JP2008508251A5 - - Google Patents
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- Publication number
- JP2008508251A5 JP2008508251A5 JP2007523164A JP2007523164A JP2008508251A5 JP 2008508251 A5 JP2008508251 A5 JP 2008508251A5 JP 2007523164 A JP2007523164 A JP 2007523164A JP 2007523164 A JP2007523164 A JP 2007523164A JP 2008508251 A5 JP2008508251 A5 JP 2008508251A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- carboxylic acid
- group
- acid amide
- benzylidene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- -1 heterocyclic carboxylic acid Chemical class 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 7
- 238000004519 manufacturing process Methods 0.000 claims 6
- 241000725303 Human immunodeficiency virus Species 0.000 claims 4
- 208000002193 Pain Diseases 0.000 claims 4
- ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 claims 4
- 125000005843 halogen group Chemical group 0.000 claims 4
- 208000015122 neurodegenerative disease Diseases 0.000 claims 4
- 208000024891 symptom Diseases 0.000 claims 4
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims 3
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 claims 3
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 150000003335 secondary amines Chemical class 0.000 claims 3
- 208000024827 Alzheimer disease Diseases 0.000 claims 2
- 208000019901 Anxiety disease Diseases 0.000 claims 2
- 206010058019 Cancer Pain Diseases 0.000 claims 2
- 208000000094 Chronic Pain Diseases 0.000 claims 2
- 206010011878 Deafness Diseases 0.000 claims 2
- 206010012289 Dementia Diseases 0.000 claims 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- 208000010412 Glaucoma Diseases 0.000 claims 2
- 241000282412 Homo Species 0.000 claims 2
- 208000023105 Huntington disease Diseases 0.000 claims 2
- 208000013016 Hypoglycemia Diseases 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 208000019695 Migraine disease Diseases 0.000 claims 2
- 208000007101 Muscle Cramp Diseases 0.000 claims 2
- 208000018737 Parkinson disease Diseases 0.000 claims 2
- 208000028017 Psychotic disease Diseases 0.000 claims 2
- 208000005392 Spasm Diseases 0.000 claims 2
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 claims 2
- 208000009205 Tinnitus Diseases 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 2
- 239000000654 additive Substances 0.000 claims 2
- 230000000996 additive effect Effects 0.000 claims 2
- 229940126574 aminoglycoside antibiotic Drugs 0.000 claims 2
- 239000002647 aminoglycoside antibiotic agent Substances 0.000 claims 2
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 2
- 230000036506 anxiety Effects 0.000 claims 2
- 208000006673 asthma Diseases 0.000 claims 2
- 210000004556 brain Anatomy 0.000 claims 2
- 239000000969 carrier Substances 0.000 claims 2
- 208000015114 central nervous system disease Diseases 0.000 claims 2
- 230000001684 chronic effect Effects 0.000 claims 2
- 229960003920 cocaine Drugs 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- 239000003995 emulsifying agent Substances 0.000 claims 2
- 206010015037 epilepsy Diseases 0.000 claims 2
- 239000000796 flavoring agent Substances 0.000 claims 2
- 235000013355 food flavoring agent Nutrition 0.000 claims 2
- 239000003205 fragrance Substances 0.000 claims 2
- 230000010370 hearing loss Effects 0.000 claims 2
- 231100000888 hearing loss Toxicity 0.000 claims 2
- 208000016354 hearing loss disease Diseases 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 230000002218 hypoglycaemic effect Effects 0.000 claims 2
- 208000014674 injury Diseases 0.000 claims 2
- 230000000302 ischemic effect Effects 0.000 claims 2
- 206010027599 migraine Diseases 0.000 claims 2
- 208000004296 neuralgia Diseases 0.000 claims 2
- 231100000878 neurological injury Toxicity 0.000 claims 2
- 208000021722 neuropathic pain Diseases 0.000 claims 2
- 230000003204 osmotic effect Effects 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 210000001525 retina Anatomy 0.000 claims 2
- 210000000278 spinal cord Anatomy 0.000 claims 2
- 239000003381 stabilizer Substances 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 231100000886 tinnitus Toxicity 0.000 claims 2
- 230000008736 traumatic injury Effects 0.000 claims 2
- 238000009736 wetting Methods 0.000 claims 2
- 239000000080 wetting agent Substances 0.000 claims 2
- VHYPZQAQRRBZEK-UHFFFAOYSA-N (4-benzylidenepiperidin-1-yl)-(6-hydroxy-1h-benzimidazol-2-yl)methanone Chemical compound N1C2=CC(O)=CC=C2N=C1C(=O)N(CC1)CCC1=CC1=CC=CC=C1 VHYPZQAQRRBZEK-UHFFFAOYSA-N 0.000 claims 1
- BLWXRJWPEUYHIT-UHFFFAOYSA-N (4-benzylidenepiperidin-1-yl)-(6-hydroxy-1h-indol-2-yl)methanone Chemical compound N1C2=CC(O)=CC=C2C=C1C(=O)N(CC1)CCC1=CC1=CC=CC=C1 BLWXRJWPEUYHIT-UHFFFAOYSA-N 0.000 claims 1
- GDMGMHGDROJFJP-UHFFFAOYSA-N (6-hydroxy-1h-benzimidazol-2-yl)-[4-[(4-methylphenyl)methylidene]piperidin-1-yl]methanone Chemical compound C1=CC(C)=CC=C1C=C1CCN(C(=O)C=2NC3=CC(O)=CC=C3N=2)CC1 GDMGMHGDROJFJP-UHFFFAOYSA-N 0.000 claims 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
- QMQNIKYRPSFQKB-UHFFFAOYSA-N 4-benzylidenepiperidine Chemical class C1CNCCC1=CC1=CC=CC=C1 QMQNIKYRPSFQKB-UHFFFAOYSA-N 0.000 claims 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 1
- 102100022630 Glutamate receptor ionotropic, NMDA 2B Human genes 0.000 claims 1
- 108090001041 N-Methyl-D-Aspartate Receptors Proteins 0.000 claims 1
- 102000014649 NMDA glutamate receptor activity proteins Human genes 0.000 claims 1
- 108010038912 Retinoid X Receptors Proteins 0.000 claims 1
- UUWSYEGEHUFEEH-UHFFFAOYSA-N [4-[(4-chlorophenyl)methylidene]piperidin-1-yl]-(6-hydroxy-1h-benzimidazol-2-yl)methanone Chemical compound N1C2=CC(O)=CC=C2N=C1C(=O)N(CC1)CCC1=CC1=CC=C(Cl)C=C1 UUWSYEGEHUFEEH-UHFFFAOYSA-N 0.000 claims 1
- QGKQROOGDOUXRR-UHFFFAOYSA-N [4-[(4-fluorophenyl)methylidene]piperidin-1-yl]-(6-hydroxy-1h-benzimidazol-2-yl)methanone Chemical compound N1C2=CC(O)=CC=C2N=C1C(=O)N(CC1)CCC1=CC1=CC=C(F)C=C1 QGKQROOGDOUXRR-UHFFFAOYSA-N 0.000 claims 1
- 230000003042 antagnostic effect Effects 0.000 claims 1
- 125000004421 aryl sulphonamide group Chemical group 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000002981 neuropathic effect Effects 0.000 claims 1
- 230000003287 optical effect Effects 0.000 claims 1
- 238000012856 packing Methods 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 229940127557 pharmaceutical product Drugs 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
- 0 CC[C@]1NC(C(N(C)CCC(CC)=CCC(C=C[C@@](C)(*)CC)=C)=O)=*C1(C)CC Chemical compound CC[C@]1NC(C(N(C)CCC(CC)=CCC(C=C[C@@](C)(*)CC)=C)=O)=*C1(C)CC 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU0401527A HU227119B1 (en) | 2004-07-29 | 2004-07-29 | Indole and benzimidazole carboxylic acid amide derivatives and pharmaceutical compositions containing them |
| PCT/HU2005/000082 WO2006010969A1 (en) | 2004-07-29 | 2005-07-21 | New heterocyclic carboxylic acid amide derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008508251A JP2008508251A (ja) | 2008-03-21 |
| JP2008508251A5 true JP2008508251A5 (enExample) | 2008-05-15 |
Family
ID=89985412
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007523164A Withdrawn JP2008508251A (ja) | 2004-07-29 | 2005-07-21 | 新規なヘテロ環カルボン酸アミド誘導体 |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US20080300276A1 (enExample) |
| EP (1) | EP1771437A1 (enExample) |
| JP (1) | JP2008508251A (enExample) |
| KR (1) | KR20070038503A (enExample) |
| CN (1) | CN1989126A (enExample) |
| AP (1) | AP2076A (enExample) |
| AU (1) | AU2005266164A1 (enExample) |
| BR (1) | BRPI0513900A (enExample) |
| CA (1) | CA2574169A1 (enExample) |
| EA (1) | EA011635B1 (enExample) |
| GE (1) | GEP20084494B (enExample) |
| HU (1) | HU227119B1 (enExample) |
| IL (1) | IL179483A0 (enExample) |
| MA (1) | MA28818B1 (enExample) |
| MX (1) | MX2007001049A (enExample) |
| NO (1) | NO20071112L (enExample) |
| TN (1) | TNSN07014A1 (enExample) |
| UA (1) | UA88643C2 (enExample) |
| WO (1) | WO2006010969A1 (enExample) |
| ZA (1) | ZA200700329B (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2520567A3 (en) | 2006-02-23 | 2012-12-12 | Shionogi & Co., Ltd. | Nitrogen-containing heterocycle derivatives substituted with cyclic group |
| KR20120123089A (ko) | 2010-02-16 | 2012-11-07 | 화이자 인코포레이티드 | 5-ＨＴ₄ 수용체의 부분 효능제인 (Ｒ)-4-((4-((4-(테트라히드로푸란-3-일옥시)벤조［ｄ］이속사졸-3-일옥시)메틸)피페리딘-1-일)메틸)테트라히드로-2Ｈ-피란-4-올 |
| MX381417B (es) | 2014-08-28 | 2025-03-12 | Asceneuron Sa | Inhibidores de glucosidasa. |
| WO2017106254A1 (en) * | 2015-12-18 | 2017-06-22 | Merck Sharp & Dohme Corp. | Glycosidase inhibitors and uses thereof |
| JP6971999B2 (ja) | 2016-02-25 | 2021-11-24 | エースニューロン・ソシエテ・アノニム | ピペラジン誘導体の酸付加塩 |
| JP2019506430A (ja) | 2016-02-25 | 2019-03-07 | エースニューロン・ソシエテ・アノニム | グリコシダーゼ阻害剤 |
| US11261183B2 (en) | 2016-02-25 | 2022-03-01 | Asceneuron Sa | Sulfoximine glycosidase inhibitors |
| CN108884077A (zh) | 2016-02-25 | 2018-11-23 | 阿森纽荣股份公司 | 糖苷酶抑制剂 |
| US11213525B2 (en) | 2017-08-24 | 2022-01-04 | Asceneuron Sa | Linear glycosidase inhibitors |
| WO2020039029A1 (en) | 2018-08-22 | 2020-02-27 | Asceneuron S. A. | Spiro compounds as glycosidase inhibitors |
| US11795165B2 (en) | 2018-08-22 | 2023-10-24 | Asceneuron Sa | Tetrahydro-benzoazepine glycosidase inhibitors |
| US12016852B2 (en) | 2018-08-22 | 2024-06-25 | Asceneuron Sa | Pyrrolidine glycosidase inhibitors |
| CA3110032A1 (en) | 2018-08-22 | 2020-02-27 | Asceneuron S.A. | Succinate and fumarate acid addition salts of piperazine derivatives |
| US12398143B2 (en) | 2019-06-04 | 2025-08-26 | Boehringer Ingelheim International Gmbh | Imidazopyrazine derivatives and the use thereof as medicament |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU227197B1 (en) * | 2000-10-24 | 2010-10-28 | Richter Gedeon Nyrt | Nmda receptor antagonist carboxylic acid amide derivatives and pharmaceutical compositions containing them |
-
2004
- 2004-07-29 HU HU0401527A patent/HU227119B1/hu unknown
-
2005
- 2005-07-21 US US11/658,486 patent/US20080300276A1/en not_active Abandoned
- 2005-07-21 UA UAA200702172A patent/UA88643C2/ru unknown
- 2005-07-21 CN CNA2005800241844A patent/CN1989126A/zh active Pending
- 2005-07-21 GE GEAP20059896A patent/GEP20084494B/en unknown
- 2005-07-21 MX MX2007001049A patent/MX2007001049A/es not_active Application Discontinuation
- 2005-07-21 JP JP2007523164A patent/JP2008508251A/ja not_active Withdrawn
- 2005-07-21 AP AP2006003843A patent/AP2076A/en active
- 2005-07-21 CA CA002574169A patent/CA2574169A1/en not_active Abandoned
- 2005-07-21 EP EP05764183A patent/EP1771437A1/en not_active Withdrawn
- 2005-07-21 WO PCT/HU2005/000082 patent/WO2006010969A1/en not_active Ceased
- 2005-07-21 EA EA200700360A patent/EA011635B1/ru not_active IP Right Cessation
- 2005-07-21 KR KR1020077000266A patent/KR20070038503A/ko not_active Withdrawn
- 2005-07-21 BR BRPI0513900-7A patent/BRPI0513900A/pt not_active IP Right Cessation
- 2005-07-21 AU AU2005266164A patent/AU2005266164A1/en not_active Abandoned
-
2006
- 2006-11-22 IL IL179483A patent/IL179483A0/en unknown
-
2007
- 2007-01-11 ZA ZA200700329A patent/ZA200700329B/en unknown
- 2007-01-17 TN TNP2007000014A patent/TNSN07014A1/en unknown
- 2007-02-22 MA MA29705A patent/MA28818B1/fr unknown
- 2007-02-27 NO NO20071112A patent/NO20071112L/no not_active Application Discontinuation
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