑活性之新穎雙環衍生物 |
| CN117924216A (zh) * | 2024-01-12 | 2024-04-26 | 王叔和生物医药(武汉)有限公司 | 一种1-哌啶丙酸的合成方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6750210B2 (en) | 2000-08-05 | 2004-06-15 | Smithkline Beecham Corporation | Formulation containing novel anti-inflammatory androstane derivative |
| US6858596B2 (en) | 2000-08-05 | 2005-02-22 | Smithkline Beecham Corporation | Formulation containing anti-inflammatory androstane derivative |
| US6759398B2 (en) | 2000-08-05 | 2004-07-06 | Smithkline Beecham Corporation | Anti-inflammatory androstane derivative |
| EP2067784A3 (en) | 2000-08-05 | 2012-08-22 | Glaxo Group Limited | 17.beta.-carbothioate 17.alpha.-arylcarbonyloxyloxy androstane derivatives as anti-inflammatory agents |
| UA77656C2 (en) | 2001-04-07 | 2007-01-15 | Glaxo Group Ltd | S-fluoromethyl ester of 6-alpha, 9-alpha-difluoro-17-alpha-[(2-furanylcarbonyl)oxy]-11-beta-hydroxy-16- alpha-methyl-3-oxoandrosta-1,4-dien-17-beta-carbothioacid as anti-inflammatory agent |
| PE20040950A1 (es) * | 2003-02-14 | 2005-01-01 | Theravance Inc | DERIVADOS DE BIFENILO COMO AGONISTAS DE LOS RECEPTORES ADRENERGICOS ß2 Y COMO ANTAGONISTAS DE LOS RECEPTORES MUSCARINICOS |
| WO2004089892A2 (en) * | 2003-04-01 | 2004-10-21 | Theravance, Inc. | Diarylmethyl and related compounds having beta2 andrenergic receptor agonist and muscarinic receptor antagonist activity |
| WO2005080375A1 (en) | 2004-02-13 | 2005-09-01 | Theravance, Inc. | Crystalline form of a biphenyl compound |
| WO2006023460A2 (en) * | 2004-08-16 | 2006-03-02 | Theravance, Inc. | COMPOUNDS HAVING β2 ADRENERGIC RECEPTOR AGONIST AND MUSCARINIC RECEPTOR ANTAGONIST ACTIVITY |
| TWI374883B (en) | 2004-08-16 | 2012-10-21 | Theravance Inc | Crystalline form of a biphenyl compound |
| GB0602778D0 (en) | 2006-02-10 | 2006-03-22 | Glaxo Group Ltd | Novel compound |
| TW200811104A (en) | 2006-04-25 | 2008-03-01 | Theravance Inc | Crystalline forms of a dimethylphenyl compound |
| PT2599778T (pt) * | 2009-04-23 | 2017-06-06 | Theravance Respiratory Co Llc | Compostos de diamida possuindo actividade antagonista do receptor muscarínico e agonista do receptor adrenérgico beta 2 |
-
2011
- 2011-09-26 AR ARP110103518A patent/AR083115A1/es unknown
- 2011-09-29 AU AU2011308770A patent/AU2011308770B2/en not_active Ceased
- 2011-09-29 CN CN201180046585.5A patent/CN103140485B/zh not_active Expired - Fee Related
- 2011-09-29 EA EA201390481A patent/EA022018B1/ru not_active IP Right Cessation
- 2011-09-29 US US13/248,840 patent/US8697724B2/en not_active Expired - Fee Related
- 2011-09-29 JP JP2013531861A patent/JP2013538857A/ja not_active Ceased
- 2011-09-29 WO PCT/US2011/053997 patent/WO2012044825A1/en not_active Ceased
- 2011-09-29 KR KR1020137009556A patent/KR20130139919A/ko not_active Withdrawn
- 2011-09-29 MX MX2013003558A patent/MX2013003558A/es not_active Application Discontinuation
- 2011-09-29 BR BR112013007062A patent/BR112013007062A2/pt not_active IP Right Cessation
- 2011-09-29 PH PH1/2013/500567A patent/PH12013500567A1/en unknown
- 2011-09-29 CA CA2810896A patent/CA2810896A1/en not_active Abandoned
- 2011-09-29 EP EP11771325.5A patent/EP2621917A1/en not_active Withdrawn
- 2011-09-29 NZ NZ60872111A patent/NZ608721A/en not_active IP Right Cessation
- 2011-09-29 SG SG2013016043A patent/SG188390A1/en unknown
- 2011-09-30 TW TW100135675A patent/TW201217338A/zh unknown
-
2013
- 2013-02-28 IL IL224985A patent/IL224985A/en not_active IP Right Cessation
- 2013-03-28 CL CL2013000870A patent/CL2013000870A1/es unknown
- 2013-04-02 CO CO13061812A patent/CO6700846A2/es active IP Right Grant
-
2015
- 2015-06-01 JP JP2015111163A patent/JP2015155470A/ja active Pending
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