JP2019535720A5 - - Google Patents

Download PDF

Info

Publication number
JP2019535720A5
JP2019535720A5 JP2019526226A JP2019526226A JP2019535720A5 JP 2019535720 A5 JP2019535720 A5 JP 2019535720A5 JP 2019526226 A JP2019526226 A JP 2019526226A JP 2019526226 A JP2019526226 A JP 2019526226A JP 2019535720 A5 JP2019535720 A5 JP 2019535720A5
Authority
JP
Japan
Prior art keywords
cancer
alkyl
optionally substituted
group
compound according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2019526226A
Other languages
English (en)
Japanese (ja)
Other versions
JP7150712B2 (ja
JP2019535720A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2017/062166 external-priority patent/WO2018094148A1/en
Publication of JP2019535720A publication Critical patent/JP2019535720A/ja
Publication of JP2019535720A5 publication Critical patent/JP2019535720A5/ja
Application granted granted Critical
Publication of JP7150712B2 publication Critical patent/JP7150712B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2019526226A 2016-11-18 2017-11-17 Cd73媒介免疫抑制の阻害剤 Active JP7150712B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662424241P 2016-11-18 2016-11-18
US62/424,241 2016-11-18
PCT/US2017/062166 WO2018094148A1 (en) 2016-11-18 2017-11-17 Inhibitors of cd73-mediated immunosuppression

Publications (3)

Publication Number Publication Date
JP2019535720A JP2019535720A (ja) 2019-12-12
JP2019535720A5 true JP2019535720A5 (enExample) 2020-12-24
JP7150712B2 JP7150712B2 (ja) 2022-10-11

Family

ID=62145728

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2019526226A Active JP7150712B2 (ja) 2016-11-18 2017-11-17 Cd73媒介免疫抑制の阻害剤

Country Status (6)

Country Link
US (1) US11267845B2 (enExample)
EP (1) EP3541396A4 (enExample)
JP (1) JP7150712B2 (enExample)
CN (1) CN110022881B (enExample)
TW (1) TWI786072B (enExample)
WO (1) WO2018094148A1 (enExample)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110022881B (zh) 2016-11-18 2023-05-02 艾库斯生物科学有限公司 Cd73介导的免疫抑制的抑制剂
AU2018235092B2 (en) 2017-03-16 2024-09-19 Innate Pharma Compositions and methods for treating cancer
US11129841B2 (en) 2017-05-10 2021-09-28 Oric Pharmaceuticals, Inc. CD73 inhibitors
AU2018346447B2 (en) 2017-10-06 2025-06-19 Innate Pharma Restoration of T cell activity via the CD39/CD73 axis
US11377469B2 (en) 2017-11-03 2022-07-05 Oric Pharmaceuticals, Inc. CD73 inhibitors
WO2019173682A1 (en) 2018-03-09 2019-09-12 Arcus Biosciences, Inc. Parenterally administered immune enhancing drugs
CA3098493A1 (en) 2018-04-30 2019-11-07 Oric Pharmaceuticals, Inc. Cd73 inhibitors
TW202017569A (zh) 2018-05-31 2020-05-16 美商佩樂敦治療公司 用於抑制cd73之組合物及方法
TWI870353B (zh) 2018-06-18 2025-01-21 法商天賜製藥公司 用於治療癌症之組合物及方法
CN112638389A (zh) * 2018-08-28 2021-04-09 江苏恒瑞医药股份有限公司 Cd73抑制剂及其治疗用途
MX2021002878A (es) * 2018-09-11 2021-08-16 Risen Suzhou Pharma Tech Co Ltd Inhibidores de cd73 y usos farmaceuticos de los mismos.
US11530234B2 (en) 2018-09-11 2022-12-20 Risen (Suzhou) Pharma Tech Co., Ltd. CD73 inhibitors and pharmaceutical uses thereof
CN110885352B (zh) * 2018-09-11 2023-02-24 润佳(苏州)医药科技有限公司 Cd73抑制剂及其药学应用
US12673969B2 (en) 2018-09-11 2026-07-07 Risen (Suzhou) Pharma Tech Co., Ltd. CD73 inhibitors and pharmaceutical uses thereof
WO2020146795A1 (en) 2019-01-11 2020-07-16 Omeros Corporation Methods and compositions for treating cancer
WO2020151707A1 (zh) * 2019-01-22 2020-07-30 江苏恒瑞医药股份有限公司 一种新型的小分子cd73抑制剂、其制备方法及其在医药上的应用
ES3070946T3 (en) * 2019-03-12 2026-06-18 Arcus Biosciences Inc Treatment of an oncogenene driven cancer having a kras or egfr mutation by decreasing adenosine production or antagonizing adenosine activation
CA3135487A1 (en) 2019-03-29 2020-10-08 Arcus Biosciences, Inc. Treatment of cancer utilizing an identified adenosine fingerprint
US12544391B2 (en) 2019-07-16 2026-02-10 Oric Pharmaceuticals, Inc. CD73 inhibitors
CN116854758A (zh) 2019-10-30 2023-10-10 欧瑞克制药公司 Cd73抑制剂
CA3173831A1 (en) 2020-03-19 2021-09-23 Arcus Biosciences, Inc. Tetralin and tetrahydroquinoline compounds as inhibitors of hif-2alpha
TW202210514A (zh) 2020-06-02 2022-03-16 美商阿克思生物科學有限公司 針對tigit的抗體
CN116546990B (zh) * 2020-11-25 2026-05-26 润佳(苏州)医药科技有限公司 Cd73抑制剂及其药学应用
EP4341262A1 (en) 2021-05-21 2024-03-27 Arcus Biosciences, Inc. Axl inhibitor compounds
WO2022246177A1 (en) 2021-05-21 2022-11-24 Arcus Biosciences, Inc. Axl compounds
TW202325279A (zh) 2021-10-29 2023-07-01 美商阿克思生物科學有限公司 HIF-2α抑制劑及其使用方法
AU2023252914A1 (en) 2022-04-13 2024-10-17 Arcus Biosciences, Inc. Combination therapy for treating trop-2 expressing cancers
CN119156228A (zh) 2022-05-02 2024-12-17 艾库斯生物科学有限公司 抗tigit抗体及其用途
EP4541803A4 (en) * 2022-06-17 2025-10-01 Shanghai Senhui Medicine Co Ltd CYCLOPENTYLADENOSINE DERIVATIVE AND ITS PHARMACEUTICAL USE
EP4554680A1 (en) 2022-07-15 2025-05-21 Arcus Biosciences, Inc. Inhibitors of hpk1 and methods of use thereof
WO2024020034A1 (en) 2022-07-20 2024-01-25 Arcus Biosciences, Inc. Cbl-b inhibitors and methods of use thereof
TW202421150A (zh) 2022-09-14 2024-06-01 美商阿克思生物科學有限公司 艾魯美冷之分散體
EP4602041A1 (en) 2022-10-14 2025-08-20 Arcus Biosciences, Inc. Hpk1 inhibitors and methods of use thereof
EP4705292A1 (en) 2023-05-05 2026-03-11 Arcus Biosciences, Inc. Cbl-b inhibitors and methods of use thereof
CN116298323B (zh) * 2023-05-16 2023-08-22 南京联笃生物科技有限公司 一种用于诊断狼疮性肾炎的生物标志物及应用
WO2024243502A1 (en) 2023-05-25 2024-11-28 Arcus Biosciences, Inc. Cbl-b inhibitors and methods of use thereof
WO2025054339A1 (en) 2023-09-08 2025-03-13 Arcus Biosciences, Inc. Triazolopyridine compounds as inhibitors of kit
WO2025072330A1 (en) 2023-09-26 2025-04-03 Arcus Biosciences, Inc. Kit inhibitor compounds and methods of use thereof
EP4788432A1 (en) 2023-10-06 2026-08-12 Arcus Biosciences, Inc. Cbl-b inhibitors and methods of use thereof
US12384773B2 (en) 2023-11-02 2025-08-12 Arcus Biosciences, Inc. Thiazole compounds and methods of use thereof
WO2025119278A1 (zh) * 2023-12-07 2025-06-12 无锡和誉生物医药科技有限公司 一种cd73抑制剂药物组合物,其制备方法和应用
US20250230168A1 (en) 2023-12-22 2025-07-17 Gilead Sciences, Inc. Azaspiro wrn inhibitors
WO2025193759A1 (en) 2024-03-12 2025-09-18 Gilead Sciences, Inc. Solid forms of an azolopyrimidine compound
WO2025233264A1 (en) 2024-05-07 2025-11-13 Innate Pharma Use of cd73 blocking agents in combination with anti-cd20 x cd3 t cell engagers
WO2026006759A1 (en) 2024-06-28 2026-01-02 Arcus Biosciences, Inc. Pharmaceutical compositions, dosage forms, and methods of making and using same

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5646128A (en) * 1989-09-15 1997-07-08 Gensia, Inc. Methods for treating adenosine kinase related conditions
IL108523A0 (en) * 1993-02-03 1994-05-30 Gensia Inc Pharmaceutical compositions containing adenosine kinase inhibitors for preventing or treating conditions involving inflammatory responses and pain
US5569650A (en) * 1993-06-11 1996-10-29 Sloan-Kettering Institute For Cancer Research C-nucleoside isosters of analogs thereof and pharmaceutical compositions
AU4815197A (en) * 1996-10-09 1998-05-05 Pharmasset, Ltd. Tetraphosphonate bicyclic trisanhydrides
EP1860113A1 (en) * 2006-05-24 2007-11-28 Rheinische Friedrich-Wilhelms-Universität Bonn Ectonucleotidase inhibitors
US20110245088A1 (en) 2010-04-05 2011-10-06 National Tsing Hua University Amide-based solution-phase derived library and method for screening thereof
US9090697B2 (en) 2013-03-15 2015-07-28 Bayer Healthcare Llc Methods for treating bleeding disorders
EP3134411B1 (en) 2014-04-25 2021-06-30 Boehringer Ingelheim International GmbH Purine derivatives as cd73 inhibitors for the treatment of cancer
LT3399984T (lt) 2016-01-08 2023-11-10 Arcus Biosciences, Inc. 5'-nukleotidazės, ekto moduliatoriai ir jų panaudojimas
CN110022881B (zh) 2016-11-18 2023-05-02 艾库斯生物科学有限公司 Cd73介导的免疫抑制的抑制剂

Similar Documents

Publication Publication Date Title
JP2019529500A5 (enExample)
JP2017525753A5 (enExample)
JP2019501223A5 (enExample)
JP2017538678A5 (enExample)
IL295569A (en) Tetralin and tetrahydroquinoline compounds as inhibitors of hif-2alpha
JP2010539095A5 (enExample)
JP2020111618A5 (enExample)
JP2021167351A5 (enExample)
HRP20231155T1 (hr) Modulatori 5'-nukleotidaze, ecto i njihova uporaba
JP2017537080A5 (enExample)
JP2021531314A5 (enExample)
JP2020518627A5 (enExample)
RU2014110623A (ru) Пирролопиразиновые ингибиторы киназы
JP2017538677A5 (enExample)
RU2015143717A (ru) 2-Аминопиримидин-6-оны и аналоги, проявляющие противораковые и антипролиферативные действия
JP2020519664A5 (enExample)
JP2017509689A5 (enExample)
JP2024519188A5 (enExample)
RU2014121073A (ru) Бициклические соединения пиперазина
JP2019510810A5 (enExample)
JP2017530171A5 (enExample)
RU2018128334A (ru) Ингибиторы индоламин-2,3-диоксигеназы (ido)
JP2017528502A5 (enExample)
JP2016525135A5 (enExample)
HRP20210291T1 (hr) Imunoregulatorna sredstva