EA201992883A1 - АНТИТЕЛА К TrkB - Google Patents
АНТИТЕЛА К TrkBInfo
- Publication number
- EA201992883A1 EA201992883A1 EA201992883A EA201992883A EA201992883A1 EA 201992883 A1 EA201992883 A1 EA 201992883A1 EA 201992883 A EA201992883 A EA 201992883A EA 201992883 A EA201992883 A EA 201992883A EA 201992883 A1 EA201992883 A1 EA 201992883A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- trkb
- antibodies
- therapeutic
- compositions
- relates
- Prior art date
Links
- 101150056950 Ntrk2 gene Proteins 0.000 title abstract 2
- 239000000556 agonist Substances 0.000 abstract 1
- 238000002405 diagnostic procedure Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Hospice & Palliative Care (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Psychiatry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Настоящее изобретение относится к новым агонистическим антителам к TrkB и терапевтическим и диагностическим способам и композициям для их применения.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP17175122 | 2017-06-09 | ||
PCT/EP2018/065107 WO2018224630A1 (en) | 2017-06-09 | 2018-06-08 | Anti-trkb antibodies |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201992883A1 true EA201992883A1 (ru) | 2020-05-08 |
Family
ID=59034551
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201992883A EA201992883A1 (ru) | 2017-06-09 | 2018-06-08 | АНТИТЕЛА К TrkB |
Country Status (22)
Country | Link |
---|---|
US (3) | US10793634B2 (ru) |
EP (1) | EP3635004A1 (ru) |
JP (2) | JP7267208B2 (ru) |
KR (1) | KR20200017421A (ru) |
CN (1) | CN110719916B (ru) |
AR (1) | AR112602A1 (ru) |
AU (1) | AU2018279184A1 (ru) |
BR (1) | BR112019023742A2 (ru) |
CA (1) | CA3063965A1 (ru) |
CL (1) | CL2019003557A1 (ru) |
CO (1) | CO2019013718A2 (ru) |
EA (1) | EA201992883A1 (ru) |
IL (1) | IL271067B2 (ru) |
MA (1) | MA49257A (ru) |
MX (1) | MX2019014714A (ru) |
MY (1) | MY202315A (ru) |
PE (1) | PE20200173A1 (ru) |
PH (1) | PH12019502694A1 (ru) |
SG (1) | SG11201911814UA (ru) |
TW (2) | TWI808086B (ru) |
UA (1) | UA127967C2 (ru) |
WO (1) | WO2018224630A1 (ru) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110691790A (zh) * | 2017-06-02 | 2020-01-14 | 勃林格殷格翰国际有限公司 | 抗癌联合治疗 |
AR123862A1 (es) | 2020-10-21 | 2023-01-18 | Boehringer Ingelheim Int | Moléculas de unión biespecíficas anti-vegf y anti-trkb para el tratamiento de enfermedades oculares |
WO2023125485A1 (en) * | 2021-12-28 | 2023-07-06 | 4B Technologies (Beijing) Co., Limited | TrkB ANTIBODY AND APPLICATION THEREOF |
Family Cites Families (49)
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US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
US4275149A (en) | 1978-11-24 | 1981-06-23 | Syva Company | Macromolecular environment control in specific receptor assays |
US4318980A (en) | 1978-04-10 | 1982-03-09 | Miles Laboratories, Inc. | Heterogenous specific binding assay employing a cycling reactant as label |
JPS6023084B2 (ja) | 1979-07-11 | 1985-06-05 | 味の素株式会社 | 代用血液 |
US4419446A (en) | 1980-12-31 | 1983-12-06 | The United States Of America As Represented By The Department Of Health And Human Services | Recombinant DNA process utilizing a papilloma virus DNA as a vector |
NZ201705A (en) | 1981-08-31 | 1986-03-14 | Genentech Inc | Recombinant dna method for production of hepatitis b surface antigen in yeast |
US4640835A (en) | 1981-10-30 | 1987-02-03 | Nippon Chemiphar Company, Ltd. | Plasminogen activator derivatives |
US4601978A (en) | 1982-11-24 | 1986-07-22 | The Regents Of The University Of California | Mammalian metallothionein promoter system |
US4560655A (en) | 1982-12-16 | 1985-12-24 | Immunex Corporation | Serum-free cell culture medium and process for making same |
US4657866A (en) | 1982-12-21 | 1987-04-14 | Sudhir Kumar | Serum-free, synthetic, completely chemically defined tissue culture media |
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DD266710A3 (de) | 1983-06-06 | 1989-04-12 | Ve Forschungszentrum Biotechnologie | Verfahren zur biotechnischen Herstellung van alkalischer Phosphatase |
US4767704A (en) | 1983-10-07 | 1988-08-30 | Columbia University In The City Of New York | Protein-free culture medium |
US4496689A (en) | 1983-12-27 | 1985-01-29 | Miles Laboratories, Inc. | Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer |
US4965199A (en) | 1984-04-20 | 1990-10-23 | Genentech, Inc. | Preparation of functional human factor VIII in mammalian cells using methotrexate based selection |
US4879231A (en) | 1984-10-30 | 1989-11-07 | Phillips Petroleum Company | Transformation of yeasts of the genus pichia |
US4737456A (en) | 1985-05-09 | 1988-04-12 | Syntex (U.S.A.) Inc. | Reducing interference in ligand-receptor binding assays |
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GB8610600D0 (en) | 1986-04-30 | 1986-06-04 | Novo Industri As | Transformation of trichoderma |
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ATE135397T1 (de) | 1988-09-23 | 1996-03-15 | Cetus Oncology Corp | Zellenzuchtmedium für erhöhtes zellenwachstum, zur erhöhung der langlebigkeit und expression der produkte |
FR2646437B1 (fr) | 1989-04-28 | 1991-08-30 | Transgene Sa | Nouvelles sequences d'adn, leur application en tant que sequence codant pour un peptide signal pour la secretion de proteines matures par des levures recombinantes, cassettes d'expression, levures transformees et procede de preparation de proteines correspondant |
EP0402226A1 (en) | 1989-06-06 | 1990-12-12 | Institut National De La Recherche Agronomique | Transformation vectors for yeast yarrowia |
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EA200970469A1 (ru) | 2006-11-09 | 2010-04-30 | АйАрЭм ЭлЭлСи | Антитела-агонисты рецептора trkb и их применение |
JP2010513461A (ja) | 2006-12-20 | 2010-04-30 | ライナット ニューロサイエンス コーポレイション | 自己免疫障害を治療するためのTrkBアゴニスト |
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JP6868394B2 (ja) | 2014-05-16 | 2021-05-12 | ファイザー・インク | 二重特異性抗体 |
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SG11202002665UA (en) | 2017-11-30 | 2020-04-29 | Regeneron Pharma | Anti-trkb monoclonal antibodies and methods of use |
-
2018
- 2018-06-07 US US16/002,058 patent/US10793634B2/en active Active
- 2018-06-08 EA EA201992883A patent/EA201992883A1/ru unknown
- 2018-06-08 TW TW107119755A patent/TWI808086B/zh active
- 2018-06-08 MX MX2019014714A patent/MX2019014714A/es unknown
- 2018-06-08 WO PCT/EP2018/065107 patent/WO2018224630A1/en active Application Filing
- 2018-06-08 JP JP2019567701A patent/JP7267208B2/ja active Active
- 2018-06-08 MA MA049257A patent/MA49257A/fr unknown
- 2018-06-08 KR KR1020197037817A patent/KR20200017421A/ko active Search and Examination
- 2018-06-08 AU AU2018279184A patent/AU2018279184A1/en active Pending
- 2018-06-08 TW TW112123529A patent/TW202342100A/zh unknown
- 2018-06-08 BR BR112019023742A patent/BR112019023742A2/pt unknown
- 2018-06-08 UA UAA201911908A patent/UA127967C2/uk unknown
- 2018-06-08 SG SG11201911814UA patent/SG11201911814UA/en unknown
- 2018-06-08 EP EP18731764.9A patent/EP3635004A1/en active Pending
- 2018-06-08 MY MYPI2019007297A patent/MY202315A/en unknown
- 2018-06-08 PE PE2019002525A patent/PE20200173A1/es unknown
- 2018-06-08 CN CN201880038098.6A patent/CN110719916B/zh active Active
- 2018-06-08 IL IL271067A patent/IL271067B2/en unknown
- 2018-06-08 CA CA3063965A patent/CA3063965A1/en active Pending
- 2018-06-08 AR ARP180101558 patent/AR112602A1/es unknown
-
2019
- 2019-11-28 PH PH12019502694A patent/PH12019502694A1/en unknown
- 2019-12-05 CO CONC2019/0013718A patent/CO2019013718A2/es unknown
- 2019-12-05 CL CL2019003557A patent/CL2019003557A1/es unknown
-
2020
- 2020-08-26 US US17/002,907 patent/US11866501B2/en active Active
-
2023
- 2023-04-19 JP JP2023068735A patent/JP7505084B2/ja active Active
- 2023-11-28 US US18/520,650 patent/US20240101689A1/en active Pending
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