JP2012503668A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2012503668A5 JP2012503668A5 JP2011529222A JP2011529222A JP2012503668A5 JP 2012503668 A5 JP2012503668 A5 JP 2012503668A5 JP 2011529222 A JP2011529222 A JP 2011529222A JP 2011529222 A JP2011529222 A JP 2011529222A JP 2012503668 A5 JP2012503668 A5 JP 2012503668A5
- Authority
- JP
- Japan
- Prior art keywords
- formulation
- lung
- droplets
- microns
- particles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims 16
- 238000009472 formulation Methods 0.000 claims 11
- 210000004072 lung Anatomy 0.000 claims 4
- 239000002245 particle Substances 0.000 claims 4
- 208000002815 pulmonary hypertension Diseases 0.000 claims 4
- 230000008021 deposition Effects 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 229960005032 treprostinil Drugs 0.000 claims 2
- PAJMKGZZBBTTOY-ZFORQUDYSA-N treprostinil Chemical compound C1=CC=C(OCC(O)=O)C2=C1C[C@@H]1[C@@H](CC[C@@H](O)CCCCC)[C@H](O)C[C@@H]1C2 PAJMKGZZBBTTOY-ZFORQUDYSA-N 0.000 claims 2
- 239000006199 nebulizer Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 229960001726 treprostinil sodium Drugs 0.000 claims 1
- IQKAWAUTOKVMLE-ZSESPEEFSA-M treprostinil sodium Chemical compound [Na+].C1=CC=C(OCC([O-])=O)C2=C1C[C@@H]1[C@@H](CC[C@@H](O)CCCCC)[C@H](O)C[C@@H]1C2 IQKAWAUTOKVMLE-ZSESPEEFSA-M 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10001708P | 2008-09-25 | 2008-09-25 | |
| US61/100,017 | 2008-09-25 | ||
| PCT/US2009/058217 WO2010036798A1 (en) | 2008-09-25 | 2009-09-24 | Deep lung pulmonary delivery of treprostinil |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015044671A Division JP2015129177A (ja) | 2008-09-25 | 2015-03-06 | 肺深部へのトレプロスチニルの肺送達 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012503668A JP2012503668A (ja) | 2012-02-09 |
| JP2012503668A5 true JP2012503668A5 (enExample) | 2012-11-08 |
Family
ID=42060085
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011529222A Pending JP2012503668A (ja) | 2008-09-25 | 2009-09-24 | 肺深部へのトレプロスチニルの肺送達 |
| JP2015044671A Pending JP2015129177A (ja) | 2008-09-25 | 2015-03-06 | 肺深部へのトレプロスチニルの肺送達 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015044671A Pending JP2015129177A (ja) | 2008-09-25 | 2015-03-06 | 肺深部へのトレプロスチニルの肺送達 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20120177693A1 (enExample) |
| EP (1) | EP2330893A4 (enExample) |
| JP (2) | JP2012503668A (enExample) |
| KR (1) | KR20110081204A (enExample) |
| CN (1) | CN102164487A (enExample) |
| CA (1) | CA2737350A1 (enExample) |
| WO (1) | WO2010036798A1 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007134292A2 (en) | 2006-05-15 | 2007-11-22 | United Therapeutics Corporation | Treprostinil administration using a metered dose inhaler |
| DE102006026786A1 (de) | 2006-06-07 | 2007-12-13 | Joachim Kern | Dosierinhalator |
| US8734845B2 (en) | 2009-06-12 | 2014-05-27 | Mannkind Corporation | Diketopiperazine microparticles with defined specific surface areas |
| DE102009031274A1 (de) * | 2009-06-30 | 2011-01-13 | Justus-Liebig-Universität Giessen | Liposomen zur pulmonalen Applikation |
| EP2338520A1 (de) | 2009-12-21 | 2011-06-29 | Ludwig Maximilians Universität | Konjugat mit Zielfindungsligand und dessen Verwendung |
| EP2547341B1 (en) | 2010-03-15 | 2016-09-14 | United Therapeutics Corporation | Treatment for pulmonary hypertension |
| CN103379907B (zh) | 2011-01-13 | 2018-01-09 | 塞法姆公司 | 增强造血干细胞移入的方法 |
| CA2906817C (en) | 2013-03-15 | 2022-01-18 | Mannkind Corporation | Microcrystalline diketopiperazine compositions and methods |
| EP3021834A1 (en) | 2013-07-18 | 2016-05-25 | MannKind Corporation | Heat-stable dry powder pharmaceutical compositions and methods |
| DK3060041T3 (da) | 2013-10-25 | 2021-03-22 | Insmed Inc | Prostacyclinforbindelser |
| TWI685348B (zh) * | 2014-05-08 | 2020-02-21 | 美國禮來大藥廠 | 速效胰島素組合物 |
| CA2967385C (en) | 2014-11-18 | 2023-05-16 | Insmed Incorporated | Methods of manufacturing treprostinil and treprostinil derivative prodrugs |
| WO2017132601A1 (en) * | 2016-01-29 | 2017-08-03 | Mannkind Corporation | Dry powder inhaler |
| IL262720B2 (en) | 2016-05-05 | 2024-06-01 | Liquidia Tech Inc | Dry powder treprostinil for the treatment of pulmonary hypertension |
| US10799653B2 (en) | 2017-01-09 | 2020-10-13 | United Therapeutics Corporation | Aerosol delivery device and method for manufacturing and operating the same |
| SG11202011045VA (en) * | 2018-05-07 | 2020-12-30 | Pharmosa Biopharm Inc | Pharmaceutical composition for controlled release of treprostinil |
| EP3962472A4 (en) | 2019-04-29 | 2023-01-25 | Insmed Incorporated | DRY POWDER COMPOSITIONS OF TREPROSTINIL PRODRUGS AND METHODS OF USE THEREOF |
| US20210022994A1 (en) | 2019-07-22 | 2021-01-28 | Lupin Holdings, B.V. | Sustained release trepostinil-compound microparticle compositions |
| KR20230011929A (ko) | 2020-04-17 | 2023-01-25 | 유나이티드 쎄러퓨틱스 코포레이션 | 간질성 폐 질환의 치료에 사용하기 위한 트레프로스티닐 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6521212B1 (en) * | 1999-03-18 | 2003-02-18 | United Therapeutics Corporation | Method for treating peripheral vascular disease by administering benzindene prostaglandins by inhalation |
| US20040063912A1 (en) * | 2002-03-15 | 2004-04-01 | The Brigham And Women's Hospital, Inc. | Central airway administration for systemic delivery of therapeutics |
| US7550133B2 (en) * | 2002-11-26 | 2009-06-23 | Alexza Pharmaceuticals, Inc. | Respiratory drug condensation aerosols and methods of making and using them |
| US20040265238A1 (en) * | 2003-06-27 | 2004-12-30 | Imtiaz Chaudry | Inhalable formulations for treating pulmonary hypertension and methods of using same |
| CN101090714A (zh) * | 2004-07-26 | 2007-12-19 | 康泽里克斯公司 | 通过吸入伊洛前列素和微粒制剂治疗肺动脉高血压症 |
| WO2007134292A2 (en) * | 2006-05-15 | 2007-11-22 | United Therapeutics Corporation | Treprostinil administration using a metered dose inhaler |
-
2009
- 2009-09-24 WO PCT/US2009/058217 patent/WO2010036798A1/en not_active Ceased
- 2009-09-24 JP JP2011529222A patent/JP2012503668A/ja active Pending
- 2009-09-24 US US13/120,015 patent/US20120177693A1/en not_active Abandoned
- 2009-09-24 CN CN2009801379417A patent/CN102164487A/zh active Pending
- 2009-09-24 EP EP09816849A patent/EP2330893A4/en not_active Withdrawn
- 2009-09-24 CA CA2737350A patent/CA2737350A1/en not_active Abandoned
- 2009-09-24 KR KR1020117008976A patent/KR20110081204A/ko not_active Ceased
-
2015
- 2015-03-06 JP JP2015044671A patent/JP2015129177A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2012503668A5 (enExample) | ||
| WO2009112274A3 (en) | Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease | |
| WO2009112273A3 (en) | Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease | |
| JP2016534153A5 (enExample) | ||
| HRP20130052T1 (hr) | Lijeäśenje respiratorne bolesti | |
| UA107499C2 (uk) | Склад сухого порошку, який містить антимускариновий засіб | |
| JP2013224331A5 (enExample) | ||
| JP2011201907A5 (enExample) | ||
| JP2013540123A5 (enExample) | ||
| JP2011144201A5 (enExample) | ||
| EA201401354A1 (ru) | Новая дозированная форма и препарат, содержащий абедитерол | |
| WO2013021199A3 (en) | Eutectic mixture for pulmonary administration | |
| JP2010132695A5 (enExample) | ||
| JP2014503593A5 (enExample) | ||
| JP2013515022A5 (enExample) | ||
| UA100777C2 (ru) | Вдыхаемые частички, содержащие тиотропий | |
| SI2760821T1 (en) | A salt salt of an anti-inflammatory substituted cyclobutenedione compound | |
| JP2010508365A5 (enExample) | ||
| MD4369B1 (ro) | Utilizarea glicopirolatului pentru tratarea tahicardiei, doză unică, dispozitiv de administrare, metodă de tratament şi profilaxie a tahicardiei | |
| RU2007119721A (ru) | Частицы для лечения легочной инфекции | |
| EP2682097A3 (en) | Dry Powder Inhalers Comprising A Carrier Other Than Lactose | |
| JP2008533072A5 (enExample) | ||
| HRP20120286T1 (hr) | Kombinacija antikolinergika i inhibitora fosfodiesteraze tip 4 za liječenje respiratornih bolesti | |
| PE20142441A1 (es) | Nueva dosificacion y formulacion | |
| EA201201393A1 (ru) | Ингалятор, разработанный для доставки лекарственного средства в виде сухого порошка |