JP7032311B2 - 免疫調節を使用してがんを処置するための新規手法 - Google Patents

免疫調節を使用してがんを処置するための新規手法 Download PDF

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JP7032311B2
JP7032311B2 JP2018521501A JP2018521501A JP7032311B2 JP 7032311 B2 JP7032311 B2 JP 7032311B2 JP 2018521501 A JP2018521501 A JP 2018521501A JP 2018521501 A JP2018521501 A JP 2018521501A JP 7032311 B2 JP7032311 B2 JP 7032311B2
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cancer
tarabostat
pharmaceutical composition
antagonist
tumor
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JP2018521135A (ja
JP2018521135A5 (enExample
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ディー． メータ，ヴィマル
ラステッリ，ルカ
カトッチ サプラ，アパーナ
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バイオエクセル セラピューティクス，インコーポレイテッド
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
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    • A61P35/04—Antineoplastic agents specific for metastasis
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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    • C12N2320/00—Applications; Uses
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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  • Virology (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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JP2018521501A 2015-07-16 2016-07-18 免疫調節を使用してがんを処置するための新規手法 Active JP7032311B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562193348P 2015-07-16 2015-07-16
US62/193,348 2015-07-16
US201562204495P 2015-08-13 2015-08-13
US62/204,495 2015-08-13
PCT/US2016/042798 WO2017011831A1 (en) 2015-07-16 2016-07-18 A novel approach for treatment of cancer using immunomodulation

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JP2018521135A JP2018521135A (ja) 2018-08-02
JP2018521135A5 JP2018521135A5 (enExample) 2019-06-20
JP7032311B2 true JP7032311B2 (ja) 2022-03-08

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US (3) US11564986B2 (enExample)
EP (1) EP3322448A4 (enExample)
JP (1) JP7032311B2 (enExample)
KR (1) KR20180036974A (enExample)
CN (3) CN116059219A (enExample)
AU (3) AU2016293674B2 (enExample)
BR (1) BR112018000917A2 (enExample)
CA (1) CA2991628C (enExample)
HK (1) HK1248115A1 (enExample)
MA (1) MA42459A (enExample)
MX (2) MX2018000619A (enExample)
NZ (1) NZ739503A (enExample)
RU (1) RU2711380C2 (enExample)
WO (1) WO2017011831A1 (enExample)
ZA (2) ZA201800688B (enExample)

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