JP2011103891A5 - - Google Patents
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- Publication number
- JP2011103891A5 JP2011103891A5 JP2011010411A JP2011010411A JP2011103891A5 JP 2011103891 A5 JP2011103891 A5 JP 2011103891A5 JP 2011010411 A JP2011010411 A JP 2011010411A JP 2011010411 A JP2011010411 A JP 2011010411A JP 2011103891 A5 JP2011103891 A5 JP 2011103891A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- amino acid
- seq
- acid residues
- tumor cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004881 tumor cell Anatomy 0.000 claims 24
- 125000000539 amino acid group Chemical group 0.000 claims 16
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 10
- 229920001184 polypeptide Polymers 0.000 claims 10
- 108090000765 processed proteins & peptides Proteins 0.000 claims 10
- 102000004196 processed proteins & peptides Human genes 0.000 claims 10
- 125000003275 alpha amino acid group Chemical group 0.000 claims 9
- 101150092419 STRA6 gene Proteins 0.000 claims 7
- 210000004027 cell Anatomy 0.000 claims 7
- 229940127089 cytotoxic agent Drugs 0.000 claims 7
- 150000004492 retinoid derivatives Chemical class 0.000 claims 7
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 5
- 239000002254 cytotoxic agent Substances 0.000 claims 4
- 230000002401 inhibitory effect Effects 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 206010006187 Breast cancer Diseases 0.000 claims 3
- 208000026310 Breast neoplasm Diseases 0.000 claims 3
- 101100156752 Caenorhabditis elegans cwn-1 gene Proteins 0.000 claims 3
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 3
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 3
- 102000052547 Wnt-1 Human genes 0.000 claims 3
- 108700020987 Wnt-1 Proteins 0.000 claims 3
- 239000002246 antineoplastic agent Substances 0.000 claims 3
- 231100000599 cytotoxic agent Toxicity 0.000 claims 3
- 208000023965 endometrium neoplasm Diseases 0.000 claims 3
- 230000009395 genetic defect Effects 0.000 claims 3
- 208000020816 lung neoplasm Diseases 0.000 claims 3
- 208000037841 lung tumor Diseases 0.000 claims 3
- 201000001441 melanoma Diseases 0.000 claims 3
- 230000037361 pathway Effects 0.000 claims 3
- 208000028591 pheochromocytoma Diseases 0.000 claims 3
- 102000015735 Beta-catenin Human genes 0.000 claims 2
- 108060000903 Beta-catenin Proteins 0.000 claims 2
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 2
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 2
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 2
- 239000012190 activator Substances 0.000 claims 2
- SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 claims 2
- 231100000433 cytotoxic Toxicity 0.000 claims 2
- 230000001472 cytotoxic effect Effects 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 230000012010 growth Effects 0.000 claims 2
- 229940002612 prodrug Drugs 0.000 claims 2
- 239000000651 prodrug Substances 0.000 claims 2
- 238000001959 radiotherapy Methods 0.000 claims 2
- 229930002330 retinoic acid Natural products 0.000 claims 2
- 229960001727 tretinoin Drugs 0.000 claims 2
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 1
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 1
- 230000002159 abnormal effect Effects 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 230000030833 cell death Effects 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000007547 defect Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 230000002018 overexpression Effects 0.000 claims 1
- 230000011664 signaling Effects 0.000 claims 1
- 229940126585 therapeutic drug Drugs 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 230000004565 tumor cell growth Effects 0.000 claims 1
- 230000004614 tumor growth Effects 0.000 claims 1
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17584900P | 2000-01-13 | 2000-01-13 | |
| US60/175,849 | 2000-01-13 | ||
| US19708900P | 2000-04-14 | 2000-04-14 | |
| US60/197,089 | 2000-04-14 | ||
| US22891400P | 2000-08-29 | 2000-08-29 | |
| US60/228,914 | 2000-08-29 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001551209A Division JP2003519491A (ja) | 2000-01-13 | 2001-01-11 | 新規なｓｔｒａ６ポリペプチド |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011103891A JP2011103891A (ja) | 2011-06-02 |
| JP2011103891A5 true JP2011103891A5 (enExample) | 2012-11-29 |
| JP5701624B2 JP5701624B2 (ja) | 2015-04-15 |
Family
ID=27390600
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001551209A Pending JP2003519491A (ja) | 2000-01-13 | 2001-01-11 | 新規なｓｔｒａ６ポリペプチド |
| JP2011010411A Expired - Fee Related JP5701624B2 (ja) | 2000-01-13 | 2011-01-21 | 新規なｓｔｒａ６ポリペプチド |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001551209A Pending JP2003519491A (ja) | 2000-01-13 | 2001-01-11 | 新規なｓｔｒａ６ポリペプチド |
Country Status (15)
| Country | Link |
|---|---|
| US (7) | US7173115B2 (enExample) |
| EP (1) | EP1246917B1 (enExample) |
| JP (2) | JP2003519491A (enExample) |
| KR (2) | KR20080006002A (enExample) |
| CN (2) | CN1425066B (enExample) |
| AT (1) | ATE424457T1 (enExample) |
| AU (2) | AU785055B2 (enExample) |
| CA (1) | CA2397207C (enExample) |
| DE (1) | DE60137829D1 (enExample) |
| DK (1) | DK1246917T3 (enExample) |
| ES (1) | ES2323220T3 (enExample) |
| IL (2) | IL150676A0 (enExample) |
| NZ (1) | NZ520095A (enExample) |
| PT (1) | PT1246917E (enExample) |
| WO (1) | WO2001051635A2 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001051635A2 (en) * | 2000-01-13 | 2001-07-19 | Genentech, Inc. | Novel stra6 polypeptides |
| CA2406527A1 (en) * | 2000-03-23 | 2002-10-03 | Curagen Corporation | Novel human stras-like protein and nucleic acids encoding the same |
| CN1339489A (zh) * | 2000-08-23 | 2002-03-13 | 上海博德基因开发有限公司 | 一种新的多肽——人视黄酸效应蛋白53.57和编码这种多肽的多核苷酸 |
| KR20080068147A (ko) * | 2000-08-29 | 2008-07-22 | 제넨테크, 인크. | 암 치료의 효능을 증진시키는 방법 |
| AU2002308557A1 (en) * | 2001-05-01 | 2002-11-11 | The Regents Of The University Of California | Wnt and frizzled receptors as targets for immunotherapy in head and neck squamous cell carcinomas |
| EP1488007A4 (en) * | 2002-03-13 | 2006-05-03 | Genomic Health Inc | GENE EXPRESSION PROFILING IN PUNCTUALLY TUMOR TISSUES |
| US7666627B2 (en) * | 2002-08-08 | 2010-02-23 | Targetex Kft. | Folded recombinant catalytic fragments of multidomain serine proteases, preparation and uses thereof |
| WO2004039412A2 (en) * | 2002-10-29 | 2004-05-13 | Engene, Inc. | Compositions for cancer treatment |
| US7326687B2 (en) * | 2003-04-30 | 2008-02-05 | Centocor, Inc. | CNGH0010 specific polynucleotides, polypeptides, antibodies, compositions, methods and uses |
| US20060074480A1 (en) * | 2004-09-01 | 2006-04-06 | Pst, Llc | Stent and method for manufacturing the stent |
| WO2008089438A2 (en) * | 2007-01-18 | 2008-07-24 | The Regents Of The University Of California | A membrane receptor for retinol binding protein mediates cellular uptake of vitamin a, methods of use and compositions |
| US20110159017A1 (en) * | 2008-04-11 | 2011-06-30 | Ludwig Institute For Cancer Research Ltd. | Trytophan catabolism in cancer treatment and diagnosis |
| US20120183477A1 (en) * | 2009-06-26 | 2012-07-19 | Five Prime Therapeutics, Inc. | Therapeutic Antibody Target Validation and Screening In Vivo |
| DK3178944T3 (da) * | 2010-01-11 | 2019-08-12 | Genomic Health Inc | Fremgangsmåde til anvendelse af genekspression til bestemmelse af sandsynligheden for et klinisk resultat for nyrecancer |
| IL243205A (en) * | 2010-07-27 | 2017-04-30 | Genomic Health Inc | Method for using gene expression to determine prognosis of prostate cancer |
| EP3179393B1 (en) | 2012-01-31 | 2020-07-08 | Genomic Health, Inc. | Gene expression profile algorithm and test for determining prognosis of prostate cancer |
| RU2014133069A (ru) | 2012-02-11 | 2016-04-10 | Дженентек, Инк. | Транслокации r-спондина и способы с их использованием |
| EP3825420A1 (en) | 2013-05-30 | 2021-05-26 | Genomic Health, Inc. | Gene expression profile algorithm for calculating a recurrence score for a patient with kidney cancer |
| EP3636661A1 (en) * | 2018-10-12 | 2020-04-15 | Bioc3 | Phosphate translocator |
| CN116287211B (zh) * | 2023-03-24 | 2025-10-10 | 中国医学科学院北京协和医院 | STRA6和miR-1249-5p在制备诊断子宫腺肌症的产品中的应用 |
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-
2001
- 2001-01-11 WO PCT/US2001/000847 patent/WO2001051635A2/en not_active Ceased
- 2001-01-11 PT PT01904821T patent/PT1246917E/pt unknown
- 2001-01-11 CN CN018064965A patent/CN1425066B/zh not_active Expired - Fee Related
- 2001-01-11 AU AU32768/01A patent/AU785055B2/en not_active Ceased
- 2001-01-11 US US09/759,056 patent/US7173115B2/en not_active Expired - Fee Related
- 2001-01-11 IL IL15067601A patent/IL150676A0/xx unknown
- 2001-01-11 KR KR1020077028133A patent/KR20080006002A/ko not_active Ceased
- 2001-01-11 ES ES01904821T patent/ES2323220T3/es not_active Expired - Lifetime
- 2001-01-11 NZ NZ520095A patent/NZ520095A/en not_active IP Right Cessation
- 2001-01-11 EP EP01904821A patent/EP1246917B1/en not_active Expired - Lifetime
- 2001-01-11 CN CN200910147020A patent/CN101643733A/zh active Pending
- 2001-01-11 DE DE60137829T patent/DE60137829D1/de not_active Expired - Lifetime
- 2001-01-11 CA CA2397207A patent/CA2397207C/en not_active Expired - Fee Related
- 2001-01-11 AT AT01904821T patent/ATE424457T1/de active
- 2001-01-11 DK DK01904821T patent/DK1246917T3/da active
- 2001-01-11 JP JP2001551209A patent/JP2003519491A/ja active Pending
- 2001-07-10 US US09/901,812 patent/US20020173461A1/en not_active Abandoned
-
2002
- 2002-07-10 IL IL150676A patent/IL150676A/en not_active IP Right Cessation
- 2002-07-12 KR KR1020027009049A patent/KR100929057B1/ko not_active Expired - Fee Related
-
2006
- 2006-05-22 US US11/438,488 patent/US7741439B2/en not_active Expired - Fee Related
- 2006-07-18 US US11/458,237 patent/US20070025998A1/en not_active Abandoned
- 2006-07-18 US US11/458,181 patent/US7939650B2/en not_active Expired - Fee Related
- 2006-11-24 AU AU2006241374A patent/AU2006241374B2/en not_active Ceased
-
2007
- 2007-10-31 US US11/932,861 patent/US7855278B2/en not_active Expired - Fee Related
-
2010
- 2010-11-11 US US12/944,519 patent/US20110171238A1/en not_active Abandoned
-
2011
- 2011-01-21 JP JP2011010411A patent/JP5701624B2/ja not_active Expired - Fee Related
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