JP2018504379A5 - - Google Patents
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- JP2018504379A5 JP2018504379A5 JP2017532682A JP2017532682A JP2018504379A5 JP 2018504379 A5 JP2018504379 A5 JP 2018504379A5 JP 2017532682 A JP2017532682 A JP 2017532682A JP 2017532682 A JP2017532682 A JP 2017532682A JP 2018504379 A5 JP2018504379 A5 JP 2018504379A5
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- JP
- Japan
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- alkyl
- hydrogen
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- independently selected
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000001257 hydrogen Substances 0.000 claims 26
- 229910052739 hydrogen Inorganic materials 0.000 claims 26
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical group C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims 25
- 125000005843 halogen group Chemical group 0.000 claims 21
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 18
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 14
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 13
- 239000008194 pharmaceutical composition Substances 0.000 claims 13
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims 12
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims 12
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 12
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 12
- 150000003839 salts Chemical class 0.000 claims 10
- -1 amino, hydroxy Chemical group 0.000 claims 9
- 150000001875 compounds Chemical class 0.000 claims 8
- 125000004429 atom Chemical group 0.000 claims 7
- HONIICLYMWZJFZ-UHFFFAOYSA-N azetidine Chemical compound C1CNC1 HONIICLYMWZJFZ-UHFFFAOYSA-N 0.000 claims 7
- 125000004093 cyano group Chemical group *C#N 0.000 claims 7
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 6
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 6
- 150000002431 hydrogen Chemical group 0.000 claims 5
- OGYGFUAIIOPWQD-UHFFFAOYSA-N 1,3-thiazolidine Chemical compound C1CSCN1 OGYGFUAIIOPWQD-UHFFFAOYSA-N 0.000 claims 3
- 125000003275 alpha amino acid group Chemical group 0.000 claims 3
- 150000003851 azoles Chemical class 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 3
- 125000001041 indolyl group Chemical group 0.000 claims 3
- 208000035473 Communicable disease Diseases 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 241000700605 Viruses Species 0.000 claims 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 2
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 230000028993 immune response Effects 0.000 claims 2
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 2
- 102000008096 B7-H1 Antigen Human genes 0.000 claims 1
- 108010074708 B7-H1 Antigen Proteins 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 201000009030 Carcinoma Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- 206010017993 Gastrointestinal neoplasms Diseases 0.000 claims 1
- 208000005176 Hepatitis C Diseases 0.000 claims 1
- 101000914484 Homo sapiens T-lymphocyte activation antigen CD80 Proteins 0.000 claims 1
- 101000669402 Homo sapiens Toll-like receptor 7 Proteins 0.000 claims 1
- 206010027476 Metastases Diseases 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 1
- 206010040070 Septic Shock Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 102100027222 T-lymphocyte activation antigen CD80 Human genes 0.000 claims 1
- 229940124614 TLR 8 agonist Drugs 0.000 claims 1
- 102100039390 Toll-like receptor 7 Human genes 0.000 claims 1
- 239000003443 antiviral agent Substances 0.000 claims 1
- 239000003899 bactericide agent Substances 0.000 claims 1
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims 1
- 230000000903 blocking effect Effects 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 239000002254 cytotoxic agent Substances 0.000 claims 1
- 231100000599 cytotoxic agent Toxicity 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 210000000981 epithelium Anatomy 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 230000002496 gastric effect Effects 0.000 claims 1
- 230000012010 growth Effects 0.000 claims 1
- 208000019691 hematopoietic and lymphoid cell neoplasm Diseases 0.000 claims 1
- 208000005252 hepatitis A Diseases 0.000 claims 1
- 208000002672 hepatitis B Diseases 0.000 claims 1
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims 1
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 1
- 229940121372 histone deacetylase inhibitor Drugs 0.000 claims 1
- 239000003276 histone deacetylase inhibitor Substances 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 206010022000 influenza Diseases 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 201000008443 lung non-squamous non-small cell carcinoma Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 230000009401 metastasis Effects 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 239000003607 modifier Substances 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 125000003386 piperidinyl group Chemical group 0.000 claims 1
- 230000035755 proliferation Effects 0.000 claims 1
- 230000036303 septic shock Effects 0.000 claims 1
- 230000004936 stimulating effect Effects 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 125000003831 tetrazolyl group Chemical group 0.000 claims 1
- 229940044616 toll-like receptor 7 agonist Drugs 0.000 claims 1
- 241001529453 unidentified herpesvirus Species 0.000 claims 1
- 0 CCCC[C@@](C(N[C@@](CC(C)C)C(N[C@@](CSCC(N[C@@](Cc(cc1)ccc1O)C(N(C)[C@@](C)C(N[C@@](CC(N)=O)C(N(CCC1)[C@@]1C(N[C@](C1)C(N[C@@](CCC(O)=O)C(N(C[C@@](C2)O)[C@@]2C(N[C@@](Cc2c[n]c3c2cccc3)C(N[C@@](CCN)C(N[C@@](Cc2c[n]c3c2cccc3)C(N(CCN)[C@]2C)=O)=O)=O)=O)=O)=*3C1=CN=C3)=O)=O)=O)=O)=O)C(NCC(N)=O)=O)=O)=O)N(C)C2=O Chemical compound CCCC[C@@](C(N[C@@](CC(C)C)C(N[C@@](CSCC(N[C@@](Cc(cc1)ccc1O)C(N(C)[C@@](C)C(N[C@@](CC(N)=O)C(N(CCC1)[C@@]1C(N[C@](C1)C(N[C@@](CCC(O)=O)C(N(C[C@@](C2)O)[C@@]2C(N[C@@](Cc2c[n]c3c2cccc3)C(N[C@@](CCN)C(N[C@@](Cc2c[n]c3c2cccc3)C(N(CCN)[C@]2C)=O)=O)=O)=O)=O)=*3C1=CN=C3)=O)=O)=O)=O)=O)C(NCC(N)=O)=O)=O)=O)N(C)C2=O 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462094008P | 2014-12-18 | 2014-12-18 | |
| US62/094,008 | 2014-12-18 | ||
| PCT/US2015/065723 WO2016100285A1 (en) | 2014-12-18 | 2015-12-15 | Immunomodulators |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018504379A JP2018504379A (ja) | 2018-02-15 |
| JP2018504379A5 true JP2018504379A5 (enExample) | 2018-04-26 |
| JP6625129B2 JP6625129B2 (ja) | 2019-12-25 |
Family
ID=55071200
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017532682A Active JP6625129B2 (ja) | 2014-12-18 | 2015-12-15 | 免疫修飾因子 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US9861680B2 (enExample) |
| EP (1) | EP3233888B1 (enExample) |
| JP (1) | JP6625129B2 (enExample) |
| KR (1) | KR102602643B1 (enExample) |
| CN (1) | CN107108697B (enExample) |
| AR (1) | AR103093A1 (enExample) |
| AU (1) | AU2015362703A1 (enExample) |
| BR (1) | BR112017012679A2 (enExample) |
| CA (1) | CA2971189A1 (enExample) |
| EA (1) | EA033894B1 (enExample) |
| ES (1) | ES2940632T3 (enExample) |
| IL (1) | IL252853A0 (enExample) |
| MX (1) | MX2017007677A (enExample) |
| SG (1) | SG11201704823TA (enExample) |
| TW (1) | TW201629086A (enExample) |
| WO (1) | WO2016100285A1 (enExample) |
Families Citing this family (89)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2928474T3 (en) | 2012-12-07 | 2019-02-11 | Chemocentryx Inc | Diazollactamer |
| US10538555B2 (en) | 2014-09-11 | 2020-01-21 | Bristol-Myers Squibb Company | Macrocyclic inhibitors of the PD-1/PD-L1 and CD80(B7-1)/PD-L1 protein/protein interactions |
| US9732119B2 (en) | 2014-10-10 | 2017-08-15 | Bristol-Myers Squibb Company | Immunomodulators |
| US9856292B2 (en) | 2014-11-14 | 2018-01-02 | Bristol-Myers Squibb Company | Immunomodulators |
| US9944678B2 (en) | 2014-12-19 | 2018-04-17 | Bristol-Myers Squibb Company | Immunomodulators |
| US20160222060A1 (en) | 2015-02-04 | 2016-08-04 | Bristol-Myers Squibb Company | Immunomodulators |
| US9809625B2 (en) | 2015-03-18 | 2017-11-07 | Bristol-Myers Squibb Company | Immunomodulators |
| KR102622891B1 (ko) | 2015-05-21 | 2024-01-08 | 케모센트릭스, 인크. | Ccr2 조절제 |
| US10143746B2 (en) | 2016-03-04 | 2018-12-04 | Bristol-Myers Squibb Company | Immunomodulators |
| US10358463B2 (en) * | 2016-04-05 | 2019-07-23 | Bristol-Myers Squibb Company | Immunomodulators |
| RU2745195C2 (ru) | 2016-04-07 | 2021-03-22 | Кемосентрикс, Инк. | Уменьшение массы опухоли путем введения ccr1 антагонистов в комбинации с pd-1 ингибиторами или pd-l1 ингибиторами |
| TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療 |
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| LT3458111T (lt) | 2016-05-19 | 2021-05-25 | Bristol-Myers Squibb Company | Pet vizualizacijos imunomoduliatoriai |
| EP3514167B1 (en) * | 2016-09-13 | 2022-04-13 | Daiichi Sankyo Company, Limited | Thrombospondin 1-binding peptide |
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| EP3535280B1 (en) * | 2016-11-07 | 2022-03-16 | Bristol-Myers Squibb Company | Immunomodulators |
| EP3558395A4 (en) | 2016-12-23 | 2020-08-12 | The Johns Hopkins University | IMAGING OF TUMOR CELLS AND IMMUNE CELLS BASED ON PD-L1 EXPRESSION |
| WO2018232062A1 (en) * | 2017-06-15 | 2018-12-20 | University Of Washington | Macrocyclic polypeptides |
| US11066445B2 (en) * | 2017-06-23 | 2021-07-20 | Bristol-Myers Squibb Company | Immunomodulators acting as antagonists of PD-1 |
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2015
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- 2015-12-15 BR BR112017012679A patent/BR112017012679A2/pt not_active Application Discontinuation
- 2015-12-15 CN CN201580069483.3A patent/CN107108697B/zh active Active
- 2015-12-15 ES ES15820747T patent/ES2940632T3/es active Active
- 2015-12-15 SG SG11201704823TA patent/SG11201704823TA/en unknown
- 2015-12-15 WO PCT/US2015/065723 patent/WO2016100285A1/en not_active Ceased
- 2015-12-15 EP EP15820747.2A patent/EP3233888B1/en active Active
- 2015-12-15 MX MX2017007677A patent/MX2017007677A/es unknown
- 2015-12-15 KR KR1020177019417A patent/KR102602643B1/ko active Active
- 2015-12-15 AU AU2015362703A patent/AU2015362703A1/en not_active Abandoned
- 2015-12-15 EA EA201791231A patent/EA033894B1/ru not_active IP Right Cessation
- 2015-12-15 JP JP2017532682A patent/JP6625129B2/ja active Active
- 2015-12-15 CA CA2971189A patent/CA2971189A1/en not_active Abandoned
- 2015-12-17 TW TW104142534A patent/TW201629086A/zh unknown
- 2015-12-17 AR ARP150104168A patent/AR103093A1/es unknown
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2017
- 2017-06-12 IL IL252853A patent/IL252853A0/en unknown
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