JP2019529500A5 - - Google Patents

Download PDF

Info

Publication number
JP2019529500A5
JP2019529500A5 JP2019517777A JP2019517777A JP2019529500A5 JP 2019529500 A5 JP2019529500 A5 JP 2019529500A5 JP 2019517777 A JP2019517777 A JP 2019517777A JP 2019517777 A JP2019517777 A JP 2019517777A JP 2019529500 A5 JP2019529500 A5 JP 2019529500A5
Authority
JP
Japan
Prior art keywords
cancer
group
alkyl
compound according
optionally substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2019517777A
Other languages
English (en)
Japanese (ja)
Other versions
JP2019529500A (ja
JP7184761B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2017/054694 external-priority patent/WO2018067424A1/en
Publication of JP2019529500A publication Critical patent/JP2019529500A/ja
Publication of JP2019529500A5 publication Critical patent/JP2019529500A5/ja
Priority to JP2022158467A priority Critical patent/JP2022173493A/ja
Application granted granted Critical
Publication of JP7184761B2 publication Critical patent/JP7184761B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

JP2019517777A 2016-10-03 2017-10-02 アデノシン5’-ヌクレオチダーゼの阻害剤 Active JP7184761B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2022158467A JP2022173493A (ja) 2016-10-03 2022-09-30 アデノシン5’-ヌクレオチダーゼの阻害剤

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662403598P 2016-10-03 2016-10-03
US62/403,598 2016-10-03
PCT/US2017/054694 WO2018067424A1 (en) 2016-10-03 2017-10-02 Inhibitors of adenosine 5'-nucleotidase

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2022158467A Division JP2022173493A (ja) 2016-10-03 2022-09-30 アデノシン5’-ヌクレオチダーゼの阻害剤

Publications (3)

Publication Number Publication Date
JP2019529500A JP2019529500A (ja) 2019-10-17
JP2019529500A5 true JP2019529500A5 (enExample) 2021-04-15
JP7184761B2 JP7184761B2 (ja) 2022-12-06

Family

ID=61831914

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2019517777A Active JP7184761B2 (ja) 2016-10-03 2017-10-02 アデノシン5’-ヌクレオチダーゼの阻害剤
JP2022158467A Withdrawn JP2022173493A (ja) 2016-10-03 2022-09-30 アデノシン5’-ヌクレオチダーゼの阻害剤

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2022158467A Withdrawn JP2022173493A (ja) 2016-10-03 2022-09-30 アデノシン5’-ヌクレオチダーゼの阻害剤

Country Status (6)

Country Link
US (3) US11058704B2 (enExample)
EP (1) EP3518934A4 (enExample)
JP (2) JP7184761B2 (enExample)
CN (1) CN110049767B (enExample)
TW (1) TWI781960B (enExample)
WO (1) WO2018067424A1 (enExample)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3518934A4 (en) 2016-10-03 2020-06-24 Arcus Biosciences, Inc. Inhibitors of adenosine 5'-nucleotidase
EP3600273A4 (en) * 2017-03-31 2021-01-20 Peloton Therapeutics, Inc. CD73 INHIBITORS AND USES THEREOF
WO2018208980A1 (en) 2017-05-10 2018-11-15 Oric Pharmaceuticals, Inc. Cd73 inhibitors
US11377469B2 (en) 2017-11-03 2022-07-05 Oric Pharmaceuticals, Inc. CD73 inhibitors
CN111094317B (zh) * 2017-12-29 2023-03-31 上海和誉生物医药科技有限公司 一种具有cd73抑制活性的膦酸衍生物、其制备方法和应用
CN112004541A (zh) 2018-03-09 2020-11-27 艾库斯生物科学有限公司 肠道外给药的免疫增强药物
IL304348B2 (en) 2018-04-30 2024-08-01 Oric Pharmaceuticals Inc CD73 inhibitors
WO2019232319A1 (en) 2018-05-31 2019-12-05 Peloton Therapeutics, Inc. Compositions and methods for inhibiting cd73
CN112638389A (zh) * 2018-08-28 2021-04-09 江苏恒瑞医药股份有限公司 Cd73抑制剂及其治疗用途
MX2021008094A (es) 2019-01-11 2021-09-21 Omeros Corp Metodos y composiciones para el tratamiento del cancer.
CN112955444B (zh) * 2019-01-22 2023-12-12 江苏恒瑞医药股份有限公司 一种新型的小分子cd73抑制剂、其制备方法及其在医药上的应用
CN113795267A (zh) 2019-03-12 2021-12-14 艾库斯生物科学有限公司 致癌基因驱动的癌症的治疗
WO2020190073A1 (ko) * 2019-03-20 2020-09-24 한국화학연구원 신규한 아졸로피리미딘 헤테로고리 화합물을 유효 성분으로 함유하는 약제학적 조성물
WO2020205527A1 (en) * 2019-03-29 2020-10-08 Arcus Biosciences, Inc. Treatment of cancer utilizing an identified adenosine fingerprint
WO2020210970A1 (en) * 2019-04-16 2020-10-22 Bioardis Llc Imidazotriazine derivatives as cd73 inhibitors
TWI821559B (zh) * 2019-04-28 2023-11-11 大陸商上海和譽生物醫藥科技有限公司 一種cd73抑制劑,其製備方法和應用
US20220251134A1 (en) * 2019-06-14 2022-08-11 Southern Research Institute 2,4,7-substituted-7-deaza-2'-deoxy-2'-fluoroarabinosyl nucleoside and nucleotide pro-drugs and uses thereof
JP7557522B2 (ja) * 2019-07-16 2024-09-27 オリック ファーマシューティカルズ,インク. Cd73阻害剤
WO2021040356A1 (en) * 2019-08-23 2021-03-04 Kainos Medicine, Inc. C-nucleosides, c-nucleotides and their analogs, equivalents and prodrugs thereof for ectonucleotidase inhibition
PL4051688T3 (pl) * 2019-10-30 2025-09-22 Oric Pharmaceuticals, Inc. Inhibitory cd73
CN119118872A (zh) 2020-03-19 2024-12-13 艾库斯生物科学有限公司 作为HIF-2α抑制剂的四氢化萘和四氢喹啉化合物
MX2022015157A (es) 2020-06-02 2023-01-16 Arcus Biosciences Inc Anticuerpos para tigit.
WO2022246179A1 (en) 2021-05-21 2022-11-24 Arcus Biosciences, Inc. Axl inhibitor compounds
EP4341261A1 (en) 2021-05-21 2024-03-27 Arcus Biosciences, Inc. Axl compounds
WO2023077046A1 (en) 2021-10-29 2023-05-04 Arcus Biosciences, Inc. Inhibitors of hif-2alpha and methods of use thereof
JP2025512384A (ja) 2022-04-13 2025-04-17 ギリアード サイエンシーズ, インコーポレイテッド Trop-2発現がんを治療するための併用療法
AU2023264591A1 (en) 2022-05-02 2024-11-07 Arcus Biosciences, Inc. Anti-tigit antibodies and uses of the same
CN116768949B (zh) * 2022-07-12 2026-03-03 南京工业大学 一种基于3’-脱氧腺苷经化学修饰改性的具有抗癌效应的化合物
GB2627905B (en) * 2022-07-12 2025-06-25 Nanjing University Of Technology Cordycepin-based derivatized compound with anti-tumor effect
WO2024015251A1 (en) 2022-07-15 2024-01-18 Arcus Biosciences, Inc. Inhibitors of hpk1 and methods of use thereof
EP4558501A1 (en) 2022-07-20 2025-05-28 Arcus Biosciences, Inc. Cbl-b inhibitors and methods of use thereof
CN119768155A (zh) 2022-09-14 2025-04-04 艾库斯生物科学有限公司 依曲地南的分散体
EP4602041A1 (en) 2022-10-14 2025-08-20 Arcus Biosciences, Inc. Hpk1 inhibitors and methods of use thereof
EP4704829A2 (en) * 2023-04-26 2026-03-11 Lakewood Amedex, Inc. Substituted bicyclic heterocycle compounds, compositions, and uses thereof
WO2024233360A1 (en) 2023-05-05 2024-11-14 Arcus Biosciences, Inc. Cbl-b inhibitors and methods of use thereof
EP4720055A1 (en) 2023-05-25 2026-04-08 Arcus Biosciences, Inc. Cbl-b inhibitors and methods of use thereof
WO2025054339A1 (en) 2023-09-08 2025-03-13 Arcus Biosciences, Inc. Triazolopyridine compounds as inhibitors of kit
WO2025072330A1 (en) 2023-09-26 2025-04-03 Arcus Biosciences, Inc. Kit inhibitor compounds and methods of use thereof
US20260116868A1 (en) 2023-10-06 2026-04-30 Arcus Biosciences, Inc. Cbl-b inhibitors and methods of use thereof
TW202523302A (zh) 2023-11-02 2025-06-16 美商阿克思生物科學有限公司 噻唑化合物及其使用方法
WO2025113498A1 (zh) * 2023-12-01 2025-06-05 无锡和誉生物医药科技有限公司 一种cd73抑制剂碱式盐及其制备方法和应用
CN117562915A (zh) * 2023-12-05 2024-02-20 中国药科大学 一种腺苷衍生物在制备预防、缓解或治疗纤维化疾病的药物中的应用
WO2025137640A1 (en) 2023-12-22 2025-06-26 Gilead Sciences, Inc. Azaspiro wrn inhibitors
WO2025193759A1 (en) 2024-03-12 2025-09-18 Gilead Sciences, Inc. Solid forms of an azolopyrimidine compound
WO2026006759A1 (en) 2024-06-28 2026-01-02 Arcus Biosciences, Inc. Pharmaceutical compositions, dosage forms, and methods of making and using same
CN119552122B (zh) * 2025-01-27 2025-05-09 北京悦康科创医药科技股份有限公司 5'-磷酸酯修饰核苷及其制备方法与应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0468119A1 (en) * 1990-07-24 1992-01-29 Merrell Dow Pharmaceuticals Inc. Novel carbocyclic analogs of certain nucleosides
US6617439B1 (en) * 2000-06-09 2003-09-09 Bar-Ilan University C8-substituted purine nucleotide analogs
WO2004096233A2 (en) * 2003-04-25 2004-11-11 Gilead Sciences, Inc. Nucleoside phosphonate conjugates
MX2007006961A (es) * 2004-12-10 2007-10-04 Univ Emory Analogos nucleosidos de ciclobutilo 2' y 3'-sustituidos para el tratamiento de infeccciones virales y proliferacion celular anormal.
US20090156545A1 (en) 2005-04-01 2009-06-18 Hostetler Karl Y Substituted Phosphate Esters of Nucleoside Phosphonates
EP2021350B1 (en) * 2006-03-21 2016-12-21 Rheinische Friedrich-Wilhelms-Universität Bonn Phosphorylated a2a receptor agonists
CN101528260A (zh) * 2006-10-26 2009-09-09 协和发酵麒麟株式会社 肠易激综合症治疗剂
WO2008121261A2 (en) * 2007-03-28 2008-10-09 Vioquest Pharmaceuticals, Inc. Prodrugs of triciribin suitable for treatment of tumors and cancer
US8846896B2 (en) * 2012-03-21 2014-09-30 Alios Biopharma, Inc. Methods of preparing substituted nucleotide analogs
US9090697B2 (en) 2013-03-15 2015-07-28 Bayer Healthcare Llc Methods for treating bleeding disorders
MA39986A (fr) * 2014-04-25 2017-03-01 Vitae Pharmaceuticals Inc Dérivés de purine en tant qu'inhibiteurs de cd73 pour le traitement du cancer
EP3518934A4 (en) 2016-10-03 2020-06-24 Arcus Biosciences, Inc. Inhibitors of adenosine 5'-nucleotidase
EP3600273A4 (en) 2017-03-31 2021-01-20 Peloton Therapeutics, Inc. CD73 INHIBITORS AND USES THEREOF

Similar Documents

Publication Publication Date Title
JP2019529500A5 (enExample)
JP2019535720A5 (enExample)
JP2019501223A5 (enExample)
JP2020111618A5 (enExample)
JP2021531314A5 (enExample)
JP2023518286A5 (enExample)
JP2017525753A5 (enExample)
JP2010539095A5 (enExample)
JP2017538678A5 (enExample)
JP2020518627A5 (enExample)
JP2020519664A5 (enExample)
IL295569A (en) Tetralin and tetrahydroquinoline compounds as inhibitors of hif-2alpha
JP2017537080A5 (enExample)
JP2017538677A5 (enExample)
JP2022535120A5 (enExample)
JP2018138577A5 (enExample)
JP2021523112A5 (enExample)
JP2016523973A5 (enExample)
JP2017509689A5 (enExample)
RU2018128334A (ru) Ингибиторы индоламин-2,3-диоксигеназы (ido)
JP2019529444A5 (enExample)
RU2015143717A (ru) 2-Аминопиримидин-6-оны и аналоги, проявляющие противораковые и антипролиферативные действия
JP2016538344A5 (enExample)
JP2017511360A5 (enExample)
JP2016053042A5 (enExample)