|
US5851795A
(en)
|
1991-06-27 |
1998-12-22 |
Bristol-Myers Squibb Company |
Soluble CTLA4 molecules and uses thereof
|
|
US6825169B1
(en)
|
1991-10-22 |
2004-11-30 |
Trustees Of Tufts College |
Inhibitors of dipeptidyl-aminopeptidase type IV
|
|
FR2703251B3
(fr)
|
1993-03-31 |
1995-08-04 |
Vacsyn Sa |
Compositions pour l'application en thérapeutique humaine, caractérisées par l'association d'un muramyl-peptide à une cytokine .
|
|
US5811097A
(en)
|
1995-07-25 |
1998-09-22 |
The Regents Of The University Of California |
Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling
|
|
US5855887A
(en)
|
1995-07-25 |
1999-01-05 |
The Regents Of The University Of California |
Blockade of lymphocyte down-regulation associated with CTLA-4 signaling
|
|
US6051227A
(en)
|
1995-07-25 |
2000-04-18 |
The Regents Of The University Of California, Office Of Technology Transfer |
Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling
|
|
WO1998042752A1
(en)
|
1997-03-21 |
1998-10-01 |
Brigham And Women's Hospital Inc. |
Immunotherapeutic ctla-4 binding peptides
|
|
US6979697B1
(en)
|
1998-08-21 |
2005-12-27 |
Point Therapeutics, Inc. |
Regulation of substrate activity
|
|
EE05627B1
(et)
|
1998-12-23 |
2013-02-15 |
Pfizer Inc. |
CTLA-4 vastased inimese monoklonaalsed antikehad
|
|
US7109003B2
(en)
|
1998-12-23 |
2006-09-19 |
Abgenix, Inc. |
Methods for expressing and recovering human monoclonal antibodies to CTLA-4
|
|
HRP20130077A2
(hr)
|
1998-12-23 |
2013-07-31 |
Pfizer Inc. |
Humana monoklonalna protutjela za ctla-4
|
|
US6890904B1
(en)
|
1999-05-25 |
2005-05-10 |
Point Therapeutics, Inc. |
Anti-tumor agents
|
|
CN102766210B
(zh)
|
1999-08-24 |
2015-07-08 |
E.R.施贵宝&圣斯有限责任公司 |
人ctla-4抗体及其应用
|
|
US7605238B2
(en)
|
1999-08-24 |
2009-10-20 |
Medarex, Inc. |
Human CTLA-4 antibodies and their uses
|
|
EP1261376A1
(en)
|
2000-01-27 |
2002-12-04 |
Genetics Institute, LLC |
Antibodies against ctla4(cd152), conjugates comprising same, and uses thereof
|
|
US20040241745A1
(en)
|
2001-07-31 |
2004-12-02 |
Tasuku Honjo |
Substance specific to pd-1
|
|
ES2384168T3
(es)
|
2002-04-12 |
2012-07-02 |
Medarex, Inc. |
Procedimientos de tratamiento usando anticuerpos CTLA-4
|
|
WO2004056875A1
(en)
|
2002-12-23 |
2004-07-08 |
Wyeth |
Antibodies against pd-1 and uses therefor
|
|
EP1793858A4
(en)
|
2004-09-08 |
2008-12-10 |
Univ Ohio State Res Found |
HUMAN MONOCLONAL ANTI-CTLA4 ANTIBODIES FOR CANCER TREATMENT
|
|
PL2161336T5
(pl)
|
2005-05-09 |
2017-10-31 |
Ono Pharmaceutical Co |
Ludzkie przeciwciała monoklonalne przeciwko białku Programmed Death 1 (PD-1) oraz sposoby leczenia raka z zastosowaniem samych przeciwciał anty-PD-1 lub w połączeniu z innymi środkami immunoterapeutycznymi
|
|
CA2612241C
(en)
|
2005-07-01 |
2018-11-06 |
Medarex, Inc. |
Human monoclonal antibodies to programmed death ligand 1 (pd-l1)
|
|
WO2007014754A1
(en)
|
2005-08-02 |
2007-02-08 |
I.D.M. Immuno-Designed Molecules |
Process for the preparation of liposomal formulations
|
|
WO2007058957A2
(en)
|
2005-11-10 |
2007-05-24 |
Point Therapeutics, Inc |
Boroproline compound and cytokine combination therapy
|
|
WO2007059099A2
(en)
|
2005-11-14 |
2007-05-24 |
Point Therapeutics, Inc. |
Boroproline combination therapy for cancer
|
|
US20090081157A1
(en)
|
2006-01-09 |
2009-03-26 |
Richard Syd Kornbluth |
Immunostimulatory Combinations for Vaccine Adjuvants
|
|
WO2007127204A2
(en)
*
|
2006-04-24 |
2007-11-08 |
Dara Biosciences, Inc. |
Methods and compositions relating to immunostimulation
|
|
WO2008033368A2
(en)
|
2006-09-12 |
2008-03-20 |
Dara Biosciences, Inc. |
Boroproline compound and cytokine combination therapy
|
|
WO2008066729A2
(en)
*
|
2006-11-22 |
2008-06-05 |
Dara Biosciences, Inc. |
Boronic acid containing compositions
|
|
US8603978B2
(en)
|
2006-12-01 |
2013-12-10 |
The United States of America, as represented by the Secretary, Department of Health and Humand Services |
Use of muramyl dipeptide (MDP) for treating inflammation
|
|
HUE039385T2
(hu)
|
2007-04-12 |
2018-12-28 |
Brigham & Womens Hospital Inc |
ABCB5 rákterápiás célzása
|
|
KR101586617B1
(ko)
|
2007-06-18 |
2016-01-20 |
머크 샤프 앤 도메 비.브이. |
사람 프로그램된 사멸 수용체 ｐｄ-1에 대한 항체
|
|
KR20100100949A
(ko)
|
2008-01-08 |
2010-09-15 |
브리스톨-마이어스 스큅 컴퍼니 |
증식성 질환의 치료를 위한 튜불린 조정제와 항-ｃｔｌａ４ 항체의 조합물
|
|
ES2545609T3
(es)
|
2008-08-25 |
2015-09-14 |
Amplimmune, Inc. |
Composiciones de antagonistas de PD-1 y métodos de uso
|
|
JP5794917B2
(ja)
|
2008-09-12 |
2015-10-14 |
アイシス・イノベーション・リミテッドＩｓｉｓ Ｉｎｎｏｖａｔｉｏｎｌｉｍｉｔｅｄ |
Ｐｄ−１特異抗体およびその使用
|
|
CA2736829C
(en)
|
2008-09-12 |
2018-02-27 |
Isis Innovation Limited |
Pd-1 specific antibodies and uses thereof
|
|
PL2342226T3
(pl)
|
2008-09-26 |
2017-01-31 |
Dana-Farber Cancer Institute, Inc. |
Ludzkie przeciwciała anty-PD-1, PD-L1 i PD-L2 oraz ich zastosowania
|
|
WO2010065711A1
(en)
|
2008-12-04 |
2010-06-10 |
Adimab, Inc. |
An abcb5 epitope and antibodies thereto for the treatment of cancer
|
|
EP4209510B1
(en)
|
2008-12-09 |
2024-01-31 |
F. Hoffmann-La Roche AG |
Anti-pd-l1 antibodies and their use to enhance t-cell function
|
|
EP3192811A1
(en)
|
2009-02-09 |
2017-07-19 |
Université d'Aix-Marseille |
Pd-1 antibodies and pd-l1 antibodies and uses thereof
|
|
GB0903325D0
(en)
|
2009-02-26 |
2009-04-08 |
Univ Aberdeen |
Antibody molecules
|
|
US20130017199A1
(en)
|
2009-11-24 |
2013-01-17 |
AMPLIMMUNE ,Inc. a corporation |
Simultaneous inhibition of pd-l1/pd-l2
|
|
NO2504364T3
(enExample)
|
2009-11-24 |
2018-01-06 |
|
|
|
WO2011082400A2
(en)
|
2010-01-04 |
2011-07-07 |
President And Fellows Of Harvard College |
Modulators of immunoinhibitory receptor pd-1, and methods of use thereof
|
|
PT2542590T
(pt)
|
2010-03-05 |
2017-08-31 |
Univ Johns Hopkins |
Composições e métodos para anticorpos e proteínas de fusão imunomoduladores direcionados
|
|
EP2545078A1
(en)
|
2010-03-11 |
2013-01-16 |
UCB Pharma, S.A. |
Pd-1 antibody
|
|
TW201134488A
(en)
|
2010-03-11 |
2011-10-16 |
Ucb Pharma Sa |
PD-1 antibodies
|
|
EP2545073B1
(en)
|
2010-03-12 |
2015-09-30 |
AbbVie Biotherapeutics Inc. |
Ctla4 proteins and their uses
|
|
US8907053B2
(en)
|
2010-06-25 |
2014-12-09 |
Aurigene Discovery Technologies Limited |
Immunosuppression modulating compounds
|
|
CN103261217B
(zh)
|
2010-11-11 |
2017-04-26 |
港大科桥有限公司 |
可溶性 pd‑1变体、融合构建体及其用途
|
|
GB201103955D0
(en)
|
2011-03-09 |
2011-04-20 |
Antitope Ltd |
Antibodies
|
|
JP2014513079A
(ja)
*
|
2011-04-08 |
2014-05-29 |
アフラクシス・ホールディングス・インコーポレイテッド |
神経系疾患及び癌の治療のための８−エチル−６−（アリール）ピリド［２，３−ｄ］ピリミジン−７（８ｈ）−オン
|
|
EP2739358B1
(en)
|
2011-08-01 |
2018-11-28 |
F.Hoffmann-La Roche Ag |
Methods of treating cancer using pd-1 axis binding antagonists and mek inhibitors
|
|
US9284337B2
(en)
|
2011-11-22 |
2016-03-15 |
Trustees Of Tufts College |
Small molecule enhancer for dendritic cell cancer vaccines
|
|
US9624298B2
(en)
|
2011-11-28 |
2017-04-18 |
Merck Patent Gmbh |
Anti-PD-L1 antibodies and uses thereof
|
|
AU2013263076B2
(en)
|
2012-05-15 |
2017-08-31 |
Bristol-Myers Squibb Company |
Cancer immunotherapy by disrupting PD-1/PD-L1 signaling
|
|
AR093984A1
(es)
|
2012-12-21 |
2015-07-01 |
Merck Sharp & Dohme |
Anticuerpos que se unen a ligando 1 de muerte programada (pd-l1) humano
|
|
US9376437B2
(en)
*
|
2013-03-13 |
2016-06-28 |
Oncoceutics, Inc |
7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one, salts thereof and methods of using the same in combination therapy
|
|
MX2015013163A
(es)
*
|
2013-03-15 |
2016-04-04 |
Zyngenia Inc |
Complejos multiespecificos multivalente y monovalentes y sus usos.
|
|
JP6742903B2
(ja)
|
2013-05-02 |
2020-08-19 |
アナプティスバイオ インコーポレイティッド |
プログラム死−１（ｐｄ−１）に対する抗体
|
|
CN104250302B
(zh)
|
2013-06-26 |
2017-11-14 |
上海君实生物医药科技股份有限公司 |
抗pd‑1抗体及其应用
|
|
LT3702373T
(lt)
|
2013-09-13 |
2022-11-10 |
Beigene Switzerland Gmbh |
Anti-pd1 antikūnai ir jų naudojimas terapijai ir diagnostikai
|
|
CN104558177B
(zh)
|
2013-10-25 |
2020-02-18 |
苏州思坦维生物技术股份有限公司 |
拮抗抑制程序性死亡受体pd-1与其配体结合的单克隆抗体及其编码序列与用途
|
|
IL292510A
(en)
*
|
2013-11-05 |
2022-06-01 |
Cognate Bioservices Inc |
Combinations of checkpoint inhibitors and therapeutics to treat cancer
|
|
WO2015067570A2
(en)
*
|
2013-11-06 |
2015-05-14 |
Boehringer Ingelheim International Gmbh |
Pharmaceutical combinations comprising cd33 antibodies and de-methylating agents
|
|
WO2015095423A2
(en)
|
2013-12-17 |
2015-06-25 |
Genentech, Inc. |
Combination therapy comprising ox40 binding agonists and pd-1 axis binding antagonists
|
|
NZ721908A
(en)
*
|
2013-12-20 |
2022-12-23 |
Massachusetts Gen Hospital |
Combination therapy with neoantigen vaccine
|
|
EP4124624A3
(en)
|
2013-12-20 |
2023-05-03 |
Intervet International B.V. |
Antibodies against canine pd-1
|
|
HUE054183T2
(hu)
*
|
2013-12-24 |
2021-08-30 |
Bristol Myers Squibb Co |
Triciklusos vegyület rákellenes szerekként
|
|
TWI681969B
(zh)
|
2014-01-23 |
2020-01-11 |
美商再生元醫藥公司 |
針對ｐｄ-１的人類抗體
|
|
CA2935423C
(en)
|
2014-01-24 |
2023-11-07 |
Dana-Farber Cancer Institute, Inc. |
Antibody molecules to pd-1 and uses thereof
|
|
WO2015123496A1
(en)
|
2014-02-14 |
2015-08-20 |
Immune Design Corp. |
Immunotherapy of cancer through combination of local and systemic immune stimulation
|
|
EP3834838A1
(en)
|
2014-02-21 |
2021-06-16 |
Nektar Therapeutics (India) Pvt. Ltd. |
Il-2rbeta-selective agonists in combination with an anti-pd-1 antibody
|
|
CN105330740B
(zh)
|
2014-07-30 |
2018-08-17 |
珠海市丽珠单抗生物技术有限公司 |
抗pd-1抗体及其应用
|
|
US10329570B2
(en)
|
2014-07-31 |
2019-06-25 |
Academia Sinica |
Antagonistic PD-1 aptamer and its applications in cancer therapy related applications
|
|
PL3177640T3
(pl)
|
2014-08-08 |
2020-11-02 |
The Board Of Trustees Of The Leland Stanford Junior University |
Charakteryzujące się wysokim powinowactwem środki terapeutyczne naśladujące PD-11 i sposoby ich wykorzystania
|
|
HRP20220738T1
(hr)
*
|
2014-08-11 |
2022-08-19 |
Acerta Pharma B.V. |
Terapijske kombinacije inhibitora btk, inhibitora pd-1 i/ili inhibitora pd-l1
|
|
JO3663B1
(ar)
*
|
2014-08-19 |
2020-08-27 |
Merck Sharp & Dohme |
الأجسام المضادة لمضاد lag3 وأجزاء ربط الأنتيجين
|
|
WO2016061142A1
(en)
|
2014-10-14 |
2016-04-21 |
Novartis Ag |
Antibody molecules to pd-l1 and uses thereof
|
|
WO2016077397A2
(en)
|
2014-11-11 |
2016-05-19 |
Sutro Biopharma, Inc. |
Anti-pd-1 antibodies, compositions comprising anti-pd-1 antibodies and methods of using anti-pd-1 antibodies
|
|
US20160148513A1
(en)
|
2014-11-20 |
2016-05-26 |
Here Global B.V. |
Method and apparatus for providing line-of-sight obstruction notification for navigation
|
|
TWI595006B
(zh)
|
2014-12-09 |
2017-08-11 |
禮納特神經系統科學公司 |
抗ｐｄ－１抗體類和使用彼等之方法
|
|
DK3237446T3
(en)
|
2014-12-22 |
2021-07-26 |
Pd 1 Acquisition Group Llc |
Anti-PD-1-antistoffer
|
|
CN104479020B
(zh)
|
2014-12-26 |
2019-08-02 |
上海复宏汉霖生物技术股份有限公司 |
一种抗pd-1人源抗体
|
|
CN108271359B
(zh)
|
2015-02-13 |
2021-11-09 |
索伦托药业有限公司 |
结合ctla4的抗体治疗剂
|
|
CN104761633B
(zh)
|
2015-03-25 |
2018-11-27 |
新乡学院 |
阻断猪pd-1/pd-l1通路的多肽及其应用
|
|
US20180134771A1
(en)
|
2015-05-07 |
2018-05-17 |
Bioxcel Corporation |
Novel immunomodulatory therapeutic strategies targeting tumors in cancer
|
|
HK1251474A1
(zh)
|
2015-06-08 |
2019-02-01 |
豪夫迈‧罗氏有限公司 |
使用抗ox40抗体和pd-1轴结合拮抗剂治疗癌症的方法
|
|
CN105061597B
(zh)
|
2015-06-09 |
2016-04-27 |
北京东方百泰生物科技有限公司 |
一种抗pd-1的单克隆抗体及其获得方法
|
|
RU2766890C2
(ru)
|
2015-06-16 |
2022-03-16 |
Мерк Патент Гмбх |
Комбинированные способы лечения антагонистами pd-l1
|
|
CN116059219A
(zh)
|
2015-07-16 |
2023-05-05 |
比奥克斯塞尔医疗股份有限公司 |
一种使用免疫调节治疗癌症的新颖方法
|
|
US11000521B2
(en)
|
2015-08-03 |
2021-05-11 |
Institut Pasteur |
Dipeptidylpeptidase 4 inhibition enhances lymphocyte trafficking, improving both naturally occurring tumor immunity and immunotherapy
|
|
EP3344262A4
(en)
|
2015-09-01 |
2019-03-20 |
Innate Tumor Immunity, Inc. |
IMMUNOCELLS WITH INCREASED IMMUNITY OR RESISTANCE TO AN IMMUNOSUPPRESSIVE CYTOKINE AND USE THEREOF
|
|
US10954300B2
(en)
|
2015-09-28 |
2021-03-23 |
The Trustees Of Columbia University In The City Of New York |
Use of pentoxifylline with immune checkpoint-blockade therapies for the treatment of melanoma
|
|
BR112018006578A2
(pt)
|
2015-10-01 |
2018-12-26 |
Heat Biologics, Inc. |
composições e métodos para juntar domínios extracelulares tipo i e tipo ii como proteínas quiméricas heterólogas
|
|
CN105175544B
(zh)
|
2015-10-20 |
2021-04-09 |
安徽瀚海博兴生物技术有限公司 |
一种抗pd-1人源化单克隆抗体及其应用
|
|
WO2017079303A1
(en)
|
2015-11-02 |
2017-05-11 |
The Cleveland Clinic Foundation |
Sequentially orchestrated immune checkpoint therapy for the treatment and prevention of cancer
|
|
WO2017118866A1
(en)
|
2016-01-08 |
2017-07-13 |
Replimune Limited |
Engineered virus
|
|
WO2017156152A1
(en)
|
2016-03-08 |
2017-09-14 |
Bioxcel Corporation |
Immunomodulation therapies for cancer
|
|
CN109906082A
(zh)
|
2016-09-07 |
2019-06-18 |
塔夫茨大学信托人 |
使用免疫dash抑制剂和pge2拮抗剂的组合治疗
|
|
HRP20201993T1
(hr)
|
2016-09-14 |
2021-02-05 |
Abbvie Biotherapeutics Inc. |
Protutijela protiv pd-1
|
|
ES2988845T3
(es)
|
2017-01-09 |
2024-11-21 |
Onkosxcel Therapeutics Llc |
Procedimientos predictivos y diagnósticos para cáncer de próstata
|
|
MX2020004914A
(es)
|
2017-11-13 |
2020-10-28 |
Bioxcel Therapeutics Inc |
Metodos y composiciones para tratar el cancer mediante la modificacion de multiples brazos del sistema inmunitario.
|
|
WO2020123477A1
(en)
|
2018-12-10 |
2020-06-18 |
Bioxcel Therapeutics, Inc. |
Combination therapies for treating disease using an innate immunity modifier and an ox40 agonist
|
|
BR112021011205A2
(pt)
|
2018-12-10 |
2021-08-24 |
Bioxcel Therapeutics, Inc. |
Nova abordagem para tratamento de câncer usando imunomodulação
|