JP2019527706A5 - - Google Patents
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- JP2019527706A5 JP2019527706A5 JP2019506349A JP2019506349A JP2019527706A5 JP 2019527706 A5 JP2019527706 A5 JP 2019527706A5 JP 2019506349 A JP2019506349 A JP 2019506349A JP 2019506349 A JP2019506349 A JP 2019506349A JP 2019527706 A5 JP2019527706 A5 JP 2019527706A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- pharmaceutical composition
- composition according
- protein
- dose
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662374621P | 2016-08-12 | 2016-08-12 | |
| US62/374,621 | 2016-08-12 | ||
| PCT/EP2017/070513 WO2018029367A1 (en) | 2016-08-12 | 2017-08-11 | Combination therapy for cancer |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019527706A JP2019527706A (ja) | 2019-10-03 |
| JP2019527706A5 true JP2019527706A5 (enExample) | 2020-09-24 |
| JP7573365B2 JP7573365B2 (ja) | 2024-10-25 |
Family
ID=59686928
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019506349A Active JP7573365B2 (ja) | 2016-08-12 | 2017-08-11 | 癌の併用療法 |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US20180118832A1 (enExample) |
| EP (1) | EP3497130B1 (enExample) |
| JP (1) | JP7573365B2 (enExample) |
| KR (3) | KR20190039200A (enExample) |
| CN (1) | CN109641963A (enExample) |
| AU (2) | AU2017310027A1 (enExample) |
| BR (1) | BR112019001818A2 (enExample) |
| CA (1) | CA3031168A1 (enExample) |
| CL (1) | CL2019000277A1 (enExample) |
| ES (1) | ES2905663T3 (enExample) |
| IL (1) | IL264730B2 (enExample) |
| MX (1) | MX2019001503A (enExample) |
| PH (1) | PH12019500270A1 (enExample) |
| RU (1) | RU2019106663A (enExample) |
| SG (1) | SG11201901126UA (enExample) |
| WO (1) | WO2018029367A1 (enExample) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2014308751B2 (en) | 2013-08-22 | 2020-03-05 | Acceleron Pharma, Inc. | TGF-beta receptor type II variants and uses thereof |
| CN116327952A (zh) | 2015-08-04 | 2023-06-27 | 阿塞勒隆制药公司 | 用于治疗骨髓增生性病症的方法 |
| BR112019023071A2 (pt) | 2017-05-04 | 2020-06-09 | Acceleron Pharma Inc | proteínas de fusão do receptor tgf-beta do tipo ii e uso das mesmas |
| JP2021518843A (ja) * | 2018-03-23 | 2021-08-05 | ザ ユニバーシティ オブ ウエスタン オーストラリア | 免疫治療薬処置方法 |
| KR20210006405A (ko) * | 2018-05-04 | 2021-01-18 | 메르크 파텐트 게엠베하 | 암의 치료를 위한 PD-1/PD-L1, TGFβ 및 DNA-PK의 조합 억제 |
| CA3096844A1 (en) * | 2018-05-15 | 2019-11-21 | Merck Patent Gmbh | Dosing regimens for targeted tgf-b inhibition for use in treating cancer in treatment naive subjects |
| SG11202012426WA (en) * | 2018-06-13 | 2021-01-28 | Merck Patent Gmbh | Treatment of stage iii nsclc and mitigation of pathological conditions associated with the treatment |
| TW202019405A (zh) * | 2018-07-02 | 2020-06-01 | 德商馬克專利公司 | 用於治療晚期非小細胞肺癌之標靶性TGF-β抑制之組合療法 |
| AU2019301070B2 (en) * | 2018-07-09 | 2025-09-11 | Precigen, Inc. | Fusion constructs and methods of using thereof |
| BR112021009835A2 (pt) * | 2018-11-30 | 2021-08-17 | Jiangsu Hengrui Medicine Co., Ltd. | anticorpo anti-cd40, fragmento de ligação ao antígeno e uso farmacêutico dos mesmos |
| PH12021551860A1 (en) | 2019-01-30 | 2022-05-16 | Scholar Rock Inc | Ltbp complex-specific inhibitors of tgfã and uses thereof |
| EP3693974A1 (en) * | 2019-02-07 | 2020-08-12 | Koninklijke Philips N.V. | Identifying responsiveness to radio-immuno combination therapy |
| EP3929215A4 (en) | 2019-06-10 | 2022-06-22 | Shandong Boan Biotechnology Co., Ltd. | BIFUNCTIONAL FUSION PROTEIN AGAINST PDL1 AND TGF? AND ITS USE |
| EP3990116A1 (en) | 2019-06-28 | 2022-05-04 | Gensun Biopharma Inc. | ANTITUMOR ANTAGONIST CONSISTING OF A MUTATED TGFß1 - RII EXTRACELLULAR DOMAIN AND AN IMMUNOGLOBULIN SCAFFOLD |
| CN112442132A (zh) * | 2019-09-05 | 2021-03-05 | 复旦大学 | 靶向肿瘤的重组双功能融合蛋白及其应用 |
| BR112022004563A2 (pt) * | 2019-09-12 | 2022-06-07 | Sirnaomics Inc | Coliberação de sirna tgf-ß e sirna pdl1 para tratar câncer |
| CN112574314A (zh) * | 2019-09-30 | 2021-03-30 | 和铂医药(苏州)有限公司 | 一种融合蛋白及其应用 |
| EP4048704A4 (en) | 2019-10-21 | 2023-11-22 | Nanjing Leads Biolabs Co., Ltd. | RECOMBINANT PROTEIN TARGETING PD-1 AND TGFß |
| CA3154413A1 (en) * | 2019-11-01 | 2021-05-06 | Yan Lan | Combined inhibition of pd-1, tgf.beta. and atm together with radiotherapy for the treatment of cancer |
| JP2023502585A (ja) * | 2019-11-05 | 2023-01-25 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | 癌の治療のための、ＰＤ－１、ＴＧＦβ、及びＴＩＧＩＴの組み合わせ阻害 |
| WO2021115456A1 (en) * | 2019-12-11 | 2021-06-17 | Wuxi Biologics (Shanghai) Co., Ltd. | BI-FUNCTIONAL ANTIBODY AGAINST PD-L1 AND TGFβ |
| US20230043290A1 (en) | 2019-12-20 | 2023-02-09 | Ares Trading S.A. | Igg:tgfbetarii fusion protein composition |
| EP3838260A1 (en) | 2019-12-20 | 2021-06-23 | Ares Trading S.A. | Igg:tgf rii fusion protein composition |
| CA3167427A1 (en) | 2020-01-11 | 2021-07-15 | Scholar Rock, Inc. | Tgfb inhibitors and use thereof |
| AU2021205440A1 (en) | 2020-01-11 | 2022-09-01 | Scholar Rock,Inc. | TGF-beta inhibitors and use thereof |
| CN115175942B (zh) * | 2020-02-25 | 2025-05-30 | 上海药明生物技术有限公司 | 一种双功能融合蛋白及其用途 |
| CN115461362A (zh) * | 2020-04-14 | 2022-12-09 | 葛兰素史密斯克莱知识产权发展有限公司 | 基于ICOS抗体和PD-L1抗体TGF-β受体融合蛋白的癌症组合疗法 |
| WO2021209458A1 (en) | 2020-04-14 | 2021-10-21 | Ares Trading S.A. | Combination treatment of cancer |
| IL299764A (en) | 2020-07-10 | 2023-03-01 | Precigen Inc | Fusion constructs and methods for using them |
| JP7766672B2 (ja) * | 2020-07-24 | 2025-11-10 | ▲邁▼威（上海）生物科技股▲フン▼有限公司 | ＴＧＦ－β ＲＩＩ突然変異体及びその融合タンパク質 |
| WO2022063193A1 (zh) * | 2020-09-24 | 2022-03-31 | 上海齐鲁制药研究中心有限公司 | 同时靶向PD-L1和TGFβ的双功能分子及其医药用途 |
| WO2022090529A1 (en) | 2020-11-02 | 2022-05-05 | Ares Trading S.A. | Combination treatment of cancer |
| CN116801906A (zh) | 2020-11-02 | 2023-09-22 | 阿雷斯贸易股份有限公司 | 癌症的联合治疗 |
| WO2022204581A2 (en) | 2021-03-26 | 2022-09-29 | Scholar Rock, Inc. | Tgf-beta inhibitors and use thereof |
| AU2022270880A1 (en) | 2021-05-03 | 2023-09-28 | Merck Patent Gmbh | Her2 targeting fc antigen binding fragment-drug conjugates |
| CN117999101A (zh) | 2021-05-25 | 2024-05-07 | 默克专利股份公司 | 靶向EGFR的Fc抗原结合片段-药物缀合物 |
| WO2022256723A2 (en) | 2021-06-03 | 2022-12-08 | Scholar Rock, Inc. | Tgf-beta inhibitors and therapeutic use thereof |
| JP2024520764A (ja) | 2021-06-07 | 2024-05-24 | アレス トレーディング ソシエテ アノニム | 癌の組み合わせ処置 |
| GB202215997D0 (en) * | 2022-10-28 | 2022-12-14 | Io Biotech Aps | Therapy |
| EP4650366A1 (en) | 2023-01-09 | 2025-11-19 | Beijing Tuo Jie Biopharmaceutical Co. Ltd. | Tgfbeta1 binding molecule, garp-tgfbeta1 binding molecule and medical use thereof |
| WO2024187051A1 (en) | 2023-03-07 | 2024-09-12 | Scholar Rock, Inc. | Tgf-beta inhibitors for use for treating resistant or unresponsive cancer in patients |
| WO2025240343A1 (en) | 2024-05-13 | 2025-11-20 | Scholar Rock, Inc. | Tgf-beta inhibitors for treating cancer |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5179689B2 (ja) | 2000-02-11 | 2013-04-10 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | 抗体ベース融合タンパク質の循環系内半減期の増強 |
| HUP0303428A2 (hu) | 2001-03-07 | 2004-01-28 | Merck Patent Gmbh. | Expressziós eljárás hibrid izotípusú antitestcsoportot tartalmazó fehérjékhez |
| WO2002079415A2 (en) | 2001-03-30 | 2002-10-10 | Lexigen Pharmaceuticals Corp. | Reducing the immunogenicity of fusion proteins |
| CA2612241C (en) | 2005-07-01 | 2018-11-06 | Medarex, Inc. | Human monoclonal antibodies to programmed death ligand 1 (pd-l1) |
| EP4209510B1 (en) | 2008-12-09 | 2024-01-31 | F. Hoffmann-La Roche AG | Anti-pd-l1 antibodies and their use to enhance t-cell function |
| US9624298B2 (en) * | 2011-11-28 | 2017-04-18 | Merck Patent Gmbh | Anti-PD-L1 antibodies and uses thereof |
| WO2013164694A1 (en) * | 2012-04-30 | 2013-11-07 | Biocon Limited | Targeted/immunomodulatory fusion proteins and methods for making same |
| JP6312659B2 (ja) | 2012-05-31 | 2018-04-18 | ジェネンテック， インコーポレイテッド | Ｐｄ−１系結合アンタゴニスト及びｖｅｇｆアンタゴニストを用いた癌の治療方法 |
| EP3105246B1 (en) * | 2014-02-10 | 2021-03-31 | Merck Patent GmbH | Targeted tgf beta inhibition |
-
2017
- 2017-08-11 KR KR1020197006703A patent/KR20190039200A/ko not_active Ceased
- 2017-08-11 EP EP17755458.1A patent/EP3497130B1/en active Active
- 2017-08-11 AU AU2017310027A patent/AU2017310027A1/en not_active Abandoned
- 2017-08-11 WO PCT/EP2017/070513 patent/WO2018029367A1/en not_active Ceased
- 2017-08-11 KR KR1020257005808A patent/KR20250028537A/ko active Pending
- 2017-08-11 IL IL264730A patent/IL264730B2/en unknown
- 2017-08-11 KR KR1020237028359A patent/KR20230125859A/ko not_active Ceased
- 2017-08-11 MX MX2019001503A patent/MX2019001503A/es unknown
- 2017-08-11 RU RU2019106663A patent/RU2019106663A/ru unknown
- 2017-08-11 ES ES17755458T patent/ES2905663T3/es active Active
- 2017-08-11 CN CN201780049391.8A patent/CN109641963A/zh active Pending
- 2017-08-11 BR BR112019001818A patent/BR112019001818A2/pt unknown
- 2017-08-11 JP JP2019506349A patent/JP7573365B2/ja active Active
- 2017-08-11 CA CA3031168A patent/CA3031168A1/en active Pending
- 2017-08-11 US US15/674,655 patent/US20180118832A1/en not_active Abandoned
- 2017-08-11 SG SG11201901126UA patent/SG11201901126UA/en unknown
-
2019
- 2019-02-01 CL CL2019000277A patent/CL2019000277A1/es unknown
- 2019-02-07 PH PH12019500270A patent/PH12019500270A1/en unknown
-
2021
- 2021-06-24 US US17/357,380 patent/US20220017621A1/en not_active Abandoned
-
2024
- 2024-09-06 AU AU2024219446A patent/AU2024219446A1/en not_active Abandoned
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