JP2019529500A5 - - Google Patents

Download PDF

Info

Publication number
JP2019529500A5
JP2019529500A5 JP2019517777A JP2019517777A JP2019529500A5 JP 2019529500 A5 JP2019529500 A5 JP 2019529500A5 JP 2019517777 A JP2019517777 A JP 2019517777A JP 2019517777 A JP2019517777 A JP 2019517777A JP 2019529500 A5 JP2019529500 A5 JP 2019529500A5
Authority
JP
Japan
Prior art keywords
cancer
group
alkyl
compound according
optionally substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2019517777A
Other languages
English (en)
Japanese (ja)
Other versions
JP2019529500A (ja
JP7184761B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2017/054694 external-priority patent/WO2018067424A1/en
Publication of JP2019529500A publication Critical patent/JP2019529500A/ja
Publication of JP2019529500A5 publication Critical patent/JP2019529500A5/ja
Priority to JP2022158467A priority Critical patent/JP2022173493A/ja
Application granted granted Critical
Publication of JP7184761B2 publication Critical patent/JP7184761B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

JP2019517777A 2016-10-03 2017-10-02 アデノシン5’-ヌクレオチダーゼの阻害剤 Active JP7184761B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2022158467A JP2022173493A (ja) 2016-10-03 2022-09-30 アデノシン5’-ヌクレオチダーゼの阻害剤

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662403598P 2016-10-03 2016-10-03
US62/403,598 2016-10-03
PCT/US2017/054694 WO2018067424A1 (en) 2016-10-03 2017-10-02 Inhibitors of adenosine 5'-nucleotidase

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2022158467A Division JP2022173493A (ja) 2016-10-03 2022-09-30 アデノシン5’-ヌクレオチダーゼの阻害剤

Publications (3)

Publication Number Publication Date
JP2019529500A JP2019529500A (ja) 2019-10-17
JP2019529500A5 true JP2019529500A5 (enExample) 2021-04-15
JP7184761B2 JP7184761B2 (ja) 2022-12-06

Family

ID=61831914

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2019517777A Active JP7184761B2 (ja) 2016-10-03 2017-10-02 アデノシン5’-ヌクレオチダーゼの阻害剤
JP2022158467A Withdrawn JP2022173493A (ja) 2016-10-03 2022-09-30 アデノシン5’-ヌクレオチダーゼの阻害剤

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2022158467A Withdrawn JP2022173493A (ja) 2016-10-03 2022-09-30 アデノシン5’-ヌクレオチダーゼの阻害剤

Country Status (6)

Country Link
US (3) US11058704B2 (enExample)
EP (1) EP3518934A4 (enExample)
JP (2) JP7184761B2 (enExample)
CN (1) CN110049767B (enExample)
TW (1) TWI781960B (enExample)
WO (1) WO2018067424A1 (enExample)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11058704B2 (en) 2016-10-03 2021-07-13 Arcus Biosciences, Inc. Inhibitors of adenosine 5′-nucleotidase
US20200115404A1 (en) 2017-03-31 2020-04-16 Peloton Therapeutics, Inc. Cd73 inhibitors and uses thereof
US11129841B2 (en) 2017-05-10 2021-09-28 Oric Pharmaceuticals, Inc. CD73 inhibitors
US11377469B2 (en) 2017-11-03 2022-07-05 Oric Pharmaceuticals, Inc. CD73 inhibitors
WO2019129059A1 (zh) * 2017-12-29 2019-07-04 上海和誉生物医药科技有限公司 一种具有cd73抑制活性的膦酸衍生物、其制备方法和应用
AU2019231781B2 (en) * 2018-03-09 2025-02-13 Arcus Biosciences, Inc. Parenterally administered immune enhancing drugs
KR20210018255A (ko) * 2018-04-30 2021-02-17 오릭 파마슈티칼스, 인크. Cd73 억제제
EP3810109B1 (en) 2018-05-31 2024-08-07 Peloton Therapeutics, Inc. Compounds and compositions for inhibiting cd73
CN112638389A (zh) * 2018-08-28 2021-04-09 江苏恒瑞医药股份有限公司 Cd73抑制剂及其治疗用途
WO2020146795A1 (en) 2019-01-11 2020-07-16 Omeros Corporation Methods and compositions for treating cancer
CN112955444B (zh) * 2019-01-22 2023-12-12 江苏恒瑞医药股份有限公司 一种新型的小分子cd73抑制剂、其制备方法及其在医药上的应用
JP2022524559A (ja) 2019-03-12 2022-05-06 アーカス バイオサイエンシーズ,インコーポレーテッド がん遺伝子によって促進されるがんの処置
EP3939988A4 (en) * 2019-03-20 2022-08-24 Korea Research Institute of Chemical Technology Pharmaceutical composition comprising novel azolopyrimidine heterocyclic compound as active ingredient
CN113874397A (zh) * 2019-03-29 2021-12-31 艾库斯生物科学有限公司 利用鉴定的腺苷指纹治疗癌症
WO2020210970A1 (en) * 2019-04-16 2020-10-22 Bioardis Llc Imidazotriazine derivatives as cd73 inhibitors
TWI821559B (zh) 2019-04-28 2023-11-11 大陸商上海和譽生物醫藥科技有限公司 一種cd73抑制劑,其製備方法和應用
KR20220034780A (ko) 2019-06-14 2022-03-18 써던 리서취 인스티튜트 2,4,7-치환된-7-데아자-2'-데옥시-2'-플루오로아라비노실 뉴클레오사이드 및 뉴클레오타이드 전구약물 및 이의 용도
US20220331343A1 (en) * 2019-07-16 2022-10-20 Oric Pharmaceuticals, Inc. Cd73 inhibitors
WO2021040356A1 (en) * 2019-08-23 2021-03-04 Kainos Medicine, Inc. C-nucleosides, c-nucleotides and their analogs, equivalents and prodrugs thereof for ectonucleotidase inhibition
SI4051688T1 (sl) * 2019-10-30 2025-08-29 Oric Pharmaceuticals, Inc. Inhibitorji CD73
KR20220155593A (ko) 2020-03-19 2022-11-23 아르커스 바이오사이언시즈 인코포레이티드 Hif-2알파의 억제제로서의 테트랄린 및 테트라히드로퀴놀린 화합물
MX2022015157A (es) 2020-06-02 2023-01-16 Arcus Biosciences Inc Anticuerpos para tigit.
JP2024521712A (ja) 2021-05-21 2024-06-04 アーカス バイオサイエンシーズ,インコーポレーテッド Axl阻害化合物
TW202313602A (zh) 2021-05-21 2023-04-01 美商阿克思生物科學有限公司 Axl化合物
JP2024541969A (ja) 2021-10-29 2024-11-13 アーカス バイオサイエンシズ インコーポレイティド Hif-2アルファの阻害剤及びその使用方法
KR20250004779A (ko) 2022-04-13 2025-01-08 길리애드 사이언시즈, 인코포레이티드 Trop-2 발현 암을 치료하기 위한 병용 요법
US20250179176A1 (en) 2022-05-02 2025-06-05 Arcus Biosciences, Inc. Anti-tigit antibodies and uses of the same
JP7679129B2 (ja) * 2022-07-12 2025-05-19 南京工▲業▼大学 コルジセピンの誘導体化による抗腫瘍効果を有する化合物
CN115181148B (zh) * 2022-07-12 2023-07-14 南京工业大学 一种基于虫草素经衍生化具有抗肿瘤效应的化合物
US20240124490A1 (en) 2022-07-15 2024-04-18 Arcus Biosciences, Inc. Inhibitors of hpk1 and methods of use thereof
EP4558501A1 (en) 2022-07-20 2025-05-28 Arcus Biosciences, Inc. Cbl-b inhibitors and methods of use thereof
TW202421150A (zh) 2022-09-14 2024-06-01 美商阿克思生物科學有限公司 艾魯美冷之分散體
WO2024081385A1 (en) 2022-10-14 2024-04-18 Arcus Biosciences, Inc. Hpk1 inhibitors and methods of use thereof
WO2024226872A2 (en) * 2023-04-26 2024-10-31 Lakewood Amedex, Inc. Substituted bicyclic heterocycle compounds, compositions, and uses thereof
US20240425497A1 (en) 2023-05-05 2024-12-26 Arcus Biosciences, Inc. Cbl-b Inhibitors and Methods of Use Thereof
WO2024243502A1 (en) 2023-05-25 2024-11-28 Arcus Biosciences, Inc. Cbl-b inhibitors and methods of use thereof
WO2025054339A1 (en) 2023-09-08 2025-03-13 Arcus Biosciences, Inc. Triazolopyridine compounds as inhibitors of kit
WO2025072330A1 (en) 2023-09-26 2025-04-03 Arcus Biosciences, Inc. Kit inhibitor compounds and methods of use thereof
WO2025076299A1 (en) 2023-10-06 2025-04-10 Arcus Biosciences, Inc. Cbl-b inhibitors and methods of use thereof
WO2025096979A1 (en) 2023-11-02 2025-05-08 Arcus Biosciences, Inc. Thiazole compounds as kit inhibitors and methods of use thereof
WO2025113498A1 (zh) * 2023-12-01 2025-06-05 无锡和誉生物医药科技有限公司 一种cd73抑制剂碱式盐及其制备方法和应用
CN117562915A (zh) * 2023-12-05 2024-02-20 中国药科大学 一种腺苷衍生物在制备预防、缓解或治疗纤维化疾病的药物中的应用
US20250230168A1 (en) 2023-12-22 2025-07-17 Gilead Sciences, Inc. Azaspiro wrn inhibitors
WO2025193759A1 (en) 2024-03-12 2025-09-18 Gilead Sciences, Inc. Solid forms of an azolopyrimidine compound
CN119552122B (zh) * 2025-01-27 2025-05-09 北京悦康科创医药科技股份有限公司 5'-磷酸酯修饰核苷及其制备方法与应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0468119A1 (en) 1990-07-24 1992-01-29 Merrell Dow Pharmaceuticals Inc. Novel carbocyclic analogs of certain nucleosides
US6617439B1 (en) * 2000-06-09 2003-09-09 Bar-Ilan University C8-substituted purine nucleotide analogs
WO2004096233A2 (en) 2003-04-25 2004-11-11 Gilead Sciences, Inc. Nucleoside phosphonate conjugates
JP2008523098A (ja) * 2004-12-10 2008-07-03 エモリー・ユニバーシテイ ウィルス感染および異常細胞増殖の治療用の2′および3′−置換シクロブチルヌクレオシド類縁体
US20090156545A1 (en) * 2005-04-01 2009-06-18 Hostetler Karl Y Substituted Phosphate Esters of Nucleoside Phosphonates
WO2007107598A1 (en) * 2006-03-21 2007-09-27 Heinrich-Heine-Universität Düsseldorf Phosphorylated a2a receptor agonists
CN101528260A (zh) * 2006-10-26 2009-09-09 协和发酵麒麟株式会社 肠易激综合症治疗剂
WO2008121261A2 (en) * 2007-03-28 2008-10-09 Vioquest Pharmaceuticals, Inc. Prodrugs of triciribin suitable for treatment of tumors and cancer
EP2828278A4 (en) 2012-03-21 2015-12-09 Alios Biopharma Inc PROCESSES FOR PREPARING SUBSTITUTED NUCLEOTIDE ANALOGS
US9090697B2 (en) 2013-03-15 2015-07-28 Bayer Healthcare Llc Methods for treating bleeding disorders
WO2015164573A1 (en) 2014-04-25 2015-10-29 Vitae Pharmaceuticals, Inc. Purine derivatives as cd73 inhibitors for the treatment of cancer
US11058704B2 (en) 2016-10-03 2021-07-13 Arcus Biosciences, Inc. Inhibitors of adenosine 5′-nucleotidase
US20200115404A1 (en) * 2017-03-31 2020-04-16 Peloton Therapeutics, Inc. Cd73 inhibitors and uses thereof

Similar Documents

Publication Publication Date Title
JP2019529500A5 (enExample)
JP2019535720A5 (enExample)
JP2019501223A5 (enExample)
JP2020111618A5 (enExample)
JP2017525753A5 (enExample)
JP2021167351A5 (enExample)
JP2010539095A5 (enExample)
JP2017538678A5 (enExample)
JP2020519664A5 (enExample)
IL295569A (en) Tetralin and tetrahydroquinoline compounds as inhibitors of hif-2alpha
JP2017537080A5 (enExample)
JP2017538677A5 (enExample)
JPWO2020023846A5 (enExample)
JPWO2021188769A5 (enExample)
JP2016523973A5 (enExample)
JP2017509689A5 (enExample)
JP2016506916A5 (enExample)
JP2014193925A5 (enExample)
JP2019529444A5 (enExample)
JPWO2020102646A5 (enExample)
JP2016538344A5 (enExample)
RU2015143717A (ru) 2-Аминопиримидин-6-оны и аналоги, проявляющие противораковые и антипролиферативные действия
JP2017511360A5 (enExample)
JP2016053042A5 (enExample)
JP2017509586A5 (enExample)