DK3322734T3 - Multivalente og multispecifikke DR5-bindende fusionsproteiner - Google Patents

Multivalente og multispecifikke DR5-bindende fusionsproteiner Download PDF

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Publication number
DK3322734T3
DK3322734T3 DK16825315.1T DK16825315T DK3322734T3 DK 3322734 T3 DK3322734 T3 DK 3322734T3 DK 16825315 T DK16825315 T DK 16825315T DK 3322734 T3 DK3322734 T3 DK 3322734T3
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Denmark
Prior art keywords
multispecific
multivalent
fusion proteins
binding fusion
binding
Prior art date
Application number
DK16825315.1T
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English (en)
Inventor
John C Timmer
Kyle S Jones
Amir S Razai
Abrahim Hussain
Katelyn M Willis
Quinn Deveraux
Brendan P Eckelman
Original Assignee
Inhibrx Inc
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Application filed by Inhibrx Inc filed Critical Inhibrx Inc
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Publication of DK3322734T3 publication Critical patent/DK3322734T3/da

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001136—Cytokines
    • A61K39/001138—Tumor necrosis factors [TNF] or CD70
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35—Valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Mycology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK16825315.1T 2015-07-16 2016-07-18 Multivalente og multispecifikke DR5-bindende fusionsproteiner DK3322734T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562193309P 2015-07-16 2015-07-16
PCT/US2016/042862 WO2017011837A2 (en) 2015-07-16 2016-07-18 Multivalent and multispecific dr5-binding fusion proteins

Publications (1)

Publication Number Publication Date
DK3322734T3 true DK3322734T3 (da) 2020-10-26

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
DK16825315.1T DK3322734T3 (da) 2015-07-16 2016-07-18 Multivalente og multispecifikke DR5-bindende fusionsproteiner

Country Status (25)

Country Link
US (3) US10308720B2 (da)
EP (2) EP3322734B1 (da)
JP (3) JP6807606B2 (da)
KR (1) KR20180030518A (da)
CN (2) CN114106178A (da)
AU (2) AU2016291701B2 (da)
BR (1) BR112018000584A2 (da)
CA (1) CA2991634A1 (da)
CY (1) CY1123615T1 (da)
DK (1) DK3322734T3 (da)
ES (1) ES2833773T3 (da)
HK (1) HK1254433A1 (da)
HR (1) HRP20201785T1 (da)
HU (1) HUE051896T2 (da)
IL (3) IL292037A (da)
LT (1) LT3322734T (da)
MX (2) MX2018000523A (da)
PL (1) PL3322734T3 (da)
PT (1) PT3322734T (da)
RS (1) RS61062B1 (da)
RU (2) RU2021111382A (da)
SG (1) SG10201912410TA (da)
SI (1) SI3322734T1 (da)
WO (1) WO2017011837A2 (da)
ZA (1) ZA201800238B (da)

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CA3058477A1 (en) 2017-04-11 2018-10-18 Inhibrx, Inc. Multispecific polypeptide constructs having constrained cd3 binding and methods of using the same
US20210079106A1 (en) * 2017-12-28 2021-03-18 Julius-Maximilians-Universität Würzburg TUMOR NECROSIS FACTOR (TNF) RECEPTOR SUPERFAMILY (TNFRSF) RECEPTOR-ACTIVATING ANTIBODY FUSION PROTEINS WITH FCgR-INDEPENDENT AGONISTIC ACTIVITY (TNFRSF RECEPTOR-ACTIVATING ANTIBODY FUSION PROTEINS WITH FCgR-INDEPENDENT AGONISTIC ACTIVITY; TRAAFFIAA)
CN110305210B (zh) * 2018-03-27 2023-02-28 信达生物制药(苏州)有限公司 新型抗体分子、其制备方法及其用途
WO2020047705A1 (zh) * 2018-09-03 2020-03-12 安菲尼生命科技有限公司 Dr5单域抗体及其用途
JP2024506931A (ja) * 2021-02-19 2024-02-15 インヒブルクス インコーポレイテッド Ｄｒ５結合性ポリペプチドの製剤
TW202404636A (zh) * 2022-04-08 2024-02-01 美商英伊布里克斯公司 Dr5促效劑及plk1抑制劑或cdk抑制劑之組合療法
WO2023230432A1 (en) * 2022-05-23 2023-11-30 Inhibrx, Inc. Dr5 agonist and iap antagonist combination therapy
WO2024069180A2 (en) 2022-09-28 2024-04-04 LiliumX Ltd. Multivalent proteins and screening methods

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Also Published As

Publication number Publication date
HUE051896T2 (hu) 2021-03-29
JP2018522888A (ja) 2018-08-16
WO2017011837A3 (en) 2017-03-02
AU2016291701B2 (en) 2022-09-29
RU2018102803A3 (da) 2019-12-27
CN107922491B (zh) 2021-09-28
JP7244938B2 (ja) 2023-03-23
PL3322734T3 (pl) 2021-05-04
LT3322734T (lt) 2021-02-10
ZA201800238B (en) 2021-07-28
JP2023022214A (ja) 2023-02-14
CY1123615T1 (el) 2022-03-24
AU2016291701A1 (en) 2018-01-25
US20220064318A1 (en) 2022-03-03
BR112018000584A2 (pt) 2018-09-11
CA2991634A1 (en) 2017-01-19
RU2748620C2 (ru) 2021-05-28
AU2022291498A1 (en) 2023-02-02
MX2023002379A (es) 2023-03-21
EP3322734A4 (en) 2019-04-17
HK1254433A1 (zh) 2019-07-19
SG10201912410TA (en) 2020-02-27
MX2018000523A (es) 2018-04-13
IL292037A (en) 2022-06-01
US11117973B2 (en) 2021-09-14
JP2021046414A (ja) 2021-03-25
SI3322734T1 (sl) 2021-02-26
US20190309083A1 (en) 2019-10-10
CN107922491A (zh) 2018-04-17
PT3322734T (pt) 2020-11-30
EP3322734A2 (en) 2018-05-23
RS61062B1 (sr) 2020-12-31
US10308720B2 (en) 2019-06-04
EP3798232A1 (en) 2021-03-31
US20170015753A1 (en) 2017-01-19
IL307994A (en) 2023-12-01
EP3322734B1 (en) 2020-09-09
HRP20201785T1 (hr) 2021-01-22
WO2017011837A2 (en) 2017-01-19
ES2833773T3 (es) 2021-06-15
JP6807606B2 (ja) 2021-01-06
IL256772A (en) 2018-03-29
RU2021111382A (ru) 2021-05-21
RU2018102803A (ru) 2019-08-19
US11976126B2 (en) 2024-05-07
KR20180030518A (ko) 2018-03-23
IL256772B (en) 2022-05-01
CN114106178A (zh) 2022-03-01

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