JP2019504833A5 - - Google Patents
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- Publication number
- JP2019504833A5 JP2019504833A5 JP2018535341A JP2018535341A JP2019504833A5 JP 2019504833 A5 JP2019504833 A5 JP 2019504833A5 JP 2018535341 A JP2018535341 A JP 2018535341A JP 2018535341 A JP2018535341 A JP 2018535341A JP 2019504833 A5 JP2019504833 A5 JP 2019504833A5
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- JP
- Japan
- Prior art keywords
- optionally substituted
- compound
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- compound according
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 41
- 229910052739 hydrogen Inorganic materials 0.000 claims 17
- 239000001257 hydrogen Substances 0.000 claims 17
- 125000000547 substituted alkyl group Chemical group 0.000 claims 13
- 206010028980 Neoplasm Diseases 0.000 claims 10
- 150000002431 hydrogen Chemical class 0.000 claims 10
- 229910052736 halogen Inorganic materials 0.000 claims 9
- 150000002367 halogens Chemical class 0.000 claims 9
- 239000008194 pharmaceutical composition Substances 0.000 claims 8
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 7
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 7
- 125000005415 substituted alkoxy group Chemical group 0.000 claims 7
- 201000011510 cancer Diseases 0.000 claims 6
- 229910052799 carbon Inorganic materials 0.000 claims 5
- 125000004093 cyano group Chemical group *C#N 0.000 claims 5
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 5
- 125000000753 cycloalkyl group Chemical group 0.000 claims 4
- 125000001072 heteroaryl group Chemical group 0.000 claims 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 4
- 125000003107 substituted aryl group Chemical group 0.000 claims 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 3
- 125000002947 alkylene group Chemical group 0.000 claims 3
- 125000004404 heteroalkyl group Chemical group 0.000 claims 3
- -1 methoxy, ethoxy Chemical group 0.000 claims 3
- 108010033174 Deoxycytidine kinase Proteins 0.000 claims 2
- 102100029588 Deoxycytidine kinase Human genes 0.000 claims 2
- 125000004450 alkenylene group Chemical group 0.000 claims 2
- 125000004419 alkynylene group Chemical group 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 125000002757 morpholinyl group Chemical group 0.000 claims 2
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 208000005017 glioblastoma Diseases 0.000 claims 1
- 201000010536 head and neck cancer Diseases 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 201000005787 hematologic cancer Diseases 0.000 claims 1
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 claims 1
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims 1
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000003386 piperidinyl group Chemical group 0.000 claims 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662276546P | 2016-01-08 | 2016-01-08 | |
| US62/276,546 | 2016-01-08 | ||
| PCT/US2017/012718 WO2017120585A1 (en) | 2016-01-08 | 2017-01-09 | Deoxycytidine kinase binding compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019504833A JP2019504833A (ja) | 2019-02-21 |
| JP2019504833A5 true JP2019504833A5 (enExample) | 2020-02-20 |
| JP7091244B2 JP7091244B2 (ja) | 2022-06-27 |
Family
ID=59274442
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018535341A Active JP7091244B2 (ja) | 2016-01-08 | 2017-01-09 | デオキシシチジンキナーゼ結合化合物 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US10570124B2 (enExample) |
| EP (1) | EP3400224A4 (enExample) |
| JP (1) | JP7091244B2 (enExample) |
| CN (1) | CN108779111B (enExample) |
| AU (1) | AU2017205336A1 (enExample) |
| CA (1) | CA3010723A1 (enExample) |
| WO (1) | WO2017120585A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3230259B1 (en) | 2014-12-08 | 2024-04-03 | The Research Foundation for The State University of New York | Anti-fungals targeting the synthesis of fungal shingolipids |
| US11414378B2 (en) | 2017-06-16 | 2022-08-16 | The Research Foundation For The State University Of New York | Anti-fungals compounds targeting the synthesis of fungal sphingolipids |
| CN116723845A (zh) * | 2020-11-02 | 2023-09-08 | 特雷西拉公司 | 脱氧胞苷激酶抑制剂的结晶形式及其用途 |
| JP2023548605A (ja) * | 2020-11-02 | 2023-11-17 | トレセラ コーポレーション | デオキシシチジンキナーゼ阻害剤の結晶形態およびその使用 |
| US20250092032A1 (en) * | 2022-01-17 | 2025-03-20 | Centre National De La Recherche Scientifique | Deoxycytidine kinase inhibitors |
| WO2024186827A2 (en) * | 2023-03-06 | 2024-09-12 | The Regents Of The University Of California | Novel host-directed therapeutic agent for the treatment of infectious diseases |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2529293T3 (es) | 2007-09-19 | 2015-02-18 | The Regents Of The University Of California | Sondas para tomografía de emisión de positrones para generación de imágenes de activación inmune y cánceres seleccionados |
| WO2012122368A1 (en) | 2011-03-08 | 2012-09-13 | The Regents Of The University Of California | Deoxycytidine kinase binding compounds |
| WO2015023776A2 (en) * | 2013-08-13 | 2015-02-19 | The Regents Of The University Of California | Deoxycytidine kinase inhibitors |
| JP2018510134A (ja) * | 2015-02-09 | 2018-04-12 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 組合せがん治療法 |
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2017
- 2017-01-09 JP JP2018535341A patent/JP7091244B2/ja active Active
- 2017-01-09 US US16/068,658 patent/US10570124B2/en active Active
- 2017-01-09 EP EP17736514.5A patent/EP3400224A4/en active Pending
- 2017-01-09 CA CA3010723A patent/CA3010723A1/en not_active Abandoned
- 2017-01-09 AU AU2017205336A patent/AU2017205336A1/en not_active Abandoned
- 2017-01-09 CN CN201780015566.3A patent/CN108779111B/zh active Active
- 2017-01-09 WO PCT/US2017/012718 patent/WO2017120585A1/en not_active Ceased