DK3628049T3 - Tgf-beta-receptortype-ii-fusionsproteiner og anvendelser deraf - Google Patents
Tgf-beta-receptortype-ii-fusionsproteiner og anvendelser deraf Download PDFInfo
- Publication number
- DK3628049T3 DK3628049T3 DK18794202.4T DK18794202T DK3628049T3 DK 3628049 T3 DK3628049 T3 DK 3628049T3 DK 18794202 T DK18794202 T DK 18794202T DK 3628049 T3 DK3628049 T3 DK 3628049T3
- Authority
- DK
- Denmark
- Prior art keywords
- tgf
- fusion proteins
- receptor type
- beta receptor
- beta
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Peptides Or Proteins (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762501229P | 2017-05-04 | 2017-05-04 | |
US201762510422P | 2017-05-24 | 2017-05-24 | |
US201762578674P | 2017-10-30 | 2017-10-30 | |
PCT/US2018/030816 WO2018204594A1 (en) | 2017-05-04 | 2018-05-03 | Tgf-beta receptor type ii fusion proteins and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
DK3628049T3 true DK3628049T3 (da) | 2023-08-14 |
Family
ID=64016255
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK18794202.4T DK3628049T3 (da) | 2017-05-04 | 2018-05-03 | Tgf-beta-receptortype-ii-fusionsproteiner og anvendelser deraf |
Country Status (21)
Country | Link |
---|---|
US (2) | US11021527B2 (da) |
EP (2) | EP4241848A3 (da) |
JP (2) | JP7267664B2 (da) |
KR (2) | KR20240023201A (da) |
CN (1) | CN110785431B (da) |
AU (2) | AU2018261131A1 (da) |
BR (1) | BR112019023071A2 (da) |
CA (1) | CA3061472A1 (da) |
CY (1) | CY1126121T1 (da) |
DK (1) | DK3628049T3 (da) |
ES (1) | ES2948647T3 (da) |
FI (1) | FI3628049T3 (da) |
HR (1) | HRP20230706T1 (da) |
HU (1) | HUE063840T2 (da) |
LT (1) | LT3628049T (da) |
MD (1) | MD3628049T2 (da) |
PL (1) | PL3628049T3 (da) |
PT (1) | PT3628049T (da) |
RS (1) | RS64315B1 (da) |
SI (1) | SI3628049T1 (da) |
WO (1) | WO2018204594A1 (da) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3705498A1 (en) | 2013-08-22 | 2020-09-09 | Acceleron Pharma Inc. | Tgf-beta receptor type ii variants and uses thereof |
US9884900B2 (en) | 2015-08-04 | 2018-02-06 | Acceleron Pharma Inc. | Methods for treating Janus kinase-associated disorders by administering soluble transforming growth factor beta type II receptor |
PL3496739T3 (pl) | 2016-07-15 | 2021-10-11 | Acceleron Pharma Inc. | Kompozycje zawierające polipeptydy actriia do stosowania w leczeniu nadciśnienia płucnego |
AU2018228435A1 (en) | 2017-03-02 | 2019-10-03 | National Research Council Of Canada | TGF-beta-receptor ectodomain fusion molecules and uses thereof |
AU2019288733C1 (en) | 2018-06-22 | 2023-08-03 | Kite Pharma, Inc. | Chimeric transmembrane proteins and uses thereof |
SG11202100208VA (en) | 2018-07-09 | 2021-02-25 | Precigen Inc | Fusion constructs and methods of using thereof |
US20220289824A1 (en) * | 2019-08-15 | 2022-09-15 | Nantbio, Inc. | TGF-beta TRAP |
CN110734498A (zh) * | 2019-10-15 | 2020-01-31 | 上海科棋药业科技有限公司 | 一种用于解除免疫抑制的融合蛋白及其应用 |
EP4034170A4 (en) | 2019-10-23 | 2023-06-07 | Cue Biopharma, Inc. | TGF-BETA-POLYPEPTIDES |
MX2022005491A (es) * | 2019-11-05 | 2022-07-27 | Acceleron Pharma Inc | Tratamientos contra esclerosis sistémica. |
MX2022013455A (es) * | 2020-04-28 | 2022-11-16 | Sinocelltech Ltd | Molecula truncada en el dominio extracelular de tgfbr2, proteina de fusion de molecula truncada en el dominio extracelular de tgfbr2 y anticuerpo anti-egfr, y uso antitumoral de la proteina de fusion. |
CA3174130A1 (en) * | 2020-11-23 | 2022-05-27 | Cue Biopharma, Inc. | Tgf-beta polypeptides |
EP4351723A2 (en) * | 2021-06-11 | 2024-04-17 | Acceleron Pharma Inc. | Actrii proteins and uses thereof |
Family Cites Families (101)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8529014D0 (en) | 1985-11-25 | 1986-01-02 | Biogen Nv | Enhanced secretion of heterologous proteins |
WO1987005330A1 (en) | 1986-03-07 | 1987-09-11 | Michel Louis Eugene Bergh | Method for enhancing glycoprotein stability |
DE3883899T3 (de) | 1987-03-18 | 1999-04-22 | Sb2 Inc | Geänderte antikörper. |
US5080891A (en) | 1987-08-03 | 1992-01-14 | Ddi Pharmaceuticals, Inc. | Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols |
US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
US5571714A (en) | 1988-12-22 | 1996-11-05 | Celtrix Pharmaceuticals, Inc. | Monoclonal antibodies which bind both transforming growth factors β1 and β2 and methods of use |
US5096815A (en) | 1989-01-06 | 1992-03-17 | Protein Engineering Corporation | Generation and selection of novel dna-binding proteins and polypeptides |
US5198346A (en) | 1989-01-06 | 1993-03-30 | Protein Engineering Corp. | Generation and selection of novel DNA-binding proteins and polypeptides |
ZA914750B (en) | 1990-06-20 | 1992-03-25 | Bristol Myers Squibb Co | Methods of modulating blood pressure using tgf-beta and antagonists thereof |
GB9106678D0 (en) | 1991-03-28 | 1991-05-15 | Ferguson Mark W J | Wound healing |
US6008011A (en) | 1991-10-31 | 1999-12-28 | Whitehead Institute For Biomedical Research | TGF-β type II receptor cDNAs |
JP4124815B2 (ja) | 1991-10-31 | 2008-07-23 | ホワイトヘッド インスティチュート フォー バイオメディカル リサーチ | TGF−β型受容体cDNAおよびその用途 |
US5543143A (en) | 1992-03-06 | 1996-08-06 | Corixa Corporation | Method for activating macrophages/monocytes |
JPH08504763A (ja) | 1992-10-29 | 1996-05-21 | セルトリックス ファーマシューティカルズ,インコーポレイテッド | 治療薬としてのTGF−βレセプターフラグメントの使用 |
US5677196A (en) | 1993-05-18 | 1997-10-14 | University Of Utah Research Foundation | Apparatus and methods for multi-analyte homogeneous fluoro-immunoassays |
US5885573A (en) | 1993-06-01 | 1999-03-23 | Arch Development Corporation | Methods and materials for modulation of the immunosuppressive activity and toxicity of monoclonal antibodies |
CA2163345A1 (en) | 1993-06-16 | 1994-12-22 | Susan Adrienne Morgan | Antibodies |
ATE355369T1 (de) | 1993-10-14 | 2006-03-15 | Harvard College | Verfahren zur induzierung und zur erhaltung neuronalen zellen |
US5470952A (en) | 1993-10-20 | 1995-11-28 | Regeneron Pharmaceuticals, Inc. | CNTF and IL-6 antagonists |
US5525490A (en) | 1994-03-29 | 1996-06-11 | Onyx Pharmaceuticals, Inc. | Reverse two-hybrid method |
US5541087A (en) | 1994-09-14 | 1996-07-30 | Fuji Immunopharmaceuticals Corporation | Expression and export technology of proteins as immunofusins |
US5814565A (en) | 1995-02-23 | 1998-09-29 | University Of Utah Research Foundation | Integrated optic waveguide immunosensor |
US5866323A (en) | 1995-04-07 | 1999-02-02 | Case Western Reserve University | Cancer diagnosis prognosis and therapy based on mutation of receptors for transforming growth factor β and homologous growth controlling factors |
JPH11502717A (ja) | 1995-04-11 | 1999-03-09 | ザ ジェネラル ホスピタル コーポレーション | 逆ツーハイブリッドシステム |
US6423501B2 (en) | 1996-12-13 | 2002-07-23 | Beth Israel Deaconess Medical Center | Calcium-independent negative regulation by CD81 of receptor signaling |
AU737106B2 (en) | 1997-04-18 | 2001-08-09 | Biogen, Inc. | Type II TGF-beta receptor/immunoglobulin constant region fusion proteins |
WO1998047531A2 (en) | 1997-04-21 | 1998-10-29 | Arch Development Corporation | Fc receptor non-binding anti-cd3 monoclonal antibodies deliver a partial tcr signal and induce clonal anergy |
US6294350B1 (en) | 1997-06-05 | 2001-09-25 | Dalhousie University | Methods for treating fibroproliferative diseases |
ZA988461B (en) | 1997-09-18 | 1999-03-30 | Idec Pharma Corp | Synergistic composition and methods for treating neoplastic or cancerous growths and for restoring or boosting hematopoiesis |
ATE375365T1 (de) | 1998-04-02 | 2007-10-15 | Genentech Inc | Antikörper varianten und fragmente davon |
US6194551B1 (en) | 1998-04-02 | 2001-02-27 | Genentech, Inc. | Polypeptide variants |
CA2330939A1 (en) | 1998-06-16 | 1999-12-23 | Biogen, Inc. | Variant type ii tgf-beta receptor fusion proteins and methods |
ES2146552B1 (es) | 1998-11-24 | 2001-04-16 | Inst Cientifico Tecnol Navarra | Peptidos inhibidores de tgf/31 |
DK1263464T3 (da) | 2000-03-09 | 2013-01-28 | Genzyme Corp | Anvendelse af antagonist anti-TGF-BETA-antistoffer til behandling eller til forebyggelse af tab af nyrefunktion |
WO2001073128A1 (en) | 2000-03-24 | 2001-10-04 | Dzgenes, Llc | DIAGNOSTIC POLYMORPHISMS OF TGF-β-RII PROMOTER |
US20030028905A1 (en) | 2001-07-31 | 2003-02-06 | Petra Knaus | Mutant forms of the TGF-beta type II receptor which bind all TGF-beta isoforms |
US20030180301A1 (en) | 2002-01-22 | 2003-09-25 | Shaf Keshavjee | Use of TGF-beta antagonists to treat or to prevent chronic transplant rejection |
US7919084B2 (en) | 2002-06-17 | 2011-04-05 | St. Vincent's Hospital Sydney Limited | Methods of diagnosis, prognosis and treatment of cardiovascular disease |
AU2003297460A1 (en) | 2002-12-19 | 2004-07-14 | Scios, Inc. | TREATMENT OF OBESITY AND ASSOCIATED CONDITIONS WITH TGF-Beta INHIBITORS |
JP2006525362A (ja) | 2003-04-30 | 2006-11-09 | ジェンザイム コーポレーション | 腎機能不全を治療するためのTGF−βアンタゴニストとレニン−アンジオテンシン−アルドステロン系アンタゴニストとの併用 |
WO2005019258A2 (en) | 2003-08-11 | 2005-03-03 | Genentech, Inc. | Compositions and methods for the treatment of immune related diseases |
NZ545544A (en) | 2003-08-13 | 2009-04-30 | Univ Illinois | Silencing of TGF-beta receptor type II expression by sirna |
EP1658060A2 (en) | 2003-08-22 | 2006-05-24 | Boehringer Ingelheim Pharmaceuticals Inc. | Methods of treating copd and pulmonary hypertension |
WO2005113585A2 (en) | 2004-05-20 | 2005-12-01 | Acceleron Pharma Inc. | Modified tgf-beta superfamily polypeptides |
US7786261B2 (en) | 2004-09-02 | 2010-08-31 | National Research Council Of Canada | Coiled-coil fusion proteins comprising cell receptor domains |
BRPI0515588A (pt) | 2004-09-22 | 2008-07-29 | Genzyme Corp | uso de antagonistas de tgf-beta para limitar a nefrotoxicidade de agentes imunossupressivos |
US7795389B2 (en) | 2004-09-28 | 2010-09-14 | The Board Of Regents Of The University Of Texas System | Antagonizing TGF-beta activity with various ectodomains TGF-beta receptors used in combination or as fusion proteins |
US20090004182A1 (en) | 2004-10-13 | 2009-01-01 | The Ohio State University Research Foundation | Methods to Treat or Prevent Viral-Associated Lymphoproliferative Disorders |
CA2597098C (en) | 2005-02-08 | 2016-08-02 | Steven R. Ledbetter | Antibodies to tgfbeta |
JP5342834B2 (ja) | 2008-09-05 | 2013-11-13 | 日東電工株式会社 | 骨髄線維症処置剤 |
ITMI20060181A1 (it) | 2006-02-03 | 2007-08-04 | Univ Padova | Modulatori del tgf-b e loro uso |
US8454952B2 (en) | 2006-03-13 | 2013-06-04 | The Johns Hopkins University | Augmentation of endothelial thromboresistance |
JP2009539842A (ja) | 2006-06-05 | 2009-11-19 | ノバルティス アクチエンゲゼルシャフト | 副甲状腺関連障害の処置におけるTGF−βアンタゴニストの使用 |
US8642034B2 (en) | 2006-10-03 | 2014-02-04 | Genzyme Corporation | Use of TGF-β antagonists to treat infants at risk of developing bronchopulmonary dysplasia |
EP2578684B1 (en) | 2007-03-19 | 2016-02-24 | National Research Council Of Canada | Antagonists of ligands and uses thereof |
EP2171062A1 (en) | 2007-06-15 | 2010-04-07 | Genzyme Corporation | Fusion proteins containing two tgf-beta binding domains of tgf-beta type ii receptor |
KR101171488B1 (ko) | 2007-08-22 | 2012-08-07 | 아이알엠 엘엘씨 | 키나제 억제제로서의 2-헤테로아릴아미노-피리미딘 유도체 |
US20110245107A1 (en) | 2008-01-18 | 2011-10-06 | The Brigham And Women's Hospital, Inc. | Selective differentiation, identification, amd modulation of human th17 cells |
US8658135B2 (en) | 2008-03-19 | 2014-02-25 | National Research Council Of Canada | Antagonists of ligands and uses thereof |
WO2009143309A2 (en) | 2008-05-21 | 2009-11-26 | Trustees Of Dartmouth College | Female reproductive tract and anal prophylaxes |
WO2009152610A1 (en) | 2008-06-20 | 2009-12-23 | The Royal Institution For The Advancement Of Learning/Mcgill University | Interleukin-2/soluble tgf-beta type ii receptor b conjugates and methods and uses thereof |
WO2010003118A1 (en) | 2008-07-02 | 2010-01-07 | Trubion Pharmaceuticals, Inc. | Tgf-b antagonist multi-target binding proteins |
US20120010178A1 (en) | 2008-10-21 | 2012-01-12 | President And Fellows Of Harvard College | Methods and compounds for treatment of neurodegenerative disorders |
EP2387412A4 (en) | 2009-01-13 | 2013-04-03 | Acceleron Pharma Inc | METHODS FOR INCREASING ADIPONECTIN |
US20120114640A1 (en) | 2009-05-08 | 2012-05-10 | Kulkarni Ashok B | MODULATION OF THE TGF- ß AND PI3K/AKT PATHWAYS IN THE DIAGNOSIS AND TREATMENT OF SQUAMOUS CELL CARCINOMA |
EP2524038A4 (en) | 2010-01-12 | 2013-11-20 | Isis Pharmaceuticals Inc | MODULATION OF TRANSFORMING A GROWTH FACTOR BETA-1 EXPRESSION |
IL300733A (en) * | 2010-03-05 | 2023-04-01 | Univ Johns Hopkins | Compositions and methods for antibodies and fusion proteins targeting immune modulation |
CN101852804B (zh) | 2010-03-29 | 2013-06-12 | 中国医学科学院病原生物学研究所 | Gdf15蛋白的抗体的新用途 |
US8080568B1 (en) | 2010-06-29 | 2011-12-20 | Ewha University - Industry Collaboration Foundation | 2-pyridyl substituted imidazoles as therapeutic ALK5 and/or ALK4 inhibitors |
RU2637088C2 (ru) | 2010-09-01 | 2017-11-29 | Джензим Корпорейшн | Лечение инфаркта миокарда с использованием антагонистов tgf-бета |
US20130287688A1 (en) | 2010-11-18 | 2013-10-31 | Xtuit Pharmaceuticals, Inc. | Novel compositions and uses of anti-hypertension agents for cancer therapy |
US8800906B2 (en) | 2010-12-27 | 2014-08-12 | The Board Of Trustees Of The Leland Stanford Junior University | Use of transforming growth factor-beta neutralizing antibodies and fusion proteins thereof in treating pain |
SG191762A1 (en) | 2011-01-06 | 2013-08-30 | Glaxo Group Ltd | Ligands that bind tgf-beta receptor ii |
AU2012245491C1 (en) * | 2011-04-19 | 2017-12-21 | Merrimack Pharmaceuticals, Inc. | Monospecific and bispecific anti-IGF-1R and anti-ErbB3 antibodies |
CN108178789B (zh) | 2011-04-20 | 2021-11-02 | 阿塞勒隆制药公司 | 内皮糖蛋白多肽及其用途 |
CN102850458B (zh) | 2011-06-28 | 2014-10-01 | 华博生物医药技术(上海)有限公司 | 新型重组双功能融合蛋白及其制法和用途 |
WO2013012648A1 (en) | 2011-07-15 | 2013-01-24 | Emory University | Gdf15 in diagnostic and therapeutic applications |
CA2843535C (en) | 2011-08-01 | 2021-04-06 | Tufts Medical Center, Inc. | Treatment of cardiac diseases and fibrosis with endoglin receptor antibodies and antigen-binding fragments thereof |
AU2013202269A1 (en) | 2011-10-26 | 2013-05-16 | Howard Florey Institute Of Experimental Physiology And Medicine | Compositions and methods for the treatment of fibrosis and fibrotic diseases |
MY174248A (en) | 2012-04-30 | 2020-04-01 | Biocon Ltd | Targeted/immunomodulatory fusion proteins and methods for making same |
US20150080320A1 (en) | 2012-05-16 | 2015-03-19 | Aadigen, Llc | Multi-target modulation for treating fibrosis and inflammatory conditions |
UY35384A (es) | 2013-03-11 | 2014-10-31 | Genzyme Corp | Anticuerpos y fragmentos de unión a antígeno diseñados para unirse al factor de crecimiento transformante ß (TGFß). |
PT2970512T (pt) | 2013-03-12 | 2019-01-17 | Biocon Ltd | Proteínas de fusão imunomoduladoras e métodos para produção das mesmas |
EP3470423B1 (en) | 2013-04-17 | 2021-10-06 | Baylor College of Medicine | Immunosuppressive tgf-beta signal converter |
EP3705498A1 (en) * | 2013-08-22 | 2020-09-09 | Acceleron Pharma Inc. | Tgf-beta receptor type ii variants and uses thereof |
CA2931309C (en) | 2013-11-21 | 2022-06-21 | The Brigham And Women's Hospital, Inc. | Compositions and methods for treating pulmonary hypertension |
SG10202108879SA (en) * | 2014-02-10 | 2021-09-29 | Merck Patent Gmbh | TARGETED TGFβ INHIBITION |
US10624929B2 (en) | 2014-05-18 | 2020-04-21 | Children's Medical Center Corporation | Methods and compositions relating to exosomes |
BR112016028833A2 (pt) | 2014-06-13 | 2017-08-22 | Novartis Ag | uso de serelaxinaa para reduzir gdf-15 |
CN106794233B (zh) | 2014-08-01 | 2021-11-12 | 布里格姆及妇女医院股份有限公司 | 与肺动脉高压的治疗有关的组合物和方法 |
JP6631865B2 (ja) * | 2014-08-11 | 2020-01-15 | 日本化薬株式会社 | TGFβ阻害機能を持つキメラタンパク質 |
MA53400A (fr) | 2015-04-06 | 2021-08-04 | Acceleron Pharma Inc | Hétéromultimères alk7: actriib et leurs utilisations |
KR20170141215A (ko) | 2015-04-06 | 2017-12-22 | 악셀레론 파마 인코포레이티드 | 싱글-암 유형 i과 유형 ii 수용체 융합 단백질들 및 이들의 용도 |
US9884900B2 (en) | 2015-08-04 | 2018-02-06 | Acceleron Pharma Inc. | Methods for treating Janus kinase-associated disorders by administering soluble transforming growth factor beta type II receptor |
CA2996996A1 (en) | 2015-08-31 | 2017-03-09 | National Research Council Of Canada | Tgf-.beta.-receptor ectodomain fusion molecules and uses thereof |
WO2017134592A1 (en) | 2016-02-03 | 2017-08-10 | Biocon Limited | Anti-cd20/immunomodulatory fusion proteins and methods for making same |
IL264730B1 (en) | 2016-08-12 | 2024-05-01 | Merck Patent Gmbh | A pharmaceutical preparation containing TGFbetaRII and another anti-cancer preparation |
CA3038526A1 (en) * | 2016-09-27 | 2018-04-05 | Epicentrx, Inc. | Immunomodulatory fusion proteins |
CA3048646A1 (en) | 2017-01-07 | 2018-07-12 | Merck Patent Gmbh | Dosing regimens and dosage forms for targeted tgf-b inhibition |
AU2018228435A1 (en) | 2017-03-02 | 2019-10-03 | National Research Council Of Canada | TGF-beta-receptor ectodomain fusion molecules and uses thereof |
US20220211805A1 (en) | 2018-02-09 | 2022-07-07 | Acceleron Pharma Inc. | Methods for treating heterotopic ossification |
-
2018
- 2018-05-03 DK DK18794202.4T patent/DK3628049T3/da active
- 2018-05-03 MD MDE20200304T patent/MD3628049T2/ro unknown
- 2018-05-03 FI FIEP18794202.4T patent/FI3628049T3/fi active
- 2018-05-03 PT PT187942024T patent/PT3628049T/pt unknown
- 2018-05-03 SI SI201830937T patent/SI3628049T1/sl unknown
- 2018-05-03 AU AU2018261131A patent/AU2018261131A1/en not_active Abandoned
- 2018-05-03 PL PL18794202.4T patent/PL3628049T3/pl unknown
- 2018-05-03 HU HUE18794202A patent/HUE063840T2/hu unknown
- 2018-05-03 KR KR1020247004165A patent/KR20240023201A/ko active Application Filing
- 2018-05-03 ES ES18794202T patent/ES2948647T3/es active Active
- 2018-05-03 CN CN201880041794.2A patent/CN110785431B/zh active Active
- 2018-05-03 BR BR112019023071A patent/BR112019023071A2/pt unknown
- 2018-05-03 US US15/969,957 patent/US11021527B2/en active Active
- 2018-05-03 EP EP23171804.0A patent/EP4241848A3/en active Pending
- 2018-05-03 CA CA3061472A patent/CA3061472A1/en active Pending
- 2018-05-03 HR HRP20230706TT patent/HRP20230706T1/hr unknown
- 2018-05-03 WO PCT/US2018/030816 patent/WO2018204594A1/en unknown
- 2018-05-03 LT LTEPPCT/US2018/030816T patent/LT3628049T/lt unknown
- 2018-05-03 JP JP2019559817A patent/JP7267664B2/ja active Active
- 2018-05-03 RS RS20230526A patent/RS64315B1/sr unknown
- 2018-05-03 EP EP18794202.4A patent/EP3628049B1/en active Active
- 2018-05-03 KR KR1020197035693A patent/KR102635723B1/ko active IP Right Grant
-
2021
- 2021-04-30 US US17/245,581 patent/US20210324040A1/en active Pending
-
2023
- 2023-01-17 AU AU2023200218A patent/AU2023200218A1/en active Pending
- 2023-01-31 JP JP2023012757A patent/JP2023055827A/ja active Pending
- 2023-07-28 CY CY20231100378T patent/CY1126121T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
SI3628049T1 (sl) | 2023-10-30 |
BR112019023071A2 (pt) | 2020-06-09 |
HUE063840T2 (hu) | 2024-02-28 |
PL3628049T3 (pl) | 2023-09-25 |
US20180327477A1 (en) | 2018-11-15 |
US20210324040A1 (en) | 2021-10-21 |
US11021527B2 (en) | 2021-06-01 |
EP3628049B1 (en) | 2023-05-10 |
MD3628049T2 (ro) | 2023-10-31 |
PT3628049T (pt) | 2023-07-03 |
AU2023200218A1 (en) | 2023-02-16 |
CA3061472A1 (en) | 2018-11-08 |
JP7267664B2 (ja) | 2023-05-02 |
KR20200003873A (ko) | 2020-01-10 |
KR102635723B1 (ko) | 2024-02-08 |
HRP20230706T1 (hr) | 2023-10-13 |
CN110785431B (zh) | 2024-05-07 |
WO2018204594A1 (en) | 2018-11-08 |
EP4241848A2 (en) | 2023-09-13 |
RS64315B1 (sr) | 2023-08-31 |
EP4241848A3 (en) | 2023-11-01 |
FI3628049T3 (fi) | 2023-07-26 |
JP2020518246A (ja) | 2020-06-25 |
LT3628049T (lt) | 2023-08-25 |
CN110785431A (zh) | 2020-02-11 |
AU2018261131A1 (en) | 2019-11-07 |
EP3628049A4 (en) | 2021-01-13 |
JP2023055827A (ja) | 2023-04-18 |
EP3628049A1 (en) | 2020-04-01 |
KR20240023201A (ko) | 2024-02-20 |
CY1126121T1 (el) | 2023-11-15 |
ES2948647T3 (es) | 2023-09-15 |
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