JP2008510719A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2008510719A5 JP2008510719A5 JP2007528037A JP2007528037A JP2008510719A5 JP 2008510719 A5 JP2008510719 A5 JP 2008510719A5 JP 2007528037 A JP2007528037 A JP 2007528037A JP 2007528037 A JP2007528037 A JP 2007528037A JP 2008510719 A5 JP2008510719 A5 JP 2008510719A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- piperidin
- methyl
- pharmaceutically acceptable
- ylmethoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 239000011780 sodium chloride Substances 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 2
- ZKOWUQGHMJRNLF-UHFFFAOYSA-N 1-[2-(piperidin-3-ylmethoxy)-5-(trifluoromethyl)phenyl]-3-[5-(trifluoromethyl)pyrazin-2-yl]urea;hydrochloride Chemical compound Cl.C=1N=C(C(F)(F)F)C=NC=1NC(=O)NC1=CC(C(F)(F)F)=CC=C1OCC1CCCNC1 ZKOWUQGHMJRNLF-UHFFFAOYSA-N 0.000 claims 1
- RKGDRKLDUHXCKX-UHFFFAOYSA-N 1-[5-methyl-2-(piperidin-3-ylmethoxy)phenyl]-3-[5-(trifluoromethyl)pyrazin-2-yl]urea;hydrochloride Chemical compound Cl.C=1N=C(C(F)(F)F)C=NC=1NC(=O)NC1=CC(C)=CC=C1OCC1CCCNC1 RKGDRKLDUHXCKX-UHFFFAOYSA-N 0.000 claims 1
- MKESDGQZJPYSDM-UHFFFAOYSA-N 1-[5-methyl-2-[(1-methylpiperidin-3-yl)methoxy]phenyl]-3-[5-(trifluoromethyl)pyrazin-2-yl]urea Chemical compound C1N(C)CCCC1COC1=CC=C(C)C=C1NC(=O)NC1=CN=C(C(F)(F)F)C=N1 MKESDGQZJPYSDM-UHFFFAOYSA-N 0.000 claims 1
- 125000004486 1-methylpiperidin-3-yl group Chemical group CN1CC(CCC1)* 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 206010017758 Gastric cancer Diseases 0.000 claims 1
- 210000003734 Kidney Anatomy 0.000 claims 1
- 206010024324 Leukaemias Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 206010025650 Malignant melanoma Diseases 0.000 claims 1
- 206010025310 Other lymphomas Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 208000008443 Pancreatic Carcinoma Diseases 0.000 claims 1
- 206010038038 Rectal cancer Diseases 0.000 claims 1
- 206010047741 Vulval cancer Diseases 0.000 claims 1
- 201000009030 carcinoma Diseases 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 201000010536 head and neck cancer Diseases 0.000 claims 1
- 125000001145 hydrido group Chemical group *[H] 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 201000008968 osteosarcoma Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000004483 piperidin-3-yl group Chemical group N1CC(CCC1)* 0.000 claims 1
- 125000004944 pyrazin-3-yl group Chemical group [H]C1=C([H])N=C(*)C([H])=N1 0.000 claims 1
- 201000001275 rectum cancer Diseases 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
Claims (4)
- 式：
Ｘ １ およびＸ ２ は−Ｎ（Ｈ）−であり；
ＹはＯであり；
ＷはＣＦ ３ で置換されているピラジニルであり；
Ｒ ６ はＯＲ １１ であり；
Ｒ ８ およびＲ ９ はヒドロであり；
Ｒ １０ はＣＦ ３ またはＣＨ ３ であり；
Ｒ １１ はピペリジン−３−イルまたは１−メチル−ピペリジン−３−イルで置換されているＣＨ ３ である］
で示される化合物またはその薬学的に許容可能な塩。 - 請求項１記載の化合物またはその薬学的に許容可能な塩を薬学的に許容可能な希釈剤または担体とともに含む、医薬組成物。
- 請求項１記載の化合物またはその薬学的に許容可能な塩を含む、直腸癌、頭部および頸部癌、膵臓癌、乳癌、胃癌、膀胱癌、外陰部癌、白血病、リンパ腫、黒色腫、腎細胞癌腫、卵巣癌、脳腫瘍、骨肉腫、および肺癌からなるグループから選択される癌の治療剤。
- 1-[2-(ピペリジン-3-イルメトキシ)-5-トリフルオロメチル-フェニル]-3-(5-トリフルオロメチルピラジン-2-イル)ウレア塩酸塩；
1-[5-メチル-2-(ピペリジン-3-イルメトキシ)フェニル]-3-(5-トリフルオロメチル-ピラジン-2-イル)ウレア塩酸塩；および
1-[5-メチル-2-(1-メチル-ピペリジン-3-イルメトキシ)フェニル]-3-(5-トリフルオロメチル-ピラジン-2-イル)ウレアからなるグループから選択される化合物。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60296804P | 2004-08-19 | 2004-08-19 | |
| PCT/US2005/029518 WO2006021002A2 (en) | 2004-08-19 | 2005-08-18 | Compounds useful for inhibiting chk1 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008510719A JP2008510719A (ja) | 2008-04-10 |
| JP2008510719A5 true JP2008510719A5 (ja) | 2008-10-02 |
Family
ID=35744692
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007528037A Pending JP2008510719A (ja) | 2004-08-19 | 2005-08-18 | Ｃｈｋ１の阻害に有用な化合物 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20080318974A1 (ja) |
| EP (1) | EP1778648A2 (ja) |
| JP (1) | JP2008510719A (ja) |
| KR (1) | KR20070054205A (ja) |
| CN (1) | CN101115727A (ja) |
| AU (1) | AU2005272586A1 (ja) |
| BR (1) | BRPI0514466A (ja) |
| CA (1) | CA2577880A1 (ja) |
| MX (1) | MX2007002040A (ja) |
| WO (1) | WO2006021002A2 (ja) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201008005D0 (en) | 2010-05-13 | 2010-06-30 | Sentinel Oncology Ltd | Pharmaceutical compounds |
| GB201119799D0 (en) | 2011-11-16 | 2011-12-28 | Sentinel Oncology Ltd | Pharmaceutical compounds |
| GB201402277D0 (en) | 2014-02-10 | 2014-03-26 | Sentinel Oncology Ltd | Pharmaceutical compounds |
| DK3157916T3 (en) | 2014-06-19 | 2019-03-18 | Ariad Pharma Inc | HETEROARYL COMPOUNDS FOR CHINESE INHIBITION |
| CN104628659A (zh) * | 2015-01-27 | 2015-05-20 | 广西师范大学 | 具有抗肿瘤作用的吡嗪-芳基脲衍生物及其制备方法与应用 |
| US10570119B2 (en) | 2016-01-11 | 2020-02-25 | Merrimack Pharmaceuticals, Inc. | Inhibiting ataxia telangiectasia and Rad3-related protein (ATR) |
| SI3411036T1 (sl) | 2016-02-04 | 2022-03-31 | Pharmaengine, Inc. | 3,5-disubstituirani pirazoli, uporabni kot kontrolne točke inhibitorjev kinaze 1 (CHK1), ter njihovi pripravki in uporaba |
| KR20190130621A (ko) | 2017-03-31 | 2019-11-22 | 시애틀 지네틱스, 인크. | Chk1 저해제와 wee1 저해제의 조합물 |
| JP7260718B2 (ja) * | 2019-11-29 | 2023-04-18 | メッドシャイン ディスカバリー インコーポレイテッド | ジアザインドール誘導体及びそのＣｈｋ１阻害剤としての使用 |
| WO2021119236A1 (en) | 2019-12-10 | 2021-06-17 | Seagen Inc. | Preparation of a chk1 inhibitor compound |
| GB202107924D0 (en) | 2021-06-03 | 2021-07-21 | Sentinel Oncology Ltd | A pharmaceutical salt |
| GB202107932D0 (en) | 2021-06-03 | 2021-07-21 | Sentinel Oncology Ltd | Preparation of a CHK1 Inhibitor Compound |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL254871A (ja) * | 1959-08-14 | |||
| CH493480A (de) * | 1969-01-31 | 1970-07-15 | Agripat Sa | Verfahren zur Herstellung von neuen O,N-Diphenyl-carbaminsäureestern |
| US4071524A (en) * | 1976-11-08 | 1978-01-31 | Riker Laboratories, Inc. | Derivatives of urea |
| TR200002616T2 (tr) * | 1997-12-22 | 2000-11-21 | Bayer Corporation | Simetrik ve simetrik olmayan sübstitüe edilmiş difenil üreler kullanılarak raf kinazın inhibe edilmesi |
| UA76977C2 (en) * | 2001-03-02 | 2006-10-16 | Icos Corp | Aryl- and heteroaryl substituted chk1 inhibitors and their use as radiosensitizers and chemosensitizers |
| CA2484209C (en) * | 2002-05-03 | 2013-06-11 | Exelixis, Inc. | Protein kinase modulators and methods of use |
| CA2539320A1 (en) * | 2003-09-17 | 2005-03-31 | Icos Corporation | Use of chk1 inhibitors to control cell proliferation |
| WO2006012308A1 (en) * | 2004-06-25 | 2006-02-02 | Icos Corporation | Bisarylurea derivatives useful for inhibiting chk1 |
| KR20070043996A (ko) * | 2004-07-02 | 2007-04-26 | 이코스 코포레이션 | Ｃｈｋ1의 억제에 유용한 화합물 |
-
2005
- 2005-08-18 BR BRPI0514466-3A patent/BRPI0514466A/pt not_active IP Right Cessation
- 2005-08-18 CN CNA2005800353820A patent/CN101115727A/zh active Pending
- 2005-08-18 WO PCT/US2005/029518 patent/WO2006021002A2/en active Application Filing
- 2005-08-18 MX MX2007002040A patent/MX2007002040A/es not_active Application Discontinuation
- 2005-08-18 CA CA002577880A patent/CA2577880A1/en not_active Abandoned
- 2005-08-18 JP JP2007528037A patent/JP2008510719A/ja active Pending
- 2005-08-18 AU AU2005272586A patent/AU2005272586A1/en not_active Abandoned
- 2005-08-18 KR KR1020077006216A patent/KR20070054205A/ko not_active Application Discontinuation
- 2005-08-18 EP EP05810303A patent/EP1778648A2/en not_active Withdrawn
- 2005-08-18 US US11/659,389 patent/US20080318974A1/en not_active Abandoned