JP2013515022A5 - - Google Patents

Info

Publication number

JP2013515022A5

JP2013515022A5 JP2012545143A JP2012545143A JP2013515022A5 JP 2013515022 A5 JP2013515022 A5 JP 2013515022A5 JP 2012545143 A JP2012545143 A JP 2012545143A JP 2012545143 A JP2012545143 A JP 2012545143A JP 2013515022 A5 JP2013515022 A5 JP 2013515022A5

Authority

JP

Japan

Prior art keywords

influenza virus

pharmaceutical composition

combination

carrageenan

group

Prior art date

2010-12-17

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 229940123424 Neuraminidase inhibitor Drugs 0.000 claims 9
• 239000008194 pharmaceutical composition Substances 0.000 claims 9
• 239000002911 sialidase inhibitor Substances 0.000 claims 9
• 241000712461 unidentified influenza virus Species 0.000 claims 8
• ZNOZWUKQPJXOIG-XSBHQQIPSA-L [(2r,3s,4r,5r,6s)-6-[[(1r,3s,4r,5r,8s)-3,4-dihydroxy-2,6-dioxabicyclo[3.2.1]octan-8-yl]oxy]-4-[[(1r,3r,4r,5r,8s)-8-[(2s,3r,4r,5r,6r)-3,4-dihydroxy-6-(hydroxymethyl)-5-sulfonatooxyoxan-2-yl]oxy-4-hydroxy-2,6-dioxabicyclo[3.2.1]octan-3-yl]oxy]-5-hydroxy-2-( Chemical compound O[C@@H]1[C@@H](O)[C@@H](OS([O-])(=O)=O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H]2OC[C@H]1O[C@H](O[C@H]1[C@H]([C@@H](CO)O[C@@H](O[C@@H]3[C@@H]4OC[C@H]3O[C@H](O)[C@@H]4O)[C@@H]1O)OS([O-])(=O)=O)[C@@H]2O ZNOZWUKQPJXOIG-XSBHQQIPSA-L 0.000 claims 7
• 241000700605 Viruses Species 0.000 claims 6
• 230000000241 respiratory effect Effects 0.000 claims 5
• 201000010099 disease Diseases 0.000 claims 4
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
• 208000015181 infectious disease Diseases 0.000 claims 4
• 208000024891 symptom Diseases 0.000 claims 4
• 208000003322 Coinfection Diseases 0.000 claims 3
• 241001500351 Influenzavirus A Species 0.000 claims 3
• QNRRHYPPQFELSF-CNYIRLTGSA-N Laninamivir Chemical compound OC[C@@H](O)[C@@H](OC)[C@@H]1OC(C(O)=O)=C[C@H](N=C(N)N)[C@H]1NC(C)=O QNRRHYPPQFELSF-CNYIRLTGSA-N 0.000 claims 3
• 239000003814 drug Substances 0.000 claims 3
• 229950004244 laninamivir Drugs 0.000 claims 3
• 229960003752 oseltamivir Drugs 0.000 claims 3
• VSZGPKBBMSAYNT-RRFJBIMHSA-N oseltamivir Chemical compound CCOC(=O)C1=C[C@@H](OC(CC)CC)[C@H](NC(C)=O)[C@@H](N)C1 VSZGPKBBMSAYNT-RRFJBIMHSA-N 0.000 claims 3
• XRQDFNLINLXZLB-CKIKVBCHSA-N peramivir Chemical compound CCC(CC)[C@H](NC(C)=O)[C@@H]1[C@H](O)[C@@H](C(O)=O)C[C@H]1NC(N)=N XRQDFNLINLXZLB-CKIKVBCHSA-N 0.000 claims 3
• 229960001084 peramivir Drugs 0.000 claims 3
• 230000000069 prophylactic effect Effects 0.000 claims 3
• 230000001225 therapeutic effect Effects 0.000 claims 3
• 229960001028 zanamivir Drugs 0.000 claims 3
• ARAIBEBZBOPLMB-UFGQHTETSA-N zanamivir Chemical group CC(=O)N[C@@H]1[C@@H](N=C(N)N)C=C(C(O)=O)O[C@H]1[C@H](O)[C@H](O)CO ARAIBEBZBOPLMB-UFGQHTETSA-N 0.000 claims 3
• 241000711573 Coronaviridae Species 0.000 claims 2
• 241000709661 Enterovirus Species 0.000 claims 2
• 206010006451 bronchitis Diseases 0.000 claims 2
• 239000003937 drug carrier Substances 0.000 claims 2
• 238000011321 prophylaxis Methods 0.000 claims 2
• 238000011282 treatment Methods 0.000 claims 2
• 206010006448 Bronchiolitis Diseases 0.000 claims 1
• 206010006458 Bronchitis chronic Diseases 0.000 claims 1
• 206010008531 Chills Diseases 0.000 claims 1
• 206010010356 Congenital anomaly Diseases 0.000 claims 1
• 206010011416 Croup infectious Diseases 0.000 claims 1
• 208000005156 Dehydration Diseases 0.000 claims 1
• 208000008454 Hyperhidrosis Diseases 0.000 claims 1
• 206010061218 Inflammation Diseases 0.000 claims 1
• 241001500350 Influenzavirus B Species 0.000 claims 1
• 201000008197 Laryngitis Diseases 0.000 claims 1
• 241000351643 Metapneumovirus Species 0.000 claims 1
• 208000002193 Pain Diseases 0.000 claims 1
• 208000002606 Paramyxoviridae Infections Diseases 0.000 claims 1
• 201000007100 Pharyngitis Diseases 0.000 claims 1
• 206010035664 Pneumonia Diseases 0.000 claims 1
• 206010037660 Pyrexia Diseases 0.000 claims 1
• 241000725643 Respiratory syncytial virus Species 0.000 claims 1
• 206010044302 Tracheitis Diseases 0.000 claims 1
• 208000021240 acute bronchiolitis Diseases 0.000 claims 1
• 208000006673 asthma Diseases 0.000 claims 1
• 229940113118 carrageenan Drugs 0.000 claims 1
• 235000010418 carrageenan Nutrition 0.000 claims 1
• 229920001525 carrageenan Polymers 0.000 claims 1
• 239000000679 carrageenan Substances 0.000 claims 1
• 208000007451 chronic bronchitis Diseases 0.000 claims 1
• 201000010549 croup Diseases 0.000 claims 1
• 230000018044 dehydration Effects 0.000 claims 1
• 238000006297 dehydration reaction Methods 0.000 claims 1
• 208000002173 dizziness Diseases 0.000 claims 1
• 230000004054 inflammatory process Effects 0.000 claims 1
• 239000007788 liquid Substances 0.000 claims 1
• 239000006193 liquid solution Substances 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 239000007922 nasal spray Substances 0.000 claims 1
• 229940097496 nasal spray Drugs 0.000 claims 1
• 206010039083 rhinitis Diseases 0.000 claims 1
• 201000009890 sinusitis Diseases 0.000 claims 1
• 230000035900 sweating Effects 0.000 claims 1
• UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims 1