DK3707261T3 - Fusionsproteiner baseret på humant ferritin og protease-spaltbare peptider og deres anvendelse som kemoterapi-bærestoffer - Google Patents

Fusionsproteiner baseret på humant ferritin og protease-spaltbare peptider og deres anvendelse som kemoterapi-bærestoffer Download PDF

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Publication number
DK3707261T3
DK3707261T3 DK18797162.7T DK18797162T DK3707261T3 DK 3707261 T3 DK3707261 T3 DK 3707261T3 DK 18797162 T DK18797162 T DK 18797162T DK 3707261 T3 DK3707261 T3 DK 3707261T3
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DK
Denmark
Prior art keywords
chemotherapy
protease
carriers
fusion proteins
proteins based
Prior art date
Application number
DK18797162.7T
Other languages
English (en)
Inventor
Aldo Braca
Original Assignee
Thena Biotech S R L
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Thena Biotech S R L filed Critical Thena Biotech S R L
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Publication of DK3707261T3 publication Critical patent/DK3707261T3/da

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6925—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a microcapsule, nanocapsule, microbubble or nanobubble
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/735—Fusion polypeptide containing domain for protein-protein interaction containing a domain for self-assembly, e.g. a viral coat protein (includes phage display)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nanotechnology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medical Informatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Optics & Photonics (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK18797162.7T 2017-11-06 2018-11-05 Fusionsproteiner baseret på humant ferritin og protease-spaltbare peptider og deres anvendelse som kemoterapi-bærestoffer DK3707261T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT201700116184 2017-11-06
PCT/IB2018/058655 WO2019087155A1 (en) 2017-11-06 2018-11-05 Fusion-proteins based on human ferritin and protease-cleavable peptides and their use as chemotherapeutics carriers

Publications (1)

Publication Number Publication Date
DK3707261T3 true DK3707261T3 (da) 2022-07-11

Family

ID=61581399

Family Applications (1)

Application Number Title Priority Date Filing Date
DK18797162.7T DK3707261T3 (da) 2017-11-06 2018-11-05 Fusionsproteiner baseret på humant ferritin og protease-spaltbare peptider og deres anvendelse som kemoterapi-bærestoffer

Country Status (11)

Country Link
US (1) US11987604B2 (da)
EP (1) EP3707261B1 (da)
JP (1) JP7297745B2 (da)
CN (1) CN111328346B (da)
CA (1) CA3082076A1 (da)
DK (1) DK3707261T3 (da)
EA (1) EA202090897A1 (da)
ES (1) ES2923152T3 (da)
PL (1) PL3707261T3 (da)
PT (1) PT3707261T (da)
WO (1) WO2019087155A1 (da)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2741782B1 (en) * 2011-08-12 2020-05-06 Ascendis Pharma A/S Protein carrier-linked prodrugs
CA3082076A1 (en) 2017-11-06 2019-05-09 Thena Biotech S.r.l. Fusion-proteins based on human ferritin and protease-cleavable peptides and their use as chemotherapeutics carriers
WO2021008454A1 (zh) * 2019-07-12 2021-01-21 昆山新蕴达生物科技有限公司 基于铁蛋白重链亚基的药物载体
WO2022179536A1 (zh) * 2021-02-25 2022-09-01 昆山新蕴达生物科技有限公司 铁蛋白重链亚基突变体及其应用
CN115137839A (zh) * 2021-03-30 2022-10-04 南京纳么美科技有限公司 靶向-共装载亲/疏水药物的铁蛋白笼纳米载体及其应用
CN113476588B (zh) * 2021-07-06 2022-11-22 武汉大学 靶向乳腺癌的多功能纳米颗粒、其制备方法及其应用
CN114230671B (zh) * 2021-11-18 2023-12-01 中国科学院武汉病毒研究所 寨卡病毒重组蛋白疫苗及其制备方法
CN116410333A (zh) * 2021-12-31 2023-07-11 四川大学 一类促凋亡铁蛋白纳米粒和应用
CN114292834B (zh) * 2022-03-09 2022-05-31 天津辅元生物医药科技有限公司 一种融合蛋白酶及其制备方法、其在提取i型胶原蛋白中的应用以及该i型胶原蛋白的用途
CN115181733B (zh) * 2022-05-26 2023-11-21 中国农业科学院北京畜牧兽医研究所 相对定量分析猪铁蛋白重链fth1的肽段组合物及应用
CN114886873B (zh) * 2022-06-15 2023-03-24 南京林业大学 一种负载sn-38的铁蛋白纳米粒及其制备方法和应用
WO2024110757A1 (en) * 2022-11-24 2024-05-30 King's College London Control of nanocage self-assembly

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7550263B2 (en) * 2003-09-05 2009-06-23 Gtc Biotherapeutics, Inc. Method for the production of fusion proteins in transgenic mammal milk
NZ580670A (en) * 2007-06-21 2011-09-30 Univ Muenchen Tech Biological active proteins having increased in vivo and/or vitro stability
KR20150043505A (ko) 2012-09-07 2015-04-22 사노피 대사 증후군의 치료용 융합 단백질
RU2714155C2 (ru) 2014-09-30 2020-02-12 Тена Байотек С.Р.Л. Слитый белок, наночастица, состоящая из множества мономеров указанного слитого белка, и их применение
CA3082076A1 (en) 2017-11-06 2019-05-09 Thena Biotech S.r.l. Fusion-proteins based on human ferritin and protease-cleavable peptides and their use as chemotherapeutics carriers

Also Published As

Publication number Publication date
EP3707261A1 (en) 2020-09-16
CA3082076A1 (en) 2019-05-09
PT3707261T (pt) 2022-07-13
JP7297745B2 (ja) 2023-06-26
CN111328346A (zh) 2020-06-23
US20210403515A1 (en) 2021-12-30
US11987604B2 (en) 2024-05-21
WO2019087155A1 (en) 2019-05-09
JP2021509104A (ja) 2021-03-18
EP3707261B1 (en) 2022-05-04
ES2923152T3 (es) 2022-09-23
CN111328346B (zh) 2023-06-23
PL3707261T3 (pl) 2022-09-12
EA202090897A1 (ru) 2020-08-28

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