MX2018008310A - Proteinas de fusion de union a ox40 multivalentes y multiespecificas. - Google Patents

Proteinas de fusion de union a ox40 multivalentes y multiespecificas.

Info

Publication number
MX2018008310A
MX2018008310A MX2018008310A MX2018008310A MX2018008310A MX 2018008310 A MX2018008310 A MX 2018008310A MX 2018008310 A MX2018008310 A MX 2018008310A MX 2018008310 A MX2018008310 A MX 2018008310A MX 2018008310 A MX2018008310 A MX 2018008310A
Authority
MX
Mexico
Prior art keywords
multivalent
multispecific
fusion proteins
binding fusion
specifically
Prior art date
Application number
MX2018008310A
Other languages
English (en)
Inventor
Brendan P Eckelman
John C Timmer
Quinn Deveraux
S Razai Amir
Hussain Abrahim
S Jones Kyle
Hata Chelsie
Becklund Bryan
Pandit Rajay
Kaplan Mike
Rason Lucas
Original Assignee
Inhibrx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inhibrx Inc filed Critical Inhibrx Inc
Publication of MX2018008310A publication Critical patent/MX2018008310A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35—Valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

En general, la presente invención se refiere a moléculas que interactúan específicamente con OX40, un miembro de la superfamilia de receptores de TNF (TNFRSF); más específicamente, la presente invención se refiere a moléculas multivalentes y multiespecíficas que se unen al menos a OX40.8.
MX2018008310A 2016-01-11 2017-01-11 Proteinas de fusion de union a ox40 multivalentes y multiespecificas. MX2018008310A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662277027P 2016-01-11 2016-01-11
PCT/US2017/013070 WO2017123673A2 (en) 2016-01-11 2017-01-11 Multivalent and multispecific ox40-binding fusion proteins

Publications (1)

Publication Number Publication Date
MX2018008310A true MX2018008310A (es) 2019-01-28

Family

ID=59275443

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018008310A MX2018008310A (es) 2016-01-11 2017-01-11 Proteinas de fusion de union a ox40 multivalentes y multiespecificas.

Country Status (13)

Country Link
US (3) US20170198051A1 (es)
EP (1) EP3402507A4 (es)
JP (2) JP7328761B2 (es)
KR (1) KR20180098671A (es)
CN (1) CN108883153A (es)
AU (2) AU2017207318B2 (es)
BR (1) BR112018013911A2 (es)
CA (1) CA3009075A1 (es)
IL (2) IL298686A (es)
MX (1) MX2018008310A (es)
RU (1) RU2022106508A (es)
SG (1) SG11201805422WA (es)
WO (1) WO2017123673A2 (es)

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Also Published As

Publication number Publication date
KR20180098671A (ko) 2018-09-04
EP3402507A2 (en) 2018-11-21
IL298686A (en) 2023-01-01
IL260531A (es) 2018-08-30
WO2017123673A3 (en) 2017-08-24
IL260531B2 (en) 2023-05-01
RU2018128629A (ru) 2020-02-13
BR112018013911A2 (pt) 2018-12-18
SG11201805422WA (en) 2018-07-30
AU2017207318B2 (en) 2023-12-07
US20190263916A1 (en) 2019-08-29
WO2017123673A2 (en) 2017-07-20
AU2024200551A1 (en) 2024-02-22
RU2018128629A3 (es) 2020-06-16
JP2019504062A (ja) 2019-02-14
IL260531B1 (en) 2023-01-01
EP3402507A4 (en) 2019-08-07
CA3009075A1 (en) 2017-07-20
CN108883153A (zh) 2018-11-23
JP2022185021A (ja) 2022-12-13
US20170198051A1 (en) 2017-07-13
RU2022106508A (ru) 2022-04-05
AU2017207318A1 (en) 2018-07-12
US20220106397A1 (en) 2022-04-07
US11117972B2 (en) 2021-09-14
JP7328761B2 (ja) 2023-08-17

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