AU2011308770B2 - Crystalline oxalate salts of a diamide compound - Google Patents

Crystalline oxalate salts of a diamide compound Download PDF

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Publication number
AU2011308770B2
AU2011308770B2 AU2011308770A AU2011308770A AU2011308770B2 AU 2011308770 B2 AU2011308770 B2 AU 2011308770B2 AU 2011308770 A AU2011308770 A AU 2011308770A AU 2011308770 A AU2011308770 A AU 2011308770A AU 2011308770 B2 AU2011308770 B2 AU 2011308770B2
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AU
Australia
Prior art keywords
oxalate salt
crystalline oxalate
crystalline
hydroxy
salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2011308770A
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English (en)
Other versions
AU2011308770A1 (en
Inventor
Robert Chao
Miroslav Rapta
Venkat Thalladi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Theravance Respiratory Co LLC
Original Assignee
Theravance Respiratory Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theravance Respiratory Co LLC filed Critical Theravance Respiratory Co LLC
Publication of AU2011308770A1 publication Critical patent/AU2011308770A1/en
Assigned to THERAVANCE RESPIRATORY COMPANY, LLC reassignment THERAVANCE RESPIRATORY COMPANY, LLC Request for Assignment Assignors: THERAVANCE, INC.
Application granted granted Critical
Publication of AU2011308770B2 publication Critical patent/AU2011308770B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2011308770A 2010-09-30 2011-09-29 Crystalline oxalate salts of a diamide compound Ceased AU2011308770B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US38814810P 2010-09-30 2010-09-30
US61/388,148 2010-09-30
PCT/US2011/053997 WO2012044825A1 (en) 2010-09-30 2011-09-29 Crystalline oxalate salts of a diamide compound

Publications (2)

Publication Number Publication Date
AU2011308770A1 AU2011308770A1 (en) 2013-03-28
AU2011308770B2 true AU2011308770B2 (en) 2015-03-05

Family

ID=44903347

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2011308770A Ceased AU2011308770B2 (en) 2010-09-30 2011-09-29 Crystalline oxalate salts of a diamide compound

Country Status (19)

Country Link
US (1) US8697724B2 (enExample)
EP (1) EP2621917A1 (enExample)
JP (2) JP2013538857A (enExample)
KR (1) KR20130139919A (enExample)
CN (1) CN103140485B (enExample)
AR (1) AR083115A1 (enExample)
AU (1) AU2011308770B2 (enExample)
BR (1) BR112013007062A2 (enExample)
CA (1) CA2810896A1 (enExample)
CL (1) CL2013000870A1 (enExample)
CO (1) CO6700846A2 (enExample)
EA (1) EA022018B1 (enExample)
IL (1) IL224985A (enExample)
MX (1) MX2013003558A (enExample)
NZ (1) NZ608721A (enExample)
PH (1) PH12013500567A1 (enExample)
SG (1) SG188390A1 (enExample)
TW (1) TW201217338A (enExample)
WO (1) WO2012044825A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2386555A1 (en) 2010-05-13 2011-11-16 Almirall, S.A. New cyclohexylamine derivatives having beta2 adrenergic agonist and m3 muscarinic antagonist activities
ITRM20110083U1 (it) 2010-05-13 2011-11-14 De La Cruz Jose Antonio Freire Piastra per la costruzione di carrelli per aeroplani
EP2592078A1 (en) 2011-11-11 2013-05-15 Almirall, S.A. New cyclohexylamine derivatives having beta2 adrenergic agonist and M3 muscarinic antagonist activities
EA201500651A1 (ru) 2012-12-18 2015-11-30 Альмираль, С.А. НОВЫЕ ПРОИЗВОДНЫЕ ЦИКЛОГЕКСИЛ- И ХИНУКЛИДИНИЛКАРБАМАТА, ОБЛАДАЮЩИЕ АГОНИСТИЧЕСКОЙ АКТИВНОСТЬЮ ПО ОТНОШЕНИЮ К β2 АДРЕНЕРГИЧЕСКОМУ РЕЦЕПТОРУ И АНТАГОНИСТИЧЕСКОЙ АКТИВНОСТЬЮ ПО ОТНОШЕНИЮ К МУСКАРИНОВОМУ РЕЦЕПТОРУ М3
TWI643853B (zh) 2013-02-27 2018-12-11 阿爾米雷爾有限公司 同時具有β2腎上腺素受體促效劑和M3毒蕈鹼受體拮抗劑活性之2-氨基-1-羥乙基-8-羥基喹啉-2(1H)-酮衍生物之鹽類
TW201517906A (zh) 2013-07-25 2015-05-16 Almirall Sa 含有ｍａｂａ化合物和皮質類固醇之組合
TWI641373B (zh) 2013-07-25 2018-11-21 阿爾米雷爾有限公司 具有蕈毒鹼受體拮抗劑和β２腎上腺素受體促效劑二者之活性的２－胺基－１－羥乙基－８－羥基喹啉－２（１Ｈ）－酮衍生物之鹽
CN104030933A (zh) * 2014-05-16 2014-09-10 烟台恒迪克能源科技有限公司 一种β-异烷醇基氨基戊酸环己胺的合成方法
TW201617343A (zh) 2014-09-26 2016-05-16 阿爾米雷爾有限公司 具有β２腎上腺素促效劑及Ｍ３蕈毒拮抗劑活性之新穎雙環衍生物
CN117924216A (zh) * 2024-01-12 2024-04-26 王叔和生物医药(武汉)有限公司 一种1-哌啶丙酸的合成方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040167167A1 (en) * 2003-02-14 2004-08-26 Mathai Mammen Biphenyl derivatives

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6759398B2 (en) 2000-08-05 2004-07-06 Smithkline Beecham Corporation Anti-inflammatory androstane derivative
US6750210B2 (en) 2000-08-05 2004-06-15 Smithkline Beecham Corporation Formulation containing novel anti-inflammatory androstane derivative
US6858596B2 (en) 2000-08-05 2005-02-22 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivative
AU7649701A (en) 2000-08-05 2002-02-18 Glaxo Group Ltd 17.beta.-carbothioate 17.alpha.-arylcarbonyloxyloxy androstane derivative as anti-inflammatory agents
UA77656C2 (en) 2001-04-07 2007-01-15 Glaxo Group Ltd S-fluoromethyl ester of 6-alpha, 9-alpha-difluoro-17-alpha-[(2-furanylcarbonyl)oxy]-11-beta-hydroxy-16- alpha-methyl-3-oxoandrosta-1,4-dien-17-beta-carbothioacid as anti-inflammatory agent
US7317102B2 (en) * 2003-04-01 2008-01-08 Theravance, Inc. Diarylmethyl and related compounds
US7320990B2 (en) 2004-02-13 2008-01-22 Theravance, Inc. Crystalline form of a biphenyl compound
WO2006023460A2 (en) * 2004-08-16 2006-03-02 Theravance, Inc. COMPOUNDS HAVING β2 ADRENERGIC RECEPTOR AGONIST AND MUSCARINIC RECEPTOR ANTAGONIST ACTIVITY
TWI374883B (en) 2004-08-16 2012-10-21 Theravance Inc Crystalline form of a biphenyl compound
GB0602778D0 (en) * 2006-02-10 2006-03-22 Glaxo Group Ltd Novel compound
TW200811104A (en) 2006-04-25 2008-03-01 Theravance Inc Crystalline forms of a dimethylphenyl compound
EP2421849B1 (en) * 2009-04-23 2013-04-03 Theravance, Inc. Diamide compounds having muscarinic receptor antagonist and beta2 adrenergic receptor agonist activity

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040167167A1 (en) * 2003-02-14 2004-08-26 Mathai Mammen Biphenyl derivatives

Also Published As

Publication number Publication date
AR083115A1 (es) 2013-01-30
AU2011308770A1 (en) 2013-03-28
TW201217338A (en) 2012-05-01
NZ608721A (en) 2015-03-27
BR112013007062A2 (pt) 2016-06-14
KR20130139919A (ko) 2013-12-23
CO6700846A2 (es) 2013-06-28
CL2013000870A1 (es) 2013-07-12
CN103140485A (zh) 2013-06-05
EP2621917A1 (en) 2013-08-07
PH12013500567A1 (en) 2013-05-06
EA201390481A1 (ru) 2013-08-30
SG188390A1 (en) 2013-04-30
US8697724B2 (en) 2014-04-15
CN103140485B (zh) 2014-10-22
MX2013003558A (es) 2013-05-01
CA2810896A1 (en) 2012-04-05
IL224985A (en) 2015-08-31
WO2012044825A1 (en) 2012-04-05
JP2015155470A (ja) 2015-08-27
JP2013538857A (ja) 2013-10-17
EA022018B1 (ru) 2015-10-30
US20120083478A1 (en) 2012-04-05

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Legal Events

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PC1 Assignment before grant (sect. 113)

Owner name: THERAVANCE RESPIRATORY COMPANY, LLC

Free format text: FORMER APPLICANT(S): THERAVANCE, INC.

FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired