JP2019510810A5 - - Google Patents
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- JP2019510810A5 JP2019510810A5 JP2018560739A JP2018560739A JP2019510810A5 JP 2019510810 A5 JP2019510810 A5 JP 2019510810A5 JP 2018560739 A JP2018560739 A JP 2018560739A JP 2018560739 A JP2018560739 A JP 2018560739A JP 2019510810 A5 JP2019510810 A5 JP 2019510810A5
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- JP
- Japan
- Prior art keywords
- substituted
- unsubstituted
- compound
- alkyl
- membered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims description 55
- 150000003839 salts Chemical class 0.000 claims description 22
- 229910052739 hydrogen Inorganic materials 0.000 claims description 16
- 239000001257 hydrogen Substances 0.000 claims description 16
- 150000002431 hydrogen Chemical class 0.000 claims description 12
- 239000008194 pharmaceutical composition Substances 0.000 claims description 9
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims description 6
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims description 6
- 206010028980 Neoplasm Diseases 0.000 claims description 6
- 125000003118 aryl group Chemical group 0.000 claims description 6
- 125000002618 bicyclic heterocycle group Chemical group 0.000 claims description 6
- 201000011510 cancer Diseases 0.000 claims description 6
- 229910052736 halogen Inorganic materials 0.000 claims description 6
- 150000002367 halogens Chemical class 0.000 claims description 6
- 125000000623 heterocyclic group Chemical group 0.000 claims description 6
- 125000002950 monocyclic group Chemical group 0.000 claims description 5
- 125000000081 (C5-C8) cycloalkenyl group Chemical group 0.000 claims description 4
- 208000035473 Communicable disease Diseases 0.000 claims description 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 4
- 238000011319 anticancer therapy Methods 0.000 claims description 4
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 4
- 125000001072 heteroaryl group Chemical group 0.000 claims description 4
- 208000015181 infectious disease Diseases 0.000 claims description 4
- 230000000840 anti-viral effect Effects 0.000 claims description 3
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 3
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 3
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims description 3
- 238000002560 therapeutic procedure Methods 0.000 claims description 3
- 125000005865 C2-C10alkynyl group Chemical group 0.000 claims description 2
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims description 2
- 208000006168 Ewing Sarcoma Diseases 0.000 claims description 2
- 206010017993 Gastrointestinal neoplasms Diseases 0.000 claims description 2
- 206010025323 Lymphomas Diseases 0.000 claims description 2
- 208000034578 Multiple myelomas Diseases 0.000 claims description 2
- 206010035226 Plasma cell myeloma Diseases 0.000 claims description 2
- 208000036142 Viral infection Diseases 0.000 claims description 2
- 239000002246 antineoplastic agent Substances 0.000 claims description 2
- 239000003443 antiviral agent Substances 0.000 claims description 2
- 125000004391 aryl sulfonyl group Chemical group 0.000 claims description 2
- 125000004104 aryloxy group Chemical group 0.000 claims description 2
- 210000000481 breast Anatomy 0.000 claims description 2
- 238000002659 cell therapy Methods 0.000 claims description 2
- 238000002512 chemotherapy Methods 0.000 claims description 2
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 2
- 208000024558 digestive system cancer Diseases 0.000 claims description 2
- 230000002357 endometrial effect Effects 0.000 claims description 2
- 201000010231 gastrointestinal system cancer Diseases 0.000 claims description 2
- 238000009169 immunotherapy Methods 0.000 claims description 2
- 208000032839 leukemia Diseases 0.000 claims description 2
- 201000007270 liver cancer Diseases 0.000 claims description 2
- 208000014018 liver neoplasm Diseases 0.000 claims description 2
- 210000004072 lung Anatomy 0.000 claims description 2
- 201000001441 melanoma Diseases 0.000 claims description 2
- 201000008968 osteosarcoma Diseases 0.000 claims description 2
- 230000002611 ovarian Effects 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 210000002307 prostate Anatomy 0.000 claims description 2
- 238000001959 radiotherapy Methods 0.000 claims description 2
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims description 2
- 238000001356 surgical procedure Methods 0.000 claims description 2
- 230000009385 viral infection Effects 0.000 claims description 2
- 229960004854 viral vaccine Drugs 0.000 claims description 2
- 210000004556 brain Anatomy 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 description 11
- 238000000034 method Methods 0.000 description 10
- 125000003545 alkoxy group Chemical group 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 208000003174 Brain Neoplasms Diseases 0.000 description 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 description 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662293219P | 2016-02-09 | 2016-02-09 | |
| US62/293,219 | 2016-02-09 | ||
| US201662362875P | 2016-07-15 | 2016-07-15 | |
| US62/362,875 | 2016-07-15 | ||
| PCT/US2017/017063 WO2017139414A1 (en) | 2016-02-09 | 2017-02-08 | Inhibitor of indoleamine-2,3-dioxygenase (ido) |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019510810A JP2019510810A (ja) | 2019-04-18 |
| JP2019510810A5 true JP2019510810A5 (enExample) | 2020-03-12 |
| JP6979036B2 JP6979036B2 (ja) | 2021-12-08 |
Family
ID=59563504
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018560739A Active JP6979036B2 (ja) | 2016-02-09 | 2017-02-08 | インドールアミン−２，３−ジオキシゲナーゼ（ｉｄｏ）阻害剤 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US10980807B2 (enExample) |
| EP (1) | EP3414224B1 (enExample) |
| JP (1) | JP6979036B2 (enExample) |
| KR (1) | KR102486298B1 (enExample) |
| CN (2) | CN113896685B (enExample) |
| AU (1) | AU2017217536A1 (enExample) |
| BR (1) | BR112018015413A2 (enExample) |
| CA (1) | CA3012133A1 (enExample) |
| MX (1) | MX2018009633A (enExample) |
| RU (1) | RU2018128334A (enExample) |
| WO (1) | WO2017139414A1 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018116108A1 (en) * | 2016-12-20 | 2018-06-28 | Glaxosmithkline Intellectual Property Development Limited | Modulators of indoleamine 2,3-dioxygenase |
| JP2020506895A (ja) | 2017-01-17 | 2020-03-05 | ボード オブ レジェンツ, ザ ユニバーシティ オブ テキサス システムBoard Of Regents, The University Of Texas System | インドールアミン２，３−ジオキシゲナーゼおよび／またはトリプトファンジオキシゲナーゼの阻害剤として有用な化合物 |
| CN110785408A (zh) * | 2017-06-28 | 2020-02-11 | 葛兰素史克知识产权开发有限公司 | 吲哚胺2,3-双加氧酶的调节剂 |
| WO2019027855A1 (en) * | 2017-08-02 | 2019-02-07 | Merck Sharp & Dohme Corp. | NOVEL SUBSTITUTED PHENYL COMPOUNDS AS INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE (IDO) |
| CN109422739B (zh) * | 2017-09-01 | 2022-07-12 | 药捷安康(南京)科技股份有限公司 | 氘代的吲哚胺2，3-双加氧酶抑制剂及其应用 |
| EP3694502B1 (en) * | 2017-10-09 | 2023-08-02 | Merck Sharp & Dohme LLC | Novel substituted cyclobutylbenzene compounds as indoleamine 2,3-dioxygenase (ido) inhibitors |
| WO2019074749A1 (en) | 2017-10-09 | 2019-04-18 | Merck Sharp & Dohme Corp. | NOVEL SUBSTITUTED CYCLOBUTYLPYRIMIDINE AND CYCLOBUTYLPYRIMIDINE COMPOUNDS AS INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE (IDO) |
| CN109836356B (zh) * | 2017-11-24 | 2022-03-08 | 沈阳化工研究院有限公司 | 一种芳甲醚衍生物及其应用 |
| US11447449B2 (en) | 2018-01-05 | 2022-09-20 | Bristol-Myers Squibb Company | Inhibitors of indoleamine 2,3-dioxygenase and methods of their use |
| HUE066783T2 (hu) | 2018-04-18 | 2024-09-28 | Constellation Pharmaceuticals Inc | Metil módosító enzimek modulátorai, ezek készítményei és alkalmazásuk |
| CN108715585A (zh) | 2018-04-23 | 2018-10-30 | 中国药科大学 | 苯基联三氮唑类mll1-wdr5蛋白-蛋白相互作用抑制剂 |
| WO2019226491A1 (en) | 2018-05-21 | 2019-11-28 | Constellation Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
| US11046649B2 (en) | 2018-07-17 | 2021-06-29 | Board Of Regents, The University Of Texas System | Compounds useful as inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan dioxygenase |
| CN109734674B (zh) * | 2019-02-26 | 2022-08-26 | 中国药科大学 | 苯胺类wdr5蛋白-蛋白相互作用抑制剂及其制法和用途 |
| WO2021102618A1 (en) * | 2019-11-25 | 2021-06-03 | InventisBio Co., Ltd. | Novel salts of indoleamine 2,3-dioxygenase inhibitors |
| CN111153846B (zh) * | 2020-01-17 | 2021-08-31 | 中国药科大学 | 吡咯类化合物、其制备方法和药物组合物与用途 |
| CN114369060B (zh) * | 2020-10-15 | 2023-11-03 | 杭州星鳌生物科技有限公司 | 吲哚胺2，3-双加氧酶抑制剂及其在制备抗肿瘤药物中的应用 |
| EP4052705A1 (en) | 2021-03-05 | 2022-09-07 | Universität Basel Vizerektorat Forschung | Compositions for the treatment of ebv associated diseases or conditions |
| US20240091202A1 (en) | 2021-03-05 | 2024-03-21 | Universität Basel | Compositions for the treatment of ebv associated diseases or conditions |
| CN115594655B (zh) * | 2022-09-16 | 2023-08-15 | 桂林医学院 | 色酮肟类衍生物及其制备方法和应用 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH520667A (de) | 1967-07-22 | 1972-03-31 | Merck Patent Gmbh | Verfahren zur Herstellung von Aminophenylessigsäuren |
| GR68102B (enExample) | 1978-08-08 | 1981-10-30 | Fujisawa Pharmaceutical Co | |
| DE4107857A1 (de) * | 1991-03-12 | 1992-09-17 | Thomae Gmbh Dr K | Cyclische harnstoffderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| US5852192A (en) * | 1992-03-11 | 1998-12-22 | Dr. Karl Thomae Gmbh | Cyclic urea derivatives, pharmaceutical compositions containing these compounds and processes for preparing them |
| AU2337097A (en) | 1996-03-29 | 1997-10-22 | G.D. Searle & Co. | Meta-substituted phenylene derivatives and their use as alphavbeta3 integrin antagonists or inhibitors |
| AU8270698A (en) | 1997-06-26 | 1999-01-19 | Eli Lilly And Company | Antithrombotic agents |
| CA2492593A1 (en) | 2002-07-15 | 2004-01-22 | Myriad Genetics, Inc. | Compounds, compositions, and methods employing same |
| JP2004203791A (ja) * | 2002-12-25 | 2004-07-22 | Dai Ichi Seiyaku Co Ltd | 芳香族化合物 |
| AU2004215359A1 (en) * | 2003-02-27 | 2004-09-10 | Abbott Laboratories | Heterocyclic kinase inhibitors |
| EA200501607A1 (ru) | 2003-04-14 | 2006-06-30 | ДЗЕ ИНСТИТЬЮТС ФОР ФАРМАСЬЮТИКАЛ ДИСКАВЕРИ, ЭлЭлСи | Замещённые фенилалкановые кислоты |
| GB0416508D0 (en) | 2004-07-23 | 2004-08-25 | Merck Sharp & Dohme | Therapeutic agents |
| CN101426774B (zh) * | 2006-04-19 | 2012-04-25 | 安斯泰来制药有限公司 | 唑类甲酰胺衍生物 |
| KR101251933B1 (ko) * | 2007-06-20 | 2013-04-09 | 미쓰비시 타나베 파마 코퍼레이션 | 신규한 말론산술폰아미드 유도체 및 그 의약 용도 |
| EP2393811A1 (en) * | 2009-02-04 | 2011-12-14 | Pfizer Inc. | 4-amino-7,8-dihydropyrido[4,3-d]pyrimidin-5(6h)-one derivatives |
| BRPI1011192A2 (pt) | 2009-05-07 | 2016-03-15 | Gruenenthal Gmbh | derivados de carboxamida e ureia aromáticas substituídas como ligantes de receptor de vaniloide, composição farmacêutica, uso e processo para preparação dos referidos derivados |
| WO2010138901A1 (en) | 2009-05-29 | 2010-12-02 | Biogen Idec Ma Inc | Carboxylic acid-containing compounds, derivatives thereof, and related methods of use |
| US9133123B2 (en) | 2010-04-23 | 2015-09-15 | Cytokinetics, Inc. | Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use |
| JP2013526546A (ja) | 2010-05-13 | 2013-06-24 | アムジエン・インコーポレーテツド | Ｐｄｅ１０阻害剤としてのヘテロアリ−ルオキシヘテロシクリル化合物 |
| WO2012176123A1 (en) | 2011-06-22 | 2012-12-27 | Novartis Ag | 3 - imidazolyl- indoles for the treatment of proliferative diseases |
| EP2970360A4 (en) | 2013-03-13 | 2017-02-22 | Dana-Farber Cancer Institute, Inc. | Ras inhibitors and uses thereof |
| MA38483A1 (fr) * | 2013-03-15 | 2018-02-28 | Bristol Myers Squibb Co | Inhibiteurs de l'ido |
| BR112015021999A8 (pt) | 2013-03-15 | 2019-12-03 | Bristol Myers Squibb Co | inibidores de indoleamina 2,3-dioxigenase (ido), seus usos, composição farmacêutica, e método para inibir a atiavidade de indoleamina 2,3-dioxigenase |
| WO2015006520A1 (en) | 2013-07-11 | 2015-01-15 | Bristol-Myers Squibb Company | Ido inhibitors |
| JP6461948B2 (ja) * | 2013-07-15 | 2019-01-30 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規５−置換ベンゾイミダゾリウム化合物 |
| WO2015121210A1 (en) * | 2014-02-11 | 2015-08-20 | Bayer Pharma Aktiengesellschaft | Benzimidazol-2-amines as midh1 inhibitors |
| CN106414429B (zh) * | 2014-06-03 | 2020-01-03 | 爱杜西亚药品有限公司 | 吡唑化合物及其作为t型钙通道阻断剂的用途 |
| EP3245202B1 (en) | 2015-01-12 | 2020-03-11 | Boehringer Ingelheim International GmbH | Tetrasubstituted benzimidazolium compounds useful in the treatment of respiratory diseases |
| CN107922353A (zh) * | 2015-06-26 | 2018-04-17 | 百时美施贵宝公司 | Ido抑制剂 |
-
2017
- 2017-02-08 EP EP17750724.1A patent/EP3414224B1/en active Active
- 2017-02-08 KR KR1020187025922A patent/KR102486298B1/ko active Active
- 2017-02-08 MX MX2018009633A patent/MX2018009633A/es unknown
- 2017-02-08 RU RU2018128334A patent/RU2018128334A/ru not_active Application Discontinuation
- 2017-02-08 WO PCT/US2017/017063 patent/WO2017139414A1/en not_active Ceased
- 2017-02-08 CA CA3012133A patent/CA3012133A1/en active Pending
- 2017-02-08 BR BR112018015413A patent/BR112018015413A2/pt not_active Application Discontinuation
- 2017-02-08 JP JP2018560739A patent/JP6979036B2/ja active Active
- 2017-02-08 CN CN202111190675.3A patent/CN113896685B/zh active Active
- 2017-02-08 CN CN201780009388.3A patent/CN109071423A/zh active Pending
- 2017-02-08 US US16/073,679 patent/US10980807B2/en active Active
- 2017-02-08 AU AU2017217536A patent/AU2017217536A1/en not_active Abandoned
-
2021
- 2021-02-25 US US17/185,278 patent/US20220054486A1/en not_active Abandoned
-
2023
- 2023-02-09 US US18/166,789 patent/US11969425B2/en active Active
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