CL2019003557A1 - Anticuerpos anti-trkb. - Google Patents
Anticuerpos anti-trkb.Info
- Publication number
- CL2019003557A1 CL2019003557A1 CL2019003557A CL2019003557A CL2019003557A1 CL 2019003557 A1 CL2019003557 A1 CL 2019003557A1 CL 2019003557 A CL2019003557 A CL 2019003557A CL 2019003557 A CL2019003557 A CL 2019003557A CL 2019003557 A1 CL2019003557 A1 CL 2019003557A1
- Authority
- CL
- Chile
- Prior art keywords
- trkb antibodies
- trkb
- antibodies
- therapeutic
- compositions
- Prior art date
Links
- 239000000556 agonist Substances 0.000 abstract 1
- 238000002405 diagnostic procedure Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Abstract
LA PRESENTE INVENCIÓN SE REFIERE A ANTICUERPOS AGONISTAS ANTI-TRKB NOVEDOSOS Y MÉTODOS TERAPÉUTICOS Y DE DIAGNÓSTICO Y COMPOSICIONES PARA SU USO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP17175122 | 2017-06-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2019003557A1 true CL2019003557A1 (es) | 2020-05-04 |
Family
ID=59034551
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2019003557A CL2019003557A1 (es) | 2017-06-09 | 2019-12-05 | Anticuerpos anti-trkb. |
Country Status (21)
Country | Link |
---|---|
US (3) | US10793634B2 (es) |
EP (1) | EP3635004A1 (es) |
JP (2) | JP7267208B2 (es) |
KR (1) | KR20200017421A (es) |
CN (1) | CN110719916A (es) |
AR (1) | AR112602A1 (es) |
AU (1) | AU2018279184A1 (es) |
BR (1) | BR112019023742A2 (es) |
CA (1) | CA3063965A1 (es) |
CL (1) | CL2019003557A1 (es) |
CO (1) | CO2019013718A2 (es) |
EA (1) | EA201992883A1 (es) |
IL (1) | IL271067B1 (es) |
MA (1) | MA49257A (es) |
MX (1) | MX2019014714A (es) |
PE (1) | PE20200173A1 (es) |
PH (1) | PH12019502694A1 (es) |
SG (1) | SG11201911814UA (es) |
TW (2) | TW202342100A (es) |
UA (1) | UA127967C2 (es) |
WO (1) | WO2018224630A1 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2018277227A1 (en) * | 2017-06-02 | 2019-10-31 | Boehringer Ingelheim International Gmbh | Anti-cancer combination therapy |
EP4232474A1 (en) * | 2020-10-21 | 2023-08-30 | Boehringer Ingelheim International GmbH | Bispecific anti-vegf and anti-trkb binding molecules for the treatment of eye diseases |
WO2023125485A1 (en) * | 2021-12-28 | 2023-07-06 | 4B Technologies (Beijing) Co., Limited | TrkB ANTIBODY AND APPLICATION THEREOF |
Family Cites Families (49)
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US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
US4275149A (en) | 1978-11-24 | 1981-06-23 | Syva Company | Macromolecular environment control in specific receptor assays |
US4318980A (en) | 1978-04-10 | 1982-03-09 | Miles Laboratories, Inc. | Heterogenous specific binding assay employing a cycling reactant as label |
JPS6023084B2 (ja) | 1979-07-11 | 1985-06-05 | 味の素株式会社 | 代用血液 |
US4419446A (en) | 1980-12-31 | 1983-12-06 | The United States Of America As Represented By The Department Of Health And Human Services | Recombinant DNA process utilizing a papilloma virus DNA as a vector |
NZ201705A (en) | 1981-08-31 | 1986-03-14 | Genentech Inc | Recombinant dna method for production of hepatitis b surface antigen in yeast |
US4640835A (en) | 1981-10-30 | 1987-02-03 | Nippon Chemiphar Company, Ltd. | Plasminogen activator derivatives |
US4601978A (en) | 1982-11-24 | 1986-07-22 | The Regents Of The University Of California | Mammalian metallothionein promoter system |
US4560655A (en) | 1982-12-16 | 1985-12-24 | Immunex Corporation | Serum-free cell culture medium and process for making same |
US4657866A (en) | 1982-12-21 | 1987-04-14 | Sudhir Kumar | Serum-free, synthetic, completely chemically defined tissue culture media |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
DD266710A3 (de) | 1983-06-06 | 1989-04-12 | Ve Forschungszentrum Biotechnologie | Verfahren zur biotechnischen Herstellung van alkalischer Phosphatase |
US4767704A (en) | 1983-10-07 | 1988-08-30 | Columbia University In The City Of New York | Protein-free culture medium |
US4496689A (en) | 1983-12-27 | 1985-01-29 | Miles Laboratories, Inc. | Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer |
US4965199A (en) | 1984-04-20 | 1990-10-23 | Genentech, Inc. | Preparation of functional human factor VIII in mammalian cells using methotrexate based selection |
US4879231A (en) | 1984-10-30 | 1989-11-07 | Phillips Petroleum Company | Transformation of yeasts of the genus pichia |
US4737456A (en) | 1985-05-09 | 1988-04-12 | Syntex (U.S.A.) Inc. | Reducing interference in ligand-receptor binding assays |
DE3675588D1 (de) | 1985-06-19 | 1990-12-20 | Ajinomoto Kk | Haemoglobin, das an ein poly(alkenylenoxid) gebunden ist. |
GB8516415D0 (en) | 1985-06-28 | 1985-07-31 | Celltech Ltd | Culture of animal cells |
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EP0435911B1 (en) | 1988-09-23 | 1996-03-13 | Cetus Oncology Corporation | Cell culture medium for enhanced cell growth, culture longevity and product expression |
FR2646437B1 (fr) | 1989-04-28 | 1991-08-30 | Transgene Sa | Nouvelles sequences d'adn, leur application en tant que sequence codant pour un peptide signal pour la secretion de proteines matures par des levures recombinantes, cassettes d'expression, levures transformees et procede de preparation de proteines correspondant |
EP0402226A1 (en) | 1989-06-06 | 1990-12-12 | Institut National De La Recherche Agronomique | Transformation vectors for yeast yarrowia |
US5122469A (en) | 1990-10-03 | 1992-06-16 | Genentech, Inc. | Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins |
WO1994004679A1 (en) | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
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ES2091684T3 (es) | 1992-11-13 | 1996-11-01 | Idec Pharma Corp | Aplicacion terapeutica de anticuerpos quimericos y radiomarcados contra el antigeno de diferenciacion restringida de los linfocitos b humanos para el tratamiento del linfoma de las celulas b. |
US6096871A (en) | 1995-04-14 | 2000-08-01 | Genentech, Inc. | Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life |
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US7750122B2 (en) * | 2005-06-06 | 2010-07-06 | Wyeth Llc | Anti-TrkB monoclonal antibodies and uses thereof |
AU2007316418A1 (en) | 2006-11-09 | 2008-05-15 | Irm Llc | Agonist TrkB antibodies and uses thereof |
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US9200080B2 (en) | 2010-09-03 | 2015-12-01 | Horacio Uri Saragovi | Agonistic antibodies to TrkC receptors and uses thereof |
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EP3717514A1 (en) | 2017-11-30 | 2020-10-07 | Regeneron Pharmaceuticals, Inc. | Anti-trkb monoclonal antibodies and methods of use |
-
2018
- 2018-06-07 US US16/002,058 patent/US10793634B2/en active Active
- 2018-06-08 AU AU2018279184A patent/AU2018279184A1/en active Pending
- 2018-06-08 UA UAA201911908A patent/UA127967C2/uk unknown
- 2018-06-08 AR ARP180101558 patent/AR112602A1/es unknown
- 2018-06-08 IL IL271067A patent/IL271067B1/en unknown
- 2018-06-08 TW TW112123529A patent/TW202342100A/zh unknown
- 2018-06-08 PE PE2019002525A patent/PE20200173A1/es unknown
- 2018-06-08 CA CA3063965A patent/CA3063965A1/en active Pending
- 2018-06-08 SG SG11201911814UA patent/SG11201911814UA/en unknown
- 2018-06-08 KR KR1020197037817A patent/KR20200017421A/ko active Search and Examination
- 2018-06-08 MA MA049257A patent/MA49257A/fr unknown
- 2018-06-08 CN CN201880038098.6A patent/CN110719916A/zh active Pending
- 2018-06-08 BR BR112019023742A patent/BR112019023742A2/pt unknown
- 2018-06-08 MX MX2019014714A patent/MX2019014714A/es unknown
- 2018-06-08 WO PCT/EP2018/065107 patent/WO2018224630A1/en active Application Filing
- 2018-06-08 JP JP2019567701A patent/JP7267208B2/ja active Active
- 2018-06-08 EA EA201992883A patent/EA201992883A1/ru unknown
- 2018-06-08 TW TW107119755A patent/TWI808086B/zh active
- 2018-06-08 EP EP18731764.9A patent/EP3635004A1/en active Pending
-
2019
- 2019-11-28 PH PH12019502694A patent/PH12019502694A1/en unknown
- 2019-12-05 CL CL2019003557A patent/CL2019003557A1/es unknown
- 2019-12-05 CO CONC2019/0013718A patent/CO2019013718A2/es unknown
-
2020
- 2020-08-26 US US17/002,907 patent/US11866501B2/en active Active
-
2023
- 2023-04-19 JP JP2023068735A patent/JP2023093621A/ja active Pending
- 2023-11-28 US US18/520,650 patent/US20240101689A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
UA127967C2 (uk) | 2024-02-28 |
EP3635004A1 (en) | 2020-04-15 |
MA49257A (fr) | 2020-04-15 |
US20240101689A1 (en) | 2024-03-28 |
AU2018279184A1 (en) | 2019-11-21 |
JP2023093621A (ja) | 2023-07-04 |
TWI808086B (zh) | 2023-07-11 |
PE20200173A1 (es) | 2020-01-24 |
US10793634B2 (en) | 2020-10-06 |
EA201992883A1 (ru) | 2020-05-08 |
BR112019023742A2 (pt) | 2020-06-09 |
AR112602A1 (es) | 2019-11-20 |
CA3063965A1 (en) | 2018-12-13 |
SG11201911814UA (en) | 2020-01-30 |
IL271067B1 (en) | 2024-02-01 |
JP7267208B2 (ja) | 2023-05-01 |
CN110719916A (zh) | 2020-01-21 |
JP2020522270A (ja) | 2020-07-30 |
US11866501B2 (en) | 2024-01-09 |
US20180355046A1 (en) | 2018-12-13 |
CO2019013718A2 (es) | 2020-01-17 |
TW201920271A (zh) | 2019-06-01 |
PH12019502694A1 (en) | 2020-07-13 |
KR20200017421A (ko) | 2020-02-18 |
US20200399378A1 (en) | 2020-12-24 |
TW202342100A (zh) | 2023-11-01 |
WO2018224630A1 (en) | 2018-12-13 |
IL271067A (en) | 2020-01-30 |
MX2019014714A (es) | 2020-02-07 |
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