JP2008508251A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2008508251A5 JP2008508251A5 JP2007523164A JP2007523164A JP2008508251A5 JP 2008508251 A5 JP2008508251 A5 JP 2008508251A5 JP 2007523164 A JP2007523164 A JP 2007523164A JP 2007523164 A JP2007523164 A JP 2007523164A JP 2008508251 A5 JP2008508251 A5 JP 2008508251A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- carboxylic acid
- group
- acid amide
- benzylidene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- -1 heterocyclic carboxylic acid Chemical class 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 7
- 238000004519 manufacturing process Methods 0.000 claims 6
- 241000725303 Human immunodeficiency virus Species 0.000 claims 4
- 208000002193 Pain Diseases 0.000 claims 4
- ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 claims 4
- 125000005843 halogen group Chemical group 0.000 claims 4
- 208000015122 neurodegenerative disease Diseases 0.000 claims 4
- 208000024891 symptom Diseases 0.000 claims 4
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims 3
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 claims 3
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 150000003335 secondary amines Chemical class 0.000 claims 3
- 208000024827 Alzheimer disease Diseases 0.000 claims 2
- 208000019901 Anxiety disease Diseases 0.000 claims 2
- 206010058019 Cancer Pain Diseases 0.000 claims 2
- 208000000094 Chronic Pain Diseases 0.000 claims 2
- 206010011878 Deafness Diseases 0.000 claims 2
- 206010012289 Dementia Diseases 0.000 claims 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- 208000010412 Glaucoma Diseases 0.000 claims 2
- 241000282412 Homo Species 0.000 claims 2
- 208000023105 Huntington disease Diseases 0.000 claims 2
- 208000013016 Hypoglycemia Diseases 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 208000019695 Migraine disease Diseases 0.000 claims 2
- 208000007101 Muscle Cramp Diseases 0.000 claims 2
- 208000018737 Parkinson disease Diseases 0.000 claims 2
- 208000028017 Psychotic disease Diseases 0.000 claims 2
- 208000005392 Spasm Diseases 0.000 claims 2
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 claims 2
- 208000009205 Tinnitus Diseases 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 2
- 239000000654 additive Substances 0.000 claims 2
- 230000000996 additive effect Effects 0.000 claims 2
- 229940126574 aminoglycoside antibiotic Drugs 0.000 claims 2
- 239000002647 aminoglycoside antibiotic agent Substances 0.000 claims 2
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 2
- 230000036506 anxiety Effects 0.000 claims 2
- 208000006673 asthma Diseases 0.000 claims 2
- 210000004556 brain Anatomy 0.000 claims 2
- 239000000969 carrier Substances 0.000 claims 2
- 208000015114 central nervous system disease Diseases 0.000 claims 2
- 230000001684 chronic effect Effects 0.000 claims 2
- 229960003920 cocaine Drugs 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- 239000003995 emulsifying agent Substances 0.000 claims 2
- 206010015037 epilepsy Diseases 0.000 claims 2
- 239000000796 flavoring agent Substances 0.000 claims 2
- 235000013355 food flavoring agent Nutrition 0.000 claims 2
- 239000003205 fragrance Substances 0.000 claims 2
- 230000010370 hearing loss Effects 0.000 claims 2
- 231100000888 hearing loss Toxicity 0.000 claims 2
- 208000016354 hearing loss disease Diseases 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 230000002218 hypoglycaemic effect Effects 0.000 claims 2
- 208000014674 injury Diseases 0.000 claims 2
- 230000000302 ischemic effect Effects 0.000 claims 2
- 206010027599 migraine Diseases 0.000 claims 2
- 208000004296 neuralgia Diseases 0.000 claims 2
- 231100000878 neurological injury Toxicity 0.000 claims 2
- 208000021722 neuropathic pain Diseases 0.000 claims 2
- 230000003204 osmotic effect Effects 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 210000001525 retina Anatomy 0.000 claims 2
- 210000000278 spinal cord Anatomy 0.000 claims 2
- 239000003381 stabilizer Substances 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 231100000886 tinnitus Toxicity 0.000 claims 2
- 230000008736 traumatic injury Effects 0.000 claims 2
- 238000009736 wetting Methods 0.000 claims 2
- 239000000080 wetting agent Substances 0.000 claims 2
- VHYPZQAQRRBZEK-UHFFFAOYSA-N (4-benzylidenepiperidin-1-yl)-(6-hydroxy-1h-benzimidazol-2-yl)methanone Chemical compound N1C2=CC(O)=CC=C2N=C1C(=O)N(CC1)CCC1=CC1=CC=CC=C1 VHYPZQAQRRBZEK-UHFFFAOYSA-N 0.000 claims 1
- BLWXRJWPEUYHIT-UHFFFAOYSA-N (4-benzylidenepiperidin-1-yl)-(6-hydroxy-1h-indol-2-yl)methanone Chemical compound N1C2=CC(O)=CC=C2C=C1C(=O)N(CC1)CCC1=CC1=CC=CC=C1 BLWXRJWPEUYHIT-UHFFFAOYSA-N 0.000 claims 1
- GDMGMHGDROJFJP-UHFFFAOYSA-N (6-hydroxy-1h-benzimidazol-2-yl)-[4-[(4-methylphenyl)methylidene]piperidin-1-yl]methanone Chemical compound C1=CC(C)=CC=C1C=C1CCN(C(=O)C=2NC3=CC(O)=CC=C3N=2)CC1 GDMGMHGDROJFJP-UHFFFAOYSA-N 0.000 claims 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
- QMQNIKYRPSFQKB-UHFFFAOYSA-N 4-benzylidenepiperidine Chemical class C1CNCCC1=CC1=CC=CC=C1 QMQNIKYRPSFQKB-UHFFFAOYSA-N 0.000 claims 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 1
- 102100022630 Glutamate receptor ionotropic, NMDA 2B Human genes 0.000 claims 1
- 108090001041 N-Methyl-D-Aspartate Receptors Proteins 0.000 claims 1
- 102000014649 NMDA glutamate receptor activity proteins Human genes 0.000 claims 1
- 108010038912 Retinoid X Receptors Proteins 0.000 claims 1
- UUWSYEGEHUFEEH-UHFFFAOYSA-N [4-[(4-chlorophenyl)methylidene]piperidin-1-yl]-(6-hydroxy-1h-benzimidazol-2-yl)methanone Chemical compound N1C2=CC(O)=CC=C2N=C1C(=O)N(CC1)CCC1=CC1=CC=C(Cl)C=C1 UUWSYEGEHUFEEH-UHFFFAOYSA-N 0.000 claims 1
- QGKQROOGDOUXRR-UHFFFAOYSA-N [4-[(4-fluorophenyl)methylidene]piperidin-1-yl]-(6-hydroxy-1h-benzimidazol-2-yl)methanone Chemical compound N1C2=CC(O)=CC=C2N=C1C(=O)N(CC1)CCC1=CC1=CC=C(F)C=C1 QGKQROOGDOUXRR-UHFFFAOYSA-N 0.000 claims 1
- 230000003042 antagnostic effect Effects 0.000 claims 1
- 125000004421 aryl sulphonamide group Chemical group 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000002981 neuropathic effect Effects 0.000 claims 1
- 230000003287 optical effect Effects 0.000 claims 1
- 238000012856 packing Methods 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 229940127557 pharmaceutical product Drugs 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
- 0 CC[C@]1NC(C(N(C)CCC(CC)=CCC(C=C[C@@](C)(*)CC)=C)=O)=*C1(C)CC Chemical compound CC[C@]1NC(C(N(C)CCC(CC)=CCC(C=C[C@@](C)(*)CC)=C)=O)=*C1(C)CC 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU0401527A HU227119B1 (en) | 2004-07-29 | 2004-07-29 | Indole and benzimidazole carboxylic acid amide derivatives and pharmaceutical compositions containing them |
| PCT/HU2005/000082 WO2006010969A1 (en) | 2004-07-29 | 2005-07-21 | New heterocyclic carboxylic acid amide derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008508251A JP2008508251A (ja) | 2008-03-21 |
| JP2008508251A5 true JP2008508251A5 (enExample) | 2008-05-15 |
Family
ID=89985412
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007523164A Withdrawn JP2008508251A (ja) | 2004-07-29 | 2005-07-21 | 新規なヘテロ環カルボン酸アミド誘導体 |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US20080300276A1 (enExample) |
| EP (1) | EP1771437A1 (enExample) |
| JP (1) | JP2008508251A (enExample) |
| KR (1) | KR20070038503A (enExample) |
| CN (1) | CN1989126A (enExample) |
| AP (1) | AP2076A (enExample) |
| AU (1) | AU2005266164A1 (enExample) |
| BR (1) | BRPI0513900A (enExample) |
| CA (1) | CA2574169A1 (enExample) |
| EA (1) | EA011635B1 (enExample) |
| GE (1) | GEP20084494B (enExample) |
| HU (1) | HU227119B1 (enExample) |
| IL (1) | IL179483A0 (enExample) |
| MA (1) | MA28818B1 (enExample) |
| MX (1) | MX2007001049A (enExample) |
| NO (1) | NO20071112L (enExample) |
| TN (1) | TNSN07014A1 (enExample) |
| UA (1) | UA88643C2 (enExample) |
| WO (1) | WO2006010969A1 (enExample) |
| ZA (1) | ZA200700329B (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7935706B2 (en) | 2006-02-23 | 2011-05-03 | Shionogi & Co., Ltd. | Nitrogen-containing heterocycle derivatives substituted with cyclic group |
| CN102762554A (zh) | 2010-02-16 | 2012-10-31 | 辉瑞大药厂 | 5-ht4受体的部分激动剂(r)-4-((4-((4-(四氢呋喃-3-基氧基)苯并[d]异*唑-3-基氧基)甲基)哌啶-1-基)甲基)四氢-2h-吡喃-4-醇 |
| JP6563017B2 (ja) | 2014-08-28 | 2019-08-21 | エースニューロン・ソシエテ・アノニム | グリコシダーゼ阻害剤 |
| US10913733B2 (en) | 2015-12-18 | 2021-02-09 | Alectos Therapeutics Inc. | Substituted piperidines thiazolyl acetamides as glycosidase inhibitors and uses thereof |
| CA3012624A1 (en) | 2016-02-25 | 2017-08-31 | Asceneuron S.A. | Glycosidase inhibitors |
| EP3419976B1 (en) | 2016-02-25 | 2021-04-07 | Asceneuron SA | Acid addition salts of piperazine derivatives |
| US11261183B2 (en) | 2016-02-25 | 2022-03-01 | Asceneuron Sa | Sulfoximine glycosidase inhibitors |
| CA3012560A1 (en) | 2016-02-25 | 2017-08-31 | Asceneuron S.A. | Glycosidase inhibitors |
| WO2019037860A1 (en) | 2017-08-24 | 2019-02-28 | Asceneuron S.A. | LINEAR INHIBITORS OF GLYCOSIDASE |
| WO2020039028A1 (en) | 2018-08-22 | 2020-02-27 | Asceneuron S. A. | Tetrahydro-benzoazepine glycosidase inhibitors |
| US11731972B2 (en) | 2018-08-22 | 2023-08-22 | Asceneuron Sa | Spiro compounds as glycosidase inhibitors |
| KR102839500B1 (ko) | 2018-08-22 | 2025-07-28 | 아셰뉴론 에스아 | 글리코시다제 억제제로서 유용한 피페라진 유도체의 숙시네이트 및 푸마레이트 산 부가염 |
| US12016852B2 (en) | 2018-08-22 | 2024-06-25 | Asceneuron Sa | Pyrrolidine glycosidase inhibitors |
| US12398143B2 (en) | 2019-06-04 | 2025-08-26 | Boehringer Ingelheim International Gmbh | Imidazopyrazine derivatives and the use thereof as medicament |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU227197B1 (en) * | 2000-10-24 | 2010-10-28 | Richter Gedeon Nyrt | Nmda receptor antagonist carboxylic acid amide derivatives and pharmaceutical compositions containing them |
-
2004
- 2004-07-29 HU HU0401527A patent/HU227119B1/hu unknown
-
2005
- 2005-07-21 AU AU2005266164A patent/AU2005266164A1/en not_active Abandoned
- 2005-07-21 CN CNA2005800241844A patent/CN1989126A/zh active Pending
- 2005-07-21 EP EP05764183A patent/EP1771437A1/en not_active Withdrawn
- 2005-07-21 CA CA002574169A patent/CA2574169A1/en not_active Abandoned
- 2005-07-21 MX MX2007001049A patent/MX2007001049A/es not_active Application Discontinuation
- 2005-07-21 WO PCT/HU2005/000082 patent/WO2006010969A1/en not_active Ceased
- 2005-07-21 GE GEAP20059896A patent/GEP20084494B/en unknown
- 2005-07-21 US US11/658,486 patent/US20080300276A1/en not_active Abandoned
- 2005-07-21 EA EA200700360A patent/EA011635B1/ru not_active IP Right Cessation
- 2005-07-21 AP AP2006003843A patent/AP2076A/en active
- 2005-07-21 BR BRPI0513900-7A patent/BRPI0513900A/pt not_active IP Right Cessation
- 2005-07-21 KR KR1020077000266A patent/KR20070038503A/ko not_active Withdrawn
- 2005-07-21 JP JP2007523164A patent/JP2008508251A/ja not_active Withdrawn
- 2005-07-21 UA UAA200702172A patent/UA88643C2/ru unknown
-
2006
- 2006-11-22 IL IL179483A patent/IL179483A0/en unknown
-
2007
- 2007-01-11 ZA ZA200700329A patent/ZA200700329B/en unknown
- 2007-01-17 TN TNP2007000014A patent/TNSN07014A1/en unknown
- 2007-02-22 MA MA29705A patent/MA28818B1/fr unknown
- 2007-02-27 NO NO20071112A patent/NO20071112L/no not_active Application Discontinuation
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| TWI500616B (zh) | 新穎之雙環吡啶酮 | |
| JP5815644B2 (ja) | オキサジアゾール誘導体およびそれらの代謝型グルタミン酸受容体増強剤としての使用 | |
| JP2008508251A5 (enExample) | ||
| JP2008508247A5 (enExample) | ||
| JP6643247B2 (ja) | ガンマセクレターゼモジュレーターとしてのクロメンおよび１，１ａ，２，７Ｂ−テトラヒドロシクロプロパ［Ｃ］クロメンピリドピラジンジオン | |
| JPH08504435A (ja) | タキキニン受容体拮抗剤としての４−アミノメチル／チオメチル／スルホニルメチル−４−フェニルピペリジン | |
| JPH10500944A (ja) | モルホリン誘導体及びタキキニンのアンタゴニストとしてのそれらの使用 | |
| JPH10506399A (ja) | １−アシル−４−マリファチルアミノピペリジン化合物 | |
| JPH11508552A (ja) | ピペリジン及びモルホリン誘導体並びに治療剤としてのそれらの使用 | |
| TW201443048A (zh) | 氮雜苯并咪唑化合物 | |
| JP2009526037A (ja) | トリアゾロピリジン化合物 | |
| JP2008508248A5 (enExample) | ||
| JP2010519328A (ja) | Ｈ−ｐｇｄｓの阻害剤としてのニコチンアミド誘導体およびプロスタグランジンｄ２が媒介する疾患の治療のためのそれらの使用 | |
| KR20120093425A (ko) | 지방산 아미드 가수분해효소의 아조사이클릭 억제제 | |
| JP2008508357A5 (enExample) | ||
| US9765073B2 (en) | Cyclopropabenzofuranyl pyridopyrazinediones | |
| NL1028599C2 (nl) | Verbindingen voor de behandeling van ziekten. | |
| JP2016531880A (ja) | ガンマセクレターゼモジュレーターとしての新規二環式ピリジノン | |
| JPWO2006137465A1 (ja) | 含窒素複素環誘導体 | |
| JP2008508250A5 (enExample) | ||
| JP2005517634A5 (enExample) | ||
| KR101160858B1 (ko) | 소양 치료약으로서 유용한 4-(2-푸로일)아미노피페리딘류 | |
| JP2010539154A (ja) | ムスカリン様受容体アンタゴニストとして活性な新規化合物 | |
| KR20220162159A (ko) | Sstr4 작용제로서의 n-헤테로아릴알킬-2-(헤테로사이클릴 및 헤테로사이클릴메틸)아세트아미드 유도체 | |
| WO2007045989A1 (en) | Pyridyl derivatives useful as h3 ligands |