RU2719228C2 - Вдыхаемые никотиновые композиции и способы их получения и применения - Google Patents

Вдыхаемые никотиновые композиции и способы их получения и применения Download PDF

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Publication number
RU2719228C2
RU2719228C2 RU2018113460A RU2018113460A RU2719228C2 RU 2719228 C2 RU2719228 C2 RU 2719228C2 RU 2018113460 A RU2018113460 A RU 2018113460A RU 2018113460 A RU2018113460 A RU 2018113460A RU 2719228 C2 RU2719228 C2 RU 2719228C2
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RU
Russia
Prior art keywords
nicotine
composition
particles
microns
menthol
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RU2018113460A
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English (en)
Russian (ru)
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RU2018113460A (ru
RU2018113460A3 (enExample
Inventor
Алекс СТЕНЦЛЕР
Ноэ ЗАМЕЛ
Артур СЛУЦКИЙ
Стивен ЭЛЛИС
Original Assignee
Филип Моррис Продактс С.А.
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Publication of RU2018113460A publication Critical patent/RU2018113460A/ru
Publication of RU2018113460A3 publication Critical patent/RU2018113460A3/ru
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    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/10—Chemical features of tobacco products or tobacco substitutes
    • A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/18—Treatment of tobacco products or tobacco substitutes
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/18—Treatment of tobacco products or tobacco substitutes
    • A24B15/28—Treatment of tobacco products or tobacco substitutes by chemical substances
    • A24B15/30—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances
    • A24B15/36—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances containing a heterocyclic ring
    • A24B15/40—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances containing a heterocyclic ring having only oxygen or sulfur as hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/465—Nicotine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/534—Mentha (mint)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/148—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with compounds of unknown constitution, e.g. material from plants or animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Otolaryngology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Botany (AREA)
  • Addiction (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Neurosurgery (AREA)
  • Medical Informatics (AREA)
  • Neurology (AREA)
  • Mycology (AREA)
  • Psychiatry (AREA)
  • Zoology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Manufacture Of Tobacco Products (AREA)
RU2018113460A 2015-09-16 2016-09-15 Вдыхаемые никотиновые композиции и способы их получения и применения RU2719228C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14/856,102 2015-09-16
US14/856,102 US9585835B1 (en) 2015-09-16 2015-09-16 Inhalable nicotine formulations and methods of making and using the same
PCT/US2016/051963 WO2017048974A1 (en) 2015-09-16 2016-09-15 Inhalable nicotine formulations, and methods of making and using thereof

Publications (3)

Publication Number Publication Date
RU2018113460A RU2018113460A (ru) 2019-10-18
RU2018113460A3 RU2018113460A3 (enExample) 2019-10-18
RU2719228C2 true RU2719228C2 (ru) 2020-04-17

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Application Number Title Priority Date Filing Date
RU2018113460A RU2719228C2 (ru) 2015-09-16 2016-09-15 Вдыхаемые никотиновые композиции и способы их получения и применения

Country Status (19)

Country Link
US (1) US9585835B1 (enExample)
EP (1) EP3349599B1 (enExample)
JP (3) JP7575183B2 (enExample)
KR (1) KR102760317B1 (enExample)
CN (1) CN106539794B (enExample)
AU (1) AU2016323317A1 (enExample)
BR (1) BR112018005145B1 (enExample)
CA (1) CA2999082A1 (enExample)
ES (1) ES2997334T3 (enExample)
HK (1) HK1258016A1 (enExample)
IL (1) IL258143A (enExample)
MX (1) MX394985B (enExample)
MY (1) MY184362A (enExample)
PH (1) PH12018500544A1 (enExample)
PL (1) PL3349599T3 (enExample)
RU (1) RU2719228C2 (enExample)
UA (1) UA126849C2 (enExample)
WO (1) WO2017048974A1 (enExample)
ZA (1) ZA201801569B (enExample)

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EP3478264B1 (en) * 2016-06-30 2025-11-19 Philip Morris Products S.A. Nicotine particles and compositions
CA3048677A1 (en) * 2017-03-07 2018-09-13 Philip Morris Products S.A. Inhalable nicotine formulations, and methods of making and using thereof
MX2019014671A (es) * 2017-06-28 2020-02-07 Philip Morris Products Sa Contenedor con particulas para su uso con un inhalador.
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KR20220098778A (ko) * 2019-11-14 2022-07-12 필립모리스 프로덕츠 에스.에이. 개선된 담배 향이 나는 건조 분말 제형
JP2023529411A (ja) * 2020-06-15 2023-07-10 フィリップ・モーリス・プロダクツ・ソシエテ・アノニム アナタビン粉末組成物
US20220313614A1 (en) * 2021-04-06 2022-10-06 Altria Client Services Llc Encapsulated nicotine granules and methods of preparation thereof
US20220313678A1 (en) * 2021-04-06 2022-10-06 Altria Client Services Llc Spray dried nicotine for inclusion in oral products
EP4609854A1 (en) * 2022-10-27 2025-09-03 KT&G Corporation Low-dose nicotine dry powder inhalation composition
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CN117158443B (zh) * 2023-09-05 2024-03-22 贵州大学 烟碱在制备贝莱斯芽胞杆菌生防作用增强剂中的应用

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Publication number Publication date
IL258143A (en) 2018-05-31
EP3349599B1 (en) 2024-11-20
UA126849C2 (uk) 2023-02-15
ES2997334T3 (en) 2025-02-17
US20170071856A1 (en) 2017-03-16
WO2017048974A8 (en) 2018-04-12
AU2016323317A1 (en) 2018-04-12
JP7575183B2 (ja) 2024-10-29
JP2024086897A (ja) 2024-06-28
RU2018113460A (ru) 2019-10-18
RU2018113460A3 (enExample) 2019-10-18
JP2018528966A (ja) 2018-10-04
KR102760317B1 (ko) 2025-02-03
CN106539794A (zh) 2017-03-29
EP3349599A1 (en) 2018-07-25
HK1258016A1 (zh) 2019-11-01
US9585835B1 (en) 2017-03-07
EP3349599A4 (en) 2019-04-17
MX2018003272A (es) 2018-08-16
MY184362A (en) 2021-04-01
BR112018005145B1 (pt) 2022-05-03
ZA201801569B (en) 2019-01-30
CA2999082A1 (en) 2017-03-23
WO2017048974A1 (en) 2017-03-23
PL3349599T3 (pl) 2025-03-24
CN106539794B (zh) 2020-05-15
KR20180077150A (ko) 2018-07-06
BR112018005145A2 (pt) 2018-12-11
PH12018500544A1 (en) 2018-09-24
EP3349599C0 (en) 2024-11-20
JP2022097639A (ja) 2022-06-30
MX394985B (es) 2025-03-24

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