RU2022106508A - Поливалентные и полиспецифические ох40-связывающие слитые белки - Google Patents

Поливалентные и полиспецифические ох40-связывающие слитые белки Download PDF

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Publication number
RU2022106508A
RU2022106508A RU2022106508A RU2022106508A RU2022106508A RU 2022106508 A RU2022106508 A RU 2022106508A RU 2022106508 A RU2022106508 A RU 2022106508A RU 2022106508 A RU2022106508 A RU 2022106508A RU 2022106508 A RU2022106508 A RU 2022106508A
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RU
Russia
Prior art keywords
polyspecific
polyvalent
binding function
function proteins
proteins
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RU2022106508A
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English (en)
Inventor
Брендан П. ЭКЕЛЬМАН
Джон К. ТИММЕР
Челси ХАТА
Кайл С. ДЖОНС
Абрахим ХУССЕЙН
Амир С. РАЗАИ
Брайан БЕКЛУНД
Раджай ПАНДИТ
Майк КАПЛАН
Лукас РЭСКОН
Куинн Деверо
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Инхибркс, Инк.
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Publication of RU2022106508A publication Critical patent/RU2022106508A/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35—Valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Claims (1)

  1. Выделенный полипептид, который связывает OX40 и содержит множество доменов VHH, где каждый домен VHH связывает OX40, и где указанный полипептид является по меньшей мере тетравалентным.
RU2022106508A 2016-01-11 2017-01-11 Поливалентные и полиспецифические ох40-связывающие слитые белки RU2022106508A (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662277027P 2016-01-11 2016-01-11
US62/277,027 2016-01-11

Related Parent Applications (1)

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RU2018128629A Division RU2773052C2 (ru) 2016-01-11 2017-01-11 Поливалентные и полиспецифические ох40-связывающие слитые белки

Publications (1)

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Country Link
US (3) US20170198051A1 (ru)
EP (1) EP3402507A4 (ru)
JP (2) JP7328761B2 (ru)
KR (1) KR20180098671A (ru)
CN (1) CN108883153A (ru)
AU (2) AU2017207318B2 (ru)
BR (1) BR112018013911A2 (ru)
CA (1) CA3009075A1 (ru)
IL (2) IL298686A (ru)
MX (1) MX2018008310A (ru)
RU (1) RU2022106508A (ru)
SG (1) SG11201805422WA (ru)
WO (1) WO2017123673A2 (ru)

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US20190263916A1 (en) 2019-08-29
JP2019504062A (ja) 2019-02-14
MX2018008310A (es) 2019-01-28
EP3402507A2 (en) 2018-11-21
IL260531A (ru) 2018-08-30
JP7328761B2 (ja) 2023-08-17
CA3009075A1 (en) 2017-07-20
US11117972B2 (en) 2021-09-14
EP3402507A4 (en) 2019-08-07
AU2017207318B2 (en) 2023-12-07
IL298686A (en) 2023-01-01
WO2017123673A3 (en) 2017-08-24
KR20180098671A (ko) 2018-09-04
IL260531B2 (en) 2023-05-01
US20170198051A1 (en) 2017-07-13
US20220106397A1 (en) 2022-04-07
RU2018128629A (ru) 2020-02-13
IL260531B1 (en) 2023-01-01
SG11201805422WA (en) 2018-07-30
AU2024200551A1 (en) 2024-02-22
RU2018128629A3 (ru) 2020-06-16
AU2017207318A1 (en) 2018-07-12
BR112018013911A2 (pt) 2018-12-18
WO2017123673A2 (en) 2017-07-20
CN108883153A (zh) 2018-11-23
JP2022185021A (ja) 2022-12-13

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