MX2023002379A - Proteinas de fusion de union a dr5 multivalentes y multiespecificas. - Google Patents

Proteinas de fusion de union a dr5 multivalentes y multiespecificas.

Info

Publication number
MX2023002379A
MX2023002379A MX2023002379A MX2023002379A MX2023002379A MX 2023002379 A MX2023002379 A MX 2023002379A MX 2023002379 A MX2023002379 A MX 2023002379A MX 2023002379 A MX2023002379 A MX 2023002379A MX 2023002379 A MX2023002379 A MX 2023002379A
Authority
MX
Mexico
Prior art keywords
multivalent
multispecific
fusion proteins
binding fusion
disclosure relates
Prior art date
Application number
MX2023002379A
Other languages
English (en)
Inventor
Quinn Deveraux
Amir S Razai
Abrahim Hussain
Katelyn M Willis
Kyle S Jones
Brendan P Eckelman
John C Timmer
Original Assignee
Inhibrx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inhibrx Inc filed Critical Inhibrx Inc
Publication of MX2023002379A publication Critical patent/MX2023002379A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001136—Cytokines
    • A61K39/001138—Tumor necrosis factors [TNF] or CD70
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35—Valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen

Abstract

En general, la descripción se refiere a moléculas que interactúan específicamente con el receptor de muerte 5 (DR5), un miembro de la superfamilia de receptores de TNF (TNFRSF); más específicamente, la descripción se refiere a moléculas multivalentes y multiespecíficas que se unen al menos a DR5.
MX2023002379A 2015-07-16 2018-01-12 Proteinas de fusion de union a dr5 multivalentes y multiespecificas. MX2023002379A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201562193309P 2015-07-16 2015-07-16

Publications (1)

Publication Number Publication Date
MX2023002379A true MX2023002379A (es) 2023-03-21

Family

ID=57757772

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2018000523A MX2018000523A (es) 2015-07-16 2016-07-18 Proteinas de fusion de union a dr5 multivalentes y multiespecificas.
MX2023002379A MX2023002379A (es) 2015-07-16 2018-01-12 Proteinas de fusion de union a dr5 multivalentes y multiespecificas.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2018000523A MX2018000523A (es) 2015-07-16 2016-07-18 Proteinas de fusion de union a dr5 multivalentes y multiespecificas.

Country Status (25)

Country Link
US (3) US10308720B2 (es)
EP (2) EP3798232A1 (es)
JP (3) JP6807606B2 (es)
KR (1) KR20180030518A (es)
CN (2) CN114106178A (es)
AU (2) AU2016291701B2 (es)
BR (1) BR112018000584A2 (es)
CA (1) CA2991634A1 (es)
CY (1) CY1123615T1 (es)
DK (1) DK3322734T3 (es)
ES (1) ES2833773T3 (es)
HK (1) HK1254433A1 (es)
HR (1) HRP20201785T1 (es)
HU (1) HUE051896T2 (es)
IL (3) IL292037A (es)
LT (1) LT3322734T (es)
MX (2) MX2018000523A (es)
PL (1) PL3322734T3 (es)
PT (1) PT3322734T (es)
RS (1) RS61062B1 (es)
RU (2) RU2748620C2 (es)
SG (1) SG10201912410TA (es)
SI (1) SI3322734T1 (es)
WO (1) WO2017011837A2 (es)
ZA (1) ZA201800238B (es)

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EP3619235A1 (en) 2017-04-11 2020-03-11 Inhibrx, Inc. Multispecific polypeptide constructs having constrained cd3 binding and methods of using the same
EP3732197A1 (en) * 2017-12-28 2020-11-04 Julius-Maximilians-Universität Würzburg TUMOR NECROSIS FACTOR (TNF) RECEPTOR SUPERFAMILY (TNFRSF) RECEPTOR-ACTIVATING ANTIBODY FUSION PROTEINS WITH FCyR-INDEPENDENT AGONISTIC ACTIVITY (TNFRSF RECEPTOR-ACTIVATING ANTIBODY FUSION PROTEINS WITH FCyR-INDEPENDENT AGONISTIC ACTIVITY; TRAAFFIAA)
CN110305210B (zh) * 2018-03-27 2023-02-28 信达生物制药(苏州)有限公司 新型抗体分子、其制备方法及其用途
WO2020047705A1 (zh) * 2018-09-03 2020-03-12 安菲尼生命科技有限公司 Dr5单域抗体及其用途
EP4294842A1 (en) * 2021-02-19 2023-12-27 Inhibrx, Inc. Formulations of dr5 binding polypeptides
TW202404636A (zh) * 2022-04-08 2024-02-01 美商英伊布里克斯公司 Dr5促效劑及plk1抑制劑或cdk抑制劑之組合療法
WO2023230432A1 (en) * 2022-05-23 2023-11-30 Inhibrx, Inc. Dr5 agonist and iap antagonist combination therapy
WO2024069180A2 (en) 2022-09-28 2024-04-04 LiliumX Ltd. Multivalent proteins and screening methods

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Also Published As

Publication number Publication date
JP2023022214A (ja) 2023-02-14
MX2018000523A (es) 2018-04-13
KR20180030518A (ko) 2018-03-23
US11976126B2 (en) 2024-05-07
EP3322734A4 (en) 2019-04-17
IL256772A (en) 2018-03-29
HUE051896T2 (hu) 2021-03-29
ZA201800238B (en) 2021-07-28
US10308720B2 (en) 2019-06-04
JP2021046414A (ja) 2021-03-25
US20220064318A1 (en) 2022-03-03
CA2991634A1 (en) 2017-01-19
RU2748620C2 (ru) 2021-05-28
BR112018000584A2 (pt) 2018-09-11
WO2017011837A3 (en) 2017-03-02
HK1254433A1 (zh) 2019-07-19
CY1123615T1 (el) 2022-03-24
ES2833773T3 (es) 2021-06-15
IL292037A (en) 2022-06-01
PT3322734T (pt) 2020-11-30
CN107922491B (zh) 2021-09-28
SG10201912410TA (en) 2020-02-27
US11117973B2 (en) 2021-09-14
US20170015753A1 (en) 2017-01-19
RS61062B1 (sr) 2020-12-31
WO2017011837A2 (en) 2017-01-19
JP2018522888A (ja) 2018-08-16
US20190309083A1 (en) 2019-10-10
HRP20201785T1 (hr) 2021-01-22
RU2018102803A (ru) 2019-08-19
EP3322734A2 (en) 2018-05-23
CN107922491A (zh) 2018-04-17
SI3322734T1 (sl) 2021-02-26
EP3798232A1 (en) 2021-03-31
IL307994A (en) 2023-12-01
AU2016291701A1 (en) 2018-01-25
JP7244938B2 (ja) 2023-03-23
IL256772B (en) 2022-05-01
LT3322734T (lt) 2021-02-10
EP3322734B1 (en) 2020-09-09
DK3322734T3 (da) 2020-10-26
CN114106178A (zh) 2022-03-01
AU2022291498A1 (en) 2023-02-02
RU2021111382A (ru) 2021-05-21
RU2018102803A3 (es) 2019-12-27
AU2016291701B2 (en) 2022-09-29
JP6807606B2 (ja) 2021-01-06
PL3322734T3 (pl) 2021-05-04

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