JP2016534153A5 - - Google Patents
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- JP2016534153A5 JP2016534153A5 JP2016547977A JP2016547977A JP2016534153A5 JP 2016534153 A5 JP2016534153 A5 JP 2016534153A5 JP 2016547977 A JP2016547977 A JP 2016547977A JP 2016547977 A JP2016547977 A JP 2016547977A JP 2016534153 A5 JP2016534153 A5 JP 2016534153A5
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- JP
- Japan
- Prior art keywords
- formulation
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- subject
- powder
- additive
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000009472 formulation Methods 0.000 claims 15
- 239000000203 mixture Substances 0.000 claims 15
- 238000000034 method Methods 0.000 claims 14
- 239000000654 additive Substances 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 6
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 4
- 230000000996 additive effect Effects 0.000 claims 4
- 239000000843 powder Substances 0.000 claims 4
- 230000002209 hydrophobic effect Effects 0.000 claims 3
- 229960003136 leucine Drugs 0.000 claims 3
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims 2
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 2
- 208000019693 Lung disease Diseases 0.000 claims 2
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims 2
- 229940024606 amino acid Drugs 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 239000004067 bulking agent Substances 0.000 claims 2
- 150000001720 carbohydrates Chemical class 0.000 claims 2
- 239000006199 nebulizer Substances 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- 206010061218 Inflammation Diseases 0.000 claims 1
- 235000019454 L-leucine Nutrition 0.000 claims 1
- 239000004395 L-leucine Substances 0.000 claims 1
- 206010064911 Pulmonary arterial hypertension Diseases 0.000 claims 1
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims 1
- 239000004469 amino acid formulation Substances 0.000 claims 1
- 230000009084 cardiovascular function Effects 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 125000000647 trehalose group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361889887P | 2013-10-11 | 2013-10-11 | |
| US61/889,887 | 2013-10-11 | ||
| PCT/US2014/060039 WO2015054574A1 (en) | 2013-10-11 | 2014-10-10 | Spray dry formulations |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019024568A Division JP6823095B2 (ja) | 2013-10-11 | 2019-02-14 | 噴霧乾燥製剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016534153A JP2016534153A (ja) | 2016-11-04 |
| JP2016534153A5 true JP2016534153A5 (enExample) | 2017-11-16 |
| JP6483714B2 JP6483714B2 (ja) | 2019-03-13 |
Family
ID=52813663
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016547977A Active JP6483714B2 (ja) | 2013-10-11 | 2014-10-10 | 噴霧乾燥製剤 |
| JP2019024568A Active JP6823095B2 (ja) | 2013-10-11 | 2019-02-14 | 噴霧乾燥製剤 |
| JP2021001507A Pending JP2021063119A (ja) | 2013-10-11 | 2021-01-07 | 噴霧乾燥製剤 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019024568A Active JP6823095B2 (ja) | 2013-10-11 | 2019-02-14 | 噴霧乾燥製剤 |
| JP2021001507A Pending JP2021063119A (ja) | 2013-10-11 | 2021-01-07 | 噴霧乾燥製剤 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US9925184B2 (enExample) |
| EP (1) | EP3054937B1 (enExample) |
| JP (3) | JP6483714B2 (enExample) |
| CN (2) | CN106132403B (enExample) |
| AU (3) | AU2014331796B2 (enExample) |
| CA (1) | CA2926793C (enExample) |
| ES (1) | ES2959419T3 (enExample) |
| WO (1) | WO2015054574A1 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9757529B2 (en) | 2012-12-20 | 2017-09-12 | Otitopic Inc. | Dry powder inhaler and methods of use |
| US9757395B2 (en) | 2012-12-20 | 2017-09-12 | Otitopic Inc. | Dry powder inhaler and methods of use |
| DK3007689T3 (en) | 2013-01-10 | 2018-06-14 | Pulmokine Inc | NON-SELECTIVE KINASE INHIBITORS |
| CA2910766C (en) | 2013-04-30 | 2020-12-15 | Otitopic Inc. | Dry powder formulations and methods of use |
| DK3060041T3 (da) | 2013-10-25 | 2021-03-22 | Insmed Inc | Prostacyclinforbindelser |
| CA2967385C (en) | 2014-11-18 | 2023-05-16 | Insmed Incorporated | Methods of manufacturing treprostinil and treprostinil derivative prodrugs |
| WO2017132601A1 (en) * | 2016-01-29 | 2017-08-03 | Mannkind Corporation | Dry powder inhaler |
| IL262720B2 (en) * | 2016-05-05 | 2024-06-01 | Liquidia Tech Inc | Dry powder treprostinil for the treatment of pulmonary hypertension |
| GB201609940D0 (en) * | 2016-06-07 | 2016-07-20 | Novabiotics Ltd | Microparticles |
| JP2019518049A (ja) * | 2016-06-17 | 2019-06-27 | ユナイテッド セラピューティクス コーポレイション | 高い効能を有する細胞外小胞 |
| AU2017348354B2 (en) | 2016-10-27 | 2023-06-15 | Pulmokine, Inc. | Combination therapy for treating pulmonary hypertension |
| WO2019059953A2 (en) | 2017-09-22 | 2019-03-28 | Otitopic Inc. | DRY POWDER COMPOSITIONS CONTAINING MAGNESIUM STEARATE |
| US10786456B2 (en) | 2017-09-22 | 2020-09-29 | Otitopic Inc. | Inhaled aspirin and magnesium to treat inflammation |
| WO2019157337A1 (en) * | 2018-02-08 | 2019-08-15 | Pulmokine, Inc. | Formulations of kinase inhibitors and prostanoids |
| JP7090941B2 (ja) * | 2018-10-02 | 2022-06-27 | 学校法人 名城大学 | 吸入粉末剤、その評価方法及びその用途 |
| EP3962472A4 (en) | 2019-04-29 | 2023-01-25 | Insmed Incorporated | DRY POWDER COMPOSITIONS OF TREPROSTINIL PRODRUGS AND METHODS OF USE THEREOF |
| KR20220050839A (ko) | 2019-05-16 | 2022-04-25 | 에어로베이트 테라퓨틱스, 인크. | 이마티닙 제제, 그의 제조법 및 용도 |
| US11464776B2 (en) | 2019-05-16 | 2022-10-11 | Aerovate Therapeutics, Inc. | Inhalable imatinib formulations, manufacture, and uses thereof |
| WO2021201258A1 (ja) * | 2020-04-01 | 2021-10-07 | 株式会社ＳｔａｔｅＡｒｔ | 核酸含有組成物、核酸含有組成物の製造方法及び核酸導入方法 |
| JP2023550463A (ja) * | 2020-11-23 | 2023-12-01 | エアロベイト セラピューティクス， インコーポレイテッド | イマチニブ処方物、その製造および使用 |
| KR20240006513A (ko) | 2021-05-07 | 2024-01-15 | 지비002 인코포레이티드 | N-3-[(1s)-1-[6-(3,4-다이메톡시페닐)피라진-2-일]아미노에틸]페닐-5-메틸피리딘-3-카복사마이드의 결정질 형태 및 관련 생성물 및 방법 |
| JP2025526021A (ja) | 2022-08-10 | 2025-08-07 | ジービー００２，インコーポレイティド | 肺動脈性高血圧症（ｐａｈ）を治療するためのチロシンキナーゼ阻害剤とアクチビン２型受容体アンタゴニストの併用療法 |
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| WO1997008135A1 (de) | 1995-08-30 | 1997-03-06 | Bayer Aktiengesellschaft | Acylaminosalicylsäureamide und ihre verwendung als schädlingsbekämpfungsmittel |
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-
2014
- 2014-10-10 CN CN201480067999.XA patent/CN106132403B/zh active Active
- 2014-10-10 CN CN202010266778.2A patent/CN111743901B/zh active Active
- 2014-10-10 CA CA2926793A patent/CA2926793C/en active Active
- 2014-10-10 WO PCT/US2014/060039 patent/WO2015054574A1/en not_active Ceased
- 2014-10-10 ES ES14852309T patent/ES2959419T3/es active Active
- 2014-10-10 US US15/028,347 patent/US9925184B2/en active Active
- 2014-10-10 AU AU2014331796A patent/AU2014331796B2/en active Active
- 2014-10-10 JP JP2016547977A patent/JP6483714B2/ja active Active
- 2014-10-10 EP EP14852309.5A patent/EP3054937B1/en active Active
-
2017
- 2017-11-10 US US15/809,054 patent/US20180193336A1/en not_active Abandoned
-
2019
- 2019-02-14 JP JP2019024568A patent/JP6823095B2/ja active Active
-
2020
- 2020-04-16 AU AU2020202556A patent/AU2020202556A1/en not_active Abandoned
-
2021
- 2021-01-07 JP JP2021001507A patent/JP2021063119A/ja active Pending
-
2022
- 2022-05-27 AU AU2022203611A patent/AU2022203611A1/en not_active Abandoned
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