ZA914750B - Methods of modulating blood pressure using tgf-beta and antagonists thereof - Google Patents

Methods of modulating blood pressure using tgf-beta and antagonists thereof

Info

Publication number
ZA914750B
ZA914750B ZA914750A ZA914750A ZA914750B ZA 914750 B ZA914750 B ZA 914750B ZA 914750 A ZA914750 A ZA 914750A ZA 914750 A ZA914750 A ZA 914750A ZA 914750 B ZA914750 B ZA 914750B
Authority
ZA
South Africa
Prior art keywords
tgf
antagonists
beta
methods
blood pressure
Prior art date
Application number
ZA914750A
Inventor
Frederick B Oleson Jr
B Oleson Frederick Jr
Charles R Comereski
R Comereski Charles
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of ZA914750B publication Critical patent/ZA914750B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/495—Transforming growth factor [TGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ZA914750A 1990-06-20 1991-06-20 Methods of modulating blood pressure using tgf-beta and antagonists thereof ZA914750B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US54122190A 1990-06-20 1990-06-20

Publications (1)

Publication Number Publication Date
ZA914750B true ZA914750B (en) 1992-03-25

Family

ID=24158683

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA914750A ZA914750B (en) 1990-06-20 1991-06-20 Methods of modulating blood pressure using tgf-beta and antagonists thereof

Country Status (4)

Country Link
IL (1) IL98569A0 (en)
TW (1) TW205005B (en)
WO (1) WO1991019513A1 (en)
ZA (1) ZA914750B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5571714A (en) * 1988-12-22 1996-11-05 Celtrix Pharmaceuticals, Inc. Monoclonal antibodies which bind both transforming growth factors β1 and β2 and methods of use
US5280109A (en) * 1992-01-27 1994-01-18 Ludwig Institute For Cancer Research Isolated, large latent complexes of TGF-β2 and TGF-β3, and new binding protein for latent form TGF-β1, TGF-β2 and TGF-β3 LTBP-2
DE69332026T2 (en) * 1992-10-29 2002-10-31 Celtrix Pharma TYPE II TGF-BETA BINDING RECEPTOR FRAGMENT AS A THERAPEUTIC AGENT
EP0684828A4 (en) * 1993-02-19 1996-08-07 Celtrix Pharma EXPANSION OF STEM CELLS IN LONG TERM BONE MARROW CULTURES BY NEUTRALIZATION OF TGF--g(b).
CA2221318C (en) * 1995-06-02 2012-01-24 Nexstar Pharmaceuticals, Inc. High affinity oligonucleotide ligands to growth factors
DE19613691A1 (en) 1996-04-05 1997-10-09 Boehringer Ingelheim Int Medicines for the treatment of tumor diseases
IL151369A0 (en) * 2000-03-09 2003-04-10 Genzyme Corp USE OF TGF-beta ANTAGONISTS FOR PREPARATION OF A PHARMACEUTICAL COMPOSITION
US9974759B2 (en) 2013-05-31 2018-05-22 Indiana University Research And Technology Corporation Beta 2 adrenoceptor antagonists for treating orthostatic hypotension
CN105658672A (en) 2013-08-22 2016-06-08 阿塞勒隆制药公司 TGF-beta receptor type II variants and uses thereof
CA2994413A1 (en) 2015-08-04 2017-02-09 Acceleron Pharma, Inc. Methods for treating myeloproliferative disorders
KR102635723B1 (en) 2017-05-04 2024-02-08 악셀레론 파마 인코포레이티드 TGF-beta receptor type II fusion protein and uses thereof

Also Published As

Publication number Publication date
WO1991019513A1 (en) 1991-12-26
IL98569A0 (en) 1992-07-15
TW205005B (en) 1993-05-01

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