SG181421A1 - Synergistic antiviral composition and use thereof - Google Patents
Synergistic antiviral composition and use thereof Download PDFInfo
- Publication number
- SG181421A1 SG181421A1 SG2012033643A SG2012033643A SG181421A1 SG 181421 A1 SG181421 A1 SG 181421A1 SG 2012033643 A SG2012033643 A SG 2012033643A SG 2012033643 A SG2012033643 A SG 2012033643A SG 181421 A1 SG181421 A1 SG 181421A1
- Authority
- SG
- Singapore
- Prior art keywords
- carrageenan
- kappa
- neuraminidase inhibitor
- iota
- infection
- Prior art date
Links
- 230000000840 anti-viral effect Effects 0.000 title claims description 25
- 230000002195 synergetic effect Effects 0.000 title description 9
- 239000000203 mixture Substances 0.000 title description 6
- 239000002911 sialidase inhibitor Substances 0.000 claims abstract description 55
- 229940123424 Neuraminidase inhibitor Drugs 0.000 claims abstract description 52
- ZNOZWUKQPJXOIG-XSBHQQIPSA-L [(2r,3s,4r,5r,6s)-6-[[(1r,3s,4r,5r,8s)-3,4-dihydroxy-2,6-dioxabicyclo[3.2.1]octan-8-yl]oxy]-4-[[(1r,3r,4r,5r,8s)-8-[(2s,3r,4r,5r,6r)-3,4-dihydroxy-6-(hydroxymethyl)-5-sulfonatooxyoxan-2-yl]oxy-4-hydroxy-2,6-dioxabicyclo[3.2.1]octan-3-yl]oxy]-5-hydroxy-2-( Chemical compound O[C@@H]1[C@@H](O)[C@@H](OS([O-])(=O)=O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H]2OC[C@H]1O[C@H](O[C@H]1[C@H]([C@@H](CO)O[C@@H](O[C@@H]3[C@@H]4OC[C@H]3O[C@H](O)[C@@H]4O)[C@@H]1O)OS([O-])(=O)=O)[C@@H]2O ZNOZWUKQPJXOIG-XSBHQQIPSA-L 0.000 claims abstract description 45
- 238000011282 treatment Methods 0.000 claims abstract description 43
- 208000015181 infectious disease Diseases 0.000 claims abstract description 41
- 241000712461 unidentified influenza virus Species 0.000 claims abstract description 28
- 230000001225 therapeutic effect Effects 0.000 claims abstract description 27
- 239000003814 drug Substances 0.000 claims abstract description 23
- 208000024891 symptom Diseases 0.000 claims abstract description 19
- 230000000069 prophylactic effect Effects 0.000 claims abstract description 13
- 201000010099 disease Diseases 0.000 claims abstract description 11
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 11
- 229920001525 carrageenan Polymers 0.000 claims description 49
- 229940113118 carrageenan Drugs 0.000 claims description 48
- 239000000679 carrageenan Substances 0.000 claims description 48
- VSZGPKBBMSAYNT-RRFJBIMHSA-N oseltamivir Chemical compound CCOC(=O)C1=C[C@@H](OC(CC)CC)[C@H](NC(C)=O)[C@@H](N)C1 VSZGPKBBMSAYNT-RRFJBIMHSA-N 0.000 claims description 31
- ARAIBEBZBOPLMB-UFGQHTETSA-N zanamivir Chemical group CC(=O)N[C@@H]1[C@@H](N=C(N)N)C=C(C(O)=O)O[C@H]1[C@H](O)[C@H](O)CO ARAIBEBZBOPLMB-UFGQHTETSA-N 0.000 claims description 30
- 229960001028 zanamivir Drugs 0.000 claims description 26
- 229960003752 oseltamivir Drugs 0.000 claims description 22
- 235000010418 carrageenan Nutrition 0.000 claims description 16
- 238000000034 method Methods 0.000 claims description 14
- 239000008194 pharmaceutical composition Substances 0.000 claims description 13
- 230000009385 viral infection Effects 0.000 claims description 12
- 241000700605 Viruses Species 0.000 claims description 11
- 230000000241 respiratory effect Effects 0.000 claims description 8
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims description 8
- 208000003322 Coinfection Diseases 0.000 claims description 6
- 241000711573 Coronaviridae Species 0.000 claims description 6
- 241000709661 Enterovirus Species 0.000 claims description 5
- 239000006193 liquid solution Substances 0.000 claims description 5
- 206010006451 bronchitis Diseases 0.000 claims description 4
- 206010035664 Pneumonia Diseases 0.000 claims description 3
- 206010006448 Bronchiolitis Diseases 0.000 claims description 2
- 206010006458 Bronchitis chronic Diseases 0.000 claims description 2
- 206010008531 Chills Diseases 0.000 claims description 2
- 206010011416 Croup infectious Diseases 0.000 claims description 2
- 208000005156 Dehydration Diseases 0.000 claims description 2
- 208000008454 Hyperhidrosis Diseases 0.000 claims description 2
- 241001500351 Influenzavirus A Species 0.000 claims description 2
- 241001500350 Influenzavirus B Species 0.000 claims description 2
- 201000008197 Laryngitis Diseases 0.000 claims description 2
- 241000351643 Metapneumovirus Species 0.000 claims description 2
- 208000002193 Pain Diseases 0.000 claims description 2
- 201000007100 Pharyngitis Diseases 0.000 claims description 2
- 206010037660 Pyrexia Diseases 0.000 claims description 2
- 241000725643 Respiratory syncytial virus Species 0.000 claims description 2
- 206010044302 Tracheitis Diseases 0.000 claims description 2
- 208000024716 acute asthma Diseases 0.000 claims description 2
- 208000021240 acute bronchiolitis Diseases 0.000 claims description 2
- 201000010550 acute laryngitis Diseases 0.000 claims description 2
- 208000016150 acute pharyngitis Diseases 0.000 claims description 2
- 206010001093 acute tonsillitis Diseases 0.000 claims description 2
- 208000007451 chronic bronchitis Diseases 0.000 claims description 2
- 201000010549 croup Diseases 0.000 claims description 2
- 230000018044 dehydration Effects 0.000 claims description 2
- 238000006297 dehydration reaction Methods 0.000 claims description 2
- 208000002173 dizziness Diseases 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 239000007922 nasal spray Substances 0.000 claims description 2
- 229940097496 nasal spray Drugs 0.000 claims description 2
- 230000036407 pain Effects 0.000 claims description 2
- 206010039083 rhinitis Diseases 0.000 claims description 2
- 201000009890 sinusitis Diseases 0.000 claims description 2
- 230000035900 sweating Effects 0.000 claims description 2
- 241000699670 Mus sp. Species 0.000 description 29
- PGZUMBJQJWIWGJ-ONAKXNSWSA-N oseltamivir phosphate Chemical compound OP(O)(O)=O.CCOC(=O)C1=C[C@@H](OC(CC)CC)[C@H](NC(C)=O)[C@@H](N)C1 PGZUMBJQJWIWGJ-ONAKXNSWSA-N 0.000 description 24
- 229940061367 tamiflu Drugs 0.000 description 24
- 230000004083 survival effect Effects 0.000 description 12
- 239000000902 placebo Substances 0.000 description 11
- 229940068196 placebo Drugs 0.000 description 11
- 241001465754 Metazoa Species 0.000 description 9
- 229920000642 polymer Polymers 0.000 description 9
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 8
- 229940079593 drug Drugs 0.000 description 8
- 239000000243 solution Substances 0.000 description 7
- 230000000694 effects Effects 0.000 description 6
- 239000013642 negative control Substances 0.000 description 6
- 206010022000 influenza Diseases 0.000 description 5
- 206010002091 Anaesthesia Diseases 0.000 description 4
- 230000037005 anaesthesia Effects 0.000 description 4
- 238000001949 anaesthesia Methods 0.000 description 4
- 238000011284 combination treatment Methods 0.000 description 4
- 230000000875 corresponding effect Effects 0.000 description 4
- 239000010432 diamond Substances 0.000 description 4
- 210000002345 respiratory system Anatomy 0.000 description 4
- 239000011780 sodium chloride Substances 0.000 description 4
- 230000008901 benefit Effects 0.000 description 3
- 238000002648 combination therapy Methods 0.000 description 3
- 229940042406 direct acting antivirals neuraminidase inhibitors Drugs 0.000 description 3
- 230000036541 health Effects 0.000 description 3
- 231100000518 lethal Toxicity 0.000 description 3
- 230000001665 lethal effect Effects 0.000 description 3
- 239000002207 metabolite Substances 0.000 description 3
- 238000010172 mouse model Methods 0.000 description 3
- 229960002194 oseltamivir phosphate Drugs 0.000 description 3
- 230000009885 systemic effect Effects 0.000 description 3
- 230000004580 weight loss Effects 0.000 description 3
- QNRRHYPPQFELSF-CNYIRLTGSA-N Laninamivir Chemical compound OC[C@@H](O)[C@@H](OC)[C@@H]1OC(C(O)=O)=C[C@H](N=C(N)N)[C@H]1NC(C)=O QNRRHYPPQFELSF-CNYIRLTGSA-N 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- -1 carrageenan compound Chemical class 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 229950004244 laninamivir Drugs 0.000 description 2
- 238000001325 log-rank test Methods 0.000 description 2
- 210000004877 mucosa Anatomy 0.000 description 2
- 210000003928 nasal cavity Anatomy 0.000 description 2
- 229960001084 peramivir Drugs 0.000 description 2
- XRQDFNLINLXZLB-CKIKVBCHSA-N peramivir Chemical compound CCC(CC)[C@H](NC(C)=O)[C@@H]1[C@H](O)[C@@H](C(O)=O)C[C@H]1NC(N)=N XRQDFNLINLXZLB-CKIKVBCHSA-N 0.000 description 2
- 239000000651 prodrug Substances 0.000 description 2
- 229940002612 prodrug Drugs 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 229940061374 relenza Drugs 0.000 description 2
- 238000005507 spraying Methods 0.000 description 2
- 206010061598 Immunodeficiency Diseases 0.000 description 1
- 241000712431 Influenza A virus Species 0.000 description 1
- 241000701076 Macacine alphaherpesvirus 1 Species 0.000 description 1
- 241001529936 Murinae Species 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 102000005348 Neuraminidase Human genes 0.000 description 1
- 108010006232 Neuraminidase Proteins 0.000 description 1
- 241000712464 Orthomyxoviridae Species 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 241000711504 Paramyxoviridae Species 0.000 description 1
- 206010034133 Pathogen resistance Diseases 0.000 description 1
- 238000011529 RT qPCR Methods 0.000 description 1
- 206010057190 Respiratory tract infections Diseases 0.000 description 1
- 206010061494 Rhinovirus infection Diseases 0.000 description 1
- 238000000692 Student's t-test Methods 0.000 description 1
- 206010046306 Upper respiratory tract infection Diseases 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 229940124393 anti-influenza virus drug Drugs 0.000 description 1
- 239000003443 antiviral agent Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 239000013066 combination product Substances 0.000 description 1
- 229940127555 combination product Drugs 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 229930182830 galactose Natural products 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 208000037797 influenza A Diseases 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 231100000636 lethal dose Toxicity 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 208000020029 respiratory tract infectious disease Diseases 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000012353 t test Methods 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 238000011285 therapeutic regimen Methods 0.000 description 1
- 230000029812 viral genome replication Effects 0.000 description 1
- 230000007482 viral spreading Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/731—Carrageenans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Inorganic Chemistry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Otolaryngology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28214809P | 2009-12-22 | 2009-12-22 | |
| PCT/EP2010/007726 WO2011076367A2 (en) | 2009-12-22 | 2010-12-17 | Synergistic antiviral composition and use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG181421A1 true SG181421A1 (en) | 2012-07-30 |
Family
ID=44063696
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG2012033643A SG181421A1 (en) | 2009-12-22 | 2010-12-17 | Synergistic antiviral composition and use thereof |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US10022449B2 (enExample) |
| EP (1) | EP2515889B1 (enExample) |
| JP (1) | JP5902628B2 (enExample) |
| KR (1) | KR101862415B1 (enExample) |
| CN (1) | CN102652017A (enExample) |
| AU (1) | AU2010335594B2 (enExample) |
| BR (1) | BR112012015202B1 (enExample) |
| CA (1) | CA2779532C (enExample) |
| CL (1) | CL2012001695A1 (enExample) |
| DK (1) | DK2515889T3 (enExample) |
| EA (1) | EA022840B1 (enExample) |
| ES (1) | ES2531367T3 (enExample) |
| IL (1) | IL219552A (enExample) |
| MX (1) | MX2012007166A (enExample) |
| NZ (1) | NZ599839A (enExample) |
| PL (1) | PL2515889T3 (enExample) |
| PT (1) | PT2515889E (enExample) |
| SG (1) | SG181421A1 (enExample) |
| SI (1) | SI2515889T1 (enExample) |
| WO (1) | WO2011076367A2 (enExample) |
| ZA (1) | ZA201202482B (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012126777A1 (en) * | 2011-03-18 | 2012-09-27 | Marinomed Biotechnologie Gmbh | Inhibition of neuraminidase activity |
| RU2469020C1 (ru) * | 2011-11-08 | 2012-12-10 | Александр Васильевич Иващенко | (3r,4r,5s)-5-амино-4-ациламино-3-(1-этил-пропокси)-циклогекс-1-ен-карбоновые кислоты, их эфиры и способ применения |
| RU2520836C1 (ru) * | 2013-02-27 | 2014-06-27 | Александр Васильевич Иващенко | (3r,4r,5s)-4-амино-5-(2,2-дифторацетиламино)-3-(1-этилпропокси)-циклогекс-1-енкарбоновая кислота и ее эфиры, способ их получения и применения |
| PT2898888T (pt) * | 2014-01-22 | 2019-07-16 | Visufarma B V | Composição que compreende iota-carragenina contra conjuntivite viral |
| US12594285B2 (en) | 2016-02-25 | 2026-04-07 | Applied Biological Laboratories, Inc. | Compositions and methods for protecting against airborne pathogens and irritants |
| EP3419629A4 (en) * | 2016-02-25 | 2019-10-30 | Applied Biological Laboratories, Inc. | COMPOSITIONS AND PROCEDURES FOR PROTECTION AGAINST AIRBORNE PATHOGENES AND IRRITATES |
| US11304989B2 (en) * | 2017-10-06 | 2022-04-19 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd | Peptides for use in the treatment of viral infections |
| WO2019160261A1 (ko) * | 2018-02-14 | 2019-08-22 | (주)나노메디카 | 항바이러스 처리 방법, 항바이러스 필터, 및 이를 구비한 마스크 |
| KR102316819B1 (ko) * | 2018-04-20 | 2021-10-25 | 한미약품 주식회사 | 카라기난을 유효성분으로 포함하는 보존성이 개선된 액상 제제 |
| GB2579600B (en) | 2018-12-05 | 2023-07-05 | Byotrol Plc | Anti-viral composition |
| MX2021016040A (es) * | 2019-07-03 | 2022-03-11 | Aillis Inc | Composicion farmaceutica para el tratamiento de infecciones de virus de influenza. |
| WO2021184123A1 (en) * | 2020-03-18 | 2021-09-23 | Encyt Technologies, Inc. | Compositions and methods for the treatment of coronavirus infection and respiratory compromise |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6593314B1 (en) * | 1999-10-19 | 2003-07-15 | Abbott Laboratories | Neuraminidase inhibitors |
| JP2001181188A (ja) * | 1999-12-28 | 2001-07-03 | Marine Biotechnol Inst Co Ltd | インフルエンザウイルス感染阻害剤 |
| SI2101792T1 (sl) | 2006-12-05 | 2010-08-31 | Marinomed Biotechnologie Gmbh | Uporaba karagenana za zdravljenje rinovirusnih infekcij |
| EP1930015A1 (en) * | 2006-12-05 | 2008-06-11 | Marinomed Biotechnologie GmbH | Use of carrageenan for treating rhinovirus infections |
| WO2008147468A2 (en) | 2006-12-18 | 2008-12-04 | Amcol International | Compositions comprising virus-interacting layered phyllosilicates and a therapeutic agent, and methods of use |
| SI2178533T1 (sl) * | 2007-08-24 | 2013-07-31 | Marinomed Biotechnologie Gmbh | Antivirusni sestavek, ki obsega sulfatiran polisaharid: iota-karagenan |
-
2010
- 2010-12-17 AU AU2010335594A patent/AU2010335594B2/en not_active Ceased
- 2010-12-17 EP EP10810910.9A patent/EP2515889B1/en active Active
- 2010-12-17 BR BR112012015202-5A patent/BR112012015202B1/pt active IP Right Grant
- 2010-12-17 NZ NZ599839A patent/NZ599839A/en unknown
- 2010-12-17 CN CN2010800551771A patent/CN102652017A/zh active Pending
- 2010-12-17 SI SI201030883T patent/SI2515889T1/sl unknown
- 2010-12-17 EA EA201290373A patent/EA022840B1/ru unknown
- 2010-12-17 PL PL10810910T patent/PL2515889T3/pl unknown
- 2010-12-17 SG SG2012033643A patent/SG181421A1/en unknown
- 2010-12-17 MX MX2012007166A patent/MX2012007166A/es active IP Right Grant
- 2010-12-17 ES ES10810910T patent/ES2531367T3/es active Active
- 2010-12-17 KR KR1020127016072A patent/KR101862415B1/ko active Active
- 2010-12-17 DK DK10810910.9T patent/DK2515889T3/en active
- 2010-12-17 JP JP2012545143A patent/JP5902628B2/ja active Active
- 2010-12-17 US US13/513,961 patent/US10022449B2/en active Active
- 2010-12-17 PT PT10810910T patent/PT2515889E/pt unknown
- 2010-12-17 CA CA2779532A patent/CA2779532C/en active Active
- 2010-12-17 WO PCT/EP2010/007726 patent/WO2011076367A2/en not_active Ceased
-
2012
- 2012-05-03 IL IL219552A patent/IL219552A/en active IP Right Grant
- 2012-05-04 ZA ZA2012/02482A patent/ZA201202482B/en unknown
- 2012-06-21 CL CL2012001695A patent/CL2012001695A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK2515889T3 (en) | 2015-03-02 |
| AU2010335594B2 (en) | 2015-05-21 |
| IL219552A0 (en) | 2012-06-28 |
| NZ599839A (en) | 2014-02-28 |
| AU2010335594A1 (en) | 2012-05-24 |
| CL2012001695A1 (es) | 2013-03-08 |
| ZA201202482B (en) | 2012-12-27 |
| SI2515889T1 (sl) | 2015-04-30 |
| US20120302522A1 (en) | 2012-11-29 |
| WO2011076367A2 (en) | 2011-06-30 |
| PT2515889E (pt) | 2015-03-20 |
| KR20120107970A (ko) | 2012-10-04 |
| EA022840B1 (ru) | 2016-03-31 |
| CN102652017A (zh) | 2012-08-29 |
| WO2011076367A3 (en) | 2011-09-01 |
| EP2515889A2 (en) | 2012-10-31 |
| JP5902628B2 (ja) | 2016-04-13 |
| KR101862415B1 (ko) | 2018-05-29 |
| BR112012015202A2 (pt) | 2016-04-05 |
| EA201290373A1 (ru) | 2012-11-30 |
| MX2012007166A (es) | 2012-07-23 |
| CA2779532A1 (en) | 2011-06-30 |
| JP2013515022A (ja) | 2013-05-02 |
| EP2515889B1 (en) | 2014-12-10 |
| BR112012015202B1 (pt) | 2020-12-08 |
| IL219552A (en) | 2016-11-30 |
| US10022449B2 (en) | 2018-07-17 |
| CA2779532C (en) | 2018-05-22 |
| PL2515889T3 (pl) | 2015-05-29 |
| ES2531367T3 (es) | 2015-03-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP2515889B1 (en) | Synergistic antiviral composition and use thereof | |
| FI2265257T4 (fi) | Aklidiniumia käsittävä inhalaatiokoostumus kroonisen keuhkoahtaumataudin hoitamiseksi | |
| TW202615055A (zh) | 用於治療、改善或預防冠狀病毒感染之製品與方法 | |
| EP3474842A1 (en) | Compositions, devices, and methods for the treatment of alcohol use disorder | |
| CA3180854A1 (en) | Products of manufacture and methods for treating, ameliorating or preventing microbial infections | |
| US20220387455A1 (en) | Treatment of moderate to severe influenza | |
| CA3177500A1 (en) | Method of treating a person afflicted with covid-19 and pharmaceutical formulation including dapsone | |
| JP2022019937A (ja) | ヒト又は動物の慢性若しくは急性のウイルス感染症及び／又は敗血症の予防若しくは治療のための組成物 | |
| JP2023520703A (ja) | コロナウイルス感染症の防止および治療における使用のためのシアル酸組成物 | |
| AU2021249053A1 (en) | Dapsone formulations and methods of using same | |
| WO2013094682A1 (ja) | 局所投与型の嚥下障害改善用医薬品 | |
| AU2021235223A1 (en) | Composition for the treatment of lesions of the respiratory system | |
| HK1174835A (en) | Synergistic antiviral composition and use thereof | |
| EP3906934B1 (en) | Application of dalargin for the prevention of viral respiratory infections and prevention of the development of complications during viral respiratory infections | |
| US20240415944A1 (en) | Aqueous aprotinin-containing antiviral pharmaceutical composition | |
| WO2025067689A1 (en) | 5-amino-2,3-dihydro-1,4-phthalazinedione for the treatment of infections with an rna virus | |
| WO2014199486A1 (ja) | 嚥下障害改善用医薬品 |