JP2008525530A5 - - Google Patents
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- Publication number
- JP2008525530A5 JP2008525530A5 JP2007549605A JP2007549605A JP2008525530A5 JP 2008525530 A5 JP2008525530 A5 JP 2008525530A5 JP 2007549605 A JP2007549605 A JP 2007549605A JP 2007549605 A JP2007549605 A JP 2007549605A JP 2008525530 A5 JP2008525530 A5 JP 2008525530A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- alkoxy
- compound
- aryl
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63983404P | 2004-12-28 | 2004-12-28 | |
| US60/639,834 | 2004-12-28 | ||
| US70455105P | 2005-08-01 | 2005-08-01 | |
| US60/704,551 | 2005-08-01 | ||
| US72734105P | 2005-10-17 | 2005-10-17 | |
| US60/727,341 | 2005-10-17 | ||
| PCT/US2005/047333 WO2006071960A2 (en) | 2004-12-28 | 2005-12-28 | Compositions and methods of treating cell proliferation disorders |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012009251A Division JP2012082222A (ja) | 2004-12-28 | 2012-01-19 | 細胞増殖性障害を処置する組成物および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008525530A JP2008525530A (ja) | 2008-07-17 |
| JP2008525530A5 true JP2008525530A5 (enExample) | 2009-02-19 |
| JP5124285B2 JP5124285B2 (ja) | 2013-01-23 |
Family
ID=36615518
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007549605A Expired - Lifetime JP5124285B2 (ja) | 2004-12-28 | 2005-12-28 | 細胞増殖性障害を処置する組成物および方法 |
| JP2012009251A Withdrawn JP2012082222A (ja) | 2004-12-28 | 2012-01-19 | 細胞増殖性障害を処置する組成物および方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012009251A Withdrawn JP2012082222A (ja) | 2004-12-28 | 2012-01-19 | 細胞増殖性障害を処置する組成物および方法 |
Country Status (19)
| Country | Link |
|---|---|
| US (5) | US7300931B2 (enExample) |
| EP (1) | EP1836169B9 (enExample) |
| JP (2) | JP5124285B2 (enExample) |
| KR (2) | KR101478933B1 (enExample) |
| CN (2) | CN103274961B (enExample) |
| AT (1) | ATE544748T1 (enExample) |
| AU (1) | AU2005321966B2 (enExample) |
| BE (1) | BE2021C001I2 (enExample) |
| BR (1) | BRPI0519424B8 (enExample) |
| CA (1) | CA2594345C (enExample) |
| CY (1) | CY2022001I2 (enExample) |
| DK (1) | DK1836169T5 (enExample) |
| ES (1) | ES2382068T3 (enExample) |
| FR (1) | FR21C1064I2 (enExample) |
| HU (1) | HUS2100051I1 (enExample) |
| LU (1) | LUC00235I2 (enExample) |
| NL (1) | NL301145I2 (enExample) |
| PL (1) | PL1836169T3 (enExample) |
| WO (1) | WO2006071960A2 (enExample) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7968574B2 (en) | 2004-12-28 | 2011-06-28 | Kinex Pharmaceuticals, Llc | Biaryl compositions and methods for modulating a kinase cascade |
| WO2006071960A2 (en) | 2004-12-28 | 2006-07-06 | Kinex Pharmaceuticals, Llc | Compositions and methods of treating cell proliferation disorders |
| EP1856075A1 (en) | 2005-01-25 | 2007-11-21 | Epix Delaware, Inc. | Substituted arylamine compounds and their use as 5-ht6 modulators |
| AU2007265373B2 (en) * | 2006-06-29 | 2013-02-21 | Atnx Spv, Llc | Biaryl compositions and methods for modulating a kinase cascade |
| WO2008002676A2 (en) * | 2006-06-29 | 2008-01-03 | Kinex Pharmaceuticals, Llc | Biaryl compositions and methods for modulating a kinase cascade |
| US7935697B2 (en) | 2006-12-28 | 2011-05-03 | Kinex Pharmaceuticals, Llc | Compositions for modulating a kinase cascade and methods of use thereof |
| US7939529B2 (en) | 2007-05-17 | 2011-05-10 | Kinex Pharmaceuticals, Llc | Process for the preparation of compositions for modulating a kinase cascade and methods of use thereof |
| US20210198202A1 (en) * | 2006-12-28 | 2021-07-01 | Athenex, Inc. | Compositions for modulating a kinase cascade and methods of use thereof |
| AU2014200559B2 (en) * | 2006-12-28 | 2016-05-26 | Atnx Spv, Llc | Composition and Methods for Modulating a Kinase Cascade |
| TWI457336B (zh) * | 2006-12-28 | 2014-10-21 | Kinex Pharmaceuticals Llc | 調節激酶級聯之組成物及方法 |
| US20100256147A1 (en) * | 2007-04-13 | 2010-10-07 | Hangauer Jr David G | Biaryl acetamide derivatives as modulators of the kinase cascade for the treatment of hearing loss, osteoporosis and cell proliferation disorders |
| AU2008254500B2 (en) * | 2007-05-17 | 2014-01-23 | Atnx Spv, Llc | Process for the preparation of compositions for modulating a kinase cascade and methods of use thereof |
| AU2014202221B2 (en) * | 2007-05-17 | 2016-06-23 | Atnx Spv, Llc | Process for the Preparation of Compositions for Modulating a Kinase Cascade and Methods of Use Thereof |
| US8124605B2 (en) | 2007-07-06 | 2012-02-28 | Kinex Pharmaceuticals, Llc | Compositions and methods for modulating a kinase cascade |
| AU2008314569B2 (en) * | 2007-10-20 | 2014-10-02 | Atnx Spv, Llc | Pharmaceutical compositions for modulating a kinase cascade and methods of use thereof |
| US8598165B2 (en) * | 2007-11-26 | 2013-12-03 | University Of Kansas | Morpholines as selective inhibitors of cytochrome P450 2A13 |
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| ES2550667T3 (es) | 2010-02-18 | 2015-11-11 | Vtv Therapeutics Llc | Derivados de fenilheteroarilo y métodos de uso de los mismos |
| EP2558085B1 (en) | 2010-04-16 | 2017-08-30 | Athenex, Inc. | Compositions and methods for the prevention and treatment of cancer |
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| UY34632A (es) | 2012-02-24 | 2013-05-31 | Novartis Ag | Compuestos de oxazolidin- 2- ona y usos de los mismos |
| CN102746255A (zh) * | 2012-07-24 | 2012-10-24 | 安徽中医学院 | 具有抗肿瘤活性的化合物、制备方法及应用 |
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| PE20191245A1 (es) | 2013-01-15 | 2019-09-18 | Incyte Holdings Corp | Compuestos de tiazolcarboxamidas y piridinacarboxamida utiles como inhibidores de quinasa pim |
| WO2014141104A1 (en) | 2013-03-14 | 2014-09-18 | Novartis Ag | 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant idh |
| CN105658653A (zh) | 2013-08-23 | 2016-06-08 | 因赛特公司 | 可用作pim激酶抑制剂的呋喃并-和噻吩并-吡啶甲酰胺化合物 |
| US9822124B2 (en) | 2014-07-14 | 2017-11-21 | Incyte Corporation | Bicyclic heteroaromatic carboxamide compounds useful as Pim kinase inhibitors |
| US9580418B2 (en) | 2014-07-14 | 2017-02-28 | Incyte Corporation | Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors |
| RS58813B1 (sr) * | 2014-09-10 | 2019-07-31 | Glaxosmithkline Ip Dev Ltd | Piridonski derivati korišćeni kao inhibitori kinaze reorganizovane tokom transfekcije (ret) |
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| AR105967A1 (es) | 2015-09-09 | 2017-11-29 | Incyte Corp | Sales de un inhibidor de pim quinasa |
| WO2017059251A1 (en) | 2015-10-02 | 2017-04-06 | Incyte Corporation | Heterocyclic compounds useful as pim kinase inhibitors |
| CN106902358B (zh) * | 2015-12-21 | 2020-07-10 | 广州市香雪制药股份有限公司 | 口服制剂及其制备方法 |
| CN106902357B (zh) * | 2015-12-21 | 2021-08-03 | 广州市香雪制药股份有限公司 | 药物组合物及其应用、药物包合物、静脉制剂及制备方法 |
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| CN106810490A (zh) * | 2017-02-06 | 2017-06-09 | 重庆泰润制药有限公司 | 一种二芳基化合物的晶型及其制备方法和应用 |
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| MX388196B (es) | 2017-04-26 | 2025-03-19 | Basilea Pharm Int Ag | Procesos para la preparacion de furazanobencimidazoles y formas cristalinas de estos. |
| SG11202001868RA (en) | 2017-09-07 | 2020-03-30 | Athenex Hk Innovative Ltd | Solid forms of 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-n-benzylacetamide |
| WO2019113487A1 (en) | 2017-12-08 | 2019-06-13 | Incyte Corporation | Low dose combination therapy for treatment of myeloproliferative neoplasms |
| CN113117376B (zh) * | 2019-12-30 | 2022-08-19 | 中国科学院高能物理研究所 | 一种邻菲罗啉衍生的萃取剂及其制法和应用 |
| CN113461665B (zh) * | 2020-03-31 | 2023-05-19 | 成都赜灵生物医药科技有限公司 | 二芳基衍生物及其制备方法和用途 |
| CN113354575B (zh) * | 2021-06-07 | 2022-09-27 | 河南应用技术职业学院 | 一种特班布林的合成方法 |
| EP4186890A1 (en) | 2021-11-29 | 2023-05-31 | Moehs Ibérica, S.L. | Preparation of n-benzyl-2-(5-bromo-pyridin-2-yl)-acetamide for the synthesis of tirbanibulin |
| CA3240263A1 (en) | 2021-12-09 | 2023-06-15 | Daniel L. Flynn | Raf kinase inhibitors and methods of use thereof |
| CN116444426A (zh) * | 2022-01-14 | 2023-07-18 | 武汉人福创新药物研发中心有限公司 | 微管蛋白-Src双靶点抑制剂和用途 |
| CA3248059A1 (en) * | 2022-01-14 | 2025-07-10 | Wuhan Humanwell Innovative Drug Research and Development Center Limited Company | DIARYL COMPOUND USED AS A DUAL-TARGET TUBULIN/SRC INHIBITOR |
| WO2023134753A1 (zh) * | 2022-01-14 | 2023-07-20 | 武汉人福创新药物研发中心有限公司 | 微管蛋白-src双靶点抑制剂 |
| ES3042510T3 (en) | 2022-07-04 | 2025-11-21 | Trifarma S P A | Process for synthesis of tirbanibulin |
| CN115073362A (zh) * | 2022-08-04 | 2022-09-20 | 重庆迈德凯医药有限公司 | 一种替尼布林的合成方法 |
| WO2024041628A1 (zh) * | 2022-08-25 | 2024-02-29 | 武汉人福创新药物研发中心有限公司 | 二芳基类化合物及其制备方法和用途 |
| WO2026022219A1 (en) | 2024-07-24 | 2026-01-29 | Almirall, S.A. | Injectable formulations comprising tirbanibulin |
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2005
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2007
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2010
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2012
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2015
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2021
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2022
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2023
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