JP7032311B2 - 免疫調節を使用してがんを処置するための新規手法 - Google Patents
免疫調節を使用してがんを処置するための新規手法 Download PDFInfo
- Publication number
- JP7032311B2 JP7032311B2 JP2018521501A JP2018521501A JP7032311B2 JP 7032311 B2 JP7032311 B2 JP 7032311B2 JP 2018521501 A JP2018521501 A JP 2018521501A JP 2018521501 A JP2018521501 A JP 2018521501A JP 7032311 B2 JP7032311 B2 JP 7032311B2
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- tarabostat
- pharmaceutical composition
- antagonist
- tumor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/69—Boron compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/31—Combination therapy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mycology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Physics & Mathematics (AREA)
- Virology (AREA)
- Plant Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562193348P | 2015-07-16 | 2015-07-16 | |
| US62/193,348 | 2015-07-16 | ||
| US201562204495P | 2015-08-13 | 2015-08-13 | |
| US62/204,495 | 2015-08-13 | ||
| PCT/US2016/042798 WO2017011831A1 (en) | 2015-07-16 | 2016-07-18 | A novel approach for treatment of cancer using immunomodulation |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018521135A JP2018521135A (ja) | 2018-08-02 |
| JP2018521135A5 JP2018521135A5 (enExample) | 2019-06-20 |
| JP7032311B2 true JP7032311B2 (ja) | 2022-03-08 |
Family
ID=57757732
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018521501A Active JP7032311B2 (ja) | 2015-07-16 | 2016-07-18 | 免疫調節を使用してがんを処置するための新規手法 |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US11564986B2 (enExample) |
| EP (1) | EP3322448A4 (enExample) |
| JP (1) | JP7032311B2 (enExample) |
| KR (1) | KR20180036974A (enExample) |
| CN (3) | CN116059218A (enExample) |
| AU (3) | AU2016293674B2 (enExample) |
| BR (1) | BR112018000917A2 (enExample) |
| CA (1) | CA2991628C (enExample) |
| HK (1) | HK1248115A1 (enExample) |
| MA (1) | MA42459A (enExample) |
| MX (2) | MX2018000619A (enExample) |
| NZ (1) | NZ739503A (enExample) |
| RU (1) | RU2711380C2 (enExample) |
| WO (1) | WO2017011831A1 (enExample) |
| ZA (2) | ZA201800688B (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9980956B2 (en) * | 2014-08-01 | 2018-05-29 | 3M Innovative Properties Company | Methods and therapeutic combinations for treating tumors |
| BR112018000917A2 (pt) | 2015-07-16 | 2018-09-11 | Bioxcel Therapeutics Inc | abordagem inovadora para o tratamento de câncer através da imunomodulação |
| US10912776B2 (en) | 2015-12-24 | 2021-02-09 | Corvus Pharmaceuticals, Inc. | Methods of treating cancer |
| US11096924B2 (en) * | 2016-09-07 | 2021-08-24 | Trustees Of Tufts College | Combination therapies using immuno-dash inhibitors and PGE2 antagonists |
| EP4541423A3 (en) * | 2016-10-06 | 2025-06-25 | Pfizer Inc. | Dosing regimen of avelumab for the treatment of cancer |
| WO2018129497A1 (en) | 2017-01-09 | 2018-07-12 | Bioxcel Therapeutics, Inc. | Predictive and diagnostic methods for prostate cancer |
| CN110461362A (zh) * | 2017-03-28 | 2019-11-15 | 迪克纳制药公司 | 减少β-连环蛋白表达以加强免疫疗法 |
| US11040040B2 (en) | 2017-04-04 | 2021-06-22 | Corvus Pharmaceuticals, Inc. | Methods of treating cancer |
| US11559537B2 (en) | 2017-04-07 | 2023-01-24 | Trustees Of Tufts College | Combination therapies using caspase-1 dependent anticancer agents and PGE2 antagonists |
| JP2021502423A (ja) * | 2017-11-13 | 2021-01-28 | バイオエクセル セラピューティクス,インコーポレイテッド | 免疫系の複数のアームを修飾することによってがんを治療するための方法及び組成物 |
| SG11202005563YA (en) * | 2017-12-15 | 2020-07-29 | Praxis Biotech LLC | Inhibitors of fibroblast activation protein |
| WO2019202473A1 (en) * | 2018-04-16 | 2019-10-24 | Université de Lausanne | Ucp2 inducing agents for the treatment of cancer resistant to immune checkpoint blockade |
| EP3856144A1 (en) * | 2018-09-28 | 2021-08-04 | CanImGuide Therapeutics AB | Pharmaceutical formulations of peptide inhibitors |
| GB201819853D0 (en) * | 2018-12-05 | 2019-01-23 | Innovation Ulster Ltd | Therapy |
| EP3893869A4 (en) * | 2018-12-10 | 2022-08-17 | Bioxcel Therapeutics, Inc. | NEW APPROACH FOR THE TREATMENT OF CANCER USING IMMUNOMODULATION |
| US20220025061A1 (en) * | 2018-12-10 | 2022-01-27 | Bioxcel Therapeutics, Inc. | Combination therapies for treating disease using an innate immunity modifier and an ox40 agonist |
| WO2020132661A2 (en) | 2018-12-21 | 2020-06-25 | Praxis Biotech LLC | Inhibitors of fibroblast activation protein |
| US12396992B2 (en) | 2019-01-07 | 2025-08-26 | Intra-Cellular Therapies, Inc. | Organic compounds |
| JP2023514056A (ja) * | 2020-02-07 | 2023-04-05 | バイオエクセル セラピューティクス,インコーポレイテッド | 免疫調節を使用した癌の治療レジメン |
| AU2021218422A1 (en) * | 2020-02-14 | 2022-09-22 | Bioxcel Therapeutics, Inc. | Systems and methods for detection and prevention of emergence of agitation |
| DK4117667T3 (da) * | 2020-03-13 | 2025-02-10 | Univ Texas | Sekventiel behandling af kræft ved hjælp af 6-thio-dg og checkpointhæmmere |
| CA3176497A1 (en) * | 2020-05-07 | 2021-11-11 | Fatima MECHTA-GRIGORIOU | Antxr1 as a biomarker of immunosuppressive fibroblast populations and its use for predicting response to immunotherapy |
| US20220257759A1 (en) * | 2021-02-17 | 2022-08-18 | Bioxcel Therapeutics, Inc. | Treatment of sarcoma using immunomodulation |
| WO2023172958A1 (en) * | 2022-03-08 | 2023-09-14 | Onkosxcel Therapeutics, Llc | Stable formulations of talabostat |
| US20250186446A1 (en) * | 2022-03-11 | 2025-06-12 | Intra-Cellular Therapies, Inc. | Organic compounds |
| WO2024107832A2 (en) * | 2022-11-16 | 2024-05-23 | Onkosxcel Therapeutics, Llc | Treatment regimen for treating cancers |
| WO2024155790A2 (en) * | 2023-01-18 | 2024-07-25 | Onkosxcel Therapeutics, Llc | Novel approach for treatment of cancer using immunomodulation |
| WO2025076445A1 (en) * | 2023-10-04 | 2025-04-10 | Agenus Inc. | Anti-fap antibodies and methods of use thereof |
| CN117482249B (zh) * | 2023-11-28 | 2024-09-17 | 辽宁中医药大学 | 一种肝癌干细胞niche响应型逐级靶向脂质体及其应用 |
| CN117695397A (zh) * | 2024-02-06 | 2024-03-15 | 北京肿瘤医院(北京大学肿瘤医院) | 用于提高肿瘤靶向cldn18.2治疗疗效的药物 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2014513079A (ja) | 2011-04-08 | 2014-05-29 | アフラクシス・ホールディングス・インコーポレイテッド | 神経系疾患及び癌の治療のための8−エチル−6−(アリール)ピリド[2,3−d]ピリミジン−7(8h)−オン |
| WO2015100282A1 (en) | 2013-12-24 | 2015-07-02 | Bristol-Myers Squibb Company | Tricyclic compounds as anticancer agents |
Family Cites Families (102)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5851795A (en) | 1991-06-27 | 1998-12-22 | Bristol-Myers Squibb Company | Soluble CTLA4 molecules and uses thereof |
| US6825169B1 (en) | 1991-10-22 | 2004-11-30 | Trustees Of Tufts College | Inhibitors of dipeptidyl-aminopeptidase type IV |
| FR2703251B3 (fr) | 1993-03-31 | 1995-08-04 | Vacsyn Sa | Compositions pour l'application en thérapeutique humaine, caractérisées par l'association d'un muramyl-peptide à une cytokine . |
| US6051227A (en) | 1995-07-25 | 2000-04-18 | The Regents Of The University Of California, Office Of Technology Transfer | Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling |
| US5811097A (en) | 1995-07-25 | 1998-09-22 | The Regents Of The University Of California | Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling |
| US5855887A (en) | 1995-07-25 | 1999-01-05 | The Regents Of The University Of California | Blockade of lymphocyte down-regulation associated with CTLA-4 signaling |
| WO1998042752A1 (en) | 1997-03-21 | 1998-10-01 | Brigham And Women's Hospital Inc. | Immunotherapeutic ctla-4 binding peptides |
| US6979697B1 (en) | 1998-08-21 | 2005-12-27 | Point Therapeutics, Inc. | Regulation of substrate activity |
| ES2706547T3 (es) | 1998-12-23 | 2019-03-29 | Pfizer | Anticuerpos monoclonales humanos para CTLA-4 |
| US7109003B2 (en) | 1998-12-23 | 2006-09-19 | Abgenix, Inc. | Methods for expressing and recovering human monoclonal antibodies to CTLA-4 |
| EE05627B1 (et) | 1998-12-23 | 2013-02-15 | Pfizer Inc. | CTLA-4 vastased inimese monoklonaalsed antikehad |
| US6890904B1 (en) | 1999-05-25 | 2005-05-10 | Point Therapeutics, Inc. | Anti-tumor agents |
| US7605238B2 (en) | 1999-08-24 | 2009-10-20 | Medarex, Inc. | Human CTLA-4 antibodies and their uses |
| WO2001014424A2 (en) | 1999-08-24 | 2001-03-01 | Medarex, Inc. | Human ctla-4 antibodies and their uses |
| JP2003520828A (ja) | 2000-01-27 | 2003-07-08 | ジェネティクス インスティテュート,エルエルシー | Ctla4(cd152)に対する抗体、これを含む結合体、およびその使用 |
| EP1445264B1 (en) | 2001-07-31 | 2011-09-14 | Ono Pharmaceutical Co., Ltd. | Substance specific to pd-1 |
| WO2003086459A1 (en) | 2002-04-12 | 2003-10-23 | Medarex, Inc. | Methods of treatement using ctla-4 antibodies |
| ES2367430T3 (es) | 2002-12-23 | 2011-11-03 | Wyeth Llc | Anticuerpos contra pd-1 y sus usos. |
| US20090252741A1 (en) | 2004-09-08 | 2009-10-08 | Ohio State University Research Foundation | Human monoclonal anti-ctla4 antibodies in cancer treatment |
| EP1896582A4 (en) | 2005-05-09 | 2009-04-08 | Ono Pharmaceutical Co | HUMAN MONOCLONAL ANTIBODIES AGAINST PROGRAMMED CELL DEATH 1 (PD-1) AND METHOD FOR CREATING TREATMENT WITH ANTI-PD-1 ANTIBODIES ALONE OR IN COMBINATION WITH OTHER IMMUNOTHERAPEUTICS |
| CN104356236B (zh) | 2005-07-01 | 2020-07-03 | E.R.施贵宝&圣斯有限责任公司 | 抗程序性死亡配体1(pd-l1)的人单克隆抗体 |
| WO2007014754A1 (en) | 2005-08-02 | 2007-02-08 | I.D.M. Immuno-Designed Molecules | Process for the preparation of liposomal formulations |
| WO2007058957A2 (en) | 2005-11-10 | 2007-05-24 | Point Therapeutics, Inc | Boroproline compound and cytokine combination therapy |
| WO2007059099A2 (en) | 2005-11-14 | 2007-05-24 | Point Therapeutics, Inc. | Boroproline combination therapy for cancer |
| EP2441846A3 (en) | 2006-01-09 | 2012-07-25 | The Regents Of the University of California | Immunostimulatory combinations of TNFRSF, TLR, NLR, RHR, purinergic receptor, and cytokine receptor agoinsts for vaccines and tumor immunotherapy |
| WO2007127204A2 (en) * | 2006-04-24 | 2007-11-08 | Dara Biosciences, Inc. | Methods and compositions relating to immunostimulation |
| WO2008033368A2 (en) | 2006-09-12 | 2008-03-20 | Dara Biosciences, Inc. | Boroproline compound and cytokine combination therapy |
| WO2008066729A2 (en) * | 2006-11-22 | 2008-06-05 | Dara Biosciences, Inc. | Boronic acid containing compositions |
| US8603978B2 (en) | 2006-12-01 | 2013-12-10 | The United States of America, as represented by the Secretary, Department of Health and Humand Services | Use of muramyl dipeptide (MDP) for treating inflammation |
| EP2155248B1 (en) | 2007-04-12 | 2015-06-10 | The Brigham and Women's Hospital, Inc. | Targeting abcb5 for cancer therapy |
| WO2008156712A1 (en) | 2007-06-18 | 2008-12-24 | N. V. Organon | Antibodies to human programmed death receptor pd-1 |
| ES2558568T3 (es) | 2008-01-08 | 2016-02-05 | Bristol-Myers Squibb Company | Combinación de anticuerpo anti-CTLA4 con agentes moduladores de la tubulina para el tratamiento de enfermedades proliferativas |
| EP2350129B1 (en) | 2008-08-25 | 2015-06-10 | Amplimmune, Inc. | Compositions of pd-1 antagonists and methods of use |
| EP2342228B1 (en) | 2008-09-12 | 2017-09-06 | Oxford University Innovation Limited | Pd-1 specific antibodies and uses thereof |
| WO2010029435A1 (en) | 2008-09-12 | 2010-03-18 | Isis Innovation Limited | Pd-1 specific antibodies and uses thereof |
| US8552154B2 (en) | 2008-09-26 | 2013-10-08 | Emory University | Anti-PD-L1 antibodies and uses therefor |
| WO2010065711A1 (en) | 2008-12-04 | 2010-06-10 | Adimab, Inc. | An abcb5 epitope and antibodies thereto for the treatment of cancer |
| TW202442680A (zh) | 2008-12-09 | 2024-11-01 | 美商建南德克公司 | 抗pd-l1抗體及其於增進t細胞功能之用途 |
| WO2010089411A2 (en) | 2009-02-09 | 2010-08-12 | Universite De La Mediterranee | Pd-1 antibodies and pd-l1 antibodies and uses thereof |
| GB0903325D0 (en) | 2009-02-26 | 2009-04-08 | Univ Aberdeen | Antibody molecules |
| WO2011066342A2 (en) | 2009-11-24 | 2011-06-03 | Amplimmune, Inc. | Simultaneous inhibition of pd-l1/pd-l2 |
| MX343747B (es) | 2009-11-24 | 2016-11-22 | Medimmune Ltd | Agentes de union diana contra b7-h1. |
| WO2011082400A2 (en) | 2010-01-04 | 2011-07-07 | President And Fellows Of Harvard College | Modulators of immunoinhibitory receptor pd-1, and methods of use thereof |
| CA3253628A1 (en) | 2010-03-05 | 2025-11-29 | The Johns Hopkins University | Compositions and methods for targeted immunomodulatory antibodies and fusion proteins |
| TW201134488A (en) | 2010-03-11 | 2011-10-16 | Ucb Pharma Sa | PD-1 antibodies |
| WO2011110604A1 (en) | 2010-03-11 | 2011-09-15 | Ucb Pharma, S.A. | Pd-1 antibody |
| KR20130049775A (ko) | 2010-03-12 | 2013-05-14 | 애브비 바이오테라퓨틱스 인크. | Ctla4 단백질 및 이의 용도 |
| US8907053B2 (en) | 2010-06-25 | 2014-12-09 | Aurigene Discovery Technologies Limited | Immunosuppression modulating compounds |
| WO2012062218A1 (en) | 2010-11-11 | 2012-05-18 | The University Of Hong Kong | Soluble pd-1 variants, fusion constructs, and uses thereof |
| GB201103955D0 (en) | 2011-03-09 | 2011-04-20 | Antitope Ltd | Antibodies |
| TWI835048B (zh) | 2011-08-01 | 2024-03-11 | 美商建南德克公司 | 利用pd-1軸結合拮抗劑及mek抑制劑治療癌症之方法 |
| AU2012340887A1 (en) * | 2011-11-22 | 2014-07-03 | Trustees Of Tufts College | Small molecule enhancer for dendritic cell cancer vaccines |
| MX349096B (es) | 2011-11-28 | 2017-07-11 | Merck Patent Gmbh | Anticuerpos anti-pd-l1 y sus usos. |
| EA037351B8 (ru) | 2012-05-15 | 2021-04-29 | Бристол-Майерс Сквибб Компани | Способ лечения злокачественных опухолей с использованием комбинации антител против pd-1 и ctla-4 |
| AR093984A1 (es) | 2012-12-21 | 2015-07-01 | Merck Sharp & Dohme | Anticuerpos que se unen a ligando 1 de muerte programada (pd-l1) humano |
| US9376437B2 (en) * | 2013-03-13 | 2016-06-28 | Oncoceutics, Inc | 7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one, salts thereof and methods of using the same in combination therapy |
| EA201890895A1 (ru) * | 2013-03-15 | 2019-02-28 | Зинджения, Инк. | Мультивалентные и моновалентные мультиспецифические комплексы и их применение |
| ES2845609T3 (es) | 2013-05-02 | 2021-07-27 | Anaptysbio Inc | Anticuerpos dirigidos contra muerte programada-1 (PD-1) |
| CN104250302B (zh) | 2013-06-26 | 2017-11-14 | 上海君实生物医药科技股份有限公司 | 抗pd‑1抗体及其应用 |
| EA034666B1 (ru) | 2013-09-13 | 2020-03-04 | Бейджин Свитзерланд Гмбх | Антитело против pd-1 и его применение для лечения рака или вирусной инфекции и фрагмент антитела |
| CN104558177B (zh) | 2013-10-25 | 2020-02-18 | 苏州思坦维生物技术股份有限公司 | 拮抗抑制程序性死亡受体pd-1与其配体结合的单克隆抗体及其编码序列与用途 |
| EP3065772B1 (en) * | 2013-11-05 | 2024-07-24 | Cognate Bioservices, Inc. | Combinations of checkpoint inhibitors and therapeutics to treat cancer |
| JP2016536361A (ja) * | 2013-11-06 | 2016-11-24 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Cd33抗体及び脱メチル剤を含む医薬配合物 |
| EP3527587A1 (en) | 2013-12-17 | 2019-08-21 | F. Hoffmann-La Roche AG | Combination therapy comprising ox40 binding agonists and pd-l1 binding antagonists |
| CA2934073A1 (en) * | 2013-12-20 | 2015-06-25 | The Broad Institute, Inc. | Combination therapy with neoantigen vaccine |
| AU2014368449C1 (en) | 2013-12-20 | 2021-05-06 | Intervet International B.V. | Canine antibodies with modified CH2-CH3 sequences |
| TWI681969B (zh) | 2014-01-23 | 2020-01-11 | 美商再生元醫藥公司 | 針對pd-1的人類抗體 |
| JOP20200094A1 (ar) | 2014-01-24 | 2017-06-16 | Dana Farber Cancer Inst Inc | جزيئات جسم مضاد لـ pd-1 واستخداماتها |
| EP3542816A1 (en) | 2014-02-14 | 2019-09-25 | Immune Design Corp. | Immunotherapy of cancer through combination of local and systemic immune stimulation |
| PL3134123T3 (pl) | 2014-02-21 | 2021-07-12 | Nektar Therapeutics (India) Pvt. Ltd. | Agoniści selektywni względem IL-2Rbeta w kombinacji z przeciwciałem anty-CTLA-4 lub z przeciwciałem anty-PD-1 |
| CN105330740B (zh) | 2014-07-30 | 2018-08-17 | 珠海市丽珠单抗生物技术有限公司 | 抗pd-1抗体及其应用 |
| KR20170055474A (ko) | 2014-07-31 | 2017-05-19 | 아카데미아 시니카 | 길항 pd-1 압타머 및 암 요법 관련 적용에서의 그의 적용 |
| PL3177640T3 (pl) | 2014-08-08 | 2020-11-02 | The Board Of Trustees Of The Leland Stanford Junior University | Charakteryzujące się wysokim powinowactwem środki terapeutyczne naśladujące PD-11 i sposoby ich wykorzystania |
| HRP20220738T1 (hr) * | 2014-08-11 | 2022-08-19 | Acerta Pharma B.V. | Terapijske kombinacije inhibitora btk, inhibitora pd-1 i/ili inhibitora pd-l1 |
| JO3663B1 (ar) * | 2014-08-19 | 2020-08-27 | Merck Sharp & Dohme | الأجسام المضادة لمضاد lag3 وأجزاء ربط الأنتيجين |
| EA201790834A1 (ru) | 2014-10-14 | 2018-01-31 | Новартис Аг | Молекулы антител к pd-l1 и их применение |
| US10822414B2 (en) | 2014-11-11 | 2020-11-03 | Sutro Biopharma, Inc. | Anti-PD-1 antibodies, compositions comprising anti-PD-1 antibodies and methods of using anti-PD-1 antibodies |
| US20160148513A1 (en) | 2014-11-20 | 2016-05-26 | Here Global B.V. | Method and apparatus for providing line-of-sight obstruction notification for navigation |
| TWI595006B (zh) | 2014-12-09 | 2017-08-11 | 禮納特神經系統科學公司 | 抗pd-1抗體類和使用彼等之方法 |
| US10239942B2 (en) | 2014-12-22 | 2019-03-26 | Pd-1 Acquisition Group, Llc | Anti-PD-1 antibodies |
| CN104479020B (zh) | 2014-12-26 | 2019-08-02 | 上海复宏汉霖生物技术股份有限公司 | 一种抗pd-1人源抗体 |
| EP4151231A1 (en) | 2015-02-13 | 2023-03-22 | Sorrento Therapeutics, Inc. | Antibody therapeutics that bind ctla4 |
| CN104761633B (zh) | 2015-03-25 | 2018-11-27 | 新乡学院 | 阻断猪pd-1/pd-l1通路的多肽及其应用 |
| WO2016179576A1 (en) | 2015-05-07 | 2016-11-10 | Bioxcel Corporation | Novel immunomodulatory therapeutic strategies targeting tumors in cancer |
| US20170000885A1 (en) | 2015-06-08 | 2017-01-05 | Genentech, Inc. | Methods of treating cancer using anti-ox40 antibodies and pd-1 axis binding antagonists |
| CN105061597B (zh) | 2015-06-09 | 2016-04-27 | 北京东方百泰生物科技有限公司 | 一种抗pd-1的单克隆抗体及其获得方法 |
| RU2766890C2 (ru) | 2015-06-16 | 2022-03-16 | Мерк Патент Гмбх | Комбинированные способы лечения антагонистами pd-l1 |
| BR112018000917A2 (pt) | 2015-07-16 | 2018-09-11 | Bioxcel Therapeutics Inc | abordagem inovadora para o tratamento de câncer através da imunomodulação |
| WO2017020974A1 (en) | 2015-08-03 | 2017-02-09 | Institut Pasteur | Dipeptidylpeptidase 4 inhibition enhances lymphocyte trafficking, improving both naturally occurring tumor immunity and immunotherapy |
| KR20180040706A (ko) | 2015-09-01 | 2018-04-20 | 인네이트 튜머 이뮤니티, 인코포레이티드 | 면역억제 시토카인에 대해 증가된 면역 또는 저항성을 갖는 면역 세포 및 그의 용도 |
| WO2017058881A1 (en) | 2015-09-28 | 2017-04-06 | The Trustees Of Columbia University In The City Of New York | Use of pentoxifylline with immune checkpoint-blockade therapies for the treatment of melanoma |
| RU2022102624A (ru) | 2015-10-01 | 2022-03-10 | Хит Байолоджикс, Инк. | Композиции и способы для соединения внеклеточных доменов типа i и типа ii в качестве гетерологичных химерных белков |
| CN105175544B (zh) | 2015-10-20 | 2021-04-09 | 安徽瀚海博兴生物技术有限公司 | 一种抗pd-1人源化单克隆抗体及其应用 |
| WO2017079303A1 (en) | 2015-11-02 | 2017-05-11 | The Cleveland Clinic Foundation | Sequentially orchestrated immune checkpoint therapy for the treatment and prevention of cancer |
| CN109415703B (zh) | 2016-01-08 | 2024-08-30 | 雷普利穆内有限公司 | 经修饰的溶瘤病毒 |
| US20190008918A1 (en) | 2016-03-08 | 2019-01-10 | Bioxcel Corporation | Immunomodulation therapies for cancer |
| US11096924B2 (en) | 2016-09-07 | 2021-08-24 | Trustees Of Tufts College | Combination therapies using immuno-dash inhibitors and PGE2 antagonists |
| JP7079773B2 (ja) | 2016-09-14 | 2022-06-02 | アッヴィ・バイオセラピューティクス・インコーポレイテッド | 抗pd-1抗体及びその使用 |
| WO2018129497A1 (en) | 2017-01-09 | 2018-07-12 | Bioxcel Therapeutics, Inc. | Predictive and diagnostic methods for prostate cancer |
| JP2021502423A (ja) | 2017-11-13 | 2021-01-28 | バイオエクセル セラピューティクス,インコーポレイテッド | 免疫系の複数のアームを修飾することによってがんを治療するための方法及び組成物 |
| US20220025061A1 (en) | 2018-12-10 | 2022-01-27 | Bioxcel Therapeutics, Inc. | Combination therapies for treating disease using an innate immunity modifier and an ox40 agonist |
| EP3893869A4 (en) | 2018-12-10 | 2022-08-17 | Bioxcel Therapeutics, Inc. | NEW APPROACH FOR THE TREATMENT OF CANCER USING IMMUNOMODULATION |
-
2016
- 2016-07-18 BR BR112018000917A patent/BR112018000917A2/pt not_active Application Discontinuation
- 2016-07-18 KR KR1020187003641A patent/KR20180036974A/ko not_active Ceased
- 2016-07-18 WO PCT/US2016/042798 patent/WO2017011831A1/en not_active Ceased
- 2016-07-18 EP EP16825310.2A patent/EP3322448A4/en active Pending
- 2016-07-18 MA MA042459A patent/MA42459A/fr unknown
- 2016-07-18 HK HK18107658.8A patent/HK1248115A1/zh unknown
- 2016-07-18 CN CN202211308353.9A patent/CN116059218A/zh active Pending
- 2016-07-18 JP JP2018521501A patent/JP7032311B2/ja active Active
- 2016-07-18 NZ NZ739503A patent/NZ739503A/en unknown
- 2016-07-18 CA CA2991628A patent/CA2991628C/en active Active
- 2016-07-18 AU AU2016293674A patent/AU2016293674B2/en active Active
- 2016-07-18 MX MX2018000619A patent/MX2018000619A/es unknown
- 2016-07-18 CN CN201680045055.1A patent/CN108136025B/zh active Active
- 2016-07-18 RU RU2018105985A patent/RU2711380C2/ru active
- 2016-07-18 CN CN202211308354.3A patent/CN116059219A/zh active Pending
-
2017
- 2017-03-23 US US15/467,781 patent/US11564986B2/en active Active
-
2018
- 2018-01-12 MX MX2022010270A patent/MX2022010270A/es unknown
- 2018-02-01 ZA ZA2018/00688A patent/ZA201800688B/en unknown
-
2019
- 2019-05-30 ZA ZA2019/03442A patent/ZA201903442B/en unknown
-
2020
- 2020-02-10 AU AU2020200953A patent/AU2020200953B2/en active Active
-
2022
- 2022-03-21 AU AU2022201950A patent/AU2022201950A1/en not_active Abandoned
- 2022-12-21 US US18/069,489 patent/US20240000928A1/en not_active Abandoned
-
2024
- 2024-08-13 US US18/802,908 patent/US20250213681A1/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2014513079A (ja) | 2011-04-08 | 2014-05-29 | アフラクシス・ホールディングス・インコーポレイテッド | 神経系疾患及び癌の治療のための8−エチル−6−(アリール)ピリド[2,3−d]ピリミジン−7(8h)−オン |
| WO2015100282A1 (en) | 2013-12-24 | 2015-07-02 | Bristol-Myers Squibb Company | Tricyclic compounds as anticancer agents |
Also Published As
| Publication number | Publication date |
|---|---|
| NZ739503A (en) | 2023-06-30 |
| AU2020200953B2 (en) | 2021-12-23 |
| CN116059219A (zh) | 2023-05-05 |
| ZA201800688B (en) | 2020-08-26 |
| MX2022010270A (es) | 2022-09-19 |
| RU2018105985A3 (enExample) | 2019-08-16 |
| EP3322448A4 (en) | 2019-03-06 |
| RU2711380C2 (ru) | 2020-01-16 |
| KR20180036974A (ko) | 2018-04-10 |
| MA42459A (fr) | 2018-05-23 |
| AU2016293674A1 (en) | 2018-02-22 |
| AU2022201950A1 (en) | 2022-04-14 |
| EP3322448A1 (en) | 2018-05-23 |
| CA2991628A1 (en) | 2017-01-19 |
| ZA201903442B (en) | 2021-04-28 |
| RU2019144144A (ru) | 2020-03-19 |
| RU2018105985A (ru) | 2019-08-16 |
| US20250213681A1 (en) | 2025-07-03 |
| CN108136025B (zh) | 2022-09-06 |
| US20240000928A1 (en) | 2024-01-04 |
| BR112018000917A2 (pt) | 2018-09-11 |
| MX2018000619A (es) | 2019-03-06 |
| CN116059218A (zh) | 2023-05-05 |
| AU2020200953A1 (en) | 2020-02-27 |
| JP2018521135A (ja) | 2018-08-02 |
| AU2016293674B2 (en) | 2019-11-21 |
| US11564986B2 (en) | 2023-01-31 |
| WO2017011831A1 (en) | 2017-01-19 |
| CA2991628C (en) | 2020-04-07 |
| HK1248115A1 (zh) | 2018-10-12 |
| US20170266280A1 (en) | 2017-09-21 |
| CN108136025A (zh) | 2018-06-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP7032311B2 (ja) | 免疫調節を使用してがんを処置するための新規手法 | |
| JP7569166B2 (ja) | Pd-1に対する抗体分子およびその使用 | |
| JP7654708B2 (ja) | がんを治療するための、腫瘍溶解性ウイルスの単独又はチェックポイント阻害剤との組み合わせでの使用 | |
| Guidi et al. | Chemotherapy and immunotherapy for recurrent and metastatic head and neck cancer: a systematic review | |
| CN112566661B (zh) | 喹啉衍生物与抗体的药物组合 | |
| TW201922291A (zh) | 組合療法 | |
| JP2018522027A (ja) | Pd−1に対する抗体分子を含む組み合わせ治療 | |
| JP2021502423A (ja) | 免疫系の複数のアームを修飾することによってがんを治療するための方法及び組成物 | |
| JP2018504446A (ja) | がんを処置するためのhsp90阻害剤およびpd−1阻害剤の組み合わせ治療 | |
| TWI812820B (zh) | 使用先天性免疫修飾劑及ox40促效劑治療疾病之組合療法 | |
| Suresh et al. | The emerging role of immunotherapy in head and neck squamous cell cancer | |
| CN115397459A (zh) | 用pd-1轴结合拮抗剂和rna疫苗诱导新表位特异性t细胞的方法 | |
| RU2817047C2 (ru) | Новый подход к лечению рака с применением иммуномодуляции | |
| US20240182568A1 (en) | Methods of enhancing antibody therapies | |
| JP2025501238A (ja) | Il-7タンパク質とvegfアンタゴニストの併用による腫瘍の治療方法 | |
| CA3007671C (en) | Antibody molecules to pd-1 and uses thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20180316 |
|
| A529 | Written submission of copy of amendment under article 34 pct |
Free format text: JAPANESE INTERMEDIATE CODE: A529 Effective date: 20180308 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20190513 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20190513 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20200609 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20200909 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20201105 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20201207 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20201207 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20210416 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20210623 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20210830 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20211213 |
|
| C60 | Trial request (containing other claim documents, opposition documents) |
Free format text: JAPANESE INTERMEDIATE CODE: C60 Effective date: 20211213 |
|
| C11 | Written invitation by the commissioner to file amendments |
Free format text: JAPANESE INTERMEDIATE CODE: C11 Effective date: 20211222 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20211220 |
|
| A911 | Transfer to examiner for re-examination before appeal (zenchi) |
Free format text: JAPANESE INTERMEDIATE CODE: A911 Effective date: 20220113 |
|
| C21 | Notice of transfer of a case for reconsideration by examiners before appeal proceedings |
Free format text: JAPANESE INTERMEDIATE CODE: C21 Effective date: 20220114 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20220210 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20220224 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 7032311 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |