DK3380496T3 - Forbedret proteinproduktion og fremgangsmåder hertil - Google Patents
Forbedret proteinproduktion og fremgangsmåder hertil Download PDFInfo
- Publication number
- DK3380496T3 DK3380496T3 DK16831675.0T DK16831675T DK3380496T3 DK 3380496 T3 DK3380496 T3 DK 3380496T3 DK 16831675 T DK16831675 T DK 16831675T DK 3380496 T3 DK3380496 T3 DK 3380496T3
- Authority
- DK
- Denmark
- Prior art keywords
- methods
- protein production
- improved protein
- improved
- production
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C12N15/75—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Bacillus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/32—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bacillus (G)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
- C12N9/54—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/24—Metalloendopeptidases (3.4.24)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562387578P | 2015-12-23 | 2015-12-23 | |
| US201662308440P | 2016-03-15 | 2016-03-15 | |
| PCT/US2016/067936 WO2017112733A1 (en) | 2015-12-23 | 2016-12-21 | Enhanced protein production and methods thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3380496T3 true DK3380496T3 (da) | 2020-08-24 |
Family
ID=57910120
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK16831675.0T DK3380496T3 (da) | 2015-12-23 | 2016-12-21 | Forbedret proteinproduktion og fremgangsmåder hertil |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20180371445A1 (da) |
| EP (1) | EP3380496B1 (da) |
| JP (1) | JP6993339B2 (da) |
| KR (1) | KR20180088915A (da) |
| CN (1) | CN108779154B (da) |
| DK (1) | DK3380496T3 (da) |
| WO (1) | WO2017112733A1 (da) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201508025D0 (en) | 2015-05-11 | 2015-06-24 | Ucl Business Plc | Fabry disease gene therapy |
| EP3735478B1 (en) | 2018-01-03 | 2023-08-16 | Danisco US Inc. | Mutant and genetically modified bacillus cells and methods thereof for increased protein production |
| EP3887526A1 (en) * | 2018-11-28 | 2021-10-06 | Danisco US Inc. | Novel promoter sequences and methods thereof for enhanced protein production in bacillus cells |
| CN109456929A (zh) * | 2018-12-13 | 2019-03-12 | 江南大学 | 一种产磷脂酶d的重组枯草芽孢杆菌及其应用 |
| US20220389474A1 (en) * | 2019-10-28 | 2022-12-08 | Danisco Us Inc. | Microbial host cells for the production of heterologous cyanuric acid hydrolases and biuret hydrolases |
| WO2023104846A1 (en) * | 2021-12-10 | 2023-06-15 | Novozymes A/S | Improved protein production in recombinant bacteria |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5264366A (en) | 1984-05-29 | 1993-11-23 | Genencor, Inc. | Protease deficient bacillus |
| US6762039B2 (en) * | 1997-07-15 | 2004-07-13 | Genencor International, Inc. | Bacillus subtillis with an inactivated cysteine protease-1 |
| US6509185B1 (en) | 2000-01-07 | 2003-01-21 | Genencor International, Inc. | Mutant aprE promotor |
| JP5629584B2 (ja) * | 2007-12-21 | 2014-11-19 | ダニスコ・ユーエス・インク | バチルス内での促進されたタンパク質生成 |
| AR076941A1 (es) | 2009-06-11 | 2011-07-20 | Danisco Us Inc | Cepa de bacillus para una mayor produccion de proteina |
| CN102220366B (zh) * | 2011-04-27 | 2013-12-04 | 南京农业大学 | 通过超量表达comA基因提高枯草芽孢杆菌抗菌肽产量的方法 |
| JP6378089B2 (ja) | 2011-12-09 | 2018-08-22 | ダニスコ・ユーエス・インク | 微生物におけるタンパク質産生のための、Ｂ．ズブチリス（Ｂ．ｓｕｂｔｉｌｉｓ）からのリボソームプロモーター |
-
2016
- 2016-12-21 DK DK16831675.0T patent/DK3380496T3/da active
- 2016-12-21 WO PCT/US2016/067936 patent/WO2017112733A1/en active Application Filing
- 2016-12-21 US US16/064,710 patent/US20180371445A1/en not_active Abandoned
- 2016-12-21 JP JP2018533603A patent/JP6993339B2/ja active Active
- 2016-12-21 KR KR1020187021108A patent/KR20180088915A/ko not_active Application Discontinuation
- 2016-12-21 CN CN201680082390.9A patent/CN108779154B/zh active Active
- 2016-12-21 EP EP16831675.0A patent/EP3380496B1/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP3380496B1 (en) | 2020-05-20 |
| CN108779154A (zh) | 2018-11-09 |
| JP2019505196A (ja) | 2019-02-28 |
| KR20180088915A (ko) | 2018-08-07 |
| JP6993339B2 (ja) | 2022-02-21 |
| WO2017112733A1 (en) | 2017-06-29 |
| EP3380496A1 (en) | 2018-10-03 |
| US20180371445A1 (en) | 2018-12-27 |
| CN108779154B (zh) | 2022-12-27 |
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