JP2008510719A5 - - Google Patents
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- Publication number
- JP2008510719A5 JP2008510719A5 JP2007528037A JP2007528037A JP2008510719A5 JP 2008510719 A5 JP2008510719 A5 JP 2008510719A5 JP 2007528037 A JP2007528037 A JP 2007528037A JP 2007528037 A JP2007528037 A JP 2007528037A JP 2008510719 A5 JP2008510719 A5 JP 2008510719A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- piperidin
- methyl
- pharmaceutically acceptable
- ylmethoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60296804P | 2004-08-19 | 2004-08-19 | |
| PCT/US2005/029518 WO2006021002A2 (en) | 2004-08-19 | 2005-08-18 | Compounds useful for inhibiting chk1 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008510719A JP2008510719A (ja) | 2008-04-10 |
| JP2008510719A5 true JP2008510719A5 (enExample) | 2008-10-02 |
Family
ID=35744692
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007528037A Pending JP2008510719A (ja) | 2004-08-19 | 2005-08-18 | Ｃｈｋ１の阻害に有用な化合物 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20080318974A1 (enExample) |
| EP (1) | EP1778648A2 (enExample) |
| JP (1) | JP2008510719A (enExample) |
| KR (1) | KR20070054205A (enExample) |
| CN (1) | CN101115727A (enExample) |
| AU (1) | AU2005272586A1 (enExample) |
| BR (1) | BRPI0514466A (enExample) |
| CA (1) | CA2577880A1 (enExample) |
| MX (1) | MX2007002040A (enExample) |
| WO (1) | WO2006021002A2 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201008005D0 (en) | 2010-05-13 | 2010-06-30 | Sentinel Oncology Ltd | Pharmaceutical compounds |
| GB201119799D0 (en) | 2011-11-16 | 2011-12-28 | Sentinel Oncology Ltd | Pharmaceutical compounds |
| GB201402277D0 (en) | 2014-02-10 | 2014-03-26 | Sentinel Oncology Ltd | Pharmaceutical compounds |
| CA2949793C (en) | 2014-06-19 | 2024-02-27 | Ariad Pharmaceuticals, Inc. | Heteroaryl compounds for kinase inhibition |
| CN104628659A (zh) * | 2015-01-27 | 2015-05-20 | 广西师范大学 | 具有抗肿瘤作用的吡嗪-芳基脲衍生物及其制备方法与应用 |
| US10570119B2 (en) * | 2016-01-11 | 2020-02-25 | Merrimack Pharmaceuticals, Inc. | Inhibiting ataxia telangiectasia and Rad3-related protein (ATR) |
| JP6794609B2 (ja) | 2016-02-04 | 2020-12-02 | ファーマエンジン インコーポレーテッドＰｈａｒｍａｅｎｇｉｎｅ， Ｉｎｃ． | チェックポイントキナーゼ１（ｃｈｋ１）阻害剤として有用な３，５−二置換ピラゾール、並びにその調製及び用途 |
| KR20190130621A (ko) | 2017-03-31 | 2019-11-22 | 시애틀 지네틱스, 인크. | Chk1 저해제와 wee1 저해제의 조합물 |
| KR20200144579A (ko) | 2018-05-14 | 2020-12-29 | 어리어드 파마슈티칼스, 인코포레이티드 | 피리미딘 유도체의 약학 염 및 장애의 치료 방법 |
| WO2021104461A1 (zh) * | 2019-11-29 | 2021-06-03 | 南京明德新药研发有限公司 | 二氮杂吲哚类衍生物及其作为Chk1抑制剂的应用 |
| WO2021119236A1 (en) | 2019-12-10 | 2021-06-17 | Seagen Inc. | Preparation of a chk1 inhibitor compound |
| GB202107932D0 (en) | 2021-06-03 | 2021-07-21 | Sentinel Oncology Ltd | Preparation of a CHK1 Inhibitor Compound |
| GB202107924D0 (en) | 2021-06-03 | 2021-07-21 | Sentinel Oncology Ltd | A pharmaceutical salt |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL254871A (enExample) * | 1959-08-14 | |||
| CH152169A4 (enExample) * | 1969-01-31 | 1970-11-13 | ||
| US4071524A (en) * | 1976-11-08 | 1978-01-31 | Riker Laboratories, Inc. | Derivatives of urea |
| DE1049664T1 (de) * | 1997-12-22 | 2001-05-03 | Bayer Corp., Pittsburgh | Hemmung der raf-kinase unter verwendung von symmetrisch und unsymmetrisch substituierten harnstoffen |
| UA76977C2 (en) * | 2001-03-02 | 2006-10-16 | Icos Corp | Aryl- and heteroaryl substituted chk1 inhibitors and their use as radiosensitizers and chemosensitizers |
| EP1501514B1 (en) * | 2002-05-03 | 2012-12-19 | Exelixis, Inc. | Protein kinase modulators and methods of use |
| CN1882342A (zh) * | 2003-09-17 | 2006-12-20 | 艾科斯有限公司 | Chk1抑制剂在控制细胞增殖中的应用 |
| WO2006012308A1 (en) * | 2004-06-25 | 2006-02-02 | Icos Corporation | Bisarylurea derivatives useful for inhibiting chk1 |
| BRPI0512891A (pt) * | 2004-07-02 | 2008-04-15 | Icos Corp | composto e um sal ou pró-droga ou solvato farmaceuticamente aceitável do mesmo, composição, métodos de inibir a quinase 1 do ponto de verificação em uma célula, de sensibilizar células em um indivìduo que passa por um tratamento quimioterapêutico ou radioterapêutico para uma condição médica e de inibir a proliferação de célula aberrante, uso de um composto, e artigo de fabricação para o uso farmacêutico em humano |
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2005
- 2005-08-18 BR BRPI0514466-3A patent/BRPI0514466A/pt not_active IP Right Cessation
- 2005-08-18 CA CA002577880A patent/CA2577880A1/en not_active Abandoned
- 2005-08-18 JP JP2007528037A patent/JP2008510719A/ja active Pending
- 2005-08-18 WO PCT/US2005/029518 patent/WO2006021002A2/en not_active Ceased
- 2005-08-18 KR KR1020077006216A patent/KR20070054205A/ko not_active Withdrawn
- 2005-08-18 AU AU2005272586A patent/AU2005272586A1/en not_active Abandoned
- 2005-08-18 US US11/659,389 patent/US20080318974A1/en not_active Abandoned
- 2005-08-18 CN CNA2005800353820A patent/CN101115727A/zh active Pending
- 2005-08-18 MX MX2007002040A patent/MX2007002040A/es not_active Application Discontinuation
- 2005-08-18 EP EP05810303A patent/EP1778648A2/en not_active Withdrawn