JP2007529534A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2007529534A5 JP2007529534A5 JP2007504011A JP2007504011A JP2007529534A5 JP 2007529534 A5 JP2007529534 A5 JP 2007529534A5 JP 2007504011 A JP2007504011 A JP 2007504011A JP 2007504011 A JP2007504011 A JP 2007504011A JP 2007529534 A5 JP2007529534 A5 JP 2007529534A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- optionally substituted
- alkoxy
- halogen
- hydroxyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims 21
- 229910052736 halogen Inorganic materials 0.000 claims 17
- 150000002367 halogens Chemical group 0.000 claims 16
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 13
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 12
- 125000002757 morpholinyl group Chemical group 0.000 claims 12
- 125000001424 substituent group Chemical group 0.000 claims 12
- 125000000217 alkyl group Chemical group 0.000 claims 11
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 11
- 125000003282 alkyl amino group Chemical group 0.000 claims 9
- 150000001875 compounds Chemical class 0.000 claims 9
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 9
- YLQBMQCUIZJEEH-UHFFFAOYSA-N Furan Chemical compound C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims 8
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 claims 7
- 125000004193 piperazinyl group Chemical group 0.000 claims 7
- 125000003386 piperidinyl group Chemical group 0.000 claims 7
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 claims 6
- 125000004663 dialkyl amino group Chemical group 0.000 claims 6
- 125000000466 oxiranyl group Chemical group 0.000 claims 6
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 6
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 6
- 125000004568 thiomorpholinyl group Chemical group 0.000 claims 6
- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 claims 5
- 125000005843 halogen group Chemical group 0.000 claims 5
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 239000001257 hydrogen Substances 0.000 claims 5
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 5
- DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 claims 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 4
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 claims 4
- 125000003118 aryl group Chemical group 0.000 claims 4
- 229910052799 carbon Inorganic materials 0.000 claims 4
- 125000001412 tetrahydropyranyl group Chemical group 0.000 claims 4
- QWENRTYMTSOGBR-UHFFFAOYSA-N 1H-1,2,3-Triazole Chemical compound C=1C=NNN=1 QWENRTYMTSOGBR-UHFFFAOYSA-N 0.000 claims 3
- KMTRUDSVKNLOMY-UHFFFAOYSA-N Ethylene carbonate Chemical compound O=C1OCCO1 KMTRUDSVKNLOMY-UHFFFAOYSA-N 0.000 claims 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- -1 amino, morpholinyl Chemical group 0.000 claims 3
- 125000004093 cyano group Chemical group *C#N 0.000 claims 3
- NSPMIYGKQJPBQR-UHFFFAOYSA-N 4H-1,2,4-triazole Chemical compound C=1N=CNN=1 NSPMIYGKQJPBQR-UHFFFAOYSA-N 0.000 claims 2
- KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Chemical compound C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 claims 2
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- ZLTPDFXIESTBQG-UHFFFAOYSA-N isothiazole Chemical compound C=1C=NSC=1 ZLTPDFXIESTBQG-UHFFFAOYSA-N 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 150000003536 tetrazoles Chemical class 0.000 claims 2
- 125000004649 C2-C8 alkynyl group Chemical group 0.000 claims 1
- ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical compound C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 claims 1
- PCNDJXKNXGMECE-UHFFFAOYSA-N Phenazine Natural products C1=CC=CC2=NC3=CC=CC=C3N=C21 PCNDJXKNXGMECE-UHFFFAOYSA-N 0.000 claims 1
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims 1
- 125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000005036 alkoxyphenyl group Chemical group 0.000 claims 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 1
- 125000002431 aminoalkoxy group Chemical group 0.000 claims 1
- 125000004103 aminoalkyl group Chemical group 0.000 claims 1
- CTAPFRYPJLPFDF-UHFFFAOYSA-N isoxazole Chemical compound C=1C=NOC=1 CTAPFRYPJLPFDF-UHFFFAOYSA-N 0.000 claims 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims 1
- 229930192474 thiophene Natural products 0.000 claims 1
- 150000003852 triazoles Chemical class 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55272504P | 2004-03-15 | 2004-03-15 | |
| US60/552,725 | 2004-03-15 | ||
| PCT/US2005/008481 WO2005089764A1 (en) | 2004-03-15 | 2005-03-15 | Carboline derivatives useful in the inhibition of angiogenesis |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011162351A Division JP2012012398A (ja) | 2004-03-15 | 2011-07-25 | 血管新生の抑制に有用なカルボリン誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007529534A JP2007529534A (ja) | 2007-10-25 |
| JP2007529534A5 true JP2007529534A5 (enExample) | 2010-03-18 |
| JP4857452B2 JP4857452B2 (ja) | 2012-01-18 |
Family
ID=34963165
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007504011A Expired - Fee Related JP4857452B2 (ja) | 2004-03-15 | 2005-03-15 | 血管新生の抑制に有用なカルボリン誘導体 |
| JP2011162351A Pending JP2012012398A (ja) | 2004-03-15 | 2011-07-25 | 血管新生の抑制に有用なカルボリン誘導体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011162351A Pending JP2012012398A (ja) | 2004-03-15 | 2011-07-25 | 血管新生の抑制に有用なカルボリン誘導体 |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US7601840B2 (enExample) |
| EP (2) | EP2431369A3 (enExample) |
| JP (2) | JP4857452B2 (enExample) |
| KR (2) | KR101188778B1 (enExample) |
| CN (2) | CN102408425A (enExample) |
| AU (1) | AU2005222632B2 (enExample) |
| BR (1) | BRPI0508814B8 (enExample) |
| CA (1) | CA2559408C (enExample) |
| DK (1) | DK1737461T3 (enExample) |
| EA (2) | EA016575B1 (enExample) |
| EC (1) | ECSP066928A (enExample) |
| ES (1) | ES2401335T3 (enExample) |
| IL (1) | IL178079A (enExample) |
| MX (1) | MXPA06010543A (enExample) |
| NO (1) | NO338270B1 (enExample) |
| NZ (1) | NZ588388A (enExample) |
| PL (1) | PL1737461T3 (enExample) |
| PT (1) | PT1737461E (enExample) |
| SG (2) | SG184755A1 (enExample) |
| UA (1) | UA92317C2 (enExample) |
| WO (1) | WO2005089764A1 (enExample) |
| ZA (1) | ZA200608176B (enExample) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9068234B2 (en) * | 2003-01-21 | 2015-06-30 | Ptc Therapeutics, Inc. | Methods and agents for screening for compounds capable of modulating gene expression |
| US8460864B2 (en) | 2003-01-21 | 2013-06-11 | Ptc Therapeutics, Inc. | Methods for identifying compounds that modulate untranslated region-dependent gene expression and methods of using same |
| US8426194B2 (en) * | 2003-01-21 | 2013-04-23 | Ptc Therapeutics, Inc. | Methods and agents for screening for compounds capable of modulating VEGF expression |
| EP1637521B1 (en) * | 2003-06-23 | 2013-06-19 | Ono Pharmaceutical Co., Ltd. | Novel tricyclic heterocycle compound |
| US8076352B2 (en) * | 2004-03-15 | 2011-12-13 | Ptc Therapeutics, Inc. | Administration of carboline derivatives useful in the treatment of cancer and other diseases |
| US8076353B2 (en) | 2004-03-15 | 2011-12-13 | Ptc Therapeutics, Inc. | Inhibition of VEGF translation |
| US7767689B2 (en) * | 2004-03-15 | 2010-08-03 | Ptc Therapeutics, Inc. | Carboline derivatives useful in the treatment of cancer |
| ZA200608176B (en) | 2004-03-15 | 2008-05-28 | Ptc Therapeutics Inc | Carboline derivatives useful in the inhibition of angiogenesis |
| WO2006015035A1 (en) * | 2004-08-02 | 2006-02-09 | Smithkline Beecham Corporation | Useful compounds for hpv infection |
| PT1829874E (pt) | 2004-12-22 | 2014-04-10 | Ono Pharmaceutical Co | Composto tricíclico e sua utilização |
| WO2007002051A1 (en) * | 2005-06-22 | 2007-01-04 | Smithkline Beecham Corporation | Carboline derivatives and their use as inhibitors of flaviviridae infections |
| ITMI20061581A1 (it) * | 2006-08-04 | 2008-02-05 | Univ Bari | Ligandi del recettore beta-3 adrenergico e loro uso in terapia |
| WO2008103470A2 (en) * | 2007-02-21 | 2008-08-28 | Trustees Of Columbia University In The City Of New York | Oncogenic-ras-signal dependent lethal compounds |
| US8642067B2 (en) | 2007-04-02 | 2014-02-04 | Allergen, Inc. | Methods and compositions for intraocular administration to treat ocular conditions |
| US8283115B1 (en) | 2007-06-20 | 2012-10-09 | Ptc Therapeutics, Inc. | Methods of screening for compounds for treating muscular dystrophy using UTRN mRNA translation regulation |
| US8283116B1 (en) | 2007-06-22 | 2012-10-09 | Ptc Therapeutics, Inc. | Methods of screening for compounds for treating spinal muscular atrophy using SMN mRNA translation regulation |
| EP2214485B1 (en) * | 2007-09-25 | 2016-07-20 | Minerva Biotechnologies Corp. | Methods for treatment of cancer |
| US11202775B2 (en) | 2007-09-25 | 2021-12-21 | Minerva Biotechnologies Corporation | Methods for treatment of cancer |
| WO2010138652A1 (en) | 2009-05-27 | 2010-12-02 | Ptc Therapeutics, Inc. | Methods for treating kaposi sarcoma |
| WO2010138695A1 (en) * | 2009-05-27 | 2010-12-02 | Ptc Therapeutics, Inc. | Methods for treating neurofibromatosis |
| WO2010138659A1 (en) * | 2009-05-27 | 2010-12-02 | Ptc Therapeutics, Inc. | Methods for treating brain tumors |
| US8703726B2 (en) | 2009-05-27 | 2014-04-22 | Ptc Therapeutics, Inc. | Methods for treating prostate conditions |
| MX373926B (es) | 2009-05-27 | 2020-07-10 | Ptc Therapeutics Inc | Metodos para tratar cancer y estados no neoplasicos. |
| TW201100419A (en) * | 2009-05-27 | 2011-01-01 | Ptc Therapeutics Inc | Processes for the preparation of substituted tetrahydro beta-carbolines |
| WO2011063223A1 (en) | 2009-11-20 | 2011-05-26 | Southern Research Institute | TETRAHYDRO-β-CARBOLINE DERIVATIVES, SYNTHESIS AND USE THEREOF |
| CN102250127B (zh) * | 2010-05-19 | 2013-06-19 | 首都医科大学 | 两个氨基酸修饰的四氢咔啉衍生物及其制备方法和应用 |
| JP5649170B2 (ja) * | 2010-11-26 | 2015-01-07 | 国立大学法人 千葉大学 | テトラヒドロ−β−カルボリン誘導体及びその製造方法 |
| CN102424681B (zh) * | 2011-10-24 | 2014-10-15 | 华东师范大学 | 酰基四氢-β-咔啉类化合物及其衍生物、用途及其制备方法 |
| US20130116219A1 (en) * | 2011-11-04 | 2013-05-09 | Alcon Research, Ltd. | Antimicrobial carboline compounds |
| US9353150B2 (en) | 2012-12-04 | 2016-05-31 | Massachusetts Institute Of Technology | Substituted pyrazino[1′,2′:1 ,5]pyrrolo[2,3-b]-indole-1,4-diones for cancer treatment |
| US10307406B2 (en) | 2013-08-31 | 2019-06-04 | The Wistar Institute Of Anatomy And Biology | Methods and compositions for re-activating Epstein-Barr virus and screening compounds therefor |
| CN111978319B (zh) | 2014-06-27 | 2023-08-11 | 诺格拉制药有限公司 | 芳基受体调制剂及其制备和使用方法 |
| CN112375078B (zh) * | 2014-12-18 | 2023-12-19 | 豪夫迈·罗氏有限公司 | 四氢-吡啶并[3,4-b]吲哚雌激素受体调节剂及其用途 |
| WO2016187767A1 (en) * | 2015-05-25 | 2016-12-01 | Hutchison Medipharma Limited | Pharmaceutical compositions and use thereof |
| CN108513537A (zh) * | 2015-09-23 | 2018-09-07 | 米纳瓦生物技术公司 | 筛选分化干细胞的试剂的方法 |
| KR102710603B1 (ko) | 2015-10-01 | 2024-09-27 | 올레마 파마슈티컬스 인코포레이티드 | 테트라히드로-1H-피리도[3,4-b]인돌 항에스트로겐 약물 |
| CN105330665B (zh) * | 2015-11-04 | 2017-10-03 | 衡阳师范学院 | 一种抑制激肽释放酶klk7的化合物、制备方法和用途 |
| WO2017136688A1 (en) | 2016-02-05 | 2017-08-10 | Inventisbio Inc. | Selective estrogen receptor degraders and uses thereof |
| WO2017197045A1 (en) * | 2016-05-11 | 2017-11-16 | Movassaghi Mohammad | Convergent and enantioselective total synthesis of communesin analogs |
| CN109311876B (zh) * | 2016-06-16 | 2022-05-03 | 豪夫迈·罗氏有限公司 | 杂芳基雌激素受体调节剂及其用途 |
| US20180002344A1 (en) | 2016-06-16 | 2018-01-04 | Genentech, Inc. | Heteroaryl estrogen receptor modulators and uses thereof |
| WO2018209239A1 (en) | 2017-05-11 | 2018-11-15 | Massachusetts Institute Of Technology | Potent agelastatin derivatives as modulators for cancer invasion and metastasis |
| EP3664803A4 (en) | 2017-08-01 | 2021-05-05 | PTC Therapeutics, Inc. | DHODH INHIBITOR FOR USE IN THE TREATMENT OF HEMATOLOGICAL CANCERS |
| US10640508B2 (en) | 2017-10-13 | 2020-05-05 | Massachusetts Institute Of Technology | Diazene directed modular synthesis of compounds with quaternary carbon centers |
| MX389626B (es) | 2017-11-17 | 2025-03-20 | Cellix Bio Private Ltd | Compuestos de pilocarpina con ácido lipoico para el tratamiento de trastornos oculares. |
| IL278063B2 (en) | 2018-06-21 | 2025-08-01 | Hoffmann La Roche | Solid forms of 3-((1r,3r)-1-(2,6-difluoro-4-((1-(3-fluoropropyl)azetidin-3-yl)amino)phenyl)-3-methyl-1,3,4,9-tetrahydro-2h-pyrido[3,4-b]indol-2-yl)-2,2-difluoropropan-1-ol and processes for preparing fused tricyclic compounds comprising a substituted phenyl or pyridinyl moiety, including methods of their use |
| MX2021001364A (es) | 2018-08-03 | 2021-04-13 | Ptc Therapeutics Inc | Formas farmaceuticas orales biodisponibles. |
| AU2019340402B2 (en) | 2018-08-17 | 2025-04-03 | Ptc Therapeutics, Inc. | Method for treating pancreatic cancer |
| WO2020072675A1 (en) * | 2018-10-02 | 2020-04-09 | Northwestern University | Beta-carbolines as positive allosteric modulators of the human serotonin receptor 2c (5-ht2c) |
| CN109400604B (zh) * | 2018-10-25 | 2021-09-03 | 河北科技大学 | 2,3,4,9-四氢-1H-吡啶并[3,4-b]吲哚类化合物及用途 |
| BR112021013913A2 (pt) | 2019-01-15 | 2021-09-21 | Ptc Therapeutics, Inc. | Método para tratar uma leucemia mieloide aguda |
| WO2020247054A1 (en) | 2019-06-05 | 2020-12-10 | Massachusetts Institute Of Technology | Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof |
| JP7616794B2 (ja) | 2019-07-07 | 2025-01-17 | オレマ ファーマシューティカルズ インク． | エストロゲン受容体アンタゴニストのレジメン |
| CN110698474B (zh) * | 2019-11-14 | 2021-11-02 | 福州大学 | 一种α位取代四氢-γ-咔啉类化合物及其制备方法和应用 |
| CN113121527B (zh) * | 2019-12-31 | 2024-09-06 | 上海辉启生物医药科技有限公司 | 三环类化合物及其用途 |
| CN113546172A (zh) * | 2020-04-24 | 2021-10-26 | 山东大学齐鲁医院 | Vegf抑制剂在制备治疗缺氧相关疾病药物中的应用 |
| JP2024502270A (ja) | 2020-12-23 | 2024-01-18 | リキュリウム アイピー ホールディングス リミテッド ライアビリティー カンパニー | エストロゲン受容体調節薬 |
| WO2022182415A1 (en) | 2021-02-24 | 2022-09-01 | Massachusetts Institute Of Technology | Himastatin derivatives, and processes of preparation thereof, and uses thereof |
| KR20240144093A (ko) * | 2021-12-31 | 2024-10-02 | 피티씨 테라퓨틱스, 인크. | 카르볼린 화합물 및 이의 용도 |
| AU2023318665A1 (en) | 2022-08-05 | 2025-01-23 | Nextgen Bioscience Co., Ltd. | Novel compound as hypoxia-inducible factor 1(hif-1) inhibitor or vascular endothelial growth factor (vegf) inhibitor, and pharmaceutical composition comprising same |
| CN116375702B (zh) * | 2023-03-16 | 2025-06-17 | 贵州大学 | 一种含烷基或芳基的1，2，3，4-四氢-β-咔啉类化合物、组合物、制备方法和应用 |
| CN116531371A (zh) * | 2023-04-28 | 2023-08-04 | 中国人民解放军中部战区总医院 | 一类化合物在制备治疗与醛脱氢酶2活性相关的疾病或症状的药物中的用途 |
Family Cites Families (109)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1055203A (en) * | 1964-09-16 | 1967-01-18 | Ici Ltd | -ß-carboline derivatives, a process for their manufacture, and compositions containing them |
| US3492304A (en) * | 1968-06-24 | 1970-01-27 | Warner Lambert Pharmaceutical | 5,6,7,7a,8,8a,9,10,12,12a-decahydro-11h-benz(b)indolo(3,2,1-ij) 1,5 naphthyridin-11-ones |
| US4014890A (en) * | 1976-03-23 | 1977-03-29 | Pfizer Inc. | Process for preparing indole derivatives |
| EP0008249B1 (fr) | 1978-07-28 | 1981-08-26 | Synthelabo | Dérivés de fluorènes et fluoranthènes, leur procédé de préparation et leur application en thérapeutique |
| FR2432025A1 (fr) | 1978-07-28 | 1980-02-22 | Synthelabo | Derives d'imidazo et de pyrimido-pyrido-indoles, leur preparation et leur application en therapeutique |
| FR2575753B1 (fr) * | 1985-01-07 | 1987-02-20 | Adir | Nouveaux derives peptidiques a structure polycyclique azotee, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| US5039801A (en) | 1985-12-20 | 1991-08-13 | The United States Of America As Represented By The Department Of Health & Human Services | Thermal fragmentation of methylbenzylurea disastereomers or secondary amines and preparation of optically active secondary amines |
| US4754038A (en) * | 1987-02-26 | 1988-06-28 | American Home Products Corporation | Carboline histamine H1 antagonists |
| EP0300541B1 (en) | 1987-07-20 | 1996-03-27 | Duphar International Research B.V | 8,9-anellated-1,2,3,4-tetrahydro-beta-carboline derivatives |
| EP0357122A3 (en) * | 1988-08-29 | 1991-10-23 | Duphar International Research B.V | Use of beta-carbolines, their bio-isosteric benzofuran and benzothiophene analogues for the manufacture of a medicament having cytostatic properties |
| US5166170A (en) | 1989-07-03 | 1992-11-24 | Hoechst-Roussel Pharmaceuticals Incorporated | 2-(aminoaryl) indoles and indolines as topical antiinflammatory agents for the treatment of skin disorders |
| US5166204A (en) * | 1989-11-01 | 1992-11-24 | Toyama Chemical Co., Ltd. | Isoindole derivatives and salts thereof and antitumor agent comprising the same |
| US5120543A (en) | 1989-12-21 | 1992-06-09 | The United States Of America As Represented By The Secretary Of Agriculture | Molluscicidal β-carboline carboxylic acids and methods using the same |
| JPH03287586A (ja) | 1990-04-02 | 1991-12-18 | Taisho Pharmaceut Co Ltd | テトラヒドロ―β―カルボリン誘導体 |
| FR2662940B1 (fr) | 1990-06-08 | 1994-10-14 | Roussel Uclaf | Utilisation de derives de la tetrahydro isoquinoleine pour la preparation de medicaments anti-tumoraux, application a titre de medicaments de derives de la tetrahydro isoquinoleine et produits derives de cette structure. |
| US5162336A (en) | 1990-06-21 | 1992-11-10 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Tetrahydro-pyrido-indoles as cholecystokinin and gastrin antagonists |
| US5187180A (en) | 1990-07-26 | 1993-02-16 | Merck Frosst Canada, Inc. | (quinolin-2-ylmethoxy)heterotetrahydrocarbazoles as inhibitors of the biosynthesis of leukotrienes |
| JPH04275221A (ja) | 1991-03-01 | 1992-09-30 | Taisho Pharmaceut Co Ltd | 制癌効果増強剤 |
| US5382569A (en) | 1991-05-16 | 1995-01-17 | Warner-Lambert Company | Endotherlin antagonists |
| JP3287586B2 (ja) | 1991-07-09 | 2002-06-04 | キヤノン株式会社 | カラー画像処理方法、及びカラー画像処理装置 |
| US5206377A (en) * | 1991-12-05 | 1993-04-27 | Whitby Research, Inc. | Compounds useful as antiproliferative agents |
| US5622960A (en) | 1992-04-14 | 1997-04-22 | The United States Of America As Represented By The Department Of Health And Human Services | Topoisomerase II inhibitors and therapeutic uses therefor |
| US5314898A (en) | 1992-06-29 | 1994-05-24 | Merck & Co., Inc. | Aryl thiopyrano[4,3,2-cd]indoles as inhibitors of leukotriene biosynthesis |
| US5314900A (en) | 1992-11-19 | 1994-05-24 | Merck Frosst Canada, Inc. | Aryl thiopyrano[2,3,4-C,D]indoles as inhibitors of leukotriene biosynthesis |
| US6824976B1 (en) * | 1993-04-02 | 2004-11-30 | Rigel Pharmaceuticals, Inc. | Method for selective inactivation of viral replication |
| US5500431A (en) * | 1993-04-14 | 1996-03-19 | Eli Lilly And Company | Tetrahydro-β-carbolines |
| EP0620222A3 (en) * | 1993-04-14 | 1995-04-12 | Lilly Co Eli | Tetrahydro-beta-carbolines. |
| US5403851A (en) | 1994-04-05 | 1995-04-04 | Interneuron Pharmaceuticals, Inc. | Substituted tryptamines, phenalkylamines and related compounds |
| US5451600A (en) * | 1994-04-19 | 1995-09-19 | Hoffmann-La Roche Inc. | Substituted tetrahydrobenzopyrrolylfuranoic acid derivatives as phospholipase A2 inhibitors |
| FR2724384B1 (fr) | 1994-09-14 | 1999-04-16 | Cemaf | Nouveaux derives de la 3,4-dihydro beta-carboline agonistes de la melatonine, leur procede de preparation et leur utilisation a titre de medicament |
| DE59508602D1 (de) | 1994-12-12 | 2000-08-31 | Ciba Sc Holding Ag | Azofarbstoffe, Verfahren zu deren Herstellung und deren Verwendung |
| IL117208A0 (en) | 1995-02-23 | 1996-06-18 | Nissan Chemical Ind Ltd | Indole type thiazolidines |
| US6376529B1 (en) | 1995-06-07 | 2002-04-23 | Peng Cho Tang | Mono- and bis-indolylquinones and prophylactic and therapeutic uses thereof |
| GB9514473D0 (en) | 1995-07-14 | 1995-09-13 | Glaxo Lab Sa | Chemical compounds |
| US5633388A (en) | 1996-03-29 | 1997-05-27 | Viropharma Incorporated | Compounds, compositions and methods for treatment of hepatitis C |
| EP0891187B1 (en) * | 1996-04-04 | 2002-01-30 | F. Hoffmann-La Roche Ag | Use of derivatives of tetrahydro-beta-carbolines as antimetastatic agents |
| FR2748026B1 (fr) * | 1996-04-26 | 1998-06-05 | Adir | Nouveaux inhibiteurs de metalloproteases, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| EE9800390A (et) * | 1996-05-10 | 1999-06-15 | Icos Corporation | Karboliini derivaadid |
| US6013633A (en) | 1997-08-07 | 2000-01-11 | University Of Cincinnati | Compounds for control of appetite, blood pressure, cardiovascular response, libido, and circadian rhythm |
| US5892041A (en) * | 1996-08-12 | 1999-04-06 | Neurogen Corporation | Fused indolecarboxamides: dopamine receptor subtype specific ligands |
| US6331543B1 (en) | 1996-11-01 | 2001-12-18 | Nitromed, Inc. | Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use |
| WO1998037189A1 (en) * | 1997-02-25 | 1998-08-27 | Qbi Enterprises Ltd. | Ires sequences with high translational efficiency and expression vectors containing the sequence |
| US6043252A (en) | 1997-05-05 | 2000-03-28 | Icos Corporation | Carboline derivatives |
| AR016133A1 (es) | 1997-07-31 | 2001-06-20 | Wyeth Corp | Compuesto de carbamiloxi que inhiben la adhesion de leucocitos mediada por vla-4, compuestos que son prodrogas de dichos compuestos, composicionfarmaceutica, metodo para fijar vla-4 a una muestra biologica, metodo para el tratamiento de una condicion inflamatoria |
| US6514981B1 (en) * | 1998-04-02 | 2003-02-04 | Sugen, Inc. | Methods of modulating tyrosine protein kinase function with indolinone compounds |
| JP4275221B2 (ja) | 1998-07-06 | 2009-06-10 | リンテック株式会社 | 粘接着剤組成物および粘接着シート |
| GB9828709D0 (en) | 1998-12-24 | 1999-02-17 | Novartis Ag | Assay |
| MXPA01012914A (es) | 1999-06-15 | 2004-04-21 | Bristol Myers Squibb Co | Gama-carbolinas fundidas de heterociclo substituido. |
| FR2796644B1 (fr) | 1999-07-23 | 2001-09-07 | Adir | Nouveaux derives de beta-carboline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| GB9918962D0 (en) * | 1999-08-11 | 1999-10-13 | Cerebrus Ltd | Chemical compounds xxii |
| US20020016298A1 (en) | 1999-09-01 | 2002-02-07 | Hay Bruce A. | Somatostatin antagonists and agonists that act at the sst subtype 2 receptor |
| US6696418B1 (en) * | 1999-09-01 | 2004-02-24 | Pfizer Inc. | Somatostatin antagonists and agonists that act at the SST subtype 2 receptor |
| JP2003509488A (ja) | 1999-09-24 | 2003-03-11 | ジェネンテック・インコーポレーテッド | チロシン誘導体 |
| DE19962936A1 (de) | 1999-12-24 | 2001-06-28 | Bayer Ag | Neue beta-Aminosäureverbindungen als Integrinantagonisten |
| US6890933B1 (en) | 2000-02-24 | 2005-05-10 | President And Fellows Of Harvard College | Kinesin inhibitors |
| UA74826C2 (en) | 2000-05-17 | 2006-02-15 | Ortho Mcneil Pharm Inc | ?-carboline derivatives as phosphodiesterase inhibitors |
| UA72611C2 (uk) | 2000-05-17 | 2005-03-15 | Орто-Макнейл Фармацевтикал, Інк. | Похідні заміщеного піролопіридинону, корисні як інгібітори фосфодіестерази |
| US7498304B2 (en) | 2000-06-16 | 2009-03-03 | Curis, Inc. | Angiogenesis-modulating compositions and uses |
| WO2002011705A2 (en) * | 2000-08-09 | 2002-02-14 | Pharmacia Italia Spa | Composition for combined use of aromatase inhibitors |
| US6720330B2 (en) * | 2000-11-17 | 2004-04-13 | Pfizer Inc. | Somatostatin antagonists and agonists that act at the SST subtype 2 receptor |
| WO2002062339A1 (en) * | 2000-12-08 | 2002-08-15 | Smithkline Beecham Corporation | Antibacterial compounds |
| US6849619B2 (en) | 2000-12-20 | 2005-02-01 | Bristol-Myers Squibb Company | Substituted pyridoindoles as serotonin agonists and antagonists |
| MXPA03005438A (es) | 2000-12-20 | 2004-05-05 | Bristol Myers Squibb Co | Pirioindoles substituidos como agonistas y antagonistas de serotonina. |
| WO2002051805A1 (de) | 2000-12-27 | 2002-07-04 | Bayer Aktiengesellschaft | Indol-derivate |
| JP4220779B2 (ja) * | 2001-02-12 | 2009-02-04 | リリー アイコス リミテッド ライアビリティ カンパニー | 化学化合物 |
| MXPA03007142A (es) | 2001-02-12 | 2004-05-24 | Lilly Icos Llc | Derivados de carbolina. |
| US6630589B1 (en) * | 2001-03-26 | 2003-10-07 | Message Pharmaceuticals | Identification of compounds for the treatment or prevention of proliferative diseases |
| US6720331B2 (en) * | 2001-04-03 | 2004-04-13 | National Sun Yat-Sen University | 1-substituted 1,2,3,4-tetrahydro-β-carboline and 3,4-dihydro-β-carboline and analogs as antitumor agents |
| CA2441792C (en) * | 2001-04-25 | 2010-08-03 | Lilly Icos Llc | Carboline derivatives as inhibitors of phosphodiesterase 5 (pdes) for the treatment of cardiovascular diseases and erectile dysfunction |
| US6701957B2 (en) * | 2001-08-16 | 2004-03-09 | Fisher Controls International Llc | Fluid pressure reduction device |
| ATE469648T1 (de) | 2001-09-05 | 2010-06-15 | Minerva Biotechnologies Corp | Zusammensetzungen und deren verwendung zur behandlung von krebs |
| ES2278064T3 (es) * | 2001-10-19 | 2007-08-01 | Transtech Pharma Inc. | Derivados de beta-carbolina como inhibidores de ptp. |
| US20030130171A1 (en) | 2001-10-30 | 2003-07-10 | Schoenhard Grant L. | Inhibitors of ABC drug transporters in multidrug resistant microbial cells |
| KR20040068240A (ko) | 2001-12-14 | 2004-07-30 | 노보 노르디스크 에이/에스 | 호르몬 민감성 리파아제의 활성을 감소시키기 위한 화합물및 그들의 사용 |
| EP1348434A1 (en) * | 2002-03-27 | 2003-10-01 | Fujisawa Deutschland GmbH | Use of pyridyl amides as inhibitors of angiogenesis |
| JP4328058B2 (ja) * | 2002-04-12 | 2009-09-09 | 株式会社エイ・エル・エイ | 糖尿病合併症を予防する組成物 |
| AU2003226820A1 (en) | 2002-04-17 | 2003-10-27 | Novartis Ag | Method for the identification of inhibitors of the binding of are-containing mrn a and an hur protein |
| US20030220377A1 (en) | 2002-05-08 | 2003-11-27 | Richard Chesworth | Indole compounds and their use as estrogen agonists/antagonists |
| TWI329111B (en) | 2002-05-24 | 2010-08-21 | X Ceptor Therapeutics Inc | Azepinoindole and pyridoindole derivatives as pharmaceutical agents |
| US7595311B2 (en) | 2002-05-24 | 2009-09-29 | Exelixis, Inc. | Azepinoindole derivatives as pharmaceutical agents |
| AU2003242118B2 (en) | 2002-06-06 | 2008-09-11 | Institute Of Medicinal Molecular Design, Inc | O-substituted hydroxyaryl derivatives |
| WO2004035047A1 (en) | 2002-10-18 | 2004-04-29 | F. Hoffmann-La Roche Ag | 4-piperazinyl benzenesulfonyl indoles with 5-ht6 receptor affinity |
| US8426194B2 (en) * | 2003-01-21 | 2013-04-23 | Ptc Therapeutics, Inc. | Methods and agents for screening for compounds capable of modulating VEGF expression |
| WO2004069831A1 (en) | 2003-02-10 | 2004-08-19 | Glenmark Pharmaceuticals Ltd. | Tricyclic compounds useful for the treatment of inflammatory and allergic disorders: process for their preparation |
| AU2003902023A0 (en) | 2003-04-29 | 2003-05-15 | The Australian National University | A method of indole synthesis |
| GB0311201D0 (en) | 2003-05-15 | 2003-06-18 | Merck Sharp & Dohme | Therapeutic agents |
| WO2004110999A1 (en) | 2003-06-10 | 2004-12-23 | Smithkline Beecham Corporation | Tetrahydrocarbazole derivatives and their pharmaceutical use |
| AU2004256052A1 (en) | 2003-06-12 | 2005-01-20 | Smithkline Beecham Corporation | Tetrahydrocarbazole derivatives and their pharmaceutical use |
| WO2004113336A1 (en) | 2003-06-16 | 2004-12-29 | Chroma Therapeutics Limited | Carboline and betacarboline derivatives for use as hdac enzyme inhibitors |
| EA200600069A1 (ru) | 2003-06-20 | 2006-08-25 | Коли Фармасьютикал Гмбх | Низкомолекулярные антагонисты toll-подобных рецепторов (tlr) |
| EP1637521B1 (en) | 2003-06-23 | 2013-06-19 | Ono Pharmaceutical Co., Ltd. | Novel tricyclic heterocycle compound |
| PE20050232A1 (es) | 2003-06-25 | 2005-04-01 | Elan Pharm Inc | Metodo y composiciones para tratar la artritis reumatoide |
| US20050137220A1 (en) | 2003-07-23 | 2005-06-23 | Pharmacia Corporation | Beta-carboline compounds and analogues thereof as mitogen-activated protein kinase-activated protein kinase-2 inhibitors |
| WO2005014543A1 (ja) | 2003-08-06 | 2005-02-17 | Japan Tobacco Inc. | 縮合環化合物及びそのｈｃｖポリメラーゼ阻害剤としての利用 |
| US7491794B2 (en) | 2003-10-14 | 2009-02-17 | Intermune, Inc. | Macrocyclic compounds as inhibitors of viral replication |
| JP2007509057A (ja) | 2003-10-15 | 2007-04-12 | カイロン コーポレイション | ウイルス阻害のための組成物および方法 |
| JP2007518822A (ja) | 2004-01-23 | 2007-07-12 | カイロン コーポレイション | 抗癌剤としてのテトラヒドロカルボリン化合物 |
| US20080103213A1 (en) * | 2004-03-05 | 2008-05-01 | Board Of Regents, The University Of Texas System | Liposomal curcumin for treatment of neurofibromatosis |
| ZA200608176B (en) | 2004-03-15 | 2008-05-28 | Ptc Therapeutics Inc | Carboline derivatives useful in the inhibition of angiogenesis |
| US7767689B2 (en) | 2004-03-15 | 2010-08-03 | Ptc Therapeutics, Inc. | Carboline derivatives useful in the treatment of cancer |
| US8076352B2 (en) * | 2004-03-15 | 2011-12-13 | Ptc Therapeutics, Inc. | Administration of carboline derivatives useful in the treatment of cancer and other diseases |
| US8076353B2 (en) * | 2004-03-15 | 2011-12-13 | Ptc Therapeutics, Inc. | Inhibition of VEGF translation |
| CA2561164A1 (en) | 2004-04-01 | 2005-10-20 | Elan Pharmaceuticals, Inc. | Steroid sparing agents and their use |
| AU2005244751A1 (en) | 2004-04-16 | 2005-12-01 | Genentech, Inc. | Method for augmenting B cell depletion |
| EP1776105A2 (en) * | 2004-07-18 | 2007-04-25 | Coley Pharmaceutical Group, Ltd | Methods and compositions for inducing innate immune responses |
| WO2006015035A1 (en) | 2004-08-02 | 2006-02-09 | Smithkline Beecham Corporation | Useful compounds for hpv infection |
| JP2008520742A (ja) | 2004-11-23 | 2008-06-19 | ピーティーシー セラピューティクス， インコーポレイテッド | Ｖｅｇｆ産生の阻害に有用なカルバゾール誘導体、カルボリン誘導体およびインドール誘導体 |
| WO2008128100A1 (en) * | 2007-04-13 | 2008-10-23 | The Regents Of The University Of California | Small-molecule inhibitors of the androgen receptor |
| EP2139476A1 (en) * | 2007-04-13 | 2010-01-06 | PTC Therapeutics, Inc. | Administration of carboline derivatives useful in the treatment of cancer and other diseases |
-
2005
- 2005-03-15 ZA ZA200608176A patent/ZA200608176B/en unknown
- 2005-03-15 CN CN2011100576737A patent/CN102408425A/zh active Pending
- 2005-03-15 EP EP11178488A patent/EP2431369A3/en not_active Withdrawn
- 2005-03-15 US US11/079,420 patent/US7601840B2/en active Active
- 2005-03-15 JP JP2007504011A patent/JP4857452B2/ja not_active Expired - Fee Related
- 2005-03-15 WO PCT/US2005/008481 patent/WO2005089764A1/en not_active Ceased
- 2005-03-15 CN CN2005800149439A patent/CN1980672B/zh not_active Expired - Fee Related
- 2005-03-15 EA EA200601697A patent/EA016575B1/ru unknown
- 2005-03-15 EA EA201200555A patent/EA201200555A1/ru unknown
- 2005-03-15 CA CA2559408A patent/CA2559408C/en not_active Expired - Fee Related
- 2005-03-15 AU AU2005222632A patent/AU2005222632B2/en not_active Ceased
- 2005-03-15 UA UAA200610306A patent/UA92317C2/ru unknown
- 2005-03-15 SG SG2012068193A patent/SG184755A1/en unknown
- 2005-03-15 MX MXPA06010543A patent/MXPA06010543A/es active IP Right Grant
- 2005-03-15 EP EP05725560A patent/EP1737461B1/en not_active Expired - Lifetime
- 2005-03-15 ES ES05725560T patent/ES2401335T3/es not_active Expired - Lifetime
- 2005-03-15 PT PT57255606T patent/PT1737461E/pt unknown
- 2005-03-15 DK DK05725560.6T patent/DK1737461T3/da active
- 2005-03-15 PL PL05725560T patent/PL1737461T3/pl unknown
- 2005-03-15 NZ NZ588388A patent/NZ588388A/en not_active IP Right Cessation
- 2005-03-15 KR KR1020067021300A patent/KR101188778B1/ko not_active Expired - Fee Related
- 2005-03-15 BR BRPI0508814A patent/BRPI0508814B8/pt not_active IP Right Cessation
- 2005-03-15 KR KR1020127010279A patent/KR20120073287A/ko not_active Ceased
- 2005-03-15 SG SG200901748-4A patent/SG151267A1/en unknown
-
2006
- 2006-09-14 IL IL178079A patent/IL178079A/en active IP Right Grant
- 2006-10-05 NO NO20064519A patent/NO338270B1/no unknown
- 2006-10-16 EC EC2006006928A patent/ECSP066928A/es unknown
-
2009
- 2009-07-21 US US12/506,485 patent/US8367694B2/en not_active Expired - Fee Related
-
2011
- 2011-07-25 JP JP2011162351A patent/JP2012012398A/ja active Pending