CA2926793C - Spray-dry formulations for treating pulmonary arterial hypertension - Google Patents
Spray-dry formulations for treating pulmonary arterial hypertension Download PDFInfo
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- 125000000341 threoninyl group Chemical group [H]OC([H])(C([H])([H])[H])C([H])(N([H])[H])C(*)=O 0.000 description 1
- 230000009424 thromboembolic effect Effects 0.000 description 1
- 238000000954 titration curve Methods 0.000 description 1
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- 229940044693 topoisomerase inhibitor Drugs 0.000 description 1
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- 150000003624 transition metals Chemical class 0.000 description 1
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- PAJMKGZZBBTTOY-ZFORQUDYSA-N treprostinil Chemical compound C1=CC=C(OCC(O)=O)C2=C1C[C@@H]1[C@@H](CC[C@@H](O)CCCCC)[C@H](O)C[C@@H]1C2 PAJMKGZZBBTTOY-ZFORQUDYSA-N 0.000 description 1
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- 229960004799 tryptophan Drugs 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
- 102000003298 tumor necrosis factor receptor Human genes 0.000 description 1
- 125000002948 undecyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
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Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
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- Engineering & Computer Science (AREA)
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- Biophysics (AREA)
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- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| US201361889887P | 2013-10-11 | 2013-10-11 | |
| US61/889,887 | 2013-10-11 | ||
| PCT/US2014/060039 WO2015054574A1 (en) | 2013-10-11 | 2014-10-10 | Spray dry formulations |
Publications (2)
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| CA2926793A1 CA2926793A1 (en) | 2015-04-16 |
| CA2926793C true CA2926793C (en) | 2022-11-22 |
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| CA2926793A Active CA2926793C (en) | 2013-10-11 | 2014-10-10 | Spray-dry formulations for treating pulmonary arterial hypertension |
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| US (2) | US9925184B2 (enExample) |
| EP (1) | EP3054937B1 (enExample) |
| JP (3) | JP6483714B2 (enExample) |
| CN (2) | CN111743901B (enExample) |
| AU (3) | AU2014331796B2 (enExample) |
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| ES (1) | ES2959419T3 (enExample) |
| WO (1) | WO2015054574A1 (enExample) |
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| CA2910766C (en) | 2013-04-30 | 2020-12-15 | Otitopic Inc. | Dry powder formulations and methods of use |
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| IL319790A (en) * | 2016-05-05 | 2025-05-01 | Liquidia Tech Inc | Terpostinil in dry powder form for the treatment of pulmonary hypertension |
| GB201609940D0 (en) * | 2016-06-07 | 2016-07-20 | Novabiotics Ltd | Microparticles |
| US20170360840A1 (en) * | 2016-06-17 | 2017-12-21 | United Therapeutics Corporation | Extracellular vesicles with enhanced potency |
| KR20230093341A (ko) * | 2016-10-27 | 2023-06-27 | 풀모킨 인코포레이티드 | 폐고혈압을 치료하기 위한 병용 요법 |
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2014
- 2014-10-10 EP EP14852309.5A patent/EP3054937B1/en active Active
- 2014-10-10 CA CA2926793A patent/CA2926793C/en active Active
- 2014-10-10 CN CN202010266778.2A patent/CN111743901B/zh active Active
- 2014-10-10 ES ES14852309T patent/ES2959419T3/es active Active
- 2014-10-10 AU AU2014331796A patent/AU2014331796B2/en active Active
- 2014-10-10 JP JP2016547977A patent/JP6483714B2/ja active Active
- 2014-10-10 CN CN201480067999.XA patent/CN106132403B/zh active Active
- 2014-10-10 WO PCT/US2014/060039 patent/WO2015054574A1/en not_active Ceased
- 2014-10-10 US US15/028,347 patent/US9925184B2/en active Active
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2017
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2019
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2020
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2021
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2022
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| EP3054937A4 (en) | 2017-05-03 |
| EP3054937A1 (en) | 2016-08-17 |
| US20160235742A1 (en) | 2016-08-18 |
| CN111743901A (zh) | 2020-10-09 |
| JP6823095B2 (ja) | 2021-01-27 |
| JP2021063119A (ja) | 2021-04-22 |
| AU2020202556A1 (en) | 2020-05-07 |
| WO2015054574A1 (en) | 2015-04-16 |
| AU2022203611A1 (en) | 2022-06-16 |
| AU2014331796A1 (en) | 2016-04-28 |
| CN106132403B (zh) | 2020-04-28 |
| JP6483714B2 (ja) | 2019-03-13 |
| JP2016534153A (ja) | 2016-11-04 |
| US9925184B2 (en) | 2018-03-27 |
| CN111743901B (zh) | 2023-09-12 |
| EP3054937B1 (en) | 2023-07-26 |
| ES2959419T3 (es) | 2024-02-26 |
| AU2014331796B2 (en) | 2020-05-07 |
| CA2926793A1 (en) | 2015-04-16 |
| JP2019089830A (ja) | 2019-06-13 |
| CN106132403A (zh) | 2016-11-16 |
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