JP2019535720A5 - - Google Patents
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- JP2019535720A5 JP2019535720A5 JP2019526226A JP2019526226A JP2019535720A5 JP 2019535720 A5 JP2019535720 A5 JP 2019535720A5 JP 2019526226 A JP2019526226 A JP 2019526226A JP 2019526226 A JP2019526226 A JP 2019526226A JP 2019535720 A5 JP2019535720 A5 JP 2019535720A5
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- Prior art keywords
- cancer
- alkyl
- optionally substituted
- group
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662424241P | 2016-11-18 | 2016-11-18 | |
| US62/424,241 | 2016-11-18 | ||
| PCT/US2017/062166 WO2018094148A1 (en) | 2016-11-18 | 2017-11-17 | Inhibitors of cd73-mediated immunosuppression |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019535720A JP2019535720A (ja) | 2019-12-12 |
| JP2019535720A5 true JP2019535720A5 (enExample) | 2020-12-24 |
| JP7150712B2 JP7150712B2 (ja) | 2022-10-11 |
Family
ID=62145728
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019526226A Active JP7150712B2 (ja) | 2016-11-18 | 2017-11-17 | Ｃｄ７３媒介免疫抑制の阻害剤 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US11267845B2 (enExample) |
| EP (1) | EP3541396A4 (enExample) |
| JP (1) | JP7150712B2 (enExample) |
| CN (1) | CN110022881B (enExample) |
| TW (1) | TWI786072B (enExample) |
| WO (1) | WO2018094148A1 (enExample) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110022881B (zh) | 2016-11-18 | 2023-05-02 | 艾库斯生物科学有限公司 | Cd73介导的免疫抑制的抑制剂 |
| KR102584011B1 (ko) | 2017-03-16 | 2023-09-27 | 이나뜨 파르마 에스.에이. | 암 치료를 위한 조성물 및 방법 |
| US11129841B2 (en) | 2017-05-10 | 2021-09-28 | Oric Pharmaceuticals, Inc. | CD73 inhibitors |
| BR112020006809A2 (pt) | 2017-10-06 | 2020-10-06 | Innate Pharma | anticorpos, agente, uso, composto, composição farmacêutica, kits e composição ou uso |
| WO2019090111A1 (en) | 2017-11-03 | 2019-05-09 | Oric Pharmaceuticals, Inc. | Cd73 inhibitors |
| WO2019173682A1 (en) | 2018-03-09 | 2019-09-12 | Arcus Biosciences, Inc. | Parenterally administered immune enhancing drugs |
| WO2019213174A1 (en) | 2018-04-30 | 2019-11-07 | Oric Pharmaceuticals, Inc. | Cd73 inhibitors |
| TW202017569A (zh) | 2018-05-31 | 2020-05-16 | 美商佩樂敦治療公司 | 用於抑制cd73之組合物及方法 |
| PT3807316T (pt) | 2018-06-18 | 2024-07-29 | Innate Pharma | Composições e métodos para tratamento de cancro |
| CN112638389A (zh) * | 2018-08-28 | 2021-04-09 | 江苏恒瑞医药股份有限公司 | Cd73抑制剂及其治疗用途 |
| CN110885352B (zh) * | 2018-09-11 | 2023-02-24 | 润佳（苏州）医药科技有限公司 | Cd73抑制剂及其药学应用 |
| EP3849992A4 (en) * | 2018-09-11 | 2022-06-29 | Risen (Suzhou) Pharma Tech Co., Ltd. | Cd73 inhibitors and pharmaceutical uses thereof |
| US11530234B2 (en) | 2018-09-11 | 2022-12-20 | Risen (Suzhou) Pharma Tech Co., Ltd. | CD73 inhibitors and pharmaceutical uses thereof |
| JOP20210164A1 (ar) | 2019-01-11 | 2023-01-30 | Omeros Corp | طرق وتركيبات علاج السرطان |
| CN112955444B (zh) * | 2019-01-22 | 2023-12-12 | 江苏恒瑞医药股份有限公司 | 一种新型的小分子cd73抑制剂、其制备方法及其在医药上的应用 |
| CN113795267A (zh) * | 2019-03-12 | 2021-12-14 | 艾库斯生物科学有限公司 | 致癌基因驱动的癌症的治疗 |
| CN113874397A (zh) | 2019-03-29 | 2021-12-31 | 艾库斯生物科学有限公司 | 利用鉴定的腺苷指纹治疗癌症 |
| JP7557522B2 (ja) | 2019-07-16 | 2024-09-27 | オリック ファーマシューティカルズ，インク． | Ｃｄ７３阻害剤 |
| EP4051688B1 (en) * | 2019-10-30 | 2025-04-23 | Oric Pharmaceuticals, Inc. | Cd73 inhibitors |
| CN115298165B (zh) | 2020-03-19 | 2024-09-17 | 艾库斯生物科学有限公司 | 作为HIF-2α抑制剂的四氢化萘和四氢喹啉化合物 |
| CR20220611A (es) | 2020-06-02 | 2023-06-07 | Arcus Biosciences Inc | Anticuerpos anti-tigit |
| US20240226115A1 (en) | 2021-05-21 | 2024-07-11 | Arcus Biosciences, Inc. | Axl inhibitor compounds |
| JP2024521706A (ja) | 2021-05-21 | 2024-06-04 | アーカス バイオサイエンシーズ，インコーポレーテッド | Ａｘｌ化合物 |
| AU2022376961A1 (en) | 2021-10-29 | 2024-05-16 | Arcus Biosciences, Inc. | Inhibitors of hif-2alpha and methods of use thereof |
| AU2023252914A1 (en) | 2022-04-13 | 2024-10-17 | Arcus Biosciences, Inc. | Combination therapy for treating trop-2 expressing cancers |
| US20250179176A1 (en) | 2022-05-02 | 2025-06-05 | Arcus Biosciences, Inc. | Anti-tigit antibodies and uses of the same |
| JP2025520300A (ja) * | 2022-06-17 | 2025-07-03 | 上海森輝医薬有限公司 | シクロペンチルアデノシン誘導体及びその医薬的使用 |
| WO2024015251A1 (en) | 2022-07-15 | 2024-01-18 | Arcus Biosciences, Inc. | Inhibitors of hpk1 and methods of use thereof |
| EP4558501A1 (en) | 2022-07-20 | 2025-05-28 | Arcus Biosciences, Inc. | Cbl-b inhibitors and methods of use thereof |
| KR20250065402A (ko) | 2022-09-14 | 2025-05-12 | 아르커스 바이오사이언시즈 인코포레이티드 | 에트루마데난트 분산체 |
| WO2024081385A1 (en) | 2022-10-14 | 2024-04-18 | Arcus Biosciences, Inc. | Hpk1 inhibitors and methods of use thereof |
| WO2024233360A1 (en) | 2023-05-05 | 2024-11-14 | Arcus Biosciences, Inc. | Cbl-b inhibitors and methods of use thereof |
| CN116298323B (zh) * | 2023-05-16 | 2023-08-22 | 南京联笃生物科技有限公司 | 一种用于诊断狼疮性肾炎的生物标志物及应用 |
| US20250011318A1 (en) | 2023-05-25 | 2025-01-09 | Arcus Biosciences, Inc. | Cbl-b inhibitors and methods of use thereof |
| WO2025054339A1 (en) | 2023-09-08 | 2025-03-13 | Arcus Biosciences, Inc. | Triazolopyridine compounds as inhibitors of kit |
| WO2025072330A1 (en) | 2023-09-26 | 2025-04-03 | Arcus Biosciences, Inc. | Kit inhibitor compounds and methods of use thereof |
| WO2025076299A1 (en) | 2023-10-06 | 2025-04-10 | Arcus Biosciences, Inc. | Cbl-b inhibitors and methods of use thereof |
| US12384773B2 (en) | 2023-11-02 | 2025-08-12 | Arcus Biosciences, Inc. | Thiazole compounds and methods of use thereof |
| WO2025119278A1 (zh) * | 2023-12-07 | 2025-06-12 | 无锡和誉生物医药科技有限公司 | 一种cd73抑制剂药物组合物，其制备方法和应用 |
| WO2025137640A1 (en) | 2023-12-22 | 2025-06-26 | Gilead Sciences, Inc. | Azaspiro wrn inhibitors |
| WO2025193759A1 (en) | 2024-03-12 | 2025-09-18 | Gilead Sciences, Inc. | Solid forms of an azolopyrimidine compound |
| WO2025233264A1 (en) | 2024-05-07 | 2025-11-13 | Innate Pharma | Use of cd73 blocking agents in combination with anti-cd20 x cd3 t cell engagers |
| WO2026006759A1 (en) | 2024-06-28 | 2026-01-02 | Arcus Biosciences, Inc. | Pharmaceutical compositions, dosage forms, and methods of making and using same |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5646128A (en) * | 1989-09-15 | 1997-07-08 | Gensia, Inc. | Methods for treating adenosine kinase related conditions |
| IL108523A0 (en) | 1993-02-03 | 1994-05-30 | Gensia Inc | Pharmaceutical compositions containing adenosine kinase inhibitors for preventing or treating conditions involving inflammatory responses and pain |
| US5569650A (en) * | 1993-06-11 | 1996-10-29 | Sloan-Kettering Institute For Cancer Research | C-nucleoside isosters of analogs thereof and pharmaceutical compositions |
| KR100560182B1 (ko) * | 1996-10-09 | 2006-03-13 | 파마셋 인코포레이티드 | 비스포스포네이트 화합물 |
| EP1860113A1 (en) | 2006-05-24 | 2007-11-28 | Rheinische Friedrich-Wilhelms-Universität Bonn | Ectonucleotidase inhibitors |
| US20110245088A1 (en) * | 2010-04-05 | 2011-10-06 | National Tsing Hua University | Amide-based solution-phase derived library and method for screening thereof |
| US9090697B2 (en) | 2013-03-15 | 2015-07-28 | Bayer Healthcare Llc | Methods for treating bleeding disorders |
| EP3134411B1 (en) | 2014-04-25 | 2021-06-30 | Boehringer Ingelheim International GmbH | Purine derivatives as cd73 inhibitors for the treatment of cancer |
| CA3151595A1 (en) | 2016-01-08 | 2017-07-13 | Arcus Biosciences, Inc. | Modulators of 5'-nucleotidase, ecto and the use thereof |
| CN110022881B (zh) | 2016-11-18 | 2023-05-02 | 艾库斯生物科学有限公司 | Cd73介导的免疫抑制的抑制剂 |
-
2017
- 2017-11-17 CN CN201780071772.6A patent/CN110022881B/zh active Active
- 2017-11-17 TW TW106139852A patent/TWI786072B/zh active
- 2017-11-17 EP EP17871047.1A patent/EP3541396A4/en active Pending
- 2017-11-17 US US16/461,649 patent/US11267845B2/en active Active
- 2017-11-17 JP JP2019526226A patent/JP7150712B2/ja active Active
- 2017-11-17 WO PCT/US2017/062166 patent/WO2018094148A1/en not_active Ceased
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