|
US5851795A
(en)
|
1991-06-27 |
1998-12-22 |
Bristol-Myers Squibb Company |
Soluble CTLA4 molecules and uses thereof
|
|
US6825169B1
(en)
|
1991-10-22 |
2004-11-30 |
Trustees Of Tufts College |
Inhibitors of dipeptidyl-aminopeptidase type IV
|
|
FR2703251B3
(fr)
|
1993-03-31 |
1995-08-04 |
Vacsyn Sa |
Compositions pour l'application en thérapeutique humaine, caractérisées par l'association d'un muramyl-peptide à une cytokine .
|
|
US5855887A
(en)
|
1995-07-25 |
1999-01-05 |
The Regents Of The University Of California |
Blockade of lymphocyte down-regulation associated with CTLA-4 signaling
|
|
US5811097A
(en)
|
1995-07-25 |
1998-09-22 |
The Regents Of The University Of California |
Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling
|
|
US6051227A
(en)
|
1995-07-25 |
2000-04-18 |
The Regents Of The University Of California, Office Of Technology Transfer |
Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling
|
|
EP0970128A1
(en)
|
1997-03-21 |
2000-01-12 |
Brigham And Women's Hospital |
Immunotherapeutic ctla-4 binding peptides
|
|
US6979697B1
(en)
|
1998-08-21 |
2005-12-27 |
Point Therapeutics, Inc. |
Regulation of substrate activity
|
|
US6682736B1
(en)
|
1998-12-23 |
2004-01-27 |
Abgenix, Inc. |
Human monoclonal antibodies to CTLA-4
|
|
US7109003B2
(en)
|
1998-12-23 |
2006-09-19 |
Abgenix, Inc. |
Methods for expressing and recovering human monoclonal antibodies to CTLA-4
|
|
ES2706547T3
(es)
|
1998-12-23 |
2019-03-29 |
Pfizer |
Anticuerpos monoclonales humanos para CTLA-4
|
|
US6890904B1
(en)
|
1999-05-25 |
2005-05-10 |
Point Therapeutics, Inc. |
Anti-tumor agents
|
|
NZ517202A
(en)
|
1999-08-24 |
2004-05-28 |
Medarex Inc |
Human CTLA-4 antibodies and their uses
|
|
US7605238B2
(en)
|
1999-08-24 |
2009-10-20 |
Medarex, Inc. |
Human CTLA-4 antibodies and their uses
|
|
AU2001233027A1
(en)
|
2000-01-27 |
2001-08-07 |
Genetics Institute, Llc |
Antibodies against ctla4 (cd152), conjugates comprising same, and uses thereof
|
|
ATE524495T1
(de)
|
2001-07-31 |
2011-09-15 |
Ono Pharmaceutical Co |
Pd-1-spezifische substanz
|
|
NZ536420A
(en)
|
2002-04-12 |
2008-04-30 |
Medarex Inc |
Methods of treatment using CTLA-4 antibodies
|
|
ES2367430T3
(es)
|
2002-12-23 |
2011-11-03 |
Wyeth Llc |
Anticuerpos contra pd-1 y sus usos.
|
|
WO2006029219A2
(en)
|
2004-09-08 |
2006-03-16 |
Ohio State University Research Foundation |
Human monoclonal anti-ctla4 antibodies in cancer treatment
|
|
EP3530736A3
(en)
|
2005-05-09 |
2019-11-06 |
ONO Pharmaceutical Co., Ltd. |
Human monoclonal antibodies to programmed death 1 (pd-1) and methods for treating cancer using anti-pd-1 antibodies alone or in combination with other immunotherapeutics
|
|
KR101704734B1
(ko)
|
2005-07-01 |
2017-02-09 |
이. 알. 스퀴부 앤드 선즈, 엘.엘.씨. |
예정 사멸 리간드 1 (피디-엘1)에 대한 인간 모노클로날 항체
|
|
EP1909758A1
(en)
|
2005-08-02 |
2008-04-16 |
I.D.M. Immuno-Designed Molecules |
Process for the preparation of liposomal formulations
|
|
WO2007058957A2
(en)
|
2005-11-10 |
2007-05-24 |
Point Therapeutics, Inc |
Boroproline compound and cytokine combination therapy
|
|
WO2007059099A2
(en)
|
2005-11-14 |
2007-05-24 |
Point Therapeutics, Inc. |
Boroproline combination therapy for cancer
|
|
WO2007120368A2
(en)
|
2006-01-09 |
2007-10-25 |
The Regents Of The University Of California |
Immunostimulatory combinations for vaccine adjuvants
|
|
WO2007127204A2
(en)
*
|
2006-04-24 |
2007-11-08 |
Dara Biosciences, Inc. |
Methods and compositions relating to immunostimulation
|
|
WO2008033368A2
(en)
|
2006-09-12 |
2008-03-20 |
Dara Biosciences, Inc. |
Boroproline compound and cytokine combination therapy
|
|
WO2008066729A2
(en)
*
|
2006-11-22 |
2008-06-05 |
Dara Biosciences, Inc. |
Boronic acid containing compositions
|
|
WO2008070564A1
(en)
|
2006-12-01 |
2008-06-12 |
The Government Of The U.S.A, As Represented By The Secretary, Departmentof Health And Human Services |
Uses of muramyl dipeptide (mdp) for treating inflammation
|
|
PL2155248T3
(pl)
|
2007-04-12 |
2015-12-31 |
Brigham & Womens Hospital Inc |
Celowanie w ABCB5 w terapii nowotworowej
|
|
PT2170959E
(pt)
|
2007-06-18 |
2014-01-07 |
Merck Sharp & Dohme |
Anticorpos para o receptor humano de morte programada pd-1
|
|
US8449886B2
(en)
|
2008-01-08 |
2013-05-28 |
Bristol-Myers Squibb Company |
Combination of anti-CTLA4 antibody with tubulin modulating agents for the treatment of proliferative diseases
|
|
EA201500417A1
(ru)
|
2008-08-25 |
2015-11-30 |
Эмплиммьюн, Инк. |
Композиции антагонистов pd-1 и способы применения
|
|
AU2009290544B2
(en)
|
2008-09-12 |
2015-07-16 |
Oxford University Innovation Limited |
PD-1 specific antibodies and uses thereof
|
|
AU2009290543B2
(en)
|
2008-09-12 |
2015-09-03 |
Oxford University Innovation Limited |
PD-1 specific antibodies and uses thereof
|
|
WO2010036959A2
(en)
|
2008-09-26 |
2010-04-01 |
Dana-Farber Cancer Institute |
Human anti-pd-1, pd-l1, and pd-l2 antibodies and uses therefor
|
|
WO2010065711A1
(en)
|
2008-12-04 |
2010-06-10 |
Adimab, Inc. |
An abcb5 epitope and antibodies thereto for the treatment of cancer
|
|
MX356367B
(es)
|
2008-12-09 |
2018-05-25 |
Genentech Inc |
Anticuerpos anti-pd-l1 y su uso para mejorar la funcion de celulas t.
|
|
WO2010089411A2
(en)
|
2009-02-09 |
2010-08-12 |
Universite De La Mediterranee |
Pd-1 antibodies and pd-l1 antibodies and uses thereof
|
|
GB0903325D0
(en)
|
2009-02-26 |
2009-04-08 |
Univ Aberdeen |
Antibody molecules
|
|
EP3279215B1
(en)
|
2009-11-24 |
2020-02-12 |
MedImmune Limited |
Targeted binding agents against b7-h1
|
|
EP2504028A4
(en)
|
2009-11-24 |
2014-04-09 |
Amplimmune Inc |
SIMULTANEOUS INHIBITION OF PD-L1 / PD-L2
|
|
US20130022629A1
(en)
|
2010-01-04 |
2013-01-24 |
Sharpe Arlene H |
Modulators of Immunoinhibitory Receptor PD-1, and Methods of Use Thereof
|
|
US8993524B2
(en)
|
2010-03-05 |
2015-03-31 |
The Johns Hopkins University |
Compositions and methods for targeted immunomodulatory antibodies and fusion proteins
|
|
TW201134488A
(en)
|
2010-03-11 |
2011-10-16 |
Ucb Pharma Sa |
PD-1 antibodies
|
|
CN102892786B
(zh)
|
2010-03-11 |
2016-03-16 |
Ucb医药有限公司 |
Pd-1抗体
|
|
WO2011113019A2
(en)
|
2010-03-12 |
2011-09-15 |
Abbott Biotherapeutics Corp. |
Ctla4 proteins and their uses
|
|
US8907053B2
(en)
|
2010-06-25 |
2014-12-09 |
Aurigene Discovery Technologies Limited |
Immunosuppression modulating compounds
|
|
CN103261217B
(zh)
|
2010-11-11 |
2017-04-26 |
港大科桥有限公司 |
可溶性 pd‑1变体、融合构建体及其用途
|
|
GB201103955D0
(en)
|
2011-03-09 |
2011-04-20 |
Antitope Ltd |
Antibodies
|
|
BR112013025798A2
(pt)
|
2011-04-08 |
2016-12-20 |
Afraxis Holdings Inc |
8-etil-6-(aril)pirido[2,3-d]pirimidin-7(8h)-onas para o tratamento de câncer e distúrbios de sistema nervoso
|
|
BR112014002353B1
(pt)
|
2011-08-01 |
2022-09-27 |
Genentech, Inc |
Usos de antagonistas de ligação do eixo pd-1 e inibidores de mek, composições farmacêuticas, e kit
|
|
US9284337B2
(en)
*
|
2011-11-22 |
2016-03-15 |
Trustees Of Tufts College |
Small molecule enhancer for dendritic cell cancer vaccines
|
|
BR112014012819B1
(pt)
|
2011-11-28 |
2022-08-16 |
Merck Patent Gmbh |
Anticorpo anti-pd-l1 ou fragmento de ligação ao antígeno do mesmo e composição
|
|
US9856320B2
(en)
|
2012-05-15 |
2018-01-02 |
Bristol-Myers Squibb Company |
Cancer immunotherapy by disrupting PD-1/PD-L1 signaling
|
|
AR093984A1
(es)
|
2012-12-21 |
2015-07-01 |
Merck Sharp & Dohme |
Anticuerpos que se unen a ligando 1 de muerte programada (pd-l1) humano
|
|
US9376437B2
(en)
*
|
2013-03-13 |
2016-06-28 |
Oncoceutics, Inc |
7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one, salts thereof and methods of using the same in combination therapy
|
|
MX2015013163A
(es)
*
|
2013-03-15 |
2016-04-04 |
Zyngenia Inc |
Complejos multiespecificos multivalente y monovalentes y sus usos.
|
|
RS61400B1
(sr)
|
2013-05-02 |
2021-02-26 |
Anaptysbio Inc |
Antitela usmerena protiv programirane smrti-1 (pd-1)
|
|
CN104250302B
(zh)
|
2013-06-26 |
2017-11-14 |
上海君实生物医药科技股份有限公司 |
抗pd‑1抗体及其应用
|
|
SMT202300039T1
(it)
|
2013-09-13 |
2023-03-17 |
Beigene Switzerland Gmbh |
Anticorpi anti-pd1 e loro uso come terapia e per diagnostica
|
|
CN104558177B
(zh)
|
2013-10-25 |
2020-02-18 |
苏州思坦维生物技术股份有限公司 |
拮抗抑制程序性死亡受体pd-1与其配体结合的单克隆抗体及其编码序列与用途
|
|
EA201690912A1
(ru)
*
|
2013-11-05 |
2016-10-31 |
Когнейт Биосервисис, Инк. |
Комбинации ингибиторов контрольных точек и терапевтических средств для лечения рака
|
|
JP2016536361A
(ja)
*
|
2013-11-06 |
2016-11-24 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
Cd33抗体及び脱メチル剤を含む医薬配合物
|
|
MX2016007965A
(es)
|
2013-12-17 |
2016-10-28 |
Genentech Inc |
Terapia de combinacion que comprende agonistas de union a ox40 y antagonistas de union al eje pd-1.
|
|
AU2014368453B2
(en)
|
2013-12-20 |
2020-04-16 |
Intervet International B.V. |
Caninized murine anti-canine PD-1 antibodies
|
|
JP7060324B2
(ja)
*
|
2013-12-20 |
2022-04-26 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
ネオ抗原ワクチンによる併用療法
|
|
EA201990240A1
(ru)
|
2013-12-24 |
2019-06-28 |
Бристол-Маерс Сквибб Компани |
Новые трициклические соединения в качестве противораковых средств
|
|
TWI681969B
(zh)
|
2014-01-23 |
2020-01-11 |
美商再生元醫藥公司 |
針對pd-1的人類抗體
|
|
UA122479C2
(uk)
|
2014-01-24 |
2020-11-25 |
Дана-Фарбер Кенсер Інстітьют, Інк. |
Виділена молекула антитіла, яка зв’язується з людським білком програмованої смерті-1 (pd-1)
|
|
EA035259B1
(ru)
|
2014-02-14 |
2020-05-21 |
Иммьюн Дизайн Корп. |
Иммунотерапия рака с применением комбинации местной и системной иммунной стимуляции
|
|
PT3134123T
(pt)
|
2014-02-21 |
2021-03-22 |
Nektar Therapeutics India Pvt Ltd |
Agonistas seletivos de il-2rbeta em combinação com um anticorpo anti-ctla-4 ou um anticorpo anti-pd-1
|
|
CN105330740B
(zh)
|
2014-07-30 |
2018-08-17 |
珠海市丽珠单抗生物技术有限公司 |
抗pd-1抗体及其应用
|
|
WO2016019270A1
(en)
|
2014-07-31 |
2016-02-04 |
Academia Sinica |
An antagonistic pd-1 aptamer and its applications in cancer therapy related applications
|
|
EP3177640B1
(en)
|
2014-08-08 |
2020-05-06 |
The Board of Trustees of the Leland Stanford Junior University |
High affinity pd-1 agents and methods of use
|
|
RS63364B1
(sr)
*
|
2014-08-11 |
2022-07-29 |
Acerta Pharma Bv |
Terapeutske kombinacije btk inhibitora, pd-1 inhibitora i/ili pd-l1 inhibitora
|
|
JO3663B1
(ar)
*
|
2014-08-19 |
2020-08-27 |
Merck Sharp & Dohme |
الأجسام المضادة لمضاد lag3 وأجزاء ربط الأنتيجين
|
|
SG11201702401RA
(en)
|
2014-10-14 |
2017-04-27 |
Novartis Ag |
Antibody molecules to pd-l1 and uses thereof
|
|
EP3218409A2
(en)
|
2014-11-11 |
2017-09-20 |
Sutro Biopharma, Inc. |
Anti-pd-1 antibodies, compositions comprising anti-pd-1 antibodies and methods of using anti-pd-1 antibodies
|
|
US20160148513A1
(en)
|
2014-11-20 |
2016-05-26 |
Here Global B.V. |
Method and apparatus for providing line-of-sight obstruction notification for navigation
|
|
TWI595006B
(zh)
|
2014-12-09 |
2017-08-11 |
禮納特神經系統科學公司 |
抗pd-1抗體類和使用彼等之方法
|
|
CA2971734C
(en)
|
2014-12-22 |
2025-11-18 |
Pd-1 Acquisition Group, Llc |
Anti-pd-1 antibodies
|
|
CN104479020B
(zh)
|
2014-12-26 |
2019-08-02 |
上海复宏汉霖生物技术股份有限公司 |
一种抗pd-1人源抗体
|
|
CN114014930A
(zh)
|
2015-02-13 |
2022-02-08 |
索伦托药业有限公司 |
结合ctla4的抗体治疗剂
|
|
CN104761633B
(zh)
|
2015-03-25 |
2018-11-27 |
新乡学院 |
阻断猪pd-1/pd-l1通路的多肽及其应用
|
|
US20180134771A1
(en)
|
2015-05-07 |
2018-05-17 |
Bioxcel Corporation |
Novel immunomodulatory therapeutic strategies targeting tumors in cancer
|
|
EP3303397A1
(en)
|
2015-06-08 |
2018-04-11 |
H. Hoffnabb-La Roche Ag |
Methods of treating cancer using anti-ox40 antibodies and pd-1 axis binding antagonists
|
|
CN105061597B
(zh)
|
2015-06-09 |
2016-04-27 |
北京东方百泰生物科技有限公司 |
一种抗pd-1的单克隆抗体及其获得方法
|
|
RU2766890C2
(ru)
|
2015-06-16 |
2022-03-16 |
Мерк Патент Гмбх |
Комбинированные способы лечения антагонистами pd-l1
|
|
CA2991628C
(en)
|
2015-07-16 |
2020-04-07 |
Bioxcel Therapeutics, Inc. |
A novel approach for treatment of cancer using immunomodulation
|
|
US11000521B2
(en)
|
2015-08-03 |
2021-05-11 |
Institut Pasteur |
Dipeptidylpeptidase 4 inhibition enhances lymphocyte trafficking, improving both naturally occurring tumor immunity and immunotherapy
|
|
CN108289912A
(zh)
|
2015-09-01 |
2018-07-17 |
先天肿瘤免疫公司 |
具有提高的免疫力或免疫抑制性细胞因子抗性的免疫细胞及其用途
|
|
US10954300B2
(en)
|
2015-09-28 |
2021-03-23 |
The Trustees Of Columbia University In The City Of New York |
Use of pentoxifylline with immune checkpoint-blockade therapies for the treatment of melanoma
|
|
SG10201913573UA
(en)
|
2015-10-01 |
2020-03-30 |
Heat Biologics Inc |
Compositions and methods for adjoining type i and type ii extracellular domains as heterologous chimeric proteins
|
|
CN105175544B
(zh)
|
2015-10-20 |
2021-04-09 |
安徽瀚海博兴生物技术有限公司 |
一种抗pd-1人源化单克隆抗体及其应用
|
|
WO2017079303A1
(en)
|
2015-11-02 |
2017-05-11 |
The Cleveland Clinic Foundation |
Sequentially orchestrated immune checkpoint therapy for the treatment and prevention of cancer
|
|
EP3400291B2
(en)
|
2016-01-08 |
2024-02-28 |
Replimune Limited |
Engineered virus
|
|
US20190008918A1
(en)
|
2016-03-08 |
2019-01-10 |
Bioxcel Corporation |
Immunomodulation therapies for cancer
|
|
WO2018049027A1
(en)
|
2016-09-07 |
2018-03-15 |
Trustees Of Tufts College |
Combination therapies using immuno-dash inhibitors and pge2 antagonists
|
|
MX2019002946A
(es)
|
2016-09-14 |
2019-09-26 |
Abbvie Biotherapeutics Inc |
Anticuerpos anti-pd-1 y sus usos.
|
|
WO2018129497A1
(en)
|
2017-01-09 |
2018-07-12 |
Bioxcel Therapeutics, Inc. |
Predictive and diagnostic methods for prostate cancer
|
|
BR112020009363A2
(pt)
|
2017-11-13 |
2020-10-27 |
Bioxcel Therapeutics, Inc. |
métodos e composições para tratar câncer por modificação de múltiplos braços do sistema imunológico
|
|
TWI812820B
(zh)
|
2018-12-10 |
2023-08-21 |
美商百歐克斯賽爾治療公司 |
使用先天性免疫修飾劑及ox40促效劑治療疾病之組合療法
|
|
WO2020123496A1
(en)
|
2018-12-10 |
2020-06-18 |
Bioxcel Therapeutics, Inc. |
Novel approach for treatment of cancer using immunomodulation
|