JP2018521135A5 - - Google Patents
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- JP2018521135A5 JP2018521135A5 JP2018521501A JP2018521501A JP2018521135A5 JP 2018521135 A5 JP2018521135 A5 JP 2018521135A5 JP 2018521501 A JP2018521501 A JP 2018521501A JP 2018521501 A JP2018521501 A JP 2018521501A JP 2018521135 A5 JP2018521135 A5 JP 2018521135A5
- Authority
- JP
- Japan
- Prior art keywords
- composition according
- pharmaceutical composition
- cancer
- administered
- talabostat
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 claims 19
- 239000008194 pharmaceutical composition Substances 0.000 claims 16
- FKCMADOPPWWGNZ-YUMQZZPRSA-N [(2r)-1-[(2s)-2-amino-3-methylbutanoyl]pyrrolidin-2-yl]boronic acid Chemical compound CC(C)[C@H](N)C(=O)N1CCC[C@H]1B(O)O FKCMADOPPWWGNZ-YUMQZZPRSA-N 0.000 claims 6
- 229950010637 talabostat Drugs 0.000 claims 6
- 108010009573 talabostat Proteins 0.000 claims 6
- 229940076838 Immune checkpoint inhibitor Drugs 0.000 claims 5
- 108091008026 Inhibitory immune checkpoint proteins Proteins 0.000 claims 5
- 102000037984 Inhibitory immune checkpoint proteins Human genes 0.000 claims 5
- 239000012274 immune-checkpoint protein inhibitor Substances 0.000 claims 5
- 239000003826 tablet Substances 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 239000005557 antagonist Substances 0.000 claims 4
- 102000003779 Dipeptidyl-peptidases and tripeptidyl-peptidases Human genes 0.000 claims 3
- 108090000194 Dipeptidyl-peptidases and tripeptidyl-peptidases Proteins 0.000 claims 3
- 229940122344 Peptidase inhibitor Drugs 0.000 claims 3
- 239000002775 capsule Substances 0.000 claims 3
- 150000003384 small molecules Chemical group 0.000 claims 3
- 229940045513 CTLA4 antagonist Drugs 0.000 claims 2
- 238000013270 controlled release Methods 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229960005386 ipilimumab Drugs 0.000 claims 2
- 229960003301 nivolumab Drugs 0.000 claims 2
- 229960002621 pembrolizumab Drugs 0.000 claims 2
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- 229950007217 tremelimumab Drugs 0.000 claims 2
- 108010074708 B7-H1 Antigen Proteins 0.000 claims 1
- 102000008096 B7-H1 Antigen Human genes 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 101100407308 Mus musculus Pdcd1lg2 gene Proteins 0.000 claims 1
- 208000009277 Neuroectodermal Tumors Diseases 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 229940123751 PD-L1 antagonist Drugs 0.000 claims 1
- 229940121678 PD-L2 antagonist Drugs 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 108700030875 Programmed Cell Death 1 Ligand 2 Proteins 0.000 claims 1
- 102100024213 Programmed cell death 1 ligand 2 Human genes 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 108010003723 Single-Domain Antibodies Proteins 0.000 claims 1
- 108020004459 Small interfering RNA Proteins 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 208000003721 Triple Negative Breast Neoplasms Diseases 0.000 claims 1
- OXYYOEIGQRXGPI-WSZWBAFRSA-N [(2s)-1-[(2r)-2-boronopyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]azanium;methanesulfonate Chemical group CS(O)(=O)=O.CC(C)[C@H](N)C(=O)N1CCC[C@H]1B(O)O OXYYOEIGQRXGPI-WSZWBAFRSA-N 0.000 claims 1
- 210000001130 astrocyte Anatomy 0.000 claims 1
- 230000001363 autoimmune Effects 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 229950009791 durvalumab Drugs 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 208000005017 glioblastoma Diseases 0.000 claims 1
- 201000010536 head and neck cancer Diseases 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 201000005787 hematologic cancer Diseases 0.000 claims 1
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 claims 1
- 238000002513 implantation Methods 0.000 claims 1
- 238000007913 intrathecal administration Methods 0.000 claims 1
- 239000002502 liposome Substances 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 239000011859 microparticle Substances 0.000 claims 1
- 239000002105 nanoparticle Substances 0.000 claims 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 208000029340 primitive neuroectodermal tumor Diseases 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 229950007213 spartalizumab Drugs 0.000 claims 1
- 210000002784 stomach Anatomy 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 238000013268 sustained release Methods 0.000 claims 1
- 239000007939 sustained release tablet Substances 0.000 claims 1
- 239000012730 sustained-release form Substances 0.000 claims 1
- 208000022679 triple-negative breast carcinoma Diseases 0.000 claims 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
- -1 vaccines Proteins 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562193348P | 2015-07-16 | 2015-07-16 | |
| US62/193,348 | 2015-07-16 | ||
| US201562204495P | 2015-08-13 | 2015-08-13 | |
| US62/204,495 | 2015-08-13 | ||
| PCT/US2016/042798 WO2017011831A1 (en) | 2015-07-16 | 2016-07-18 | A novel approach for treatment of cancer using immunomodulation |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018521135A JP2018521135A (ja) | 2018-08-02 |
| JP2018521135A5 true JP2018521135A5 (enExample) | 2019-06-20 |
| JP7032311B2 JP7032311B2 (ja) | 2022-03-08 |
Family
ID=57757732
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018521501A Active JP7032311B2 (ja) | 2015-07-16 | 2016-07-18 | 免疫調節を使用してがんを処置するための新規手法 |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US11564986B2 (enExample) |
| EP (1) | EP3322448A4 (enExample) |
| JP (1) | JP7032311B2 (enExample) |
| KR (1) | KR20180036974A (enExample) |
| CN (3) | CN116059218A (enExample) |
| AU (3) | AU2016293674B2 (enExample) |
| BR (1) | BR112018000917A2 (enExample) |
| CA (1) | CA2991628C (enExample) |
| HK (1) | HK1248115A1 (enExample) |
| MA (1) | MA42459A (enExample) |
| MX (2) | MX2018000619A (enExample) |
| NZ (1) | NZ739503A (enExample) |
| RU (1) | RU2711380C2 (enExample) |
| WO (1) | WO2017011831A1 (enExample) |
| ZA (2) | ZA201800688B (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
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| EP3174538B1 (en) | 2014-08-01 | 2019-11-06 | 3M Innovative Properties Company | Methods and therapeutic combinations for treating tumors |
| JP7032311B2 (ja) | 2015-07-16 | 2022-03-08 | バイオエクセル セラピューティクス，インコーポレイテッド | 免疫調節を使用してがんを処置するための新規手法 |
| MX391382B (es) | 2015-12-24 | 2025-03-21 | Corvus Pharmaceuticals Inc | Métodos de tratamiento de cáncer |
| EP3509604A4 (en) * | 2016-09-07 | 2020-08-26 | Trustees of Tufts College | POLYTHERAPIES USING IMMUNO-DASH INHIBITORS AND PGE2 ANTAGONISTS |
| CA3039451A1 (en) * | 2016-10-06 | 2018-04-12 | Pfizer Inc. | Dosing regimen of avelumab for the treatment of cancer |
| EP3565560B1 (en) * | 2017-01-09 | 2024-05-29 | OnkosXcel Therapeutics, LLC | Predictive and diagnostic methods for prostate cancer |
| KR20190128692A (ko) * | 2017-03-28 | 2019-11-18 | 다이서나 파마수이티컬, 인크. | 면역요법을 강화시키기 위한 베타-카테닌 발현의 감소 |
| US11040040B2 (en) | 2017-04-04 | 2021-06-22 | Corvus Pharmaceuticals, Inc. | Methods of treating cancer |
| US11559537B2 (en) | 2017-04-07 | 2023-01-24 | Trustees Of Tufts College | Combination therapies using caspase-1 dependent anticancer agents and PGE2 antagonists |
| CA3082117A1 (en) * | 2017-11-13 | 2019-05-16 | Bioxcel Therapeutics, Inc. | Methods and compositions for treating cancer by modifying multiple arms of the immune system |
| AU2018386298B2 (en) * | 2017-12-15 | 2023-09-07 | Praxis Biotech LLC | Inhibitors of fibroblast activation protein |
| WO2019202473A1 (en) * | 2018-04-16 | 2019-10-24 | Université de Lausanne | Ucp2 inducing agents for the treatment of cancer resistant to immune checkpoint blockade |
| CN112789030A (zh) * | 2018-09-28 | 2021-05-11 | 卡尼姆盖德治疗学公司 | 肽抑制剂的药物制剂 |
| GB201819853D0 (en) * | 2018-12-05 | 2019-01-23 | Innovation Ulster Ltd | Therapy |
| TWI812820B (zh) * | 2018-12-10 | 2023-08-21 | 美商百歐克斯賽爾治療公司 | 使用先天性免疫修飾劑及ox40促效劑治療疾病之組合療法 |
| BR112021011205A2 (pt) * | 2018-12-10 | 2021-08-24 | Bioxcel Therapeutics, Inc. | Nova abordagem para tratamento de câncer usando imunomodulação |
| US11504364B2 (en) | 2018-12-21 | 2022-11-22 | Praxis Biotech LLC | Inhibitors of fibroblast activation protein |
| WO2020146384A1 (en) | 2019-01-07 | 2020-07-16 | Intra-Cellular Therapies, Inc. | Organic compounds |
| EP4099994A4 (en) * | 2020-02-07 | 2024-02-14 | OnkosXcel Therapeutics, LLC | Treatment regimen for cancer using immunomodulation |
| JP2023513306A (ja) * | 2020-02-14 | 2023-03-30 | バイオエクセル セラピューティクス，インコーポレイテッド | 激越の出現を検出及び防止するためのシステム及び方法 |
| AU2021233023A1 (en) * | 2020-03-13 | 2022-11-03 | The Board Of Regents Of The University Of Texas System | Sequential treatment of cancers using 6-thio-dg, checkpoint inhibitors and radiation therapy |
| EP4147053A1 (en) * | 2020-05-07 | 2023-03-15 | Institut Curie | Antxr1 as a biomarker of immunosuppressive fibroblast populations and its use for predicting response to immunotherapy |
| US20220257759A1 (en) * | 2021-02-17 | 2022-08-18 | Bioxcel Therapeutics, Inc. | Treatment of sarcoma using immunomodulation |
| TW202345857A (zh) * | 2022-03-08 | 2023-12-01 | 美商昂科斯克塞爾醫療有限責任公司 | 他波司他之穩定調配物 |
| WO2023173131A2 (en) * | 2022-03-11 | 2023-09-14 | Intra-Cellular Therapies, Inc. | Organic compounds |
| WO2024107832A2 (en) * | 2022-11-16 | 2024-05-23 | Onkosxcel Therapeutics, Llc | Treatment regimen for treating cancers |
| WO2024155790A2 (en) * | 2023-01-18 | 2024-07-25 | Onkosxcel Therapeutics, Llc | Novel approach for treatment of cancer using immunomodulation |
| WO2025076445A1 (en) * | 2023-10-04 | 2025-04-10 | Agenus Inc. | Anti-fap antibodies and methods of use thereof |
| CN117482249B (zh) * | 2023-11-28 | 2024-09-17 | 辽宁中医药大学 | 一种肝癌干细胞niche响应型逐级靶向脂质体及其应用 |
| CN117695397A (zh) * | 2024-02-06 | 2024-03-15 | 北京肿瘤医院(北京大学肿瘤医院) | 用于提高肿瘤靶向cldn18.2治疗疗效的药物 |
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2016
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- 2016-07-18 RU RU2018105985A patent/RU2711380C2/ru active
- 2016-07-18 BR BR112018000917A patent/BR112018000917A2/pt not_active Application Discontinuation
- 2016-07-18 EP EP16825310.2A patent/EP3322448A4/en active Pending
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2017
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