JP2013538857A - ジアミド化合物の結晶性シュウ酸塩 - Google Patents

ジアミド化合物の結晶性シュウ酸塩 Download PDF

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JP2013538857A
JP2013538857A JP2013531861A JP2013531861A JP2013538857A JP 2013538857 A JP2013538857 A JP 2013538857A JP 2013531861 A JP2013531861 A JP 2013531861A JP 2013531861 A JP2013531861 A JP 2013531861A JP 2013538857 A JP2013538857 A JP 2013538857A
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crystalline oxalate
crystalline
hydroxy
oxalate
salt
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Japanese (ja)
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JP2013538857A5 (enExample
Inventor
ミロスラフ ラプタ，
ベンカット サラディー，
ロバート チャオ，
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セラヴァンス， インコーポレーテッド
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Publication of JP2013538857A publication Critical patent/JP2013538857A/ja
Publication of JP2013538857A5 publication Critical patent/JP2013538857A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2013531861A 2010-09-30 2011-09-29 ジアミド化合物の結晶性シュウ酸塩 Ceased JP2013538857A (ja)

Applications Claiming Priority (3)

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US38814810P 2010-09-30 2010-09-30
US61/388,148 2010-09-30
PCT/US2011/053997 WO2012044825A1 (en) 2010-09-30 2011-09-29 Crystalline oxalate salts of a diamide compound

Related Child Applications (1)

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JP2015111163A Division JP2015155470A (ja) 2010-09-30 2015-06-01 ジアミド化合物の結晶性シュウ酸塩

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JP2013538857A true JP2013538857A (ja) 2013-10-17
JP2013538857A5 JP2013538857A5 (enExample) 2014-09-04

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JP2013531861A Ceased JP2013538857A (ja) 2010-09-30 2011-09-29 ジアミド化合物の結晶性シュウ酸塩
JP2015111163A Pending JP2015155470A (ja) 2010-09-30 2015-06-01 ジアミド化合物の結晶性シュウ酸塩

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JP2015111163A Pending JP2015155470A (ja) 2010-09-30 2015-06-01 ジアミド化合物の結晶性シュウ酸塩

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US (1) US8697724B2 (enExample)
EP (1) EP2621917A1 (enExample)
JP (2) JP2013538857A (enExample)
KR (1) KR20130139919A (enExample)
CN (1) CN103140485B (enExample)
AR (1) AR083115A1 (enExample)
AU (1) AU2011308770B2 (enExample)
BR (1) BR112013007062A2 (enExample)
CA (1) CA2810896A1 (enExample)
CL (1) CL2013000870A1 (enExample)
CO (1) CO6700846A2 (enExample)
EA (1) EA022018B1 (enExample)
IL (1) IL224985A (enExample)
MX (1) MX2013003558A (enExample)
NZ (1) NZ608721A (enExample)
PH (1) PH12013500567A1 (enExample)
SG (1) SG188390A1 (enExample)
TW (1) TW201217338A (enExample)
WO (1) WO2012044825A1 (enExample)

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ITRM20110083U1 (it) 2010-05-13 2011-11-14 De La Cruz Jose Antonio Freire Piastra per la costruzione di carrelli per aeroplani
EP2386555A1 (en) 2010-05-13 2011-11-16 Almirall, S.A. New cyclohexylamine derivatives having beta2 adrenergic agonist and m3 muscarinic antagonist activities
EP2592078A1 (en) 2011-11-11 2013-05-15 Almirall, S.A. New cyclohexylamine derivatives having beta2 adrenergic agonist and M3 muscarinic antagonist activities
BR112015013628A2 (pt) 2012-12-18 2017-07-11 Almirall Sa derivados de carbamato de ciclo-hexila e quinuclidinila tendo atividades agonista adrenérgica de beta2 e antagonista muscarínica de m3
TWI643853B (zh) 2013-02-27 2018-12-11 阿爾米雷爾有限公司 同時具有β2腎上腺素受體促效劑和M3毒蕈鹼受體拮抗劑活性之2-氨基-1-羥乙基-8-羥基喹啉-2(1H)-酮衍生物之鹽類
TWI641373B (zh) 2013-07-25 2018-11-21 阿爾米雷爾有限公司 具有蕈毒鹼受體拮抗劑和β２腎上腺素受體促效劑二者之活性的２－胺基－１－羥乙基－８－羥基喹啉－２（１Ｈ）－酮衍生物之鹽
TW201517906A (zh) 2013-07-25 2015-05-16 Almirall Sa 含有ｍａｂａ化合物和皮質類固醇之組合
CN104030933A (zh) * 2014-05-16 2014-09-10 烟台恒迪克能源科技有限公司 一种β-异烷醇基氨基戊酸环己胺的合成方法
TW201617343A (zh) 2014-09-26 2016-05-16 阿爾米雷爾有限公司 具有β２腎上腺素促效劑及Ｍ３蕈毒拮抗劑活性之新穎雙環衍生物
CN117924216A (zh) * 2024-01-12 2024-04-26 王叔和生物医药(武汉)有限公司 一种1-哌啶丙酸的合成方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006522134A (ja) * 2003-04-01 2006-09-28 セラヴァンス インコーポレーテッド β２アドレナリン作用性レセプターアゴニスト活性およびムスカリン性レセプターアンタゴニスト活性を有するジアリールメチル化合物および関連化合物
JP2008510015A (ja) * 2004-08-16 2008-04-03 セラヴァンス， インコーポレーテッド β２アドレナリン作用性レセプターアゴニスト活性およびムスカリン性レセプターアンタゴニスト活性を有する化合物
JP2009526018A (ja) * 2006-02-10 2009-07-16 グラクソ グループ リミテッド ビフェニル−２−イルカルバミン酸１−［２−（２−クロロ−４−｛［（ｒ）−２−ヒドロキシ−２−（８−ヒドロキシ−２−オキソ−１，２−ジヒドロキノリン−５−イル）エチルアミノメチル］｝−５−メトキシフェニルカルバモイル）エチル］ピペリジン−４−イルエステルのコハク酸塩および肺疾患治療におけるその使用

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US6759398B2 (en) 2000-08-05 2004-07-06 Smithkline Beecham Corporation Anti-inflammatory androstane derivative
CO5310534A1 (es) 2000-08-05 2003-08-29 Glaxo Group Ltd Nuevos derivados de androstano anti-inflamatorios
US6750210B2 (en) 2000-08-05 2004-06-15 Smithkline Beecham Corporation Formulation containing novel anti-inflammatory androstane derivative
US6858596B2 (en) 2000-08-05 2005-02-22 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivative
UA77656C2 (en) 2001-04-07 2007-01-15 Glaxo Group Ltd S-fluoromethyl ester of 6-alpha, 9-alpha-difluoro-17-alpha-[(2-furanylcarbonyl)oxy]-11-beta-hydroxy-16- alpha-methyl-3-oxoandrosta-1,4-dien-17-beta-carbothioacid as anti-inflammatory agent
PE20040950A1 (es) * 2003-02-14 2005-01-01 Theravance Inc DERIVADOS DE BIFENILO COMO AGONISTAS DE LOS RECEPTORES ADRENERGICOS ß2 Y COMO ANTAGONISTAS DE LOS RECEPTORES MUSCARINICOS
WO2005080375A1 (en) 2004-02-13 2005-09-01 Theravance, Inc. Crystalline form of a biphenyl compound
TWI374883B (en) 2004-08-16 2012-10-21 Theravance Inc Crystalline form of a biphenyl compound
TW200811104A (en) 2006-04-25 2008-03-01 Theravance Inc Crystalline forms of a dimethylphenyl compound
CN103936716B (zh) * 2009-04-23 2016-09-07 施万呼吸有限责任公司 具蕈毒碱受体拮抗剂和β2肾上腺素受体激动剂活性的二酰胺化合物

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006522134A (ja) * 2003-04-01 2006-09-28 セラヴァンス インコーポレーテッド β２アドレナリン作用性レセプターアゴニスト活性およびムスカリン性レセプターアンタゴニスト活性を有するジアリールメチル化合物および関連化合物
JP2008510015A (ja) * 2004-08-16 2008-04-03 セラヴァンス， インコーポレーテッド β２アドレナリン作用性レセプターアゴニスト活性およびムスカリン性レセプターアンタゴニスト活性を有する化合物
JP2009526018A (ja) * 2006-02-10 2009-07-16 グラクソ グループ リミテッド ビフェニル−２−イルカルバミン酸１−［２−（２−クロロ−４−｛［（ｒ）−２−ヒドロキシ−２−（８−ヒドロキシ−２−オキソ−１，２−ジヒドロキノリン−５−イル）エチルアミノメチル］｝−５−メトキシフェニルカルバモイル）エチル］ピペリジン−４−イルエステルのコハク酸塩および肺疾患治療におけるその使用

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Publication number Publication date
EP2621917A1 (en) 2013-08-07
IL224985A (en) 2015-08-31
EA201390481A1 (ru) 2013-08-30
MX2013003558A (es) 2013-05-01
AR083115A1 (es) 2013-01-30
JP2015155470A (ja) 2015-08-27
CA2810896A1 (en) 2012-04-05
NZ608721A (en) 2015-03-27
US20120083478A1 (en) 2012-04-05
AU2011308770A1 (en) 2013-03-28
BR112013007062A2 (pt) 2016-06-14
EA022018B1 (ru) 2015-10-30
CN103140485B (zh) 2014-10-22
CL2013000870A1 (es) 2013-07-12
SG188390A1 (en) 2013-04-30
CN103140485A (zh) 2013-06-05
CO6700846A2 (es) 2013-06-28
WO2012044825A1 (en) 2012-04-05
KR20130139919A (ko) 2013-12-23
AU2011308770B2 (en) 2015-03-05
PH12013500567A1 (en) 2013-05-06
TW201217338A (en) 2012-05-01
US8697724B2 (en) 2014-04-15

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