JP2010539095A5 - - Google Patents

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JP2010539095A5
JP2010539095A5 JP2010524243A JP2010524243A JP2010539095A5 JP 2010539095 A5 JP2010539095 A5 JP 2010539095A5 JP 2010524243 A JP2010524243 A JP 2010524243A JP 2010524243 A JP2010524243 A JP 2010524243A JP 2010539095 A5 JP2010539095 A5 JP 2010539095A5
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JP5688840B2 (ja
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Priority claimed from PCT/US2008/075848 external-priority patent/WO2009036059A2/en
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JP2010524243A 2007-09-10 2008-09-10 新規のＳｔａｔ３経路阻害剤及び癌幹細胞阻害剤 Expired - Fee Related JP5688840B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US97114407P 2007-09-10 2007-09-10
US60/971,144 2007-09-10
US1337207P 2007-12-13 2007-12-13
US61/013,372 2007-12-13
PCT/US2008/075848 WO2009036059A2 (en) 2007-09-10 2008-09-10 Novel stat3 pathway inhibitors and cancer stem cell inhibitors

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2014232397A Division JP2015034179A (ja) 2007-09-10 2014-11-17 新規のＳｔａｔ３経路阻害剤及び癌幹細胞阻害剤
JP2014232396A Division JP6106149B2 (ja) 2007-09-10 2014-11-17 新規のＳｔａｔ３経路阻害剤及び癌幹細胞阻害剤

Publications (3)

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JP2010539095A JP2010539095A (ja) 2010-12-16
JP2010539095A5 true JP2010539095A5 (enExample) 2012-09-27
JP5688840B2 JP5688840B2 (ja) 2015-03-25

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Family Applications (16)

Application Number Title Priority Date Filing Date
JP2010524249A Expired - Fee Related JP5701603B2 (ja) 2007-09-10 2008-09-10 Ｓｔａｔ３経路阻害剤および癌幹細胞経路阻害剤の新規のグループ
JP2010524251A Expired - Fee Related JP5872160B2 (ja) 2007-09-10 2008-09-10 癌治療のための新規の組成物および方法
JP2010524243A Expired - Fee Related JP5688840B2 (ja) 2007-09-10 2008-09-10 新規のＳｔａｔ３経路阻害剤及び癌幹細胞阻害剤
JP2014177908A Expired - Fee Related JP5925849B2 (ja) 2007-09-10 2014-09-02 Ｓｔａｔ３経路阻害剤および癌幹細胞経路阻害剤の新規のグループ
JP2014177915A Expired - Fee Related JP5938072B2 (ja) 2007-09-10 2014-09-02 癌治療のための新規の組成物および方法
JP2014232396A Expired - Fee Related JP6106149B2 (ja) 2007-09-10 2014-11-17 新規のＳｔａｔ３経路阻害剤及び癌幹細胞阻害剤
JP2014232397A Withdrawn JP2015034179A (ja) 2007-09-10 2014-11-17 新規のＳｔａｔ３経路阻害剤及び癌幹細胞阻害剤
JP2015230291A Expired - Fee Related JP6358659B2 (ja) 2007-09-10 2015-11-26 Ｓｔａｔ３経路阻害剤および癌幹細胞経路阻害剤の新規のグループ
JP2016004076A Expired - Fee Related JP6347795B2 (ja) 2007-09-10 2016-01-13 癌治療のための新規の組成物および方法
JP2016016973A Expired - Fee Related JP6346628B2 (ja) 2007-09-10 2016-02-01 Ｓｔａｔ３経路阻害剤および癌幹細胞経路阻害剤の新規のグループ
JP2016097607A Withdrawn JP2016147906A (ja) 2007-09-10 2016-05-16 新規のＳｔａｔ３経路阻害剤及び癌幹細胞阻害剤
JP2017242778A Withdrawn JP2018076349A (ja) 2007-09-10 2017-12-19 Ｓｔａｔ３経路阻害剤および癌幹細胞経路阻害剤の新規のグループ
JP2018102234A Withdrawn JP2018131464A (ja) 2007-09-10 2018-05-29 癌治療のための新規の組成物および方法
JP2019029436A Pending JP2019073560A (ja) 2007-09-10 2019-02-21 新規のＳｔａｔ３経路阻害剤及び癌幹細胞阻害剤
JP2020085065A Pending JP2020117547A (ja) 2007-09-10 2020-05-14 癌治療のための新規の組成物および方法
JP2020091326A Pending JP2020143135A (ja) 2007-09-10 2020-05-26 Ｓｔａｔ３経路阻害剤および癌幹細胞経路阻害剤の新規のグループ

Family Applications Before (2)

Application Number Title Priority Date Filing Date
JP2010524249A Expired - Fee Related JP5701603B2 (ja) 2007-09-10 2008-09-10 Ｓｔａｔ３経路阻害剤および癌幹細胞経路阻害剤の新規のグループ
JP2010524251A Expired - Fee Related JP5872160B2 (ja) 2007-09-10 2008-09-10 癌治療のための新規の組成物および方法

Family Applications After (13)

Application Number Title Priority Date Filing Date
JP2014177908A Expired - Fee Related JP5925849B2 (ja) 2007-09-10 2014-09-02 Ｓｔａｔ３経路阻害剤および癌幹細胞経路阻害剤の新規のグループ
JP2014177915A Expired - Fee Related JP5938072B2 (ja) 2007-09-10 2014-09-02 癌治療のための新規の組成物および方法
JP2014232396A Expired - Fee Related JP6106149B2 (ja) 2007-09-10 2014-11-17 新規のＳｔａｔ３経路阻害剤及び癌幹細胞阻害剤
JP2014232397A Withdrawn JP2015034179A (ja) 2007-09-10 2014-11-17 新規のＳｔａｔ３経路阻害剤及び癌幹細胞阻害剤
JP2015230291A Expired - Fee Related JP6358659B2 (ja) 2007-09-10 2015-11-26 Ｓｔａｔ３経路阻害剤および癌幹細胞経路阻害剤の新規のグループ
JP2016004076A Expired - Fee Related JP6347795B2 (ja) 2007-09-10 2016-01-13 癌治療のための新規の組成物および方法
JP2016016973A Expired - Fee Related JP6346628B2 (ja) 2007-09-10 2016-02-01 Ｓｔａｔ３経路阻害剤および癌幹細胞経路阻害剤の新規のグループ
JP2016097607A Withdrawn JP2016147906A (ja) 2007-09-10 2016-05-16 新規のＳｔａｔ３経路阻害剤及び癌幹細胞阻害剤
JP2017242778A Withdrawn JP2018076349A (ja) 2007-09-10 2017-12-19 Ｓｔａｔ３経路阻害剤および癌幹細胞経路阻害剤の新規のグループ
JP2018102234A Withdrawn JP2018131464A (ja) 2007-09-10 2018-05-29 癌治療のための新規の組成物および方法
JP2019029436A Pending JP2019073560A (ja) 2007-09-10 2019-02-21 新規のＳｔａｔ３経路阻害剤及び癌幹細胞阻害剤
JP2020085065A Pending JP2020117547A (ja) 2007-09-10 2020-05-14 癌治療のための新規の組成物および方法
JP2020091326A Pending JP2020143135A (ja) 2007-09-10 2020-05-26 Ｓｔａｔ３経路阻害剤および癌幹細胞経路阻害剤の新規のグループ

Country Status (14)

Country Link
US (12) US9745278B2 (enExample)
EP (6) EP3067054B1 (enExample)
JP (16) JP5701603B2 (enExample)
CN (6) CN101854802B (enExample)
CA (4) CA2911990C (enExample)
CY (3) CY1117604T1 (enExample)
DK (4) DK2190429T3 (enExample)
ES (3) ES2584904T3 (enExample)
HR (3) HRP20160949T1 (enExample)
HU (3) HUE029111T2 (enExample)
PL (4) PL3067054T3 (enExample)
PT (2) PT2194987T (enExample)
SI (3) SI2194987T1 (enExample)
WO (3) WO2009036059A2 (enExample)

Families Citing this family (132)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA200706804B (en) 2005-02-03 2008-10-29 Gen Hospital Corp Method for treating gefitinib resistant cancer
KR101354828B1 (ko) 2005-11-04 2014-02-18 와이어쓰 엘엘씨 ｍＴＯＲ 저해자, 헤르셉틴, 및/또는 ＨＫＩ-272의항신생물성 조합
EP3067054B1 (en) * 2007-09-10 2020-12-30 Boston Biomedical, Inc. Novel compositions and methods for cancer treatment
US8022216B2 (en) 2007-10-17 2011-09-20 Wyeth Llc Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof
WO2009062199A1 (en) * 2007-11-09 2009-05-14 Fox Chase Cancer Center EGFR/NEDD9/TGF-β LNTERACTOME AND METHODS OF USE THEREOF FOR THE IDENTIFICATION OF AGENTS HAVING EFFICACY IN THE TREATMENT OF HYPERPROLIFERATIVE DISORDERS
US20130331294A1 (en) 2007-11-09 2013-12-12 Fox Chase Cancer Center Egfr/nedd9/tgf-beta interactome and methods of use thereof for the identification of agents having efficacy in the treatment of hyperproliferative disorders
UY31800A (es) * 2008-05-05 2009-11-10 Smithkline Beckman Corp Metodo de tratamiento de cancer usando un inhibidor de cmet y axl y un inhibidor de erbb
CA2725598C (en) 2008-06-17 2013-10-08 Wyeth Llc Antineoplastic combinations containing hki-272 and vinorelbine
UA103492C2 (ru) 2008-07-08 2013-10-25 Борд Оф Риджентс, Дзе Юниверсити Оф Техас Систем Ингибиторы пролиферации и активации переносчика сигнала и активатора транскрипции (stats)
MX2011001318A (es) 2008-08-04 2011-03-04 Wyeth Llc Combinaciones antineoplasicas de 4-anilino-3-cianoquinolinas y capecitabina.
EP2370082A4 (en) * 2008-12-01 2012-05-30 Univ Central Florida Res Found FOR BELLY CANCER CELLS CYTOTOXIC DRUG COMPOSITION
EP2416774B1 (en) 2009-04-06 2015-11-04 Wyeth LLC Treatment regimen utilizing neratinib for breast cancer
CN101897979B (zh) * 2009-05-27 2012-08-22 上海市计划生育科学研究所 治疗前列腺疾病的靶向药物
EP2506852A4 (en) 2009-12-04 2013-06-19 Univ Texas INTERFERONTHERAPIES IN COMBINATION WITH BLOCKING OF STAT3 ACTIVATION
PL2520575T3 (pl) 2009-12-28 2017-05-31 General Incorporated Association Pharma Valley Project Supporting Organization Związek 1,3,4-oksadiazolo-2-karboksyamidowy
US20110275577A1 (en) * 2010-01-08 2011-11-10 Moleculin, Llc Methods of treating dermatologic, gynecologic, and genital disorders with caffeic acid analogs
CA2787673A1 (en) 2010-03-01 2011-09-09 Tau Therapeutics Llc Cancer diagnosis and imaging
BR112012023661A2 (pt) * 2010-03-19 2020-11-24 Boston Biomedical, Inc. novos compostos e novas composições direcionadas a células-tronco cancerosas
CN104016951B (zh) * 2010-03-19 2016-07-13 北京强新生物科技有限公司 靶向癌症干细胞的化合物和组合物
AU2015218436B9 (en) * 2010-03-19 2017-03-09 Boston Biomedical, Inc. Novel Methods For Targeting Cancer Stem Cells
AU2011227023B2 (en) 2010-03-19 2015-05-28 Boston Biomedical, Inc. Novel methods for targeting cancer stem cells
WO2011130677A1 (en) * 2010-04-16 2011-10-20 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Inhibitors of cancer stem cells
US20110301194A1 (en) * 2010-06-02 2011-12-08 Arqule, Inc. Method for Determining Treatment Efficacy
CN103153975B (zh) * 2010-08-24 2016-01-20 杭州益尔生物科技有限公司 用于疾病治疗的新型萘醌
WO2012036214A1 (ja) * 2010-09-16 2012-03-22 国立大学法人大阪大学 自己免疫疾患、炎症性疾患、アレルギー性疾患、臓器移植に伴う症状の治療薬および予防薬
JP2013543011A (ja) * 2010-11-22 2013-11-28 グラクソスミスクライン、インテレクチュアル、プロパティー、ナンバー２、リミテッド 癌の治療法
US20130230581A1 (en) * 2010-11-30 2013-09-05 Qingping Feng Egfr antagonist for the treatment of heart disease
WO2012078982A2 (en) * 2010-12-09 2012-06-14 The Ohio State University Xzh-5 inhibits constitutive and interleukin-6-induced stat3 phosphorylation in human hepatocellular carcinoma cells
WO2012119265A1 (en) * 2011-03-04 2012-09-13 Zhoushan Haizhongzhou Xinsheng Pharmaceuticals Co., Ltd. NOVEL ESTERS OF 4,9-DIHYDROXY-NAPHTHO[2,3-b]FURANS FOR DISEASE THERAPIES
KR20120130658A (ko) * 2011-05-23 2012-12-03 주식회사 파멥신 펩타이드가 융합된 이중표적항체 및 그 용도
MX2013014310A (es) * 2011-06-06 2014-01-23 Akebia Therapeutics Inc Compuestos y composiciones para estabilizar el factor-2 alfa inducible por hipoxia como un metodo para tratar el cancer.
CA2848311A1 (en) * 2011-09-12 2013-03-21 Tau Therapeutics Llc Antagonists of products of the hs.459642 unigene cluster for the inhibition of proliferation, development or differentiation of stem cells including cancer stem cells
WO2013071163A2 (en) * 2011-11-11 2013-05-16 Millennium Pharamaceuticals, Inc. Biomarkers of response to proteasome inhibitors
JP2015506990A (ja) * 2012-02-17 2015-03-05 ゾウシャン ハイジョンジョウ シンシェン ファーマシューティカルズ カンパニー リミテッドＺｈｏｕｓｈａｎ Ｈａｉｚｈｏｎｇｚｈｏｕ Ｘｉｎｓｈｅｎｇ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｃｏ．， Ｌｔｄ． ４，９−ジヒドロキシ−ナフト［２，３−ｂ］フラン脂肪族酸エステルの誘導体の水性ナノ粒子懸濁液を調製する方法
US8940742B2 (en) 2012-04-10 2015-01-27 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
WO2013166618A1 (en) * 2012-05-08 2013-11-14 Zhoushan Haizhongzhou Xinsheng Pharmaceuticals Co., Ltd. PRODRUGS OF 4,9-DIHYDROXY-NAPHTHO[2,3-b]FURANS FOR CIRCUMVENTING CANCER MULTIDRUG RESISTANCE
CA2880896C (en) 2012-06-26 2021-11-16 Del Mar Pharmaceuticals Methods for treating tyrosine-kinase-inhibitor-resistant malignancies in patients with genetic polymorphisms or ahi1 dysregulations or mutations employing dianhydrogalactitol, diacetyldianhydrogalactitol, dibromodulcitol, or analogs or derivatives thereof
CN106421795A (zh) * 2012-10-08 2017-02-22 贾力 预防原发性肿瘤在手术切除后再转移的药用组合物
DE102013003107A1 (de) 2013-02-25 2014-09-11 Thomas Rühl Naphthofurandione mit einer 1-Bromalkylgruppe oder einer 1-Hydroxyalkylgruppe in 2-Position und einer Alkylgruppe in 3-Position zum Furanring-Sauerstoff und Verfahren zu deren Herstellung
CN105492011A (zh) 2013-04-08 2016-04-13 丹尼斯·M·布朗 不理想给药化学化合物的治疗增效
MX2015014181A (es) * 2013-04-09 2016-05-24 Boston Biomedical Inc 2-acetilnafto [2,3-b]furano -4,9-diona para uso en el tratamiento del cáncer.
RU2702428C2 (ru) * 2013-04-29 2019-10-08 Огд2 Фарма Использование о-ацетилированного gd2 ганглиозида в качестве мишени как новый терапевтический и диагностический подход при злокачественных новообразованиях, содержащих опухолевые стволовые клетки
US10745489B2 (en) 2013-04-29 2020-08-18 Ogd2 Pharma Targeting o-acetylated gd2 ganglioside as a new therapeutic and diagnostic strategy for Cancer Stem Cells cancer
WO2015051241A1 (en) 2013-10-04 2015-04-09 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
MX389256B (es) 2013-10-04 2025-03-20 Infinity Pharmaceuticals Inc Compuestos heterociclicos y usos de los mismos.
US9795595B2 (en) * 2014-01-27 2017-10-24 Boston Biomedical, Inc. Methods for treating cancer
JP6695275B2 (ja) * 2014-02-07 2020-05-20 ボストン バイオメディカル， インコーポレイテッド ３−置換カルボニル−ナフト［２，３−ｂ］フラン誘導体又はその薬学的に許容される塩
US11406707B2 (en) 2014-02-10 2022-08-09 H. Lee Moffitt Cancer Center And Research Institute, Inc. STAT3 phosphorylation during graft-versus-host disease
EP4066834A1 (en) 2014-03-19 2022-10-05 Infinity Pharmaceuticals, Inc. Heterocyclic compounds for use in the treatment of pi3k-gamma mediated disorders
JP6894236B2 (ja) * 2014-03-26 2021-06-30 デノボ バイオファーマ エルエルシー 免疫刺激活性を有するレトロウイルスベクター
WO2015164870A1 (en) 2014-04-25 2015-10-29 H. Lee Moffitt Cancer Center And Research Institute, Inc. Gamma-aa-peptide stat3/dna inhibitors and methods of use
WO2015171985A1 (en) * 2014-05-09 2015-11-12 The Brigham And Women's Hospital, Inc. Treatment of igg-immune complex-mediated organ damage
US10005752B2 (en) 2014-06-09 2018-06-26 Kyoto Pharmaceutical Industries, Ltd. Anticancer agent
WO2016010879A1 (en) * 2014-07-15 2016-01-21 The Johns Hopkins University Suppression of myeloid derived suppressor cells and immune checkpoint blockade
WO2016054491A1 (en) 2014-10-03 2016-04-07 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
KR20160066490A (ko) * 2014-12-02 2016-06-10 주식회사 씨앤드씨신약연구소 헤테로사이클 유도체 및 그의 용도
CN113501826B (zh) 2015-01-08 2025-04-04 美国政府健康及人类服务部 作为tdp2的抑制剂的呋喃并喹啉二酮
CN107660202B (zh) 2015-03-27 2021-12-24 大日本住友制药肿瘤公司 水溶性前药
CN104725480A (zh) * 2015-04-06 2015-06-24 苏州普罗达生物科技有限公司 一种信号传导及转录激活因子抑制多肽及其应用
CN104693279A (zh) * 2015-04-06 2015-06-10 苏州普罗达生物科技有限公司 关于信号传导及转录激活因子抑制多肽及其应用
CN104693280A (zh) * 2015-04-06 2015-06-10 苏州普罗达生物科技有限公司 信号传导及转录激活因子抑制多肽及其应用
WO2016168858A1 (en) * 2015-04-17 2016-10-20 Boston Biomedical, Inc. Methods for treating cancer
JP2018511645A (ja) * 2015-04-17 2018-04-26 ボストン バイオメディカル， インコーポレイテッド 癌を治療するための方法
EA201792287A1 (ru) 2015-04-17 2018-03-30 Бостон Биомедикал, Инк. Способы лечения рака
MX2017013816A (es) * 2015-04-27 2018-11-12 Boston Biomedical Inc Métodos para tratar el cáncer con un inhibidor de la vía de stat3 e inhibidor de cinasas.
CA2985540C (en) * 2015-05-14 2021-08-24 NuCana plc Use of nuc-1031 in the treatment of cancer
EP3294299A1 (en) * 2015-05-15 2018-03-21 Novartis AG Methods for treating egfr mutant cancers
JP2018521979A (ja) 2015-06-03 2018-08-09 ボストン バイオメディカル， インコーポレイテッド 癌の治療に使用するための癌幹細胞性阻害剤および免疫療法剤を含む組成物
US10329267B2 (en) 2015-07-17 2019-06-25 Sumitomo Dainippon Pharma Co., Ltd. Method for producing 2-acetyl-4H,9H-naphtho[2,3-b]furan-4,9-dione
WO2017013270A1 (en) 2015-07-23 2017-01-26 Universite De Strasbourg Use of leptin signaling inhibitor for protecting kidneys from patients having ciliopathy
WO2017023866A1 (en) * 2015-07-31 2017-02-09 Boston Biomedical, Inc. Method of targeting stat3 and other non-druggable proteins
CN108349985A (zh) 2015-09-14 2018-07-31 无限药品股份有限公司 异喹啉酮的固体形式、其制备方法、包含其的组合物及其使用方法
CA2994502C (en) 2015-10-05 2023-08-01 NuCana plc Combination therapy comprising nuc-1031 and carboplatin for cancer treatment
EP3400070A4 (en) * 2016-01-07 2019-07-03 Virginia Commonwealth University METHOD FOR MODULATING THE SURVIVAL AND STEM CELL CAPACITY OF CANCER STRAIN CELLS BY MDA-9 / SYNTENIN (SDCBP)
US20190076392A1 (en) * 2016-01-20 2019-03-14 Boston Biomedical, Inc. Methods for treating cancer
CN109104862A (zh) * 2016-03-01 2018-12-28 中央研究院 4,9-二氧代-4,9-二氢萘并[2,3-b]呋喃-3-羧酰胺衍生物及其用于治疗增生性疾病与感染性疾病的用途
US11946927B2 (en) 2016-03-14 2024-04-02 Musidora Biotechnology Llc Process and system for identifying individuals having a high risk of inflammatory bowel disease and a method of treatment
US10295527B2 (en) 2016-03-14 2019-05-21 Bruce Yacyshyn Process and system for predicting responders and non-responders to mesalamine treatment of ulcerative colitis
US10759806B2 (en) 2016-03-17 2020-09-01 Infinity Pharmaceuticals, Inc. Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as PI3K kinase inhibitors
JP6936214B2 (ja) * 2016-03-25 2021-09-15 大日本住友製薬株式会社 ２−アルキルカルボニルナフト［２，３−ｂ］フラン−４，９−ジオンの関連物質の製造方法、及びその関連物質
JP2017171640A (ja) * 2016-03-25 2017-09-28 学校法人兵庫医科大学 癌の治療システム
CN105906595A (zh) * 2016-04-23 2016-08-31 陈斌 丙酸倍氯米松的药物组合物及其在生物医药中的应用
CN105837541A (zh) * 2016-04-23 2016-08-10 何淑琼 磷酸苯丙哌林的药物组合物及其在生物医药中的应用
GB201609600D0 (en) 2016-06-01 2016-07-13 Nucuna Biomed Ltd Cancer treatments
WO2017214269A1 (en) 2016-06-08 2017-12-14 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
WO2018005444A2 (en) 2016-06-28 2018-01-04 Boston Biomedical, Inc. Methods for treating cancer
CN106380456B (zh) * 2016-08-29 2019-03-26 中南大学 一种合成苯并呋喃萘醌衍生物的方法
WO2018098352A2 (en) 2016-11-22 2018-05-31 Jun Oishi Targeting kras induced immune checkpoint expression
US20190375723A1 (en) 2016-11-22 2019-12-12 Boston Biomedical, Inc. New Naphtho[2,3-B]Furan Derivatives
JP7106563B2 (ja) * 2016-11-29 2022-07-26 スミトモ ファーマ オンコロジー， インコーポレイテッド ナフトフラン誘導体、その調製、および使用方法
KR20190089191A (ko) * 2016-11-30 2019-07-30 타임, 인크. 티로신 유도체 및 이들을 포함하는 조성물
TW201827050A (zh) * 2017-01-22 2018-08-01 大陸商江蘇恆瑞醫藥股份有限公司 Ｅｇｆｒ／ｈｅｒ２抑制劑聯合嘧啶類抗代謝藥物的用途
US11963966B2 (en) 2017-03-31 2024-04-23 Dana-Farber Cancer Institute, Inc. Compositions and methods for treating ovarian tumors
US11166953B2 (en) 2017-04-17 2021-11-09 Yale University Compounds, compositions and methods of treating or preventing acute lung injury
US10646464B2 (en) 2017-05-17 2020-05-12 Boston Biomedical, Inc. Methods for treating cancer
CA3066054A1 (en) * 2017-06-04 2018-12-13 Rappaport Family Institute For Research In The Medical Sciences Method of predicting personalized response to cancer therapy and kit therefor
CN111132614A (zh) * 2017-07-20 2020-05-08 路易斯安娜州立大学监测委员会，农业和机械学院 使用脉冲磁场梯度对恶性癌细胞的靶向渗透裂解
WO2019059344A1 (ja) 2017-09-22 2019-03-28 大日本住友製薬株式会社 化学活性化型水溶性プロドラッグ
CN120361207A (zh) * 2017-11-16 2025-07-25 特尔诺沃有限公司 用于治疗癌症的irs/stat3双重调节剂和抗pd-1/pd-l1抗体的组合
EP3501511A1 (en) * 2017-12-22 2019-06-26 Fundación Centro Nacional De Investigaciones Oncológicas Carlos III Means for preventing and treating brain metastasis
CN111542598B (zh) * 2017-12-28 2024-07-30 株式会社钟化 多能干细胞聚集抑制剂
CN107973788B (zh) * 2018-01-09 2021-07-09 沈阳药科大学 Bbi608衍生物及其制备与用途
CN111886237B (zh) * 2018-03-20 2025-02-07 住友制药株式会社 二氢色烯衍生物
PL3773537T3 (pl) * 2018-04-19 2022-05-23 Tvardi Therapeutics, Inc. Inhibitory stat3
WO2019232214A1 (en) 2018-05-31 2019-12-05 Boston Biomedical, Inc. Methods of using napabucasin
JPWO2020059705A1 (ja) * 2018-09-18 2021-08-30 株式会社ヤクルト本社 キノリンカルボキサミド誘導体を用いるがん併用療法
BR112021006898A2 (pt) 2018-10-12 2021-07-20 1Globe Biomedical Co., Ltd. nova solução de combinação para tratar câncer refratário à quimioterapia
CN109331004A (zh) * 2018-10-31 2019-02-15 南京先进生物材料与过程装备研究院有限公司 一种紫杉醇和二苯并[b,d]噻吩类STAT抑制剂甲磺酸盐A晶型联合用药物组合物
CN109288845A (zh) * 2018-10-31 2019-02-01 南京先进生物材料与过程装备研究院有限公司 一种咔唑类stat抑制剂马来酸盐晶型ii联合用药物组合物及其制备方法
CN109288847A (zh) * 2018-10-31 2019-02-01 南京先进生物材料与过程装备研究院有限公司 一种紫杉醇和咔唑类stat抑制剂甲磺酸盐晶型p联合用药物组合物
CN109223758A (zh) * 2018-10-31 2019-01-18 南京先进生物材料与过程装备研究院有限公司 一种紫杉醇和芴类stat3抑制剂联合用药物组合物
CN109172563A (zh) * 2018-10-31 2019-01-11 南京先进生物材料与过程装备研究院有限公司 一种噻吨酮类紫杉醇和stat3抑制剂联合用药物组合物
CN109200052A (zh) * 2018-10-31 2019-01-15 南京先进生物材料与过程装备研究院有限公司 一种紫杉醇和芴酮类stat3抑制剂联合用药物组合物
CN109966297A (zh) * 2018-10-31 2019-07-05 南京先进生物材料与过程装备研究院有限公司 一种紫杉醇和咔唑类stat抑制剂马来酸盐晶型i联合用药物组合物
CN109846888A (zh) * 2018-10-31 2019-06-07 南京先进生物材料与过程装备研究院有限公司 一种紫杉醇和吲哚类stat3抑制剂联合用药物组合物
CN109200044A (zh) * 2018-10-31 2019-01-15 南京先进生物材料与过程装备研究院有限公司 一种紫杉醇和二苯并[b,d]噻吩类STAT抑制剂酒石酸盐联合用药物组合物
CN109288846A (zh) * 2018-10-31 2019-02-01 南京先进生物材料与过程装备研究院有限公司 一种紫杉醇和咔唑类stat3抑制剂晶型a联合用药物组合物
CN109364252B (zh) * 2018-11-21 2021-09-28 南京大学 抑制ifn-i至arg1诱导通路在制备抗肿瘤药物组合物中的应用
EP3954374A4 (en) 2019-04-09 2023-05-03 Generos Biopharma Ltd. PHARMACEUTICAL COMBINATION OF PIMOZIDE AND METHOTREXATE AND ITS USE
US11564913B2 (en) 2019-05-03 2023-01-31 Children's Hospital Medical Center Compositions and methods for treating cancer
CN110218198B (zh) * 2019-05-22 2022-06-28 广州中医药大学(广州中医药研究院) 一种萘醌并三氮唑核心骨架衍生物化合物及其制备方法和应用
US20220315551A1 (en) * 2019-06-14 2022-10-06 Sumitomo Dainippon Pharma Co., Ltd. 2-ALKYLCARBONYL[2,3-b]FURAN-4,9-DIONE PRODUCTION METHOD AND PRODUCTION INTERMEDIATE THEREFOR
JP7287929B2 (ja) * 2019-09-25 2023-06-06 住友ファーマ株式会社 ジヒドロクロメン誘導体を含有する医薬
CA3159348A1 (en) * 2019-11-08 2021-05-14 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods for the treatment of cancers that have acquired resistance to kinase inhibitors
EP4061374A1 (en) * 2019-11-20 2022-09-28 Yale University Compounds, compositions, and methods for treating ischemia-reperfusion injury and/or lung injury
JP7674354B2 (ja) * 2019-12-05 2025-05-09 ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム 肝線維症および線維症に関連する他の疾患に対するエキソソームベースの療法
US12441707B2 (en) 2019-12-30 2025-10-14 Tyra Biosciences, Inc. Indazole compounds
WO2021185234A1 (zh) * 2020-03-16 2021-09-23 正大天晴药业集团股份有限公司 作为c-Met激酶抑制剂的化合物的联用药物组合物及其用途
US20230192601A1 (en) * 2020-05-11 2023-06-22 Purdue Research Foundation Scaled-up synthesis of lomustine under control flow conditions
CN114286684B (zh) * 2020-07-27 2024-01-05 华中科技大学 与stat3相关的疾病的预防和/或治疗
WO2022216930A1 (en) * 2021-04-08 2022-10-13 Virginia Commonwealth University Novel mda-9 antagonist with anti-metastatic potential
CN114591306B (zh) * 2022-03-03 2024-03-01 陕西中医药大学 一种1,2,4-三唑环的1,4萘醌类stat3抑制剂及其应用

Family Cites Families (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2472133A (en) * 1947-03-20 1949-06-07 Du Pont Thiophanthraquinone derivatives
SU1049490A1 (ru) 1982-05-18 1983-10-23 Ордена Трудового Красного Знамени Институт Химии Ан Мсср (3 @ ,9 @ ,9 @ )-6,6,9 @ -Триметилтранспергидронафто(2,1- @ )фуран,в качестве душистого компонента парфюмерной композиции
JPS616149A (ja) 1984-06-20 1986-01-11 Mitsubishi Electric Corp 無機絶縁体の製法
JPS63196576A (ja) * 1987-02-10 1988-08-15 Tetsuo Ikegawa フラルナフトキノン誘導体と制癌剤及びその製造方法
EP0309926A3 (de) 1987-09-29 1990-12-05 Siemens Aktiengesellschaft Verfahren zur Herstellung vollparametrisierbarer Schaltungen in integrierter Schaltkreistechnik
JPH01121284A (ja) 1987-11-06 1989-05-12 Eisai Co Ltd トコフェロール　ｎ，ｎ−ジアルキルアミノアルキルカルボン酸エステルの胆汁酸塩
EP0402192A1 (fr) 1989-05-31 1990-12-12 BODET, Jean Augustin Article en carton ou matière analogue et procédé de fabrication
JPH04139177A (ja) * 1989-12-28 1992-05-13 Dainippon Ink & Chem Inc フラルベンゾキノン誘導体及びその製造方法並びに制癌剤
EP0757292B1 (en) * 1990-07-10 1999-12-22 Canon Kabushiki Kaisha Electrophotographic photosensitive member
JP2942015B2 (ja) * 1990-07-10 1999-08-30 キヤノン株式会社 電子写真感光体およびそれを用いた電子写真装置
TW252136B (enExample) 1992-10-08 1995-07-21 Ciba Geigy
JP3598168B2 (ja) 1996-03-18 2004-12-08 独立行政法人 科学技術振興機構 抗ウイルス剤
JPH1121284A (ja) 1997-06-30 1999-01-26 Kotobuki:Kk フラノナフトキノン誘導体及びこれを含有する医薬
JPH1165141A (ja) * 1997-08-11 1999-03-05 Canon Inc 電子写真感光体、該電子写真感光体を有するプロセスカ−トリッジ及び電子写真装置
US6174913B1 (en) * 1998-06-05 2001-01-16 The University Of North Carolina At Chapel Hill Naphtho- and dihydrobenzo-thiophene derivatives as cytotoxic antitumor agents
JP2003525862A (ja) 1999-01-27 2003-09-02 ザ ユニヴァーシティー オブ サウス フロリダ ヒト癌の治療のためのｓｔａｔ３シグナル伝達の阻害
ES2333400T3 (es) 1999-04-01 2010-02-22 Hana Biosciences, Inc. Composiciones y procedimientos para tratar linfonas.
US6482943B1 (en) 1999-04-30 2002-11-19 Slil Biomedical Corporation Quinones as disease therapies
PT1206436E (pt) 1999-08-02 2004-12-31 Hoffmann La Roche Retinoides para o tratamento de enfisema
JP2001097860A (ja) 1999-09-29 2001-04-10 Japan Science & Technology Corp 抗薬剤耐性菌剤と抗クラミジア剤
UA75055C2 (uk) 1999-11-30 2006-03-15 Пфайзер Продактс Інк. Похідні бензоімідазолу, що використовуються як антипроліферативний засіб, фармацевтична композиція на їх основі
KR20010100194A (ko) 2000-03-13 2001-11-14 박호군 여러 가지 물질의 가용화용 조성물과 제형 및 그들의제조방법
AU2002307217A1 (en) 2001-03-28 2002-10-15 University Of South Florida Materials and methods for treatment of cancer and identification of anti-cancer compounds
GB0117696D0 (en) 2001-07-20 2001-09-12 Bradford Particle Design Plc Particle information
AU2002357012A1 (en) 2001-11-27 2003-06-10 Transform Pharmaceuticals, Inc. Oral pharmaceutical formulations comprising paclitaxel, derivatives and methods of administration thereof
CN1310652C (zh) 2001-11-29 2007-04-18 特拉科斯有限公司 用体外光提取法和/或凋亡细胞对被试者进行预治疗的方法
AU2003217961B2 (en) * 2002-03-08 2008-02-28 Signal Pharmaceuticals, Llc Combination therapy for treating, preventing or managing proliferative disorders and cancers
AU2003215524A1 (en) 2002-03-15 2003-09-29 Natimmune A/S Pharmaceutical compositions comprising mannose binding lectin
AU2002336473A1 (en) 2002-09-10 2004-04-30 Dabur Research Foundation Anti-cancer activity of carvedilol and its isomers
EP1551392A4 (en) * 2002-09-17 2006-09-20 Arqule Inc NEW LAPACHO COMPOUNDS AND APPLICATION METHOD THEREFOR
TWI335913B (en) 2002-11-15 2011-01-11 Vertex Pharma Diaminotriazoles useful as inhibitors of protein kinases
TWI323662B (en) 2002-11-15 2010-04-21 Telik Inc Combination cancer therapy with a gst-activated anticancer compound and another anticancer therapy
IS6633A (is) 2002-11-22 2004-05-23 Omega Farma Ehf. Samsetningar af fínasteríð töflum
EP2003196A3 (en) 2003-06-09 2009-01-07 The Regents of the University of Michigan Compositions and methods for treating and diagnosing cancer
ATE453653T1 (de) 2003-08-13 2010-01-15 Univ South Florida Platinkomplexe zur behandlung von tumoren
US20050049207A1 (en) * 2003-09-03 2005-03-03 Kaufmann Doug A. Method of treating and preventing cancer
WO2005033048A2 (en) * 2003-09-29 2005-04-14 The Johns Hopkins University Wnt pathway antagonists
PT1706133E (pt) 2003-12-02 2010-12-07 Cleveland Clinic Foundation Métodos para protecção contra radiação utilizando flagelina
DK1701941T3 (da) * 2003-12-11 2012-08-13 Univ Texas Forbindelser til behandling af sygdomme med celleproliferation
DE10359828A1 (de) 2003-12-12 2005-07-28 Zoser B. Dr.Rer.Nat. Salama CHP-Gemcitabin- Kombinationsmittel und ihre Verwendung als Antitumorwirkstoffe, insbesondere Antimetastasierungswirkstoffe
WO2005110477A2 (en) 2004-04-09 2005-11-24 University Of South Florida Combination therapies for cancer and proliferative angiopathies
JP2004224802A (ja) 2004-04-21 2004-08-12 Japan Science & Technology Agency 抗菌剤
CN101010316A (zh) * 2004-07-02 2007-08-01 艾科斯有限公司 用于抑制chk1的化合物
EP1781673B1 (en) * 2004-08-18 2009-10-21 AstraZeneca AB Selected fused heterocyclics and uses thereof
BRPI0517652A (pt) * 2004-11-08 2008-10-14 Baxter Healthcare Sa composições farmacêuticas nanoparticuladas de inibidores de tubulina, métodos para as suas preparações e respectivos usos
BRPI0517887A (pt) * 2004-11-24 2008-10-21 Novartis Ag combinações de inibidores de jaks
WO2006071812A2 (en) 2004-12-23 2006-07-06 H. Lee Moffitt Cancer Center And Research Institute Platinum iv complex inhibitor
WO2006091837A2 (en) * 2005-02-25 2006-08-31 The Regent Of The University Of Michigan Small molecule inhibitors of stat3 and the uses thereof
JP2006248978A (ja) 2005-03-10 2006-09-21 Mebiopharm Co Ltd 新規なリポソーム製剤
JP2006290871A (ja) 2005-03-16 2006-10-26 Taheebo Japan Kk 抗癌性を示す化合物およびその中間体ならびにそれらの製造方法
US20060252073A1 (en) * 2005-04-18 2006-11-09 Regents Of The University Of Michigan Compositions and methods for the treatment of cancer
JPWO2006126505A1 (ja) 2005-05-26 2008-12-25 国立大学法人 東京大学 Ｓｔａｔ機能阻害剤およびその応用
US8133692B2 (en) * 2005-07-20 2012-03-13 University Of South Florida Methods of predicting responsiveness to chemotherapeutic agents and selecting treatments
BRPI0617364A2 (pt) 2005-10-13 2011-07-26 Orchid Res Lab Ltd compostos heterocÍclicos como inibidores de pstat3/il-6
UA96139C2 (uk) * 2005-11-08 2011-10-10 Дженентек, Інк. Антитіло до нейропіліну-1 (nrp1)
AR057579A1 (es) * 2005-11-23 2007-12-05 Merck & Co Inc Compuestos espirociclicos como inhibidores de histona de acetilasa (hdac)
JP2007145680A (ja) 2005-11-30 2007-06-14 Idemitsu Kosan Co Ltd 水素発生材料および水素発生方法
US20090209494A1 (en) * 2005-12-24 2009-08-20 Christine Janet Martin 21-deoxymacbecin analogues useful as antitumor agents
CA2635209A1 (en) * 2006-01-12 2007-08-02 Merck & Co., Inc. Fluorinated arylamide derivatives
WO2007092620A2 (en) * 2006-02-09 2007-08-16 Macusight, Inc. Stable formulations, and methods of their preparation and use
WO2007100640A2 (en) * 2006-02-21 2007-09-07 The Regents Of The University Of Michigan Growth hormone receptor antagonist cancer treatment
EP1989187A4 (en) * 2006-02-24 2009-07-08 Merck Frosst Canada Ltd 2- (PHENYL OR HETEROCYCLYL) -1H-PHENANTHRO (9,10-D) IMIDAZOLE
US8779151B2 (en) 2006-03-31 2014-07-15 The Board Of Regents Of The University Of Texas System Orally bioavailable caffeic acid related anticancer drugs
US20070238770A1 (en) 2006-04-05 2007-10-11 Bristol-Myers Squibb Company Process for preparing novel crystalline forms of peliglitazar, novel stable forms produced therein and formulations
US8828451B2 (en) 2006-10-04 2014-09-09 University Of South Florida Akt sensitization of cancer cells
WO2008077062A2 (en) * 2006-12-19 2008-06-26 Board Of Regents, The University Of Texas System Suppression of stat3 reactivation after src kinase inhibition to treat cancer
JP4077863B1 (ja) 2007-05-31 2008-04-23 タヒボジャパン株式会社 抗癌活性を有する光学活性２−（１−ヒドロキシエチル）−５−ヒドロキシナフト［２，３−ｂ］フラン−４，９−ジオンの製法
EP3067054B1 (en) * 2007-09-10 2020-12-30 Boston Biomedical, Inc. Novel compositions and methods for cancer treatment
US20100298402A1 (en) 2007-11-06 2010-11-25 Orchid Research Laboratories Limited Stilbene derivatives as pstat3/il-6 inhibitors
AU2015218436B9 (en) 2010-03-19 2017-03-09 Boston Biomedical, Inc. Novel Methods For Targeting Cancer Stem Cells
CN104016951B (zh) 2010-03-19 2016-07-13 北京强新生物科技有限公司 靶向癌症干细胞的化合物和组合物
AU2011227023B2 (en) 2010-03-19 2015-05-28 Boston Biomedical, Inc. Novel methods for targeting cancer stem cells
BR112012023661A2 (pt) 2010-03-19 2020-11-24 Boston Biomedical, Inc. novos compostos e novas composições direcionadas a células-tronco cancerosas
WO2012119265A1 (en) 2011-03-04 2012-09-13 Zhoushan Haizhongzhou Xinsheng Pharmaceuticals Co., Ltd. NOVEL ESTERS OF 4,9-DIHYDROXY-NAPHTHO[2,3-b]FURANS FOR DISEASE THERAPIES
US8977803B2 (en) 2011-11-21 2015-03-10 Western Digital Technologies, Inc. Disk drive data caching using a multi-tiered memory
WO2013166618A1 (en) 2012-05-08 2013-11-14 Zhoushan Haizhongzhou Xinsheng Pharmaceuticals Co., Ltd. PRODRUGS OF 4,9-DIHYDROXY-NAPHTHO[2,3-b]FURANS FOR CIRCUMVENTING CANCER MULTIDRUG RESISTANCE
MX2015014181A (es) 2013-04-09 2016-05-24 Boston Biomedical Inc 2-acetilnafto [2,3-b]furano -4,9-diona para uso en el tratamiento del cáncer.
EA201792287A1 (ru) 2015-04-17 2018-03-30 Бостон Биомедикал, Инк. Способы лечения рака
JP2018511645A (ja) 2015-04-17 2018-04-26 ボストン バイオメディカル， インコーポレイテッド 癌を治療するための方法
WO2016168858A1 (en) 2015-04-17 2016-10-20 Boston Biomedical, Inc. Methods for treating cancer
MX2017013816A (es) 2015-04-27 2018-11-12 Boston Biomedical Inc Métodos para tratar el cáncer con un inhibidor de la vía de stat3 e inhibidor de cinasas.
JP2018521979A (ja) 2015-06-03 2018-08-09 ボストン バイオメディカル， インコーポレイテッド 癌の治療に使用するための癌幹細胞性阻害剤および免疫療法剤を含む組成物
US20190076392A1 (en) 2016-01-20 2019-03-14 Boston Biomedical, Inc. Methods for treating cancer
US10646464B2 (en) 2017-05-17 2020-05-12 Boston Biomedical, Inc. Methods for treating cancer

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