CA3031168A1 - Combination therapy for cancer - Google Patents
Combination therapy for cancer Download PDFInfo
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- CA3031168A1 CA3031168A1 CA3031168A CA3031168A CA3031168A1 CA 3031168 A1 CA3031168 A1 CA 3031168A1 CA 3031168 A CA3031168 A CA 3031168A CA 3031168 A CA3031168 A CA 3031168A CA 3031168 A1 CA3031168 A1 CA 3031168A1
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- C07—ORGANIC CHEMISTRY
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- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
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- Health & Medical Sciences (AREA)
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- General Health & Medical Sciences (AREA)
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- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
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- Endocrinology (AREA)
- Radiology & Medical Imaging (AREA)
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| US201662374621P | 2016-08-12 | 2016-08-12 | |
| US62/374,621 | 2016-08-12 | ||
| PCT/EP2017/070513 WO2018029367A1 (en) | 2016-08-12 | 2017-08-11 | Combination therapy for cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3031168A1 true CA3031168A1 (en) | 2018-02-15 |
Family
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Family Applications (1)
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| CA3031168A Pending CA3031168A1 (en) | 2016-08-12 | 2017-08-11 | Combination therapy for cancer |
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| EP (1) | EP3497130B1 (enExample) |
| JP (1) | JP7573365B2 (enExample) |
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| CN (1) | CN109641963A (enExample) |
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| BR (1) | BR112019001818A2 (enExample) |
| CA (1) | CA3031168A1 (enExample) |
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| RU (1) | RU2019106663A (enExample) |
| SG (1) | SG11201901126UA (enExample) |
| WO (1) | WO2018029367A1 (enExample) |
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| WO2015027082A1 (en) | 2013-08-22 | 2015-02-26 | Acceleron Pharma, Inc. | Tgf-beta receptor type ii variants and uses thereof |
| CA2994413A1 (en) | 2015-08-04 | 2017-02-09 | Acceleron Pharma, Inc. | Methods for treating myeloproliferative disorders |
| DK3628049T3 (da) | 2017-05-04 | 2023-08-14 | Acceleron Pharma Inc | Tgf-beta-receptortype-ii-fusionsproteiner og anvendelser deraf |
| CA3094500A1 (en) * | 2018-03-23 | 2019-09-26 | The University Of Western Australia | Method for immunotherapy drug treatment |
| KR20210006405A (ko) * | 2018-05-04 | 2021-01-18 | 메르크 파텐트 게엠베하 | 암의 치료를 위한 PD-1/PD-L1, TGFβ 및 DNA-PK의 조합 억제 |
| SG11202011148VA (en) * | 2018-05-15 | 2020-12-30 | Merck Patent Gmbh | Dosing regimens for targeted tgf-b inhibition for use in treating cancer in treatment naive subjects |
| EP3806842A4 (en) * | 2018-06-13 | 2022-03-16 | Merck Patent GmbH | Treatment of stage iii nsclc and mitigation of pathological conditions associated with the treatment |
| KR20210028219A (ko) * | 2018-07-02 | 2021-03-11 | 메르크 파텐트 게엠베하 | 진행성 비소세포 폐암의 치료를 위한 표적화된 TGF-β 억제와의 조합 요법 |
| KR20210042909A (ko) * | 2018-07-09 | 2021-04-20 | 프레시전 인코포레이티드 | 융합 구조물 및 그의 이용 방법 |
| AU2019389354A1 (en) * | 2018-11-30 | 2021-07-15 | Jiangsu Hengrui Medicine Co., Ltd. | Anti-CD40 antibody, antigen binding fragment and pharmaceutical use thereof |
| SG11202108099WA (en) | 2019-01-30 | 2021-08-30 | Scholar Rock Inc | LTBP COMPLEX-SPECIFIC INHIBITORS OF TGFβ AND USES THEREOF |
| EP3693974A1 (en) * | 2019-02-07 | 2020-08-12 | Koninklijke Philips N.V. | Identifying responsiveness to radio-immuno combination therapy |
| WO2020248926A1 (zh) * | 2019-06-10 | 2020-12-17 | 山东博安生物技术有限公司 | 抗PDL1和TGFβ的双功能融合蛋白及其用途 |
| EP3990116A1 (en) * | 2019-06-28 | 2022-05-04 | Gensun Biopharma Inc. | ANTITUMOR ANTAGONIST CONSISTING OF A MUTATED TGFß1 - RII EXTRACELLULAR DOMAIN AND AN IMMUNOGLOBULIN SCAFFOLD |
| CN112442132A (zh) * | 2019-09-05 | 2021-03-05 | 复旦大学 | 靶向肿瘤的重组双功能融合蛋白及其应用 |
| AU2020352441A1 (en) * | 2019-09-12 | 2022-04-28 | Sirnaomics, Inc. | Co-delivery of TGF-β siRNA and PDL1 siRNA to treat cancer |
| CN112574314A (zh) * | 2019-09-30 | 2021-03-30 | 和铂医药(苏州)有限公司 | 一种融合蛋白及其应用 |
| US11802145B2 (en) | 2019-10-21 | 2023-10-31 | Nanjing Leads Biolabs Co., Ltd. | Recombinant protein targeting PD-1 and TGFß |
| JP2023501971A (ja) * | 2019-11-01 | 2023-01-20 | アレス トレーディング ソシエテ アノニム | 癌の治療のための、放射線療法と共に用いるＰＤ－１、ＴＧＦβ、及びＡＴＭの組み合わせ阻害 |
| US20230340122A1 (en) * | 2019-11-05 | 2023-10-26 | Glaxosmithkline Intellectual Property (No. 4) Ltd. | Combined inhibition of pd-1, tgfb and tigit for the treatment of cancer |
| CN115996955A (zh) * | 2019-12-11 | 2023-04-21 | 上海药明生物技术有限公司 | 针对PD-L1和TGFβ的双功能抗体 |
| EP3838260A1 (en) | 2019-12-20 | 2021-06-23 | Ares Trading S.A. | Igg:tgf rii fusion protein composition |
| EP4076388A1 (en) | 2019-12-20 | 2022-10-26 | Ares Trading S.A. | Igg:tgfbetarii fusion protein composition |
| BR112022013733A2 (pt) | 2020-01-11 | 2022-11-01 | Scholar Rock Inc | Inibidores de tgfbeta e uso dos mesmos |
| WO2021142448A2 (en) | 2020-01-11 | 2021-07-15 | Scholar Rock,Inc. | Tgf-beta inhibitors and use thereof |
| CN115175942B (zh) * | 2020-02-25 | 2025-05-30 | 上海药明生物技术有限公司 | 一种双功能融合蛋白及其用途 |
| WO2021209458A1 (en) | 2020-04-14 | 2021-10-21 | Ares Trading S.A. | Combination treatment of cancer |
| JP2023521465A (ja) * | 2020-04-14 | 2023-05-24 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッド | ＩＣＯＳ抗体とＰＤ－Ｌ１抗体ＴＧＦ－β－受容体融合タンパク質とに基づく癌の併用治療 |
| CA3188596A1 (en) | 2020-07-10 | 2022-01-13 | Precigen, Inc. | Fusion constructs and methods of using thereof |
| EP4194002A4 (en) * | 2020-07-24 | 2024-08-14 | Mabwell (Shanghai) Bioscience Co., Ltd. | TGF-BETA RII MUTANT AND ASSOCIATED FUSION PROTEIN |
| CN116323657B (zh) * | 2020-09-24 | 2023-12-08 | 上海齐鲁制药研究中心有限公司 | 同时靶向PD-L1和TGFβ的双功能分子及其医药用途 |
| CN116801906A (zh) | 2020-11-02 | 2023-09-22 | 阿雷斯贸易股份有限公司 | 癌症的联合治疗 |
| JP2023550900A (ja) * | 2020-11-02 | 2023-12-06 | アレス トレーディング ソシエテ アノニム | がんの組み合わせ治療 |
| WO2022204581A2 (en) | 2021-03-26 | 2022-09-29 | Scholar Rock, Inc. | Tgf-beta inhibitors and use thereof |
| WO2022233718A2 (en) | 2021-05-03 | 2022-11-10 | Merck Patent Gmbh | Her2 targeting fc antigen binding fragment-drug conjugates |
| IL308818A (en) | 2021-05-25 | 2024-01-01 | Merck Patent Gmbh | Egfr targeting fc antigen binding fragment-drug conjugates |
| EP4348260A2 (en) | 2021-06-03 | 2024-04-10 | Scholar Rock, Inc. | Tgf-beta inhibitors and therapeutic use thereof |
| WO2022258622A1 (en) | 2021-06-07 | 2022-12-15 | Ares Trading S.A. | Combination treatment of cancer |
| GB202215997D0 (en) * | 2022-10-28 | 2022-12-14 | Io Biotech Aps | Therapy |
| TW202434643A (zh) | 2023-01-09 | 2024-09-01 | 大陸商北京拓界生物醫藥科技有限公司 | ＴＧＦβ１結合分子、ＧＡＲＰ－ＴＧＦβ１結合分子及其醫藥用途 |
| WO2024187051A1 (en) | 2023-03-07 | 2024-09-12 | Scholar Rock, Inc. | Tgf-beta inhibitors for use for treating resistant or unresponsive cancer in patients |
| WO2025240343A1 (en) | 2024-05-13 | 2025-11-20 | Scholar Rock, Inc. | Tgf-beta inhibitors for treating cancer |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2399832C (en) | 2000-02-11 | 2011-09-20 | Stephen D. Gillies | Enhancing the circulating half-life of antibody-based fusion proteins |
| CA2440221C (en) | 2001-03-07 | 2013-02-05 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Expression technology for proteins containing a hybrid isotype antibody moiety |
| WO2002079415A2 (en) | 2001-03-30 | 2002-10-10 | Lexigen Pharmaceuticals Corp. | Reducing the immunogenicity of fusion proteins |
| HRP20151102T1 (xx) | 2005-07-01 | 2015-11-20 | E. R. Squibb & Sons, L.L.C. | Humana monoklonska antitijela za ligand programirane smrti 1 (pd-l1) |
| KR20250091300A (ko) | 2008-12-09 | 2025-06-20 | 제넨테크, 인크. | 항-ｐｄ-ｌ１ 항체 및 ｔ 세포 기능을 향상시키기 위한 그의 용도 |
| SMT202000561T1 (it) * | 2011-11-28 | 2021-01-05 | Merck Patent Gmbh | Anticorpi anti-pd-l1 e usi relativi |
| NZ714549A (en) * | 2012-04-30 | 2016-10-28 | Biocon Ltd | Targeted/immunomodulatory fusion proteins and methods for making same |
| RU2689760C2 (ru) * | 2012-05-31 | 2019-05-30 | Дженентек, Инк. | Способы лечения рака с применением антагонистов аксиального связывания pd-1 и vegf антагонистов |
| SG10202108879SA (en) * | 2014-02-10 | 2021-09-29 | Merck Patent Gmbh | TARGETED TGFβ INHIBITION |
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2017
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- 2017-08-11 IL IL264730A patent/IL264730B2/en unknown
- 2017-08-11 CN CN201780049391.8A patent/CN109641963A/zh active Pending
- 2017-08-11 WO PCT/EP2017/070513 patent/WO2018029367A1/en not_active Ceased
- 2017-08-11 BR BR112019001818A patent/BR112019001818A2/pt unknown
- 2017-08-11 US US15/674,655 patent/US20180118832A1/en not_active Abandoned
- 2017-08-11 SG SG11201901126UA patent/SG11201901126UA/en unknown
- 2017-08-11 KR KR1020237028359A patent/KR20230125859A/ko not_active Ceased
- 2017-08-11 CA CA3031168A patent/CA3031168A1/en active Pending
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- 2017-08-11 MX MX2019001503A patent/MX2019001503A/es unknown
- 2017-08-11 JP JP2019506349A patent/JP7573365B2/ja active Active
- 2017-08-11 RU RU2019106663A patent/RU2019106663A/ru unknown
- 2017-08-11 AU AU2017310027A patent/AU2017310027A1/en not_active Abandoned
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2019
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- 2019-02-07 PH PH12019500270A patent/PH12019500270A1/en unknown
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2021
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2024
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Also Published As
| Publication number | Publication date |
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| IL264730B2 (en) | 2024-09-01 |
| US20220017621A1 (en) | 2022-01-20 |
| US20180118832A1 (en) | 2018-05-03 |
| MX2019001503A (es) | 2019-06-03 |
| AU2024219446A1 (en) | 2024-09-26 |
| JP2019527706A (ja) | 2019-10-03 |
| AU2017310027A1 (en) | 2019-01-31 |
| PH12019500270A1 (en) | 2019-07-01 |
| ES2905663T3 (es) | 2022-04-11 |
| RU2019106663A (ru) | 2020-09-14 |
| KR20190039200A (ko) | 2019-04-10 |
| EP3497130A1 (en) | 2019-06-19 |
| EP3497130B1 (en) | 2021-10-27 |
| IL264730B1 (en) | 2024-05-01 |
| WO2018029367A1 (en) | 2018-02-15 |
| JP7573365B2 (ja) | 2024-10-25 |
| RU2019106663A3 (enExample) | 2020-11-26 |
| KR20250028537A (ko) | 2025-02-28 |
| IL264730A (en) | 2019-03-31 |
| KR20230125859A (ko) | 2023-08-29 |
| BR112019001818A2 (pt) | 2019-05-07 |
| SG11201901126UA (en) | 2019-03-28 |
| CL2019000277A1 (es) | 2019-07-05 |
| CN109641963A (zh) | 2019-04-16 |
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