JP2015510886A5 - - Google Patents

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Publication number

JP2015510886A5

JP2015510886A5 JP2014561101A JP2014561101A JP2015510886A5 JP 2015510886 A5 JP2015510886 A5 JP 2015510886A5 JP 2014561101 A JP2014561101 A JP 2014561101A JP 2014561101 A JP2014561101 A JP 2014561101A JP 2015510886 A5 JP2015510886 A5 JP 2015510886A5

Authority

JP

Japan

Prior art keywords

alkyl

hydroxy

substituted

compound according

aryl

Prior art date

2013-03-07

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 150000001875 compounds Chemical class 0.000 claims 24
• -1 C 1 -C 5 alkyl Chemical group 0.000 claims 17
• 125000003118 aryl group Chemical group 0.000 claims 16
• 125000001072 heteroaryl group Chemical group 0.000 claims 15
• 229910052739 hydrogen Inorganic materials 0.000 claims 13
• 125000001475 halogen functional group Chemical group 0.000 claims 12
• 239000001257 hydrogen Substances 0.000 claims 12
• 125000004356 hydroxy functional group Chemical group O* 0.000 claims 12
• 125000000217 alkyl group Chemical group 0.000 claims 11
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 10
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 9
• 125000004093 cyano group Chemical group *C#N 0.000 claims 8
• 150000002431 hydrogen Chemical class 0.000 claims 8
• 125000003396 thiol group Chemical class [H]S* 0.000 claims 8
• 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 6
• 239000003112 inhibitor Substances 0.000 claims 6
• 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 5
• 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 5
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 4
• 150000003839 salts Chemical class 0.000 claims 4
• 125000004650 C1-C8 alkynyl group Chemical group 0.000 claims 3
• 125000003342 alkenyl group Chemical group 0.000 claims 3
• 125000001188 haloalkyl group Chemical group 0.000 claims 3
• 125000004464 hydroxyphenyl group Chemical group 0.000 claims 3
• 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 3
• 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 3
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
• 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 3
• 125000004076 pyridyl group Chemical group 0.000 claims 3
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
• 125000005189 alkyl hydroxy group Chemical group 0.000 claims 2
• 125000004429 atom Chemical group 0.000 claims 2
• 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 2
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
• 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 2
• 125000002088 tosyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])S(*)(=O)=O 0.000 claims 2
• GOVYBPLHWIEHEJ-UHFFFAOYSA-N tubastatin A Chemical group C1N(C)CCC2=C1C1=CC=CC=C1N2CC1=CC=C(C(=O)NO)C=C1 GOVYBPLHWIEHEJ-UHFFFAOYSA-N 0.000 claims 2
• 229940122617 Histone deacetylase 6 inhibitor Drugs 0.000 claims 1
• 208000025205 Mantle-Cell Lymphoma Diseases 0.000 claims 1
• BHUZLJOUHMBZQY-YXQOSMAKSA-N N-[4-[(2R,4R,6S)-4-[[(4,5-diphenyl-2-oxazolyl)thio]methyl]-6-[4-(hydroxymethyl)phenyl]-1,3-dioxan-2-yl]phenyl]-N'-hydroxyoctanediamide Chemical compound C1=CC(CO)=CC=C1[C@H]1O[C@@H](C=2C=CC(NC(=O)CCCCCCC(=O)NO)=CC=2)O[C@@H](CSC=2OC(=C(N=2)C=2C=CC=CC=2)C=2C=CC=CC=2)C1 BHUZLJOUHMBZQY-YXQOSMAKSA-N 0.000 claims 1
• 102000004495 STAT3 Transcription Factor Human genes 0.000 claims 1
• 108010017324 STAT3 Transcription Factor Proteins 0.000 claims 1
• 125000003545 alkoxy group Chemical group 0.000 claims 1
• GXJABQQUPOEUTA-RDJZCZTQSA-N bortezomib Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)B(O)O)NC(=O)C=1N=CC=NC=1)C1=CC=CC=C1 GXJABQQUPOEUTA-RDJZCZTQSA-N 0.000 claims 1
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 229940121372 histone deacetylase inhibitor Drugs 0.000 claims 1
• 239000003276 histone deacetylase inhibitor Substances 0.000 claims 1
• 229960005386 ipilimumab Drugs 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 201000001441 melanoma Diseases 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
• 125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
• 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
• 229910052757 nitrogen Inorganic materials 0.000 claims 1
• 125000000714 pyrimidinyl group Chemical group 0.000 claims 1
• 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
• 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
• 229940099039 velcade Drugs 0.000 claims 1
• GPXBXXGIAQBQNI-UHFFFAOYSA-N vemurafenib Chemical compound CCCS(=O)(=O)NC1=CC=C(F)C(C(=O)C=2C3=CC(=CN=C3NC=2)C=2C=CC(Cl)=CC=2)=C1F GPXBXXGIAQBQNI-UHFFFAOYSA-N 0.000 claims 1
• 229960003862 vemurafenib Drugs 0.000 claims 1