JP2018528966A5 - - Google Patents
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- Publication number
- JP2018528966A5 JP2018528966A5 JP2018514451A JP2018514451A JP2018528966A5 JP 2018528966 A5 JP2018528966 A5 JP 2018528966A5 JP 2018514451 A JP2018514451 A JP 2018514451A JP 2018514451 A JP2018514451 A JP 2018514451A JP 2018528966 A5 JP2018528966 A5 JP 2018528966A5
- Authority
- JP
- Japan
- Prior art keywords
- formulation
- nicotine
- menthol
- concentration
- amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000009472 formulation Methods 0.000 claims 41
- 239000000203 mixture Substances 0.000 claims 41
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 claims 25
- 229960002715 nicotine Drugs 0.000 claims 22
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 claims 22
- 238000000034 method Methods 0.000 claims 16
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims 14
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims 14
- 229940041616 menthol Drugs 0.000 claims 14
- 239000002245 particle Substances 0.000 claims 9
- 150000001413 amino acids Chemical class 0.000 claims 6
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 4
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 229940124597 therapeutic agent Drugs 0.000 claims 4
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims 3
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 claims 3
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims 3
- GUBGYTABKSRVRQ-CUHNMECISA-N D-Cellobiose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-CUHNMECISA-N 0.000 claims 3
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims 3
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 claims 3
- 229930006000 Sucrose Natural products 0.000 claims 3
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims 3
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims 3
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 claims 3
- 239000000796 flavoring agent Substances 0.000 claims 3
- 235000019634 flavors Nutrition 0.000 claims 3
- 239000008101 lactose Substances 0.000 claims 3
- 239000005720 sucrose Substances 0.000 claims 3
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 2
- 229940112141 dry powder inhaler Drugs 0.000 claims 2
- 235000006679 Mentha X verticillata Nutrition 0.000 claims 1
- 235000002899 Mentha suaveolens Nutrition 0.000 claims 1
- 235000001636 Mentha x rotundifolia Nutrition 0.000 claims 1
- 239000003434 antitussive agent Substances 0.000 claims 1
- 229940124584 antitussives Drugs 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 125000000185 sucrose group Chemical group 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022077936A JP2022097639A (ja) | 2015-09-16 | 2022-05-11 | 吸入可能なニコチン製剤、ならびにその作製方法および使用方法 |
| JP2024065173A JP2024086897A (ja) | 2015-09-16 | 2024-04-15 | 吸入可能なニコチン製剤、ならびにその作製方法および使用方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14/856,102 | 2015-09-16 | ||
| US14/856,102 US9585835B1 (en) | 2015-09-16 | 2015-09-16 | Inhalable nicotine formulations and methods of making and using the same |
| PCT/US2016/051963 WO2017048974A1 (en) | 2015-09-16 | 2016-09-15 | Inhalable nicotine formulations, and methods of making and using thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022077936A Division JP2022097639A (ja) | 2015-09-16 | 2022-05-11 | 吸入可能なニコチン製剤、ならびにその作製方法および使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018528966A JP2018528966A (ja) | 2018-10-04 |
| JP2018528966A5 true JP2018528966A5 (enExample) | 2019-10-17 |
| JP7575183B2 JP7575183B2 (ja) | 2024-10-29 |
Family
ID=58162192
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018514451A Active JP7575183B2 (ja) | 2015-09-16 | 2016-09-15 | 吸入可能なニコチン製剤、ならびにその作製方法および使用方法 |
| JP2022077936A Pending JP2022097639A (ja) | 2015-09-16 | 2022-05-11 | 吸入可能なニコチン製剤、ならびにその作製方法および使用方法 |
| JP2024065173A Pending JP2024086897A (ja) | 2015-09-16 | 2024-04-15 | 吸入可能なニコチン製剤、ならびにその作製方法および使用方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022077936A Pending JP2022097639A (ja) | 2015-09-16 | 2022-05-11 | 吸入可能なニコチン製剤、ならびにその作製方法および使用方法 |
| JP2024065173A Pending JP2024086897A (ja) | 2015-09-16 | 2024-04-15 | 吸入可能なニコチン製剤、ならびにその作製方法および使用方法 |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US9585835B1 (enExample) |
| EP (1) | EP3349599B1 (enExample) |
| JP (3) | JP7575183B2 (enExample) |
| KR (1) | KR102760317B1 (enExample) |
| CN (1) | CN106539794B (enExample) |
| AU (1) | AU2016323317A1 (enExample) |
| BR (1) | BR112018005145B1 (enExample) |
| CA (1) | CA2999082A1 (enExample) |
| ES (1) | ES2997334T3 (enExample) |
| HK (1) | HK1258016A1 (enExample) |
| IL (1) | IL258143A (enExample) |
| MX (1) | MX394985B (enExample) |
| MY (1) | MY184362A (enExample) |
| PH (1) | PH12018500544A1 (enExample) |
| PL (1) | PL3349599T3 (enExample) |
| RU (1) | RU2719228C2 (enExample) |
| UA (1) | UA126849C2 (enExample) |
| WO (1) | WO2017048974A1 (enExample) |
| ZA (1) | ZA201801569B (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9968125B2 (en) * | 2015-01-09 | 2018-05-15 | Philip Morris Products S.A. | Nicotine—diketopiperazine microparticle formulations and methods of making the same |
| US11224594B2 (en) * | 2015-09-16 | 2022-01-18 | Philip Morris Products S.A. | Nicotine formulations and methods of making and using the same |
| US10149844B2 (en) | 2015-09-16 | 2018-12-11 | Philip Morris Products S.A. | Inhalable nicotine formulations, and methods of making and using thereof |
| MX385972B (es) * | 2016-06-30 | 2025-03-18 | Philip Morris Products Sa | Partículas y composiciones de nicotina. |
| JP7680823B2 (ja) * | 2017-03-07 | 2025-05-21 | フィリップ・モーリス・プロダクツ・ソシエテ・アノニム | 吸入可能なニコチン製剤、およびその作製および使用方法 |
| WO2019003118A1 (en) | 2017-06-28 | 2019-01-03 | Philip Morris Products S.A. | CONTAINER WITH PARTICLES FOR USE WITH INHALER |
| GB201817868D0 (en) * | 2018-11-01 | 2018-12-19 | Nicoventures Trading Ltd | Aerosolised formulation |
| GB201817862D0 (en) | 2018-11-01 | 2018-12-19 | Nicoventures Trading Ltd | Aerosolisable formulation |
| WO2021094160A1 (en) * | 2019-11-14 | 2021-05-20 | Philip Morris Products S.A. | Improved tobacco flavoured dry powder formulation |
| CN115697299A (zh) * | 2020-06-15 | 2023-02-03 | 菲利普莫里斯生产公司 | 新烟草碱粉末组合物 |
| JP2023540190A (ja) | 2020-09-03 | 2023-09-22 | フィリップ・モーリス・プロダクツ・ソシエテ・アノニム | 低吸湿性活性粉末組成物 |
| US20220313678A1 (en) * | 2021-04-06 | 2022-10-06 | Altria Client Services Llc | Spray dried nicotine for inclusion in oral products |
| US20220313614A1 (en) * | 2021-04-06 | 2022-10-06 | Altria Client Services Llc | Encapsulated nicotine granules and methods of preparation thereof |
| CN120500327A (zh) * | 2022-10-27 | 2025-08-15 | 韩国烟草人参公社 | 用于吸入的低剂量尼古丁干粉组合物 |
| CN120417888A (zh) * | 2022-10-27 | 2025-08-01 | 韩国烟草人参公社 | 用于吸入的尼古丁干粉的制备方法 |
| CN117158443B (zh) * | 2023-09-05 | 2024-03-22 | 贵州大学 | 烟碱在制备贝莱斯芽胞杆菌生防作用增强剂中的应用 |
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| US5441060A (en) * | 1993-02-08 | 1995-08-15 | Duke University | Dry powder delivery system |
| CA2146954C (en) | 1995-04-12 | 2008-06-17 | Arthur Slutsky | Breath activated nicotine inhalers |
| AUPN862596A0 (en) * | 1996-03-12 | 1996-04-04 | F.H. Faulding & Co. Limited | Pharmaceutical compositions |
| CN1110271C (zh) * | 1997-09-22 | 2003-06-04 | 株式会社大城 | 烟草调味剂及其烟草 |
| CA2231968A1 (en) | 1998-03-11 | 1999-09-11 | Smoke-Stop, A Partnership Consisting Of Art Slutsky | Method of producing a nicotine medicament |
| US20120042886A1 (en) | 1998-03-11 | 2012-02-23 | Hanna Piskorz | Method of producing a nicotine medicament and a medicament made by the method |
| CA2265198C (en) | 1998-03-11 | 2009-01-27 | Zamel, Noe | Method of producing a nicotine medicament and a medicament made by the method |
| US6234169B1 (en) | 1998-08-14 | 2001-05-22 | Arthur Slutsky | Inhaler |
| ES2395096T3 (es) | 1999-06-29 | 2013-02-08 | Mannkind Corporation | Purificación y estabilización de agentes farmacéuticos a base de péptidos y proteínas |
| US8256433B2 (en) | 1999-07-16 | 2012-09-04 | Aradigm Corporation | Systems and methods for effecting cessation of tobacco use |
| US6799576B2 (en) | 1999-07-16 | 2004-10-05 | Aradigm Corporation | System for effecting smoking cessation |
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| WO2001049274A2 (en) | 1999-12-30 | 2001-07-12 | Chiron Corporation | Methods for pulmonary delivery of interleukin-2 |
| US7871598B1 (en) | 2000-05-10 | 2011-01-18 | Novartis Ag | Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use |
| MXPA03001092A (es) | 2000-08-07 | 2003-09-25 | Nektar Therapeutics Al Corp | Polvos de proteina de haz de 4 helices secados por rocio, inhalables, que tienen agregacion minimizada. |
| FR2815987B1 (fr) | 2000-10-27 | 2003-02-28 | Michel Petiot | Embase enfichable pour poteau ou piquet |
| JP2002161030A (ja) | 2000-11-27 | 2002-06-04 | Unisia Jecs Corp | 異なる粒径をもった混合粉体の吸入方法 |
| ITMI20012174A1 (it) * | 2001-10-18 | 2003-04-18 | Univ Parma | Polvere per somministrazione nasale di farmaci |
| EP1578422B1 (en) | 2002-12-20 | 2007-04-11 | NicoNovum AB | A physically and chemically stable nicotine and micorcrystalline cellulose containing particulate material |
| JP2006522634A (ja) | 2003-04-14 | 2006-10-05 | ベクトゥラ・リミテッド | 投与効率を向上させるデバイス及び製薬組成 |
| WO2005000267A2 (en) | 2003-05-28 | 2005-01-06 | Nektar Therapeutics | Spray drying of an alcoholic aqueous solution for the manufacture of a water-insoluble active agentmicroparticle with a partial or complete amino acid and/or phospholipid coat |
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| US20130017259A1 (en) * | 2011-07-06 | 2013-01-17 | The Parkinson's Institute | Compositions and Methods for Treatment of Symptoms in Parkinson's Disease Patients |
| RS58456B1 (sr) * | 2011-08-01 | 2019-04-30 | Univ Monash | Postupak i formulacije za inhalaciju |
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| US9907748B2 (en) | 2011-10-21 | 2018-03-06 | Niconovum Usa, Inc. | Excipients for nicotine-containing therapeutic compositions |
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| US9056057B2 (en) | 2012-05-03 | 2015-06-16 | Kala Pharmaceuticals, Inc. | Nanocrystals, compositions, and methods that aid particle transport in mucus |
| GB201215273D0 (en) * | 2012-08-28 | 2012-10-10 | Kind Consumer Ltd | Nicotine composition |
| US20140088045A1 (en) * | 2012-09-21 | 2014-03-27 | Basil Rigas | Product comprising a nicotine-containing material and an anti-cancer agent |
| US20140166027A1 (en) | 2012-12-14 | 2014-06-19 | Richard C. Fuisz | Enhanced Delivery of Nicotine, THC, Tobacco, Cannabidiol or Base Alkaloid from an Electronic Cigarette or Other Vapor Producing Device Through Use of an Absorption Conditioning Unit |
| US20140261474A1 (en) | 2013-03-15 | 2014-09-18 | Aradigm Corporation | Methods for inhalation of smoke-free nicotine |
| KR20190075168A (ko) * | 2014-04-08 | 2019-06-28 | 필립모리스 프로덕츠 에스.에이. | 니코틴 제형 및 이의 제조방법 |
| CA2943459C (en) | 2014-04-28 | 2023-05-02 | Philip Morris Products S.A. | Nicotine powder inhaler |
| CN106170313B (zh) | 2014-04-28 | 2020-11-10 | 菲利普莫里斯生产公司 | 带香味尼古丁粉末吸入器 |
| FR3035826B1 (fr) * | 2015-05-07 | 2018-11-16 | Saint-Gobain Glass France | Vitrage de vehicule comprenant une platine pour la fixation de plusieurs accessoires, platine et procede de fixation. |
| US11224594B2 (en) * | 2015-09-16 | 2022-01-18 | Philip Morris Products S.A. | Nicotine formulations and methods of making and using the same |
-
2015
- 2015-09-16 US US14/856,102 patent/US9585835B1/en active Active
- 2015-10-29 CN CN201510717990.5A patent/CN106539794B/zh active Active
-
2016
- 2016-09-15 BR BR112018005145-4A patent/BR112018005145B1/pt active IP Right Grant
- 2016-09-15 HK HK19100385.2A patent/HK1258016A1/zh unknown
- 2016-09-15 JP JP2018514451A patent/JP7575183B2/ja active Active
- 2016-09-15 UA UAA201803890A patent/UA126849C2/uk unknown
- 2016-09-15 AU AU2016323317A patent/AU2016323317A1/en not_active Abandoned
- 2016-09-15 PL PL16847315.5T patent/PL3349599T3/pl unknown
- 2016-09-15 ES ES16847315T patent/ES2997334T3/es active Active
- 2016-09-15 KR KR1020187007673A patent/KR102760317B1/ko active Active
- 2016-09-15 WO PCT/US2016/051963 patent/WO2017048974A1/en not_active Ceased
- 2016-09-15 MY MYPI2018700899A patent/MY184362A/en unknown
- 2016-09-15 EP EP16847315.5A patent/EP3349599B1/en active Active
- 2016-09-15 RU RU2018113460A patent/RU2719228C2/ru active
- 2016-09-15 CA CA2999082A patent/CA2999082A1/en not_active Abandoned
- 2016-09-15 MX MX2018003272A patent/MX394985B/es unknown
-
2018
- 2018-03-07 ZA ZA2018/01569A patent/ZA201801569B/en unknown
- 2018-03-13 PH PH12018500544A patent/PH12018500544A1/en unknown
- 2018-03-15 IL IL258143A patent/IL258143A/en unknown
-
2022
- 2022-05-11 JP JP2022077936A patent/JP2022097639A/ja active Pending
-
2024
- 2024-04-15 JP JP2024065173A patent/JP2024086897A/ja active Pending
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